Effect of Mandatory Radiology Consultation on Inpatient Imaging Use : A Randomized Controlled Trial

Bree, Robert L.,Kazerooni, Ella A.,Katz, Steven J. MediMedia Korea 1997 JAMA-Korea Vol.12 No.2

Lebesgue’s criterion for the Riemann integration with respect to a state on a separable unital C*- algebra

A. I. Shtern 장전수학회 2016 Advanced Studies in Contemporary Mathematics Vol.26 No.2

In the paper “Semicontinuous envelopes, Riemann integral, and uniform distribution in C*-algebras” (Funct. Anal. Appl. 29 (4), 268– 275 (1995)(1996)), the author had constructed the Riemann integral with respect to a state on a separable unital C*-algebra A. In particular, the semicontinuous hulls of elements of the enveloping von Neumann algebra A of A were introduced and studied and, for a given state ! on A, a class of selfadjoint elements of the algebra A that are Riemann integrable with respect to the state ω were introduced. It was also proved that this class is the self-adjoint part of a C*-algebra, and relations to the uniform distribution of states of the C*-algebra A with respect to the state ω were indicated. In the present note, we supplement these results by a version of Lebesgue’s criterion for the Riemann integrability of self-adjoint elements of A.

Van der Waerden's continuity theorem for the commutator subgroups of connected Lie groups and Mishchenko's conjecture

A. I. Shtern 장전수학회 2006 Advanced Studies in Contemporary Mathematics Vol.13 No.2

As was proved by van der Waerden in 1933, every finite-dimensional locally bounded representation of a semisimple compact Lie group is continuous. In this paper, with the help of an earlier result of the author claiming that the van der Waerden theorem holds for any connected semisimple Lie group, it is proved that every locally bounded finite-dimensional representation of a connected Lie group is continuous on the commutator subgroup of the group; moreover, it turns out that a connected Lie group satis¯es the assertion of the van der Waerden theorem (i.e., all locally bounded finite-dimensional representations of the group are continuous) if and only if the group is perfect (i.e., coincides with the commutator subgroup). Thus, for perfect connected linear Lie groups, the structure of (totally) bounded sets de¯nes the topology, and any boundedness-preserving group isomorphism of a perfect connected linear Lie group onto another perfect connected linear Lie group is automatically continuous. To study this phenomenon, the notion of discontinuity group of a locally bounded finite-dimensional representation of a topological group is introduced and studied. The notion of local boundedness of a representation is naturally related to the notion of point oscillation (at the identity element of the group) introduced by the author in 2002. According to a conjecture expressed by A. S. Mishchenko, the finite-dimensional representations of Lie groups can take only three possible values for the (reasonably defined) point oscillation, namely, 0, 2, and 1. We prove the validity of the conjecture. As a corollary, we prove that the class of connected Lie groups for which the point oscillation of a finite-dimensional representation can take only two values, 0 and 1, is the very class of perfect connected Lie groups. Related open problems are indicated.

Couette-Taylor crystallizer: Effective control of crystal size distribution and recovery of l-lysine in cooling crystallization

Nguyen, A.T.,Yu, T.,Kim, W.S. North-Holland Pub. Co 2017 Journal of crystal growth Vol.469 No.-

