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아키텍처 노력 도입 수준의 영향 요인에 관한 실증적 연구
홍용덕,김성근,Hong, Yong-Duck,Kim, Sung-Kun 한국데이터전략학회 2007 Journal of information technology applications & m Vol.14 No.1
Enterprise Architecture (EA) is one of controversial subjects theses days. Some organizations, public or private, are very impetuous in adopting it and some are quite Indifferent to it. What makes this difference come about? This is our research question. One previous research has studied on this issue under the theory of diffusion of innovation. Instead, we here attempt to investigate, in the context of technology transfer theory, the influencing factors on the adoption of EA. We are especially interested In whether korea local organizations are more Influenced by 'need pull' factors than 'institutional push' factors or vice versa.
광나무의 주성분, Ursolic acid와 Oleanolic acid의 항노화 효능
홍용덕 ( Yong Deog Hong ),유대성 ( Dae Sung Yoo ),남미희 ( Mi Hee Nam ),김현정 ( Hyeon Chung Kim ),박시준 ( Si Jun Park ),신송석 ( Song Seok Shin ),천종우 ( Jong Woo Cheon ),박영호 ( Young Ho Park ) 대한화장품학회 2012 대한화장품학회지 Vol.38 No.2
광나무(L. lucidum)는 ursolic acid와 oleanolic acid를 다량 포함하고 있다. 본 연구에서는 광나무 열매, 줄기, 잎 세 부위 추출물의 항주름 효능을 평가하였다. 광나무 추출물은 human skin fibroblasts에서 독성이 없을 뿐만 아니라 MMP-1과 MMP-2의 발현을 감소시키고 COL1A1의 발현을 증가시켰다. 이들 추출물은 모두 농도 의존적으로 COL1A1의 발현을 증가시켰으며 MMP-1과 MMP-2의 발현을 감소시켰다. 광나무 세 부위 추출물 가운데, 열매 부위에 가장 많은 양의 ursolic acid 와 oleanolic acid가 함유되어 있었으며 가장 강한 COL1A1 upregulating 효과와 MMP-1과 MMP-2 downregulating 효과를 나타냈다. 이처럼 항주름 효능을 보이는 광나무 열매 추출물은 기능성 화장품 소재로 개발될 수 있는 가능성이 있다. Ligustrum lucidum (L. lucidum) contains large quantities of ursolic acid and oleanolic acid. In this study, we evaluated anti-wrinkle effects of three parts of L. lucidum extracts. We found that L. lucidum extracts were not only innocuous to human skin fibroblasts but also significantly decreased the expression of both MMP-1 and MMP-2 and increased the expression of COL1A1. Among the three parts of L. lucidum extracts (i.e., fruit, cane, and leaf extracts), the fruit extract was found to contain the greatest amounts of ursolic acid and oleanolic acid. These three parts of L. lucidum extracts increased the expression of COL1A1 and decreased the expression of MMP-1 and MMP-2 in a dose-dependent manner. Especially, the fruit extract of L. lucidum had the greatest upregulating effect on COL1A1 and the greatest downregulating effect on MMP-1 and MMP-2 in a non-toxic and dose-dependent manner. These results suggest that L. lucidum, especially the fruit, could be used as active ingredients for functional cosmetics.
