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관류 기니픽 심장에서 Mg<sup>2+</sup> 유리에 미치는 α<sup>1</sup>-adrenoceptor 자극효과
황성철,김상진,강형섭,이승옥,강창원,권오덕,김진상,Hwang, Sung-chul,Kim, Sang-jin,Kang, Hyung-sub,Lee, Seung-ok,Kang, Chang-won,Kwon, Oh-deog,Kim, Jin-sang 대한수의학회 1996 大韓獸醫學會誌 Vol.36 No.2
Recently in spite of the interest on the regulation of intracellular $Mg^{2+}$ by neurotransmitters or drugs, the magnesium ion($Mg^{2+}$) regulation by ${\alpha}_1$-adrenoceptor stimulation has not been studied in the heart yet. To elucidate the regulation of ${\alpha}_1$-adrenoceptor stimulation-induced $Mg^{2+}$ release and the effects of ${\alpha}_1$-adrenoceptor stimulation on pathophysiological conditions, in this study we have evaluated the effects of phenylephrine, PMA, $H_7$. staurosporine, verapamil and lidocaine on $Mg^{2+}$ release in perfused guinea pig heart. During preperfusion exogenous $Mg^{2+}$ was added to the medium to give 1.2mM 15min before starting to addition of drugs, and then the infusion of exogenous $Mg^{2+}$ was stopped. $Mg^{2+}$ in the perfusate leaving the heart was measured by atomic absorption spectrophotometry. $Mg^{2+}$ free solution produced an increase in heart rate and phenylephrine elicited $Mg^{2+}$ release from the heart. $Mg^{2+}$ release by phenylephrine was abolished by combined treatment with prazosin. By contrast, cardiac $Mg^{2+}$ uptake induced by a protein kinase C(PKC) activator, PMA was abolished by a selective PKC inhibitor, staurosporine. And the phenylephrine-induced $Mg^{2+}$ release was not affected by the PKC inhibitor, $H_7$. When verapamil or lidocaine was added to perfusing solution, $Mg^{2+}$ release was potentiated by phenylephrine from perfused guinea pig heart. These results suggest that ${\alpha}_1$-adrenoceptor stimulation caused $Mg^{2+}$ release and that PKC is not involved in ${\alpha}_1$-adrenoceptor mediated $Mg^{2+}$ release from perfused guinea pig heart. Under pathophysiological conditions, the $Mg^{2+}$ alteration by ${\alpha}_1$-adrenoceptor stimulation is considerable.
신경 회로망을 이용한 Wafer final polishing의 가공 결과 예측
황성철(Sung-Chul Hwang),차지완(Ji-Wan Cha),이은상(Eun-Sang Lee) 한국생산제조학회 2008 한국생산제조시스템학회 학술발표대회 논문집 Vol.2008 No.5
Polishing is one of the important processing having influence on the surface roughness in manufacturing of Si-wafers. The surface roughness in wafer polishing is mainly affected by the many process parameters. A feed forward neural network model is developed exploiting experimental measurements from the surface in wafer final polishing. The input variables of Neural Network model are process parameters. The output variables are measured surface roughness. The neural network model is trained and performed by MATLAB. The model can be used for the analysis and prediction of the complex relationship. From this, it is clearly seen that a good agreement is observed between the predicted values and experimental measurement values.
유체-구조 상호연성 해석을 위한 입자법 시뮬레이션 기술 개발
황성철(Sung-Chul Hwang),박종천(Jong-Chun Park),송창용(Chang-Yong Song),김영훈(Young-Hun Kim) 한국해양공학회 2013 韓國海洋工學會誌 Vol.27 No.2
Recently, some fluid?structure interaction (FSI) problems involving the fluid impact loads interacting with structures, such as sloshing, slamming, green?water, etc., have been considered, especially in the ocean engineering field. The governing equations for both an elastic solid model and flow model were originally derived from similar continuum mechanics principles. In this study, an elastic model based on a particle method, the MPS method, was developed for simulating the FSI problems. The developed model was first applied to a simple cantilever deflection problem for verification. Then, the model was coupled with the fluid flow model, the PNU (Pusan National University modified)?MPS method, and applied to the numerical investigation of the coupling effects between a cantilever and a mass of water, which has variable density, free?falling to the end of the cantilever.
