http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
한국에서 반복 자연유산을 하는 535쌍의 부부에 있어서의 세포 유전학적 연구
황한성,양은석,홍원기,김미순,양영호,Hwang, Han Sung,Yang, Eun Suk,Hong, Won Ki,Kim, Mi Soon,Yang, Young Ho 대한생식의학회 2005 Clinical and Experimental Reproductive Medicine Vol.32 No.2
Objective: The purposes of this study were to investigate the types and the incidences of chromosomal abnormalities, and to provide an explanation for the genetic causations of recurrent spontaneous abortions in Korean population. Methods: Cytogenetic studies were carried out in 535 couples with at least two spontaneous first trimester abortions from January 1981 to December 2003. For karyotype analysis, we used modified Moorhead method by Giemsa staining and Giemsa-Trypsin-Giemsa banding Results: The overall incidence of chromosome abnormality was 32 out of 535 cases (5.98%). There were 25 cases (4.67%) of translocation and 7 cases (1.31%) of inversion. In translocation, 5 cases (0.93%) of Robertsonian translocation and 20 cases (3.74%) of reciprocal translocation were observed. In inversion, 6 cases (1.12%) of inversion of chromosome 9 and one case (0.19%) of inversion of chromosome 18 were found. Conclusion: In this study, overall chromosomal abnormality rate in couples with recurrent spontaneous abortions is much higher than that in the general population. So, chromosomal analysis should be offered for the prognostic information in genetic counseling such as prenatal diagnosis in couples with repetitive reproductive failure.
조기진통 임신부에서 성공적인 자궁 수축 억제의 예측 인자로서 highly sensitive C-reactive protein
황한성 ( Han Sung Hwang ),김민아 ( Min A Kim ),박용원 ( Yong Won Park ),김영한 ( Young Han Kim ) 대한산부인과학회 2007 Obstetrics & Gynecology Science Vol.50 No.4
Objective: The purpose of this study was to evaluate whether maternal serum highly sensitive C-reactive protein (hsCRP) could be use as a marker of prediction of tocolytic success in preterm labor pregnancy, and was more useful in comparison with other inflammatory factors. Methods: Maternal serum white blood cell (WBC) count, C-reactive protein (CRP), and hsCRP were determined in 87 patients in preterm labor and 68 controls. Preterm labor group was divided into tocolytic success group (n=44) and failure group (n=43). The levels of maternal serum WBC count, CRP, and hsCRP were evaluated using receiver operating characteristic (ROC) curve and area under the curve (AUC) to evaluate the relative value as prediction marker of tocolytic success in two preterm labor groups. The data were analyzed using student t-test. Results: There was no significant difference for maternal age, body mass index (BMI), gestational age, and parity between normal group and preterm labor group. But, WBC count and hsCRP were significantly higher in preterm labor group in comparison to normal group (p<0.001). In preterm labor group, there was no significant difference in maternal age, BMI, gestational age, and parity between tocolytic success group and failure group. But, WBC count, CRP, and hsCRP were significantly lower in tocolytic success group. In the prediction of tocolytic success, the AUCs of WBC count, CRP, and hsCRP were 0.65, 0.77, and 0.82, respectively. Conclusion: This study showed that serum levels of hsCRP may be used as a marker of prediction of tocolytic success in preterm labor pregnancy.
정상 산모와 전자간증 산모의 태반에서 Adenosine 수용체의 발현 양상
김영한 ( Young Han Kim ),조남훈 ( Nam Hoon Cho ),황한성 ( Han Sung Hwang ),권자영 ( Ja Young Kwon ),강명화 ( Myoung Hwa Kang ),박용원 ( Yong Won Park ) 대한산부인과학회 2007 Obstetrics & Gynecology Science Vol.50 No.5
Objective: The aim of the study was to investigate the differential expression of adenosine receptors (ADORs) in the normal and preeclamptic placenta. Methods: Placentas were obtained from women undergoing cesarean section with normal and preeclamptic pregnancies at term. Total RNA was reverse transcribed using ADORs gene specific primers. RT-PCR measurements were made semi-quantitatively. Western blot analysis was performed for protein quantitation. Immunohistochemical staining with anti-adenosine receptor antibodies were employed to localize adenosine receptors in placental tissues. Results: RT-PCR revealed that A2aR, A2bR, and A3R mRNA, not A1 receptor mRNA were expressed in both normal and preeclamptic placenta. Interestingly, there were somewhat higher expressions of A2aR, A2bR, and A3R mRNA in preeclamptic placenta than in normal placenta. Western blotting revealed that A2a, A2b, and A3 receptors were all present in the placental tissue as verified by immunoreactive protein bands. The bands for the A2a, A2b, and A3 receptors were stronger in preeclamptic placenta than in normal placenta. A2a and A2b receptors were detected in endothelial cell, whereas we could not find the staining for A3 receptor in endothelial cells. Importantly, A3 antibody had high intensity of staining in trophoblasts in preeclampsia. Conclusion: To our knowledge, this study is the first to evaluate the expression of ADORs in normal placenta, and to compare ADOR subtypes in normal versus preeclamptic placenta. This study suggests that the specific subtype of ADORs may have a role in the development of preeclampsia.
남가현 ( Ka Hyun Nam ),황한성 ( Han Sung Hwang ),곽동욱 ( Dong Wook Kwak ),박용원 ( Yong Won Park ),김영한 ( Young Han Kim ) 대한산부인과학회 2008 Obstetrics & Gynecology Science Vol.51 No.9
Objective: The objective of this study was to evaluate the ultrasonographic appearance of suspected fetal cardiac tumor and their evolution until delivery and in the postnatal period, and to document the associated problems including tuberous sclerosis. Methods: We retrospectively reviewed the medical records of all cases born in Yonsei University Health System, Seoul, Korea, between September 1996 and August 2006, and diagnosed as fetal cardiac tumor prenatally. Results: 10 cases were found in all medical records. The mean age of the mothers on delivery was 30.2±2.4 and the mean gestational age on diagnosis was 30.6±5.4 weeks. The cardiac tumors were single in five cases and multiple in the other five cases. The size ranged from 7 to 34mm. Most of the tumors were located in right ventricle (RV, n=9), left ventricle (LV, n=6), but they also located in interventricular septum (IVS, n=4), right atrium (RA, n=1). In one case, fetal arrhythmia was found, which was normalized in two days after birth, and in another case, mild intracardiac flow obstruction was noted. The duration of postnatal follow-up ranged from 2 months to 36 months (mean, 18.9±13.1 months). In most cases the tumor masses decreased after birth (n=6), but had no change in utero (n=5). Three of them were diagnosed as tuberous sclerosis after birth, and none of them needed surgical intervention. Conclusion: Fetal cardiac tumors and their effect on the fetal cardiac function could be well evaluated by two-dimensional and Doppler echocardiography. The fetal cardiac tumors may have little effect on the fetal well being both prenatally and postnatally from the cardiovascular standpoint in most affected fetuses, but are important in the early diagnosis of tuberous sclerosis and in suggesting careful follow-up and management.