물푸레나무로부터 분리된 Esculetin와 Esculin의 미백 효능
홍용덕 ( Yong Deog Hong ),남미희 ( Mi Hee Nam ),이창석 ( Chang Suk Lee ),신송석 ( Song Seok Shin ),박영호 ( Young Ho Park ) 대한화장품학회 2014 대한화장품학회지 Vol.40 No.1
물푸레나무 수피 추출물은 주요 생활성 물질로서 esculetin과 esculin을 포함하고 있다. 이 가운데, Esculetin은 B16F10 melanoma cells에서 IC<sub>50</sub> value 2.8 μM의 아주 좋은 melanogenesis 억제 활성을 나타내며, 이를 통해 Melan-A cell에서 melanin 합성을 감소시킨다. 더욱이, esculetin은 mushroom tyrosinase에서도 IC<sub>50</sub> value 40 μM의 억제 활성을 나타내어 melanin biosynthesis를 저해한다. 위의 결과들로서, 우리는 melanogenic enzyme 활성 조절에 의해 melanin 생성을 저해하는 효과적인 피부미백 물질로서 esculetin을 제안하고자 한다. Stem bark extracts of Fraxinus rhynchophylla Hance were found to contain two major bioactive components, esculetin and esculin. Esculetin substantially inhibited melanogenesis in B16F10 melanoma cells, with an IC<sub>50</sub> value of 2.8 μm, and reduced melanin synthesis in Melan-A cells. Moreover, esculetin suppressed melanin biosynthesis by inhibiting mushroom tyrosinase activity, with an IC<sub>50</sub> value of 40 μM. Taken together, these results suggest that esculetin could serve as an effective skin-lightening agent that inhibits melanin production by regulating the activity of melanogenic enzymes.
3,7-Diarylpyrazolo[1,5-α]pyrimidines의 개선된 One-pot Regioselective 합성과 CB1R 활성
홍용덕 ( Yong Deog Hong ),변경희 ( Kyoung Hee Byoun ),박미영 ( Miyoung Park ),박준성 ( Jun Seong Park ),신송석 ( Song Seok Shin ) 대한화장품학회 2015 대한화장품학회지 Vol.41 No.2
본 연구는 3,7-diarylpyrazolo [1,5-α]pyrimidines의 효과적인 one-pot regioselective 합성을 보여준다. 더욱이, 그 유도체는 뛰어난 CB1R 저해 활성을 나타냈다. 3,7-position에 diaryl group이 치환된 pyrazolo [1,5-α]pyrimidine은 CB1R 후보로서 가능성 있는 pharmacophore이다. This study demonstrates an effective one-pot regioselective synthesis of 3,7-diarylpyrazolo [1,5-α]pyrimidines. Moreover, the derivatives obtained were effective CB1R antagonists. These pyrazolo [1,5-α]pyrimidines with diaryl groups at the 3,7-positions are potential pharmacophores for CB1R candidates.
Anti-Graying Effect of Pueraria Lobata Root Extract on Stress-Induced Hair Graying
홍민정,박병철,홍용덕,김수나 사단법인 대한화장품학회 2022 대한화장품학회지 Vol.48 No.3
Gray hair is a representative sign of aging. Intrinsic aging, stress, and the external environment cause hair graying. Stress is known to be a major factor in the early onset of hair graying. We previously found that Pueraia lobata root extract (PLRE) can prevent hair graying by promoting melanin formation. However, it remains unknown whether PLRE can prevent hair graying induced by conditions of stress. In this study, we confirmed the effect of PLRE on stress-induced hair graying. A reporter cell line was newly constructed to confirm the expression of microphthalamia-associated transcription factor (MITF), the main transcription factor for melanin production. MITF expression and melanin pigmentation were reduced in human hair follicle tissue treated with the stress hormone cortisol or H2O2 to induce oxidative stress. PLRE treatment restored MITF expression and increased the amount of melanin pigment in the hair follicle. The expression of Tyrosinase related proteins-2 (TRP-2), a melanin synthesis enzyme in the hair follicle, also increased. In conclusion, PLRE can effectively prevent the inhibition of melanin synthesis by stress hormones and oxidative stress.
김정기,정현우,김아영,홍용덕,이지해,최진규,황재성 한국식품과학회 2019 Food Science and Biotechnology Vol.28 No.3
Increased fat mass, which is induced by thestorage of excess nutrients, is considered a causal factor forvarious metabolic disorders, including insulin resistance,type 2 diabetes, hyperlipidemia, hyperglycemia, hypertension,atherosclerosis, and non-alcoholic fatty liver disease. Therefore, it is necessary to prevent hyperadiposity tosustain a healthy life. Recently, uncoupling proteins(UCPs) were suggested to be molecular targets for curingobesity and its complications. In this study, green satsumamandarin orange (Citrus unshiu) extract (GME) increasedUCP3 expression in cultured myocytes. In a diet-inducedobese animal model, administration of GME reduced fatmass and average fat cell size. Similar to in vitro experiments,GME restored expression of UCP3 in skeletalmuscle. Moreover, GME also induced UCP2 expression inskeletal muscle. In conclusion, GME is suggested to be anovel functional dietary supplement for adiposity controlthrough induction of UCPs.