황성철(Sung-Chul Hwang),이병혁(Byung-Hyuk Lee),박종천(Jong-Chun Park),성홍근(Hong-Gun Sung) 한국해양공학회 2010 韓國海洋工學會誌 Vol.24 No.5
The Floating storage and re-gasification unit (FSRU), which has large cargo storage tanks, is a floating liquefied natural gas (LNG) import terminal. The sloshing motion in tanks that are partially filled with LNG can cause impact pressure on the containment system and affect the global motion of the FSRU. Therefore, the accurate prediction of sloshing motion has been a significant issue in the offshore gas production industry. In this paper, a particle method based on the moving particle semi-implicit (MPS) method proposed by Koshizuka and Oka (1996) has been modified to predict sloshing motion accurately in a rectangular tank with the filling ratio of water. The simulation results, including the violent sloshing of the fluid, were validated by comparison with the original MPS method.
황성철 ( Sung-chul Hwang ),유찬서 ( Chan-seo You ),정정조 ( Cheong-jo Cheong ),정상철 ( Sang-chul Jung ),이경동 ( Gyeong-dong Lee ),라덕관 ( Deog-gwan Ra ) 한국환경기술학회 2010 한국환경기술학회지 Vol.11 No.1
pH 변화에 따른 클로라민의 생성 및 분해 특성에 관하여 실험한 결과, 클로라민을 최대로 생성하는 Cl<sub>2</sub>/NH<sub>3</sub>-N 비는 pH 6에서 9:1, pH 7과 8에서 5:1이었으며, 그때 잔류농도는 각각 3.4, 2.57, 2.69mg/L 이었다. Cl<sub>2</sub>/NH<sub>3</sub>-N 비에 따른 불연속점은 pH 6에서 11:1, pH 7과 8에서 9:1로 나타났으며, 이때 클로라민의 잔류농도는 각각 0.4, 0.34, 0.6mg/L이었다. 클로라민은 Cl<sub>2</sub>/NH<sub>3</sub>-N비 3:1, 5:1, 7:1에서 60시간 반응 후, pH 6에서 각각 42, 57, 75%, pH 7에서 31, 38, 46%, pH 8에서 25, 33, 43% 감소하였다. 클로라민의 분해는 Cl<sub>2</sub>/NH<sub>3</sub>-N 비가 증가하고, pH가 낮을수록 용이하였다. Several examines were carried out to explain the characteristic of chloramine formation and decomposition on each pH condition during chloramine disinfection. The Cl<sub>2</sub>/NH<sub>3</sub>-N ratio that is produce maximum chloramines was proved to be 9:1 on pH 6 and 5:1 on pH 7 and pH 8, and its residual concentration were 3.4 mg/L, 2.57 mg/L, 2.69 mg/L, respectively. The breakpoint chlorination due to Cl<sub>2</sub>/NH<sub>3</sub>-N ratio were shown at 11:1 on pH 6 and 9:1 on pH 7 and pH 8, and its residual concentration were 0.4 mg/L, 0.34 mg/L, 0.6 mg/L, respectively. After 60 hrs reaction on 3:1, 5:1, 7:1 on Cl<sub>2</sub>/NH<sub>3</sub>-N ratio, chloramine concentration was decreased such as 42%, 57%, 75% on pH 6, 31%, 38%, 46 % on pH 7 and 25%, 33%, 43% on pH 8, respectively. Chloramine decomposition reaction was tend to be easy with increasing of Cl<sub>2</sub>/NH<sub>3</sub>-N ratio and pH down.