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공기 전색증 고양이에서 Norepinephrine, Isoproterenol, Nitroglycerin 이 혈역학 및 혈액가스분석치의 변화에 미치는 영향에 대한 비교
한성민,이일옥,서병태 대한마취과학회 1988 Korean Journal of Anesthesiology Vol.21 No.4
The effects of Norepinephrine (NE), Isoproterenol (ISO) and Nitroglycerin (NTG) on the hemodynamic, arterial and venous blood gas analysis changes in air embolized cats were investigated. Under general anesthesia with Halothane, cats were injected 1 mg/kg of air acutely to decrease mean arterial pressure (MAP) about 30 to 40 percent of control value through superior vena cava. 14 cats were divided into two groups of 7 each (group 1 and 2). group 1 cats received NE and then NE with NTG therapies. IN group 2, ISO and then ISO with NTG therapies were taken. The results were as follows: 1) Hemodynamic changes Group 1: NE increased the MAP from 69±8 mmHg (mean±SD) to 116±14 mmHg (p<0.05), decreased the right atrial pressure (RAP) from 18±4 mmHg to 11±3 mmHg (p<0.05). Combined therapy with NTG decreased the MAP from 116±14 mmHg to 101±10mmHg(p<0.05), the HR from 167±16 beats/min(bpm) to 150±4 bpm (p<0.05), the RAP from 11±3 mmHg to 8±3 mmHg (p<0.05). Group 2: ISO increased the MAP from 81±8 mmHg to 112±14mmHg (p<0.05), and the HR from 152±21 bpm to 190±24bpm (p<0.05). Combined therapy with NTG decreased the HR from 190±24 bpm to 174±19 bpm (p<0.05), the CVP from 14±7 mmHg to 14±3 mmHg (p<0.05), and the RAP from 13±3 mmHg to 12±3 mmHg (p<0.05). 2) Blood gas analysis changes Groiup 1 : NE with NTG combined therapy incrased the arterial oxygen tension from 335±54 mmHg to 372±49 mmHg, decreased the venous CO_2 tension from 52±9 mmHg to 47±4 mmHg. Group 2 : ISO with NTG combined therapy increased the arterial oxygen tension from 344±85 mmHg to 375±50mmHg (p<0.05). (Paired t-test, p<0.05). In conclusion, NE and ISO increased MAP in venous air embolism with mopderately decreased MAP. Inotropic agent with NTG therapy improved arterial oxygenation.
Contributions of Public Investment to Economic Growth and Productivity
한성민 한국개발연구원 2017 KDI Journal of Economic Policy (KDI JEP) Vol.39 No.4
Whereas a large variety of previous studies show mixed results regarding the relationship between public investment and economic outcome, several studies have been conducted on related issues in Korea. The present study deals with the effect of public investment in Korea on economic growth and productivity. Using administrative data, it exploits three different methodologies: the total factor productivity approach, production function approach, and stochastic frontier production function approach. The results of this study show that public investment has a statistically significant effect on economic growth. However, it contributes little to enhance productivity. It is explained that there exists inefficiency of production in the Korean economy. These findings indicate that public investment has played a central role in the direct input factor and not in indirect role in Korea. Thus, it is necessary for public investment policies to concentrate on enhancing the efficiency of the Korean economy.
한성민,전병승,최옥경,상병인 한국공업화학회 2017 한국공업화학회 연구논문 초록집 Vol.2017 No.1
C<sub>5</sub>-C<sub>8</sub> MCFAs could be produced from waste water containing organic compounds by mixed microorganisms. The purpose of this study is to compare the production performance and microbial community according to the storage method (freeze-treatment) of the inoculum (sludge from waste water plant). The un-frozen sludge was injected into the reactor containing food waste of 100 g/L, anaerobically. The frozen sludge was pretreated under -70°C during 7 day, after that, it was injected into the reactor. Un-frozen condition showed various carboxylic acids containing MCFAs even in initial phase, while the frozen condition produced limited MCFAs after production of short-chain fatty acids. The un-frozen condition showed enrichment of Lactobacillus and Megasphaera genus. While, in the frozen sludge, Lactobacillus, Eubacterium and Caproiciproducens genus were dominated as significant ratios. This analysis showed that microbial community for MCFA production can be changed by low temperature.
