정신분열병(精祥分裂病) 환자(患者)의 사회적(社會的) 지지망(支持網) 분석(分析)

한창환,김광진,석재호,Han, Chang-Hwan,Kim, Kwang-Jin,Suk, Jae-Ho 한국정신신체의학회 1996 정신신체의학 Vol.4 No.2

This study was designed to evaluate the social support network of schizophrenic patients. 64 schizophrenic patients being treated as out-door patient were compared with 30 neurotic control patients. Schizophrenics were divided into positive, subpositive, subnegative and negative subgroups by present symptom and social network of both schizophrenics and control group were evaluated. The results are as follows: 1) Social network of schizophrenics was smaller than that of control group. Size of social network of schizophrenics was 10.6 and that of control group was 23.5. 2) In both kin and nonkin, social network of schizophrenics was smaller than that of control group. Of the kin, schizophrenics were more supported by wife or husband, father, and mother, but were less supported by brother, son and other relatives. 3) There was no difference in the kin or nonkin or total supporters between the four subgroups of schizophrenics. But, subgroup of schizophrenics which was divided as having negative symptom had smaller network than control group in active formal and informal supporters. 4) When divided into 4 support areas, schizophrenics was remarkably less supported in emotional, instrumental and appraisal support area than control group, but there was no difference in the informational support areas. 5) Compared with control group, schizophrenics more often mentioned parent and ten often mentioned nonkin supporter as the one that is most important to him. 6) Schizophrenics had smaller cluster and less leisure activity than control group. Subgroup of schizophrenics who was divided as having negative symptom had less frequency of leisure activity than other subgroups.

신경전달물질 및 신경내분비 Marker를 이용한 치료반응의 평가

한창환,Han, Chang-Hwan 대한생물정신의학회 1995 생물정신의학 Vol.2 No.1

Numerous investigators have conducted extensive investigation in the search for biological markers in psychiatric illness. There are, as a test of q biological approach to the diagnosis of the psychiatric illness, tests for the neurotransmitters, their metabolites, and related enzymes, the neurotransmitter receptors, the neuroendocrine output and response, the membrane transport, peptides and eletrolytes. They are called the biological markers, and they are helpful for the diagnosis or differential diagnosis, choice of treatment or drugs, symptom improvement, predictor of recurrence and anticipation of suicidal attempt. These studies are among the main purposes that are pursued in the neuroscience and based on the potential utility of the biological markers mentioned above. Since 1970's, lots 01 biological markers' studies for the diagnosis, differential diagnosis or subtypes differentiation have been done but varieties of different opinions have been drawn since then through they could explain the charaters of main psychiatric illness(especially schizophrenia and mood disorder). But, the search for biological markers, including displines of neuroendoclinology and neurochemistry(neurotransmitter and thair metabolite), has yielded a number of putative trait merkers and state markers for psychayric illness. This paper aims to anticipate or evaluate the good response to the therapy(Therpeutic response) with lots of markers. Acoording to the diagnosis of lots of diseases or subtypes, we are going to review the papers, mainly concern with 'Is there any Marker' or 'Is any test possible to detect the improvement clinically?' 'Is it possible to predict the recurrence or good prognsis?' or 'Is it possible to select any drug or therapy to bring the good response?' The biological tests to review are mainly the metabolites of catecholamine neurotransmitter, and especially neuroendocrine test based on the knowledge that hormons of the adenohypophysis are influenced by activity of the cerebral or limbic neurons as well as the hypothalamus ones. Among them, author introduced some clinically available tests that are DST, TRH stimulation test(TRHST), GH stimulation test, and the urine MHPG test that can give us the evaluation of the treatment response, the predictor for recurrence or choice of drug that can bring a good response. So author discussed thair potential utility in clarifying, therapeutic, and prognostic issues in psychatric illness. We hope they'll be used and look forward to more active study on the different opinion.

