고개 숙이는 언론

한규동 한국언론학회 1993 저널리즘비평 Vol.10 No.1

DNA methylation of mobile genetic elements in human cancers

한규동,이정남,김희수,양광모,이주미 한국유전학회 2013 Genes & Genomics Vol.35 No.3

Mobile genetic elements are responsible for half of the human genome, creating the host genomic instability or variability through several mechanisms. Two types of abnormal DNA methylation in the genome, hypomethylation and hypermethylation, are associated with cancer progression. Genomic hypermethylation has been most often observed on the CpG islands around gene promoter regions in cancer cells. In contrast, hypomethylation has been observed on mobile genetic elements in the cancer cells. It is recently considered that the hypomethylation of mobile genetic elements may play a biological role in cancer cells along with the DNA hypermethylation on CpG islands. Growing evidence has indicated that mobile genetic elements could be associated with the cancer initiation and progression through the hypomethylation. Here we review the recent progress on the relationship between DNA methylation and mobile genetic elements, focusing on the hypomethylation of LINE-1 and HERV elements in various human cancers and suggest that DNA hypomethylation of mobile genetic elements could have potential to be a new cancer therapy target in the future.

소리를 찾아서 외 2편

한규동 고요아침 2007 열린시학 Vol.12 No.1

가오리鳶 외 2편

한규동 고요아침 2006 열린시학 Vol.11 No.4

음악과 해학

韓圭東 숙명여자대학교 음악대학 학생위원회 1970 淑音 Vol.4 No.-

마을과 인문학 문화운동의 현장 사례 연구

한규동 한국문화융합학회 2020 한국문화융합학회 전국학술대회 Vol.2020 No.-

벤처기업 창업가의 특성과 경영전략이 경영성과에 미치는 영향

한규동 한국벤처창업학회 2019 벤처창업연구 Vol.14 No.6

This paper empirically analyzed the relationship between the characteristics of venture business founders and management performance, setting the management strategy as a parameter to provide a suggestion for the survival and development of venture companies that play an important role in the national economy and job creation. Previous studies in Korea have analyzed the relationship between the characteristics of business founders, management strategies and management performance in a single dimension. This paper, however, explained the business performance of a company from a multi-dimensional perspective while setting the characteristics of business founders as independent variables and setting the business strategy of the enterprise as a parameter. The first result of the analysis shows that the characteristics of venture business founders have a positive effect on business performance. In particular, among the characteristics of venture business founders, a progressive spirit has had the greatest impact on business performance. On the other hand, the influence of risk sensitivity was very weak. Second, the characteristics of venture business founders were found to have a positive effect on business strategy. In particular, innovation was an important variable that affected the technological innovation differentiation strategy, and a progressive spirit was the most influential factor in the marketing differentiation strategy. Third, management strategies of venture firms were found to have a positive effect on business performance. In particular, the technology innovation differentiation strategy has a greater impact on business performance than the marketing differentiation strategy. Fourth, it was revealed that management strategy partially has a mediated effect on the relationship between the characteristics of venture business founders and management performance. In other words, it was found that the characteristics of the founders have a direct impact on business performance but if it is linked to management strategy it has an indirect effect on business performance. The results of this study show that business performance improves when venture business founders' personal characteristics and the firms’ management strategy are combined. 본 연구에서는 국가경제와 일자리 창출에 중요한 역할을 수행하고 있는 벤처기업의 생존 및 발전에 시사점을 제시하고자 벤처기업 창업가의 특성과 경영성과와의 관계에 경영전략을 매개변수로 하여 실증분석을 하였다. 기존의 국내 선행연구들이 창업가의 특성과 경영전략을 경영성과에 대한 동일한 단일차원의 함수관계로 분석하는데서 벗어나서, 창업가의 특성을 독립변수로, 기업차원의 경영전략을 매개변수로 하여 다차원적인 관점에서 기업의 경영성과를 설명하려고 하였다. 분석결과는 첫째, 벤처 창업가의 특성은 경영성과에 정(+)의 영향을 미치는 것으로 나타났다. 특히, 창업가의 특성 중에서도 진취성이 경영성과에 미치는 영향력이 가장 큰 변수로 확인되었다. 반면, 위험감수성은 그 영향력이 상대적으로 매우 미미한 수준으로 분석되었다. 둘째, 벤처 창업가의 특성은 경영전략에 정(+)의 영향을 미치는 것으로 나타났다. 특히, 창업가 특성 중에서 혁신성은 기술혁신 차별화 전략에, 진취성은 마케팅 차별화 전략에 가장 큰 영향을 주는 중요한 변수로 분석되었다. 셋째, 벤처기업의 경영전략은 경영성과에 정(+)의 영향을 미치는 것으로 나타났다. 특히, 경영전략 중에서도 기술혁신 차별화전략이 마케팅 차별화 전략에 비해 경영성과에 미치는 영향력이 큰 것으로 분석되었다. 넷째, 벤처 창업가의 특성과 경영성과와의 관계에서 경영전략은 부분 매개효과가 있는 것으로 나타났다. 즉, 창업가의 특성은 경영성과에 직접적인 영향을 미치기도 하지만 경영전략과 매개되어 경영성과에 간접적인 영향을 미치는 것으로 밝혀졌다. 이런 연구결과는 벤처기업 창업가의 개인적인 특성과 기업차원의 경영전략이 연계되었을 때 더 극대화된 경영성과를 이룰 수 있다는 것을 시사해준다.

