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박기범(Kibeom Park),홍성민(Seong-ju Hong),홍성주(Seong-min Hong),오진숙(Jinsook Oh) 과학기술정책연구원 2016 정책연구 Vol.- No.-
In this study, we have brought into the discussion the autonomy and responsibility of research. Academic freedom has been regarded as the one of the inherent human rights, and been secured through the constitutional law in many countries. Below it lies the belief that autonomy is not only necessary but also the origin of creativity in academic work. However, there is no generally agreed concept on the nature of academic freedom. The debate about academic freedom ranges from definition or meaning to the extent it reaches. Further, the different level of academic freedom such as individual and institutional might bring conflict with each other. Moreover, responsibility has been accepted as the other side of freedom, but it also has been marked by a lack of clarity. Both autonomy and responsibility have not been paid much attention in science policy realm. With this in mind, we have attempted to define autonomy and responsibility of especially in publicly funded research. Autonomy is defined as the independence from interference with internal norm. When science was regarded as a common good, the curiosity-driven research was supported by public with a wide range of autonomy and freedom. However, the size of public funding to science grows and the socio-economic role of science gains more importance, the responsibility of science becomes dominating the freedom of research. We have proposed the elements of autonomy and responsibility of public research based on preceding studies, and presented preliminary survey on this familiar but unexplored topic.
냉수, 스팀 동시 발생용 하이브리드 흡수식 히트 펌프의 수치적 해석
이창현(Chang Hyun Lee),홍성주(Sung Joo Hong),김병련(Byung Ryun Kim),김재인(Jae In Kim),이승민(Seong Min Lee),김인관(In Gwan Kim),권오경(Oh Kyung Kwon),박찬우(Chan Woo Park) 대한설비공학회 2018 대한설비공학회 학술발표대회논문집 Vol.2018 No.6
This study was carried out a numerical analysis the hybrid absorption heat pump that simultaneously produces cold water and steam. The hybrid absorption heat pump is a combination of a single-effect absorption chiller and a single-stage absorption heat pump. The heat pump uses 90℃ waste heat from the industry to produce 120℃ steam that can be used in the process and produces 7℃ cooling water at the same time. In this study, numerical simulations were carried out for characteristics of each element and cycle characteristics for each variable under conditions of producing 120 steam and 7 cold water.
신규 분리된 담수미세조류 Parachlorella sp.의 지방산 생산성 향상을 위한 배지 조성 연구
박한울 ( Hanwool Park ),임경준 ( Kyung June Yim ),민지호 ( Ji-ho Min ),강성모 ( Sung-mo Kang ),한찬우 ( Chan-woo Han ),이창수 ( Chang-soo Lee ),정지영 ( Ji Young Jung ),홍성주 ( Seong-joo Hong ),이철균 ( Choul-gyun Lee ),김지훈 ( 한국미생물 · 생명공학회 2020 한국미생물·생명공학회지 Vol.48 No.3
본 연구에서는 국내 낙동강 수계에서 신규하게 분리된 미세조류인 Parachlorella sp. 종의 바이오매스 및 지방산 생산성에 대한 배지의 영향을 연구하였다. 미세조류 배양에 통상적으로 사용되는 BG-11, TAP, BBM 배지를 사용하여 바이오매스 생산성은 TAP 배지에서, 지방산 축적은 BBM 배지에서 가장 잘 일어나는 것으로 확인되었고, 지방산 생산성을 향상시키기 위해 암모니아와 아세트산을 사용하는 TAP 배지의 조성을 변화하여 BBM 배지처럼 지방산 축적을 유도하며 바이오매스 생산성을 증가시킨 MTAP 배지를 개발하였다. 전체적인 바이오매스와 지방산 생산성을 높이기 위해서는 MTAP-1 배지가 적합하여 바이오매스 생산성과 지방산 생산성은 기존의 TAP 배지 대비 각각 14%, 45% 증가하였다. 생리 활성 효과로 인해 관심도가 높은 오메가-3 지방산의 생산에는 MTAP-4 배지가 가장 적합하여 바이오매스 생산성과 오메가-3 지방산 생산성이 기존 BBM 배지 대비 각각 18%, 39% 증가하여 목표 중점 생산물질(바이오매스, 총 지방산, 또는 오메가-3 지방산)의 생산성을 향상시킬 수 있는 신규 배지 2종의 조성을 개발하였다. Parachlorella sp. is an efficient fatty acid producer that can be used in the production of biofuels, feeds, and fertilizers. Microalgae show varying responses to culture conditions, even those within the same species. In this study, growth and fatty acid composition of a newly isolated Parachlorella sp. from the Nakdong river of Korea in different culture media were investigated. The microalga was cultivated in 400 ml bubble column photobioreactors using BG-11, BBM, TAP, and modified TAP (MTAP) media. It was shown that using BBM led to greater fatty acid accumulation (34%), while using TAP medium led to greater biomass productivity (0.34 g/l/day). Composition of the TAP medium was modified to have the N:P ratio of BBM while also varying concentrations of N and P to improve fatty acid productivity. One of the modified TAP media, MTAP-1 (104.8 mgN/l, 135.2 mgP/l, N:P ratio = 0.77), showed the highest fatty acid concentration of 0.69 ± 0.04 g/l, while those from TAP and BBM were 0.48 ± 0.06 g/l and 0.40 ± 0.02 g/l, respectively. The results showed that microalgal fatty acid productivity could be enhanced by changing the N:P ratio and concentrations.