우울증 아형들의 이해

한창환,류성곤,Han, Chang-Hwan,Ryu, Seong Gon 대한생물정신의학회 2001 생물정신의학 Vol.8 No.1

우울증으로 고통받는 많은 환자들에서 보이는 다양항 양상과 다양한 경과를 자주 접하면서 분류를 어떻게 하여야 임상적으로 유용한가 의문을 가지게 된다. 이에 저자들은 우울증의 아형 평가의 필요성과 평가도구들을 문헌을 통하여 고찰하였다. 원래부터 이들이 이질적인 집단으로 구성되어 있는지, 하나의 유전적 소인이 있어 개인에 따라서 병의 진행 시기에 따라서 여러 우울증의 spectrum으로 표현되는 것인지 문제가 제기되어 왔지만, 현재로서는 분명히 알 수 없다. 저자들은 먼저 "우울증 스펙트럼" "양극성 우울과 단극성 우울이 공통의 하나의 유전적 인자를 가지는가" "양극성 스펙트럼 장애"등 강한 주장들이 있어 문헌 고찰을 통해서 알아보았다. 그리고, 최근 생물학적인 연구로부터 나온 세로토닌 관련 우울증 가설을 알아보았다. 이 우울증 가설(SeCA depression)은 조기 모성 분리 혹은 모성 박탈 같은 유년시절의 부정적 경험, 불안, 공격성, co-rtisol 증가, cortisol flattening, DST 양성, 스트레스 사건, CRF 상승, 5HIAA저하 등을 연결하여 우울증의 역동을 쉽게 설명하였고 생물-심리-사회적 접근을 가능하게끔 하는 우울증의 모델이다. 둘째로 고전적인 생물학적 지표 즉 DST, TRH 자극 검사, 및 뇨 MHPG 검사 결과에 따르는 우울증 아형을 구분하고 특징을 살펴보았고 이들의 역사적이고 임상적인 의미를 알아보았다. 그밖에 APOE epsilon 4 allele, 기질-성격이론(Temperament Character Inventory : TCI) 심박동 변이도(heart rate variability : HRV) 같은 요인들을 비롯하여 잘 알려진 증상이나 진단으로 분류된 아형들을 조사하여 임상적인 의미를 찾아보았다. The debate about whether depressive disorders should be divided into categories or arrayed along a continuum has gone for decade, without resolution. In our review, there is more evidence consistent with the spectrum concept than there is with the idea that depressive disorders constitute discrete clusters marked by relatively discontinuous boundaries. First, "depression spectrum", "is there a common genetic factors in bipolar and unipolar affective disorder", "threshold model of depression" and "bipolar spectrum disorder" are reviewed. And, a new subtype of depression is so called SeCA depression that is a stressor-precipitated, cortisol-induced, serotonin-related, anxiety/aggression-driven depression. SeCA depression is discussed. But, there is with the idea that depressive disorders constitute discrete subtypes marked by relatively discontinuous boundaries. This subtypes of depressive disorder were reviewed from a variety of theoretical frames of reference. The following issues are discussed ; Dexamethasone suppression test(DST), TRH stimulation test, MHPG, Temperament Character Inventory(TCI), and heart rate variability(HRV).

'의학적 상태에 영향을 미치는 심리적 요인들' 심혈관계 질환의 모형 개발

한창환,Han, Chang-Hwan 한국정신신체의학회 1998 정신신체의학 Vol.6 No.2

The author conducted a literature review to better characterize the current state of knowledge regarding the relationship between psychological and behavioral factors and cardiovascular disease. This review focus on several problems : Hypertension, coronary artery disease such as myocardial infarction and angina pectoris. We describe model for understanding the relation-ship of psychological factors to the disease, review the results of relevant research studies and provide recommendation for further research.

PC 그라드 환경을 위한 오픈 API 개발 동향 및 사례

한창환,한연희,길준민,윤준원,최장원,Han, Chang-Hwan,Han, Youn-Hee,Gil, Joon-Min,Yoon, Jun-Weon,Choi, Jang-Won 한국콘텐츠학회 2008 한국콘텐츠학회지 Vol.6 No.4

심혈관 질환과 관련된 심리적인 요인과 행동적 요인 - 스트레스와 성격을 중심으로 -

한창환,Han, Chang-Hwan 한국정신신체의학회 1995 정신신체의학 Vol.3 No.2

The author conducted a literature review to better characterize the current state of knowledge regardeding the relationship between psychological and behavioral factors and cardiovascular disease. This review focus on several Problems : hypertension, coronary artery disease such as myocardial infarction and angina pectoris, sudden death, arrhythmia, vasomotor(vasodepressor) syncope, and psychogenic cardiac nondisease. We describe model for understanding the relationship of psychological factors to the disease, review the results of relevant research studies and provide recommendation for further research.