A Couette-Taylor crystallizer is developed to enhance the l-Lysine crystal size distribution and recovery in the case of continuous cooling crystallization. When using the proposed Couette-Taylor (CT) crystallizer, the size distribution and crystal product recovery were much narrower and higher, respectively, than those from a conventional stirred tank (ST) crystallizer. Here, the coefficient of the size distribution for the crystal product from the CT crystallizer was only 0.45, while it was 0.78 in the case of the conventional ST crystallizer at an agitation speed of 700rpm, mean residence time of 20min, and feed concentration of 900(g/L). Furthermore, when using the CT crystallizer, the crystal product recovery was remarkably enhanced up to 100%wt with a mean residence time of only 20min, while it required a mean residence time of at least 60min when using the conventional ST crystallizer. This result indicates that the CT crystallizer was much more effective than the conventional ST crystallizer in terms of controlling a narrower size distribution and achieving a 100%wt l-lysine crystal product recovery from continuous cooling crystallization. The advantage of the CT crystallizer over the conventional ST crystallizer was explained based on the higher energy dissipation of the Taylor vortex flow and larger surface area for heat transfer of the CT crystallizer. Here, the energy dissipation of the Taylor vortex flow in the CT crystallizer was 13.6 times higher than that of the random fluid motion in the conventional ST crystallizer, while the surface area per unit volume for heat transfer of the CT crystallizer was 8.0 times higher than that of the conventional ST crystallizer. As a result, the mixing condition and heat transfer of the CT crystallizer were much more effective than those of the conventional ST crystallizer for the cooling crystallization of l-lysine, thereby enhancing the l-lysine crystal size distribution and product recovery.

A rationally designed small molecule for identifying an <i>in vivo</i> link between metal–amyloid-β complexes and the pathogenesis of Alzheimer's disease

Beck, Michael W.,Oh, Shin Bi,Kerr, Richard A.,Lee, Hyuck Jin,Kim, So Hee,Kim, Sujeong,Jang, Milim,Ruotolo, Brandon T.,Lee, Joo-Yong,Lim, Mi Hee Royal Society of Chemistry 2015 Chemical Science Vol.6 No.3

<▼1><P>An <I>in vivo</I> chemical tool designed to target metal–Aβ complexes and modulate their activity was applied to the 5XFAD mouse model of Alzheimer’s disease (AD) demonstrating the involvement of metal–Aβ in AD pathology.</P></▼1><▼2><P>Multiple factors, including amyloid-β (Aβ), metals, and reactive oxygen species (ROS), are involved in the development of Alzheimer's disease (AD). Metal ions can interact with Aβ species generating toxic oligomers and ROS <I>in vitro</I>; however, the involvement of metal–Aβ complexes in AD pathology <I>in vivo</I> remains unclear. To solve this uncertainty, we have developed a chemical tool (<B>L2-b</B>) that specifically targets metal–Aβ complexes and modulates their reactivity (<I>i.e.</I>, metal–Aβ aggregation, toxic oligomer formation, and ROS production). Through the studies presented herein, we demonstrate that <B>L2-b</B> is able to specifically interact with metal–Aβ complexes over metal-free Aβ analogues, redirect metal–Aβ aggregation into off-pathway, nontoxic less structured Aβ aggregates, and diminish metal–Aβ-induced ROS production, overall mitigating metal–Aβ-triggered toxicity, confirmed by multidisciplinary approaches. <B>L2-b</B> is also verified to enter the brain <I>in vivo</I> with relative metabolic stability. Most importantly, upon treatment of 5XFAD AD mice with <B>L2-b</B>, (i) metal–Aβ complexes are targeted and modulated in the brain; (ii) amyloid pathology is reduced; and (iii) cognition deficits are significantly improved. To the best of our knowledge, by employing an <I>in vivo</I> chemical tool specifically prepared for investigating metal–Aβ complexes, we report for the first time experimental evidence that metal–Aβ complexes are related directly to AD pathogenesis.</P></▼2>

Comparative and Structural Analysis of the Interaction between β-Lactoglobulin type A and B with a New Anticancer Component (2,2'-Bipyridin n-Hexyl Dithiocarbamato Pd(II) Nitrate)

A. Divsalar,A. A. Saboury*,H. Mansoori-Torshizi,B. Hemmatinejad 대한화학회 2006 Bulletin of the Korean Chemical Society Vol.27 No.11

