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한국에서 반복 자연유산을 하는 535쌍의 부부에 있어서의 세포 유전학적 연구
황한성,양은석,홍원기,김미순,양영호,Hwang, Han Sung,Yang, Eun Suk,Hong, Won Ki,Kim, Mi Soon,Yang, Young Ho 대한생식의학회 2005 Clinical and Experimental Reproductive Medicine Vol.32 No.2
Objective: The purposes of this study were to investigate the types and the incidences of chromosomal abnormalities, and to provide an explanation for the genetic causations of recurrent spontaneous abortions in Korean population. Methods: Cytogenetic studies were carried out in 535 couples with at least two spontaneous first trimester abortions from January 1981 to December 2003. For karyotype analysis, we used modified Moorhead method by Giemsa staining and Giemsa-Trypsin-Giemsa banding Results: The overall incidence of chromosome abnormality was 32 out of 535 cases (5.98%). There were 25 cases (4.67%) of translocation and 7 cases (1.31%) of inversion. In translocation, 5 cases (0.93%) of Robertsonian translocation and 20 cases (3.74%) of reciprocal translocation were observed. In inversion, 6 cases (1.12%) of inversion of chromosome 9 and one case (0.19%) of inversion of chromosome 18 were found. Conclusion: In this study, overall chromosomal abnormality rate in couples with recurrent spontaneous abortions is much higher than that in the general population. So, chromosomal analysis should be offered for the prognostic information in genetic counseling such as prenatal diagnosis in couples with repetitive reproductive failure.
조기진통 임신부에서 성공적인 자궁 수축 억제의 예측 인자로서 highly sensitive C-reactive protein
황한성 ( Han Sung Hwang ),김민아 ( Min A Kim ),박용원 ( Yong Won Park ),김영한 ( Young Han Kim ) 대한산부인과학회 2007 Obstetrics & Gynecology Science Vol.50 No.4
목적: 조기진통을 겪는 임신부에게서 측정된 hsCRP가 그 임신부의 성공적인 자궁 수축 억제를 예측하는 표지자가 될 수 있는지를 평가하고, 기존의 다른 염증 반응 표지자들보다 더 유용한지를 알아보고자 한다. 연구방법: 68명의 정상 임신부와 87명의 조기 진통 임신부를 대상으로 혈액을 채취하여 백혈구 수치, CRP, hsCRP를 측정하였다. 실험군은 조기 진통 억제의 성공군 (n=44)과 실패군 (n=43)으로 나누어 백혈구 수치, CRP, hsCRP를 비교하였다. 비교는 모두 student t-test를 사용하였다. 진통 억제의 성공을 예측하는데 상대적인 가치를 확인하기 위해서 ROC curve와 AUC를 사용하여 비교하였다. 결과: 모든 군들 사이의 비교에 있어서 임신부 나이, BMI, 임신 주수, 출산력은 통계적으로 유의한 차이가 없었다. 정상임신부군과 조기 진통 임신부군 사이의 비교에서는 백혈구 수치와 hsCRP가 통계적으로 유의하게 조기 진통 임신부군에서 높았다 (p<0.001). 조기 진통 억제의 성공군과 실패군 사이의 비교에서는 백혈구 수치, CRP, hsCRP가 통계적으로 유의하게 실패군에서 높았다. 조기 진통 억제의 성공을 예측하는데 있어서 백혈구 수치, CRP, hsCRP에 대한 각각의 AUC는 0.65, 0.77, 0.82이었다. 결론: 조기 진통 임신부에서 hsCRP 검사는 조기 진통 억제의 성공 여부에 대한 예측을 하는데 도움이 되고, 이로 인하여 조기 진통 임신부를 평가하는데 도움을 줄 수 있을 것이다. Objective: The purpose of this study was to evaluate whether maternal serum highly sensitive C-reactive protein (hsCRP) could be use as a marker of prediction of tocolytic success in preterm labor pregnancy, and was more useful in comparison with other inflammatory factors. Methods: Maternal serum white blood cell (WBC) count, C-reactive protein (CRP), and hsCRP were determined in 87 patients in preterm labor and 68 controls. Preterm labor group was divided into tocolytic success group (n=44) and failure group (n=43). The levels of maternal serum WBC count, CRP, and hsCRP were evaluated using receiver operating characteristic (ROC) curve and area under the curve (AUC) to evaluate the relative value as prediction marker of tocolytic success in two preterm labor groups. The data were analyzed using student t-test. Results: There was no significant difference for maternal age, body mass index (BMI), gestational age, and parity between normal group and preterm labor group. But, WBC count and hsCRP were significantly higher in preterm labor group in comparison to normal group (p<0.001). In preterm labor group, there was no significant difference in maternal age, BMI, gestational age, and parity between tocolytic success group and failure group. But, WBC count, CRP, and hsCRP were significantly lower in tocolytic success group. In the prediction of tocolytic success, the AUCs of WBC count, CRP, and hsCRP were 0.65, 0.77, and 0.82, respectively. Conclusion: This study showed that serum levels of hsCRP may be used as a marker of prediction of tocolytic success in preterm labor pregnancy.