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김지현,박창신,함대현,이혜정,심인섭,Kim, Ji-Hyun,Park, Chang-Shin,Hahm, Dae-Hyun,Lee, Hye-Jung,Shim, In-Sop 대한약침학회 2004 Journal of pharmacopuncture Vol.7 No.1
Acupuncture has fairly good weight-reducing effect in treating simple obesity due to the neuroendocrine regulation. In this study, the antiobesity effects of herbal acupuncture(HA) with Sang-hwang(phellinus linteus) at Fuai(SP16) were investigated in the rat fed on high-fat(HF) diet. Sang-hwang mushroom has been proven to have anti-carcinogenic effects and Sang-hwang extracts are highly effective in treatment and preventive treatment of AIDS, diabetes and high blood-pressure. To determine whether the Sang-hwang herbal acupuncture may have the anti-obesity effect, male Sprague-Dawley(4-wk-old) rats were fed a HF diet for 5 wk, which produced significant weight gain compared to rats were fed a normal diet, and then herbal acupuncture were treated for 3 wk in HF diet group. The body weight, food consumption, food effeciency ratio(FER), body fat mass, plasma nitric oxide(NO) were investigated in rats fed on normal diet, HF diet, and HF diet with HA(HF-diet-HA) groups. NO has been proposed to be involved in the regulation of food intake. In addition, the expression of appetite peptides such as orexigenic peptide neuropeptide Y(NPY) and the anorectic peptide cholecystokinin(CCK) were observed in the hypothalamus. HF-HA group reduced body weight gain, FER, body fat contents and NO concentration compared to HF diet group. The expression of NPY was reduced in arcuate nucleus(ARC), and CCK was increased in the paraventricular nucleus(PVN) after treatment of HA. In conclusion, Sang-hwang HA reduced adipocity, plasma NO and hypothalamic NPY, but increased CCK expression in the HF dietinduced obesity rat, therefore HA may have anti-obesity action through regulating body weight and appetite peptide of the central nervous system.
오징어 유래 포스파티딜세린(phosphatidylserine)의 in vitro 항염 효과
염미정(Mijung Yeom),박현정(Hyun-Jung Park),심현수(Hyun-Soo Shim),심인섭(Insop Shim),한정준(Jeong-Jun Han),정국훈(Guk Hoon Chung),허송욱(Song Her),정동명(Dong-Myong Jeong),함대현(Dae-Hyun Hahm) 대한스트레스학회 2011 스트레스硏究 Vol.19 No.1
본 연구에서는 Raw264.7 대식 세포주에서 lipopolysaccharide (LPS)로 유도된 tumor necrosis factor-alpha (TNF-α)와 interleukin-1 beta (IL-1β)의 분비에 대한 오징어 유래 포스파티딜세린(phosphatidylserine)의 효과를 확인하였다. Raw264.7 대식 세포주에서 PS의 세포독성 효과는 MTT 분석으로 조사하였으며, TNF-α와 IL-1β의 mRNA 및 단백질의 발현 정도는 각각 RT-PCR 및 ELISA 분석법으로 확인하였다. PS는 100μg/ml 농도까지는 세포 독성을 나타내지 않았으며, 세포 독성을 보이지 않는 농도에서 LPS로 유도된 IL-1β와 특히 TNF-α의 mRNA 및 단백질의 발현을 저해하였다. 이러한 실험 결과는 염증성 질환을 위한 유용한 물질로써 PS의 개발 가능성을 시사한다고 사료된다. In the present study, the effects of squid-derived phosphatidylserine (PS) have been evaluated on lipopolysaccharide (LPS)- induced release of tumor necrosis factor-alpha (TNF-α) and interleukin-1 beta (IL-1β) in the macrophage Raw 264.7 cells. The cytotoxicity of PS in Raw 264.7 macrophages was measured by MTT-based cytotoxicity assay. The mRNA and protein levels of tumor necrosis factor (TNF)-α and interleukin (IL)-1β were measured by quantitative reverse-transcriptase polymerase chain reaction (RT-PCR) and by enzyme-linked immunosorbent assay (ELISA), respectively. Cytotoxic effects of PS in Raw 264.7 macrophages were not observed at concentration up to 100 μg/ml. Squid PS inhibited the mRNA and protein expression of TNF-α but not IL-1β. Taken together, these results indicated that squid-originated PS exhibited a significant activity of anti-inflammation in vitro and might be a useful candidate for treating various inflammatory diseases. (Korean J Str Res 2011;19:89∼95)
한동오,최보희,이혜정,심인섭,강성길,함대현,Han Dong-Oh,Choi Bo-Hee,Lee Hye-Jung,Shim Insop,Kang Sung-Keel,Hahm Dae-Hyun 대한동의생리학회 2005 동의생리병리학회지 Vol.19 No.3
Most inflammatory disorders are usually treated using anti-inflammatory drugs including non-steroidal anti-inflammatory drugs (NSAID) and steroidal anti-inflammatory drugs (SAID). In a prolonged use, however, they may frequently produce adverse side-effects. Thus, it is necessarily required to develop a new anti-inflammatory drug with little side-effects. Nephrite has been widely used by traditional oriental medicine to cure the various chronic diseases. In order to verify the anti-inflammatory activity of nephrite, the TPA (12-O-tetradecanoylphorbol-acetate) or the croton oil-induced edema was developed in the mouse ears and the nephrite powder suspension or the nephrite water was directly applied to the ear edema. It was found that nephrite could significantly reduce the ear swelling implying its strong potential as an active anti-inflammatory agent when comparing to indomethacin, a non-steroidal anti-inflammatory drug.