The interaction between whey carrier protein b-lactoglobulin type A and B (BLG-A and -B) and 2,2'-bipyridin n-hexyl dithiocarbamato Pd(II) nitrate (BPHDC-Pd(II)), a new heavy metal complex designed for anticancer property, was investigated by fluorescence spectroscopy combined with chemometry and circular dichroism (CD) techniques. A strong fluorescence quenching reaction of BPHDC-Pd(II) to BLG-A and -B was observed. Hence, BPHDC-Pd(II) complex can be bound to both BLG-A and -B, and quench the fluorescence spectra of the proteins. The quenching constant was determined using the modified Stern-Volmer equation. The binding parameters were evaluated by fluorescence quenching method. The results of binding study provided evidences presence of two and three sets of binding sites on the BLG-B and -A, respectively, for BPHDC-Pd(II) complex. Using fluorescence spectroscopy and chemometry, the ability of BLG-A and -B to form an intermediate upon interaction with BPHDC-Pd(II) complex was assessed. CD studies displayed that under influence of different concentrations of BPHDC-Pd(II) complex, the regular secondary structure of BLG-B had no significant changes, whereas for BLG-A a transition from a-helix to b-structure was appeared. The results for both of BLG-A and -B displayed that BPHDC-Pd(II) complex can induce a conformational transition from the native form to an intermediate state with a slightly opened conformation, which is detectable with chemometry analyses.

간호대생과 의대생의 간호사 이미지 비교

구민진,김수영,방정민,서아영,양희진,윤소람,이윤재,이재은,이지연,정윤경,최수정 이화여자대학교 간호과학대학 2014 이화간호학회지 Vol.- No.48

Purpose: This study aims to analyze the difference in the perception that nursing students and medical students have regarding the image of nurses. Method: The sampling group for this study was made up of 111 nursing students and 117 medicine students, conducted from the 19th August 2013 to 3rd September 2013. The tool used for this study is the “Nurse Image Scale”. The data is analyzed using the SPSS 21.0 program, technical stats, t-test and ANOVA with Scheffe test. Result: There was a notable difference in the results(t=6.94, p<001), with the average image perception score of nurses at 3.84±0.34 amongst nursing students being higher than the 3.50±0.38 amongst Medicine students. The average score of the 4 areas tested, “Qualification of a Nurse”, “Role of a Nurse”, “Social Participation of a Nurse” and “Interpersonal Skills of a Nurse” were all marked higher by the nursing students than the medicine students. The average score became notably higher as the period of practice became shorter with nursing students (F=4.21, p=.043). Furthermore, the average score for the “Qualification of a Nurse” was notably higher as the period of practice became shorter (F=3.98, p=.049). Medical students gave an average score for the “Qualification of a Nurse”(F=3.72, p=.027) and the “Interpersonal Skills of a Nurse”(F=4.11, p=.019) which was relative to the development of a nurse’s image, while the average score for the “Role of a Nurse” was notably higher with a longer period of practice(F=6.65, p=.011). Conclusion: The results of this study suggest that the image perception of a nurse can vary depending on the experience in period of practice. Therefore, together with this study conducted with nursing students and medicine students, there is a need for further studies conducted on image perception of nurses with various experience in period of practice.