Clonidine 전투약환자에서 수술전 자율신경기능 검사에 의한 Enflurane 마취중 혈역학변화의 예측
한성민,이병희,최종무 대한마취과학회 1994 Korean Journal of Anesthesiology Vol.27 No.7
Clonidine, an a2-adrenergic agonist, has sedative and analgesic properties and reduces the inhalation anesthetic requirement and modifies the hemodynamic responses to surgery. But occasionally, severe bradycardia and hypotensian during inhalation anesthesia develops following oral clonidine premedication. To predict intraoperative hemodynamic changes during enflurane anesthesia, author evaluated noninvasive autonomic tests consisted of respiratory sinus arrhythmia (RSA), Valsalva's maneuver (VSV), R-R interval difference in head up tilt (HTR) and diastolic blood pressure difference in head up tilt (HTP) in fifty-one patients (ASA physical status I∼II ) scheduled for elective surgery. Patients were received 5 ug/kg of oral clonidine at 90 min before operation. Anesthesia was maintained with enflurane, oxygen (2 ℓ/min) and nitrous oxide (2 ℓ /min). The enflurane concentration was controlled to maintain blood pressure within ±20% of preinduction value. After anesthesia, patients were allocated to two groups ording to above and below 0.5 MAC (0.84 vo1%) enflurane concentration. Each preoperative autonomic test results revealed significant correlation with heart rate (HR), mean arterial pressure (MAP), and enflurane concentration (EC), respectively (p$lt;0.05). Values of RSA, HTR, HTP, MAP and HH wm 81±14.4 ms, 76±43.5 ms, -6±5.2 mmHg, 76+6.4 mmHg and 63±5.5 beats/min, respectively in below 0.5 MAC enflurane concentration group and were significantly different from values of RSA; 16933.7 ms, HTR; 175±41.7 ms, HTP; 6±3.1 mmHg, MAP; 90±11.0 mmHg and HR; 76±7.6 beats/min in above 0.5 MAC enflurane concen- tration group (p$lt;0.05). In conclusion, the simple noninvasive autonomic tests are recommended in prediction of intra-operative hemodynamic changes during enflurane anesthesia when oral clonidine premedication is indicated.
한성민,김종욱,임정길,최인철,박평환,이동명,서병태,함병문 대한마취과학회 1997 Korean Journal of Anesthesiology Vol.32 No.3
서 론 : 칼슘이온은 시냅스에서 신경전달물질의 분비를 조절하고 전압의존성 칼슘 채널은 세포내 칼슘농도변화에 중요한 역할을 한다. 클로니딘 및 테트라카인이 백서의 척수신경절 신경세포의 칼슘채널에 미치는 영향과 두 약제의 상호작용을 알아보고자 patch clamp 방법을 이용하여 실험하였다. 방 법 : 21∼30일된 백서의 흉,요추부위의 척수신경절을 분리적출한 후 트립신 처리하여 신경세포를 분산세포배양하였다. 미세전극을 세포에 접촉시켜 whole cell mode의 patch clamp를 시행한후 세포막전압을 60mV로 고정시키고 수직형 펄스를 주어 내향성 전류를 측정하였으며 클로니딘과 테트라카인에 의한 효과를 검사하였다. 결 과 : 클로니딘 500 μM은 칼슘전류를 46 8% 감소시켰다. GDP S(1mM)을 처치하였을 경우에는 변화가 없었으나 GTP S(1mM)를 처치한후에 칼슘전류는 23 8% 감소하였다. 클로니딘 0.1, 0.5, 1, 5, 10mM일때 칼슘전류의 감소는 각각 12 ±3, 46± 9, 53± 12, 66± 15, 88± 18%이었으며, 테트라카인 0.01, 0.1, 0.5, 1mM일때는 5 ±2, 11± 4, 52± 11, 87 ±18%로 칼슘전류가 감소하였다. 테트라카인 각각의 농도에 클로니딘 100 M 혼합한 경우에 칼슘전류는 27± 12, 46±17, 74±11, 98±9%로 더 많이 감소하였다. 결 론: 클로니딘의 칼슘채널 억제는 용량에 비례하며 이러한 과정은 G-protein에 의한 것으로 사료된다. 테트라카인도 용량의존성 칼슘채널 억제현상을 보이며 단독사용시 보다 클로니딘을 혼합사용한 경우 억제효과가 크다. 이러한 칼슘채널의 억제효과는 신경전달물질의 방출을 감소시켜 마취작용을 일으키는데 기여할 것으로 사료된다. (Korean J Anesthesiol 1997; 32: 329~335)