소아, 청소년 아토피 피부염에서의 DPCP 면역요법의 임상적 치료효과

방숙현 ( Bang Sug Hyeon ),최유원 ( Choe Yu Won ),함정희 ( Ham Jeong Hui ),황규광 ( Hwang Gyu Gwang ) 대한피부과학회 2004 大韓皮膚科學會誌 Vol.42 No.1

N/A Background: Atopic dermatitis is the most common chronic skin disease in childhood. Severe atopic dermatitis may require use of topical or systemic corticosteroids. These treatments are prone to several adverse side effects. This paper highlights the impressive effect of diphenylcycloprope-none(DPCP) sensitization in the some cases of childhood and adolescent atopic dermatitis. Objective: The purpose of this study was to examine the effect of DPCP in treating severe atopic dermatitis of children and adolescents. Methods: Twenty eight patients, who had moderate to severe atopic dermatitis, were recruited in the treatment of DPCP weekly for 10 weeks and followed up for another 4 weeks. Severity of atopic dermatitis was measured using SCORAD index. Results: Sixteen of 28 patients had finished the treatment courses. After 10 weeks of therapy with DPCP, the patient`s symptoms were improved and the mean SCORAD index was significantly reduced from 48.9±17.8 to 18.0±9.1 (p<0.01). During the follow-up period, patients could be managed by topical steroid and oral antihistamine and flare-up was no observed. Conclusion: According to our study, DPCP can be an effective, safe and well-tolerated therapy for moderate to severe atopic derm atitis in children and adolescents. We suggest that DPCP may be effective in the treatment of moderate to severe atopic dermatitis of children and adolescents without serious complications. (Korean J Dermatol 2004;42(1):29-36)

안면에 발생한 다발성, 속립성 피부골종

김소연 ( Kim So Yeon ),조영은 ( Jo Yeong Eun ),최유원 ( Choe Yu Won ),황규광 ( Hwang Gyu Gwang ),함정희 ( Ham Jeong Hui ) 대한피부과학회 2003 대한피부과학회지 Vol.41 No.10

Osteoma cutis is a rare disorder characterized by compact bone formation in the dermis and subcutaneous tissue. It is classified in primary and secondary forms according to the presence or absence of previous cutaneous lesions. Multiple miliary osteomas of the face is a form of primary miliary osteoma cutis that generally occurs in middle-aged and older women. We report a typical case of multiple miliary osteomas of the face in a 63-year-old woman.(Korean J Dermatol 2003;41(10) : 1378~1380)

전기소작술 후 발생한 Tufted Angioma 1 예

김현주,신나라,함정희,조소연,황규광 대한피부과학회 2000 大韓皮膚科學會誌 Vol.38 No.7

Tufted angioma is a benign, slowly progressive angioma with typical histologic findings of small, circumscribed angiomatous tufts and lobules scattered in the dermis. More than 50% of cases occur during the first year of life, but rarely it develops late in life. There was only one reported case of tufted angioma after trauma in the English literature. We report a case of tufted angioma, which developed after electrocautery in a 61-year-old woman showing histologic features of typical tufted angioma.

비전형적인 양상을 보인 각질하 농포성 피부증 1 예

김연진,함정희,조소연,황규광 대한피부과학회 2000 大韓皮膚科學會誌 Vol.38 No.7

Subcorneal pustular dermatosis(SPD) or Sneddon-Wilkinson disease is a chronic, relapsing, pustular eruption generally involving the intertriginous area and affecting mainly elderly women. We report a case of SPD presenting in a 24-year-old female with erythematous circinate annular peripheral scaly patches on her right thigh. Histopathologically, the subcorneal pustules contained numerous neutrophils, with only a few eosinophils. Underlying stratum malpighii was slightly edematous and contained small numbers of neutrophils. No acantholytic cells or spongiosis were found. The patient was treated by dapsone successfully.