국제 및 국내 시험인정시스템에 관한 동향 조사

한창환(Han, Chang-hwan) 한국항공우주연구원 2015 항공우주산업기술동향 Vol.13 No.1

세계 각국은 국제 자유무역을 원활하게 하기 위하여 관세를 폐지하고, 세계를 하나로 묶는 국제화 시대를 만들어가고 있다. 그러나 이면에는 자국의 산업보호를 위해 보이지 않는 또 다른 장벽을 만들고 있다. 즉, 표면적으로는 안전성등의 여러가지 이유를 내세우고 있지만 자국의 시험인정을 받아야만 수입이 허가되는 등 수입규제를 하고 있다. 이러한 문제를 해결하기 위해 시험, 검사 및 교정 등에 대하여 상호인정을 해주는 국제시험인정기구가 설립되었으며, 우리나라도 KOLAS라고 하는 한국공인인정기구를 두고 있다. 여기서 세계 각 지역별 인정기구 및 역할에 대하여 알아보고 또한 국내 시험인정기구를 살펴보기로 한다. Many countries have removed income tariffs for promotion of the free trade. On the other hand, they make technical barriers enforcing to meet their quality standards to protect their home industries. To resolve these issues the international accreditation cooperation was established to mutually accept a product when the product is tested once and accepted everywhere. South Korea has a accreditation organization called KOLAS. In this report, some basic roles of the international and regional organizations of the world including the KOLAS in Korea are presented.

냉동 보관된 인간 관절 연골의 생존력

한창환 ( Han Chang Hwan ),김원유 ( Kim Won Yu ),지종훈 ( Ji Jong Hun ),김용환 ( Kim Yong Hwan ) 대한슬관절학회 2003 정기학술대회 초록집 Vol.- No.-

Korea@Home 시스템에서 웹 서비스 Open API 활용을 위한 설계

한창환(Chang-Hwan Han),한연희(Youn-Hee Han),길준민(Joon-Min Gil),최장원(Jang-Won Choi),윤준원(Jun-Weon Yoon) 한국정보기술학회 2007 Proceedings of KIIT Conference Vol.2007 No.-

기존의 P2P기반의 분산컴퓨팅 시스템을 일반 응용수행자가 사용하기 위해서는 수동적으로 시스템에 위탁하여 수행하여 왔다. 이러한 구조에서 응용수행자가 자신이 원하는 응용을 분산컴퓨팅에서 수행하고 결과를 받아오는 것은 복잡하고 어려운 과정이었다. 본 논문에서는 이러한 과정을 간편화하고 분산컴퓨팅 시스템의 참여도를 높이기 위하여 웹 서비스 Open API를 사용하여 개방형 분산컴퓨팅 시스템을 설계하였다. 본 논문은 국내에서 2003년도부터 개발된 P2P 기반 분산컴퓨팅 시스템인 Korea@Horne을 소개하고 이 시스템에서 효율적으로 Open API를 제공하기 위한 시스템 모델을 설정하고 테스트베드를 설계한다. 또한, 응용수행자의 응용과 Korea@Home 사이의 인터페이스를 정의하고 그 인터페이스를 활용한 응용 코드의 실례를 제시한다. In the existing P2P-based distributed computing systems, application users have executed their applications passively. In this architecture, application users suffer from some complex and tedious processes, such as executing their application in the distributed systems, receiving final result from the systems, and so on. In this paper, we will design an open distributed system with web service Open APIs in order to enhance the application participation of Korea@Home by simplifying these complex and tedious processes. First, this paper introduces a P2P-based distributed system, namely Korea@Home, which has been developed in Korea from 2003. Second, we propose the system model to provide Open APIs for Korea@Home, and design a testbed under the existing Korea@Home systems. Finally, we define interfaces between applications and Korea@Home systems, and present application codes utilizing the interfaces.

PC 그리드 환경을 위한 오픈 API 개발 동향 및 사례

한창환(Chang-Hwan Han),한연희(Youn-Hee Han),길준민(Joon-Min Gil),윤준원(Jun-Weon Yoon),최장원(Jang-Won Choi) 한국콘텐츠학회 2008 한국콘텐츠학회지 Vol.6 No.4