Upper edge-to-vertex detour monophonic number of a graph

A. P. Santhakumaran,P. Titus,K. Ganesamoorthy 장전수학회 2016 Advanced Studies in Contemporary Mathematics Vol.26 No.2

For a connected graph G = (V,E) of order at least three, the monophonic distance dm(u, v) is the length of a longest u−v monophonic path in G. A u − v path of length dm(u, v) is called a u − v detour monophonic. For subsets A and B of V , the monophonic distance dm(A,B) is defined as dm(A,B) = min{dm(x, y) : x ∈ A, y ∈ B}. A u−v path of length dm(A, B) is called an A−B detour monophonic path joining the sets A,B ⊆ V, where u ∈ A and v ∈ B. A set S ⊆ E is called an edge-to-vertex detour monophonic set of G if every vertex of G is incident with an edge of S or lies on a detour monophonic path joining a pair of edges of S. The edge-to-vertex detour monophonic number dmev(G) of G is the minimum cardinality of its edge-to-vertex detour monophonic sets and any edge-to-vertex detour monophonic set of car- dinality dmev(G) is an edge-to-vertex detour monophonic basis of G. An edge-to-vertex detour monophonic set S in a connected graph G is called a minimal edge-to-vertex detour monophonic set of G if no proper subset of S is an edge-to-vertex detour monophonic set of G. The upper edge-to-vertex detour monophonic number dm+ ev(G) of G is the maxi- mum cardinality of a minimal edge-to-vertex detour monophonic set of G. We determine bounds for it and certain general properties of these concepts are studied. It is shown that for every pair a, b of integers with 2 ≤ a ≤ b, there exists a connected graph G with dmev(G) = a and dm+ ev(G) = b.

Genetic Variation of SCN5A in Korean Patients with Sick Sinus Syndrome

Young-Soo Lee,Michael A Olaopa,정병천,이상희,신동구,박형섭,조용근,한상미,이명훈,김윤년 대한심장학회 2016 Korean Circulation Journal Vol.46 No.1

Background and Objectives: Due to recent studies that have shown an association between the genetic variation of SCN5A and sick sinus syndrome (SSS), we sought to determine if a similar correlation existed in Korean patients with SSS. Subjects and Methods: We enrolled 30 patients with SSS who showed a sinus pause (longer than 3.0 s) in Holter monitoring, in addition to 80 controls. All exons including the putative splicing sites of the SCN5A gene were amplified by polymerase chain reaction and sequenced either directly or following subcloning. Wild-type and single nucleotide polymorphisms were expressed in human embryonic kidney cells, and the peak sodium current (INa) was analyzed using the whole-cell patch-clamp technique. Results: A total of 9 genetic variations were identified: 7 variations (G87A-A29A, IVS9-3C>A, A1673G-H558R, G3823A-D1275N, T5457C-D1819D, T5963G-L1988R, and C5129T-S1710L) had been previously reported, and 2 variants (A3075T-E1025D and T4847A-F1616Y) were novel; the potential structural effects of F1616Y were analyzed in a three-dimensional model of the SCN5A domain. Patch-clamp studies at room temperature demonstrated that the peak INa was significantly increased by 140% in HEK cells transfected with F1616Y comparedwith wild-type (-335.13 pA/pF±24.04, n=8 vs. -139.95 pA/pF±23.76, n=7, respectively). Furthermore, the voltage dependency of theactivation and steady-state inactivation of F1616Y were leftward-shifted compared with wild-type (Vh activation=-55.36 mv±0.22, n=8 vs. Vh activation=-44.21 mV±0.17, n=7; respectively; Vh inactivation=-104.47 mV±0.21, n=7 vs. Vh inactivation=-84.89 mV±0.09, n=12, respectively). Conclusion: F1616Y may be associated with SSS.

On the edge -to -vertex detour number of a graph

A.P. Santhakumaran 장전수학회 2014 Advanced Studies in Contemporary Mathematics Vol.24 No.3

For two vertices u and v in a graph G=(V,E), The detour distance D(u,v) s the length of a longest, u-v path in G. A u-v path of length D(u,v) is called a u-v detour. For subsets A and B of V, the detour distance D(A,B) is defined as D(A,B)=(formula). A u-v path of length D(A,B) is called an A-B detour joining the sets A, B⊆V where u∈B. A vertex x is said to lie on an A-B detour is a vertex of A-B detour. A set S⊆E is called an detour joining a pair of edges of S. The edge-to-vertex detour number dn2(G) OF G is the minimum order of its edge-to-vertex detour sets and any edge-to-vertex detour set of order dn2(G) is an edge-to-vertex detour basis of G. Graphs G of size q for which dn2(G) = q or dn2(G) = q-1 or dn2(G) = q-2 are characterized.