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선학초(仙鶴草)추출물의 대식세포에서의 LPS-유도 염증반응에 대한 효능 연구
황지혜 ( Ji Hye Hwang ),남주현 ( Joo Hyun Nam ),김우경 ( Woo Kyung Kim ),배효상 ( Hyo Sang Bae ) 대한본초학회 2016 大韓本草學會誌 Vol.31 No.2
Objectives : The aerial parts of Agrimonia pilosa Ledeb (Agrimoniae Herba; AH) has been traditionally used as a Korean medicine to treatment of abdominal pain, sore throat, headaches, bloody discharge, parasitic infections and eczema. In this study, we investigated the effect of AH ethanol extract on lipopolysaccharide (LPS)-induced inflammation in RAW264.7 macrophage cells. Methods : AH was extracted by 30% ethanol (AH-E). Raw264.7 cells were treated with AH-E extract at different concentrations for 30 min and then stimulated with LPS (1㎍/㎖) or without for indicated times. Cell viability was measured by MTT assay, and nitric oxide (NO) production was measured by Griess assay. The expression of inflammatory mediators, iNOS and COX-2 and inflammatory cytokines, TNF-α, IL-1β, and IL-6 was detected by RT-PCR, and the phosphorylation of ERK1/2, p38 and JNK MAP kinases (MAPKs) was analyzed by Western blot. Also, the expression of NF-κB in nuclear and cytosol was detected by Western blot. Results : AH-E extract significantly decreased LPS-induced NO production in RAW264.7 cells. AH-E extract inhibited the mRNA expression of iNOS, COX-2, TNF-α, IL-1β, and IL-6 in LPS-stimulated cells with a dose-dependent manner. In addition, the phosphorylation of ERK, p38 and JNK MAPKs was also inhibited by AH-E extract. AP-E extract inhibited the nuclear translocation of NF-κB in LPS-stimulated cells. Conclusions : Our results suggest that AH-E extract has an anti-inflammatory activity in macrophages-mediated inflammation.
소비자 가치가 LOHAS 지향행동에 미치는 영향요인에 관한 연구
주현식(Hyun Sik Joo),황순애(Soon Ae Hwang),정삼권(Sam Kwon Jung) 한국관광연구학회 2008 관광연구저널 Vol.22 No.3
This research is to design the relation model among the personal value, consumer trends value, hedonic value, and LOHAS value, attitude toward LOHAS and LOHAS-oriented behaviors, and analyze the effect relation in variant factors on the basis of main variances that differentiate LOHAS consumers presented in the LOHAS journal that American Natural Marketing Research Institute publishes. The subjects are the guests who accommodate the top-class hotels and restaurants in Seoul, Busan, Daegu, Gyeongju, Kangwon area. The hypothesis testing and model application on the effect relation among these variances were analyzed appropriate. The results can be summarized as follows through careful discussions. First, after testing the hypothesis that personal value, hedonic value, and LOHAS value has an effect on LOHAS attitude, we found it wrong. Second, after testing the hypothesis that personal value, consumer trends value, hedonic value, and LOHAS value affects LOHAS behavior, we found that LOHAS value and hedonic value has an effect on LOHAS behavior positively in a meaningful level. Third, after testing the hypothesis that personal value, consumer trends value, hedonic value, and LOHAS value affects LOHAS-oriented behavior, we found that LOHAS value and hedonic value has an effect on LOHAS-oriented behavior positively in a meaningful level. Fourth, after testing the hypothesis that LOHAS attitude affects LOHAS-oriented behavior, we found that LOHAS attitude has an effect on LOHAS-oriented behavior positively in a meaningful level.
김용수(Yong Soo Kim),방병기(Byung Kee Bang),양철우(Chul Woo Yang),박정희(Jung Hee Park),박주현(Joo Hyun Park),주현중(Hyun Jung Joo),오정환(Jung Hwan Oh),정정(Jung Jung),황수은(Soo Eun Hwang),고기영(Gi Young Ko) 대한신장학회 2000 Kidney Research and Clinical Practice Vol.19 No.3
Hepatic cysts are the most common extrarenal manifestations of adult polycystic kidney disease, but the hepatic cyst infection in a patient with polycystic kidney disease is rare. The infection may remain localized or may be followed by acute cholangitis or septicemia. The best management for infected hepatic cyst is drainage in combination with antibiotic therapy. We experienced a case of infected hepatic cyst in a patient with polycystic kidney disease in a 46-year-old man receiving hemodialysis. He presented with fever and abdominal pain and was found to have an infected liver cyst. Treatment with antibiotics and percutaneous drainage of the cyst resulted in clinical improvement. Thus, we report a case of infected hepatic cyst in a patient with polycystic kidney disease with review of the literature.