장기간 전신 광화학요법 시행받은 백납 환자에서 발생한 PUVA 각화증과 각화극세포종 1 예

김성현,강민정,함정희,조소연,황규광 대한피부과학회 2000 大韓皮膚科學會誌 Vol.38 No.9

Systemic PUVA therapy can produce various acute reactions and potential long-term damage including benign and malignant skin tumors. Obviously the risk is related to DNA damage, but PUVA-induced down-regulation of immune responses may play an additional role. Keratoacanthoma is etiologically related to sunlight and immunosuppression. PUVA keratoses are raised warty papules with a broad base and a diameter of several millimeters to 1 centimeter, and they are associated with an increased risk of nonmelanoma skin cancer. We report a case of solitary keratoacanthoma and multiple PUVA keratoses all developing in vitiliginous areas in a patient receiving long-term, high-dose PUVA therapy for generalized vitiligo. A 57-year-old Korean female, who had undergone intermittent systemic PUVA therapy for 11 years, noted multiple asymptomatic, yellowish, hyperkeratotic papules on the dorsa of hands and feet 1 year previously, and a bean-sized raised painful nodule filled with keratin plug on the dorsum of right hand 1 month previously. Skin biopsy confirmed the diagnoses of PUVA keratoses and keratoacanthoma, respectively. PCR-SSCP analysis revealed no mutation of p53 tumor suppressor gene in this case.

입원중 피부과로 의뢰된 환자의 통계분석 ( 96년-99년 )

김문정,함정희,조소연,황규광 대한피부과학회 2000 大韓皮膚科學會誌 Vol.38 No.8

Background: Dermatologic practice occurs mainly in the outpatient setting. The reasons for, frequency, and impact of inpatient dermatologic consultation may be quite different from outpatient practice and there has been a lot of changes in dermatologic consultation recently. Several studies about characteristics of dermatologic consultation have been reported. Objectives : The purpose of this study was to examine the characteristics of inpatient dermatologic consultation in Ewha womans university hospital for 3 years and also to compare the result of the report in 1991. Methods: During a period of 3 years (1996.2-1998.3), we prospectively recorded the demographics of the patients for whom consultation was requested, the final diagnosis of the dermatologic service, and the tests necessary to arrive at diagnosis, and reasons for dermatologic consultation. Results : 1) The consulted patients were 1019 among 38,402 inpatients (2.7%). 2) The total number of male and female patients were 547(53.7%) and 472(46.3%), respectively (M:F = 1.2:1). 3) The most frequent age group was the 6th decade(18.4%) and the highest incidence of seasonal distribution was spring. 4) The patients in internal medicine were the most frequently consulted. 5) The most common dermatoses were eczema group, followed by drug eruption, fungal infection, viral infection, acne vulgaris, urticaria, etc. 6) Distribution of dermatoses according to seasons and individual departments was statistically different in various dermatoses. 7) Frequent causes of consultation were as follows: the dermatologic diseases or conditions 68.3%, the diseases related to treatment 12.3%, the skin lesions of systemic diseases 10.0%, the dermatologic tests 3.5%, and admission to other departments with dermatologic diseases 1.9%, respectively. 8) The rate of consultation for drug eruption was increased markedly compared to that of new patients at OPD in 1998. Conclusions: The characteristics of inpatient dermatologic consultation in our hospital have been changed and furthermore the characteristics were quite different from that of oupatient practice.

AIDS 연관형 Kaposi 육종 1예

김지현,김성현,함정희,조소연,황규광 대한피부과학회 2000 大韓皮膚科學會誌 Vol.38 No.8

We report a case of AIDS-related Kaposi's sarcoma in a 65-year-old male. He developed many asymptomatic purplish colored patches and nodules on his four extremities and anterior chest with edema of both legs for 2 months. The ELISA for the anti-HIV antibody was positive and it was confirmed by Western blot. The histologic finding showed abnormally proliferated and dilated vessels, vascular slits, spindle-shaped cells and extravasated erythrocytes in the dermis. In immunohist-ochemical study, the cryptic vessels were positive with CD31. Human herpesvirus-8 was detected by PCR.