조동현,정현우,김정기,김아영,홍용덕,Ji-Hae Lee?,최진규,서대방 한국식품영양과학회 2019 Journal of medicinal food Vol.22 No.8
Green tea is reported to exert beneficial effects on metabolic disorders through the regulation of lipid metabolism. On the contrary, fermented food products have been introduced to improve human health by modulating immune response and energy metabolism. To maximize health benefit, we applied fermentation processing to green tea. Fermented green tea extract (FGT) inhibited adipogenesis and lipogenesis in cultured adipocytes, whereas it augmented mRNA expression of fatty acid oxidation-related genes in differentiated myocytes. In diet-induced obese mice, FGT blunted body weight and fat mass gain by 69.7% and 56.7%, respectively. FGT also improved circulating triglyceride concentrations by 32.6%. Similar to in vitro results, FGT suppressed lipogenesis and promoted lipid catabolism in peripheral tissues. In addition, FGT administration modulated the composition of certain gut microbiota which are associated with obesity and related metabolic disorders. Among the various components of FGT, gallocatechin gallate is suggested to mediate the effect of FGT on lipid metabolism. Taken together, we propose FGT as a novel functional food to benefit human health by controlling adiposity and lipid metabolism.
김형민,정연수,김세현,조정훈,홍용덕,박원석 사단법인 대한화장품학회 2024 대한화장품학회지 Vol.50 No.2
본 연구에서는 목서(Osmanthus fragrans, O. fragrans) 꽃 추출물을 화장품 소재로 활용하기 위해 피부에대한 다양한 효능을 확인하고자 하였다. 이를 위해 제주산 목서 꽃 추출물(O. fragrans flower extract, OFFE)을제조하여 실험에 이용하였다. 실험은 실시간 중합효소 연쇄반응인 qRT-PCR과 lipid droplet 염색법으로 평가하였다. 먼저 OFFE는 표피 각질세포에서 poly I:C로 유도된 3 종의 대표적인 전염증성 사이토카인 (IL-8, IL-6, IL-1α)과 염증 관련 효소인 PTGS2의 유전자 발현을 감소시켰다. 또한 OFFE는 진피 섬유아세포에서 콜라겐(COL1A1)과 엘라스틴(ELN) 유전자 발현을 증가시켰다. 더 나아가 OFFE는 피지세포에서 linoleic acid에 의해유도된 피지 생성을 억제하는 효능 보여주었다. 따라서 본 연구를 통해 OFFE은 항염, 항노화, 그리고 피지억제 효능을 위한 천연 화장품 소재로써 적용이 가능할 것으로 기대된다. In this study, we aimed to determine the various effects of Osmanthus fragrans (O. fragrans) flower extract on the skin in order to utilize it as a cosmetic material. For this purpose, Osmanthus fragrans flower extract (OFFE) of Jeju Island was prepared and used in the experiment. The experiments were evaluated by the quantitative real-time polymerase chain reaction (qRT-PCR) and lipid droplet staining assay. First, the OFFE decreased the gene expressions of three representative pro-inflammatory cytokines (IL-8, IL-6, and IL-1α) and an inflammation-related enzyme, PTGS2 induced by poly I:C in epidermal keratinocytes. In addition, the OFFE increased the gene expression levels of collagen (COL1A1) and elastin (ELN) in dermal fibroblasts. Further, the OFFE showed the inhibitory effect in sebum production by linoleic acid in sebocytes. Therefore, from this study, it is expected that OFFE can be used as a natural cosmetic material for anti-inflammatory, anti-aging, and sebum inhibitory efficacy.