미세조류 Chlamydomonas reinhardtii dZL 균주의 100 L 평판형광생물 반응기를 이용한 대량 배양에서의 접종 농도에 따른 바이오매스 생산성 향상 연구
박한울(Hanwool Park),강성모(Sung-Mo Kang),민지호(Ji-Ho Min),김준호(Jun-Ho Kim),조용희(Yonghee Cho),김기현(Ki-Hyun Kim),진언선(Eonseon Jin),홍성주(Seong-Joo Hong),이철균(Choul-Gyun Lee) 한국생물공학회 2020 KSBB Journal Vol.35 No.1
Beside the commercialized pigments from microalgae, such as astaxanthin, beta-carotene, and c-phycocyanin, zeaxanthin is another pigment with great potential for commercialization as it can be used to prevent or cure age-related macular degeneration. However, low zeaxanthin productivity due to its low content in microalgal biomass has been the major obstacle to commercialization. With recent advances in genome editing technology, a green microalga Chlamydomonas reinhardtii dZL was engineered to accumulate zeaxanthin with growth by knocking out enzymes that convert zeaxanthin into other carotenoids. In the present study, C. reinhardtii dZL was cultivated using TAP medium in 100 L flat-panel photobioreactors (PBRs), and the effect of initial cell density(ICD) on biomass productivity in batch operation was investigated. ICD of 0.1 g/L was predicted to yield highest biomass productivity from experiments using 2 L bubble column PBRs. In 100 L flat-panel PBRs, as ICD increased from 0.005 g/L to 0.08 g/L, biomass productivity was increased from 0.03 g/L/ day to 0.16 g/L/day. However, further increasing ICD from 0.08 g/L to 0.16 g/L reduced to 0.14 g/L/day as the maximum biomass concentration was limited by the light intensity. The results showed that ICD could affect biomass productivity in positive and negative ways, and thus ICD should carefully be determined with regards to the culture conditions. Such strategy could be applied to improve productivity for other compounds of interests in other microalgae as well.
저온 생장성이 우수한 분리 미세조류 Tetraselmis sp. 5개주의 생장 패턴 및 지방산 조성 분석
박한울(Hanwool Park),허동희(Donghee Hoh),신동우(Dong-Woo Shin),김지훈(Z-Hun Kim),홍성주(Seong-Joo Hong),임상민(Sang-Min Lim),이철균(Choul-Gyun Lee) 한국해양바이오학회 2019 한국해양바이오학회지 Vol.11 No.1
For successful microalgal biodiesel production, the strain should be selected carefully. Fast growth rate and high fatty acid contents are desired traits for algal biodiesel production. In ocean cultivation of microalgae, seawater temperature slowly changes over seasons, and rotating algal strains in accordance with their optimal temperature could improve overall productivity. Additionally, use of indigenous strain is preferred to alleviate potential impacts on the environment. In this study, five strains of Tetraselmis sp. from nearshore of Youngheung Island, Incheon, Korea, were isolated during winter and characterized for their growth patterns and fatty acid compositions in the low temperatures (5–15°C). The five strains showed various characteristics in optimal growth temperature, fatty acid contents, and compositions. Compared with a strain of Tetraselmis sp., isolated from Ganghwa island in a previous study, a rapid-growing strain with 237% higher biomass productivity and an oleaginous strain with twice higher fatty acid contents at 10°C were isolated. The oleaginous Tetraselmis strain showed the highest fatty acid productivity among the strains, having 438% higher productivity than the previous strain. Using the new isolates in the seasons with low seawater temperature would improve microalgal fatty acid productivity in ocean cultivation.