스타트업 실태 및 육성방안에 관한 연구: 성남시 스타트업을 중심으로

한규동,전병훈,Han, Kyu-Dong,Jeon, Byung-Hoon 한국벤처창업학회 2022 벤처창업연구 Vol.17 No.5

This study was conducted to derive policy measures such as fostering and supporting by examining the actual conditions of domestic startups. The subject of this study was the start-ups located in Seongnam-si, where Pangyo Techno Valley, which is the highest-level innovation cluster in Korea and is evaluated as a start-up mecca. Startups were defined as startups under 7 years old based on new technologies such as IT, BT, and CT, and the subjects of the study were selected. This can be seen as a step forward from previous research in that it embodies the concept of a startup that was previously abstract in a quantitatively measurable way. As a result of the analysis, about 94% of startups are distributed in the so-called "Death Valley" growth stage, and startups above scale-up, which means full-scale growth beyond BEP, account for about 6%. appeared to be occupied. He cited the problem of start-up funds as the biggest difficulty in the early stages of startups, and cited the loan evaluation method that prioritizes sales or collateral in raising funds as the biggest problem. In addition, start-ups rated the access to private investment capital such as VC, AC, and angel investors at a low level compared to policy funds, which are public funds. Most startups showed a lot of interest in overseas expansion, and they chose matching overseas investors such as overseas VCs as the biggest support for overseas expansion. The overall competitiveness in the overseas market was 49.6 points, which is less than 50 points out of 100, indicating that the overall competitiveness was somewhat inferior. It was analyzed that public support and investment in overseas sales channels (sales channels, distribution networks, etc.) should be prioritized along with enhancement of technological competitiveness in order for domestic startups to increase their competitiveness in overseas markets as well as in the domestic market.

PAHs를 분해하는 Sphingomonas sp. K-19의 분리 및 특성

한규동,김성환,손승렬,Kim, Seong-Hwan,Son, Seung-Ryeol 한국미생물학회 2003 미생물학회지 Vol.39 No.4

Polycyclic aromatic hydrocarbon (PAHs)들에 오염된 토양시료를 채취한 후, phenanthrene을 유일한 탄소원과 에너지원으로 배양하여 PAHs를 분해하는 균주 K-19를 분리하였다. 이 균주는 지방산 조성 실험에서 Sphingomonas 속 균주의 특징인 2-hydroxy fatty acid들과 18:1w7를 포함하고 있었으며, 16S rDNA 염기서열을 이용한 계통유전학적 분석결과 Ribosomal Database에서 Sphingomonas CF06과 가장 가까운 유연관계를 보였다. K-19는 phenanthrene 존재 하에서 빠른 성장률과 높은 phenanthrene 분해율로 10일만에 500 ppm의 phenanthrene을 92% 분해하였으며, phenanthrene 이외에 indole, naphthalene 등도 분해하였다. 또한 전 배양 방법을 통하여 phenanthrene 분해능이 더욱 증진됨을 알 수 있었다. 이러한 결과는 우리나라의 유류 오염토양에 Sphingomonas 속의 미생물이 존재하며 이 미생물은 여러 종류의 다중 고리 방향족 화합물을 분해할 수 있는 능력을 가지고 있음을 보여준다. We isolated a bacterium, K-19, which could degrade PAHs (polycyclic aromatic hydrocarbons) from a soil sample contaminated with PAHs. K-19 was cultured under the conditions where phenanthrene was a sole source of carbon and energy.

나의 음악방랑기

韓圭東 淑明女子大學校 音樂大學 學生委員會 1968 淑音 Vol.2 No.-