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- 저자 : 하혜경 ( Hyekyung Ha ) (검색결과 17 건)
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평위산 전탕액의 보관 온도 및 기간에 따른 항염증 효능 비교
하혜경,신인식,임혜선,전우영,김정훈,서창섭,신현규,Ha, Hyekyung,Shin, In-Sik,Lim, Hye-Sun,Jeon, Woo-Young,Kim, Jung-Hoon,Seo, Chang-Seob,Shin, Hyeun-Kyoo 대한한의학방제학회 2012 大韓韓醫學方劑學會誌 Vol.20 No.2
Objectives : To provide the information of preservation method for herbal decoction, we evaluated the anti-inflammatory effects according to preservation temperature and period of Pyungwi-san (PWS, Ping wei-san) decoction. Methods : The anti-inflammatory activity of PWS was investigated by carrageenin-induced paw edema in SD rats. At 0 month, PWS extract was administrated 100, 300 and 1000 mg/kg/day orally for seven days prior to induction of edema. Edema was induced by subcutaneous injection of 1% carrageenin into the right hind paw. The paw volume was measured at 4 hr following carrageenin-induced paw edema in rats. At 6 and 12 months, PWS extracts according to preservation temperatures (room temperature, $4^{\circ}C$ and $-20^{\circ}C$) were administrated in rats and then carrageenin-induced paw edema volume was measured. Results : PWS showed inhibitory effect on carrageenin-induced paw edema in rats and the optimal dose was 1000 mg/kg/day at 0 month of storage. At 6 month of storage, PWS storaged at $4^{\circ}C$ and $-20^{\circ}C$ were inhibited paw edema but that storaged at room temperature was not reduced paw edema in rats. Conclusions : These results suggest that PWS decoction pouch has anti-inflammatory activities at both $4^{\circ}C$ and $-20^{\circ}C$ during 6 month storage.
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수변경관 이용 활성화를 위한 자연형 하천 이용행태 및 만족도
하혜경 ( Hyekyung Ha ),서자유 ( Jayoo Seo ) 한국경관학회 2021 한국경관학회지 Vol.13 No.1
본 연구는 하천법 전면 개정 이후 친환경 하천계획 수립에 따라 복원된 자연형 하천을 대상으로 지역민들의 하천 이용행태 및 만족도 조사를 실시하였다. 이는 기존의 하천 자체의 환경과 생태자원에 대한 접근에서 지역민 참여와 프로그램 참여 등 자연형 하천의 수변경관 이용을 활성화하는데 목적이 있다. 연구 방법으로는 자연형 하천 유형에 따라 지역하천, 근린하천, 소하천으로 구분하여 각 하천별로 50명을 대상으로 총 291명 대상의 설문조사를 실시하였다. 연구결과 첫째, 자연형 하천은 지역하천, 근린하천, 소하천 등 하천의 규모와 길이, 고수부지의 상황에 따라 지역민들의 이용행태와 요구사항이 상이하므로 자연형 하천의 수변계획시 하천유형에 따라 구분하여 계획할 필요가 있다. 둘째, 조깅로, 운동공간, 체육시설 등 운동공간이 많은 규모가 큰 하천 일수록 만족도가 높았으며, 활동적인 운동시설에 요구도가 높고, 장시간 이용자가 많으므로 이에 대응하는 조경시설이 요구된다. 셋째, 자연형 하천이 소하천의 경우는 고수부지가 협소하고 수목량과 그늘이 부족하여 휴식시설 등에 대한 요구도가 높게 나타났는데, 추후 소하천의 수변공간에 세심한 계획이 필요하다. 본 연구는 자연형 하천의 수변환경을 개선하기 위한 기초자료로 주민들의 인식조사를 통해 하천 이용행태 및 만족도 조사를 실시함으로써 기존의 자연형 하천 연구가 수질, 수량, 동·식물 환경조사 등 생태환경연구에 치중하였던 것을 한계로 삼아 도심 내에서 자연형 하천의 수변경관 이용을 보다 활성화하기 위한 방안으로 자연형 하천 수변계획시 기초자료로서 의미가 있다. 그러나, 6개의 하천이 전국의 지방하천, 근린하천, 소하천을 대표하기에는 한계가 있으므로 연구 표본을 확대할 필요가 있다. This study conducted a survey on river usage behavior and satisfaction of local residents on natural rivers restored according to the establishment of eco-friendly river plans after the complete revision of the River Law. This aims to revitalize the use of natural rivers, such as local residents’ participation and program participation in access to the environment and ecological resources of the existing river itself. As a research method, according to the type of natural river, it was classified into regional rivers, neighboring rivers, and small rivers, and a total of 291 people were surveyed for 50 people for each river. This study conducted a survey on river usage behavior and satisfaction of local residents on natural rivers restored according to the establishment of eco-friendly river plans after the complete revision of the River Law. This aims to revitalize the use of natural rivers, such as local residents’ participation and program participation in access to the environment and ecological resources of the existing river itself. As a research method, according to the type of natural river, it was classified into regional rivers, neighboring rivers, and small rivers, and a total of 291 people were surveyed for 50 people for each river. As a result of the study, first, natural type rivers are comprehensively conceived such as rivers, waterside land use, and park green areas in the planning stage, but they are separated in the detailed design stage, and the consistency of river and waterfront planning is not maintained. Second, natural type rivers have different usage behaviors and requirements depending on the size and length of rivers such as regional rivers, neighboring rivers, and small rivers, and the situation of the reservoir site, so it is necessary to separate and plan the waterfront plans of natural type rivers. Third, in the case of small rivers of natural type rivers, the demand for rest facilities is high because the high water site is narrow and the amount of trees and shade is insufficient, while the demand for active sports facilities is high in rivers with large river sizes such as neighboring rivers or regional rivers. It is high and there are many users for a long time, so a landscaping facility corresponding to this is required. This study is the basic data for improving the water conversion landscape of natural type rivers, and by conducting a survey on river usage behavior and satisfaction through residents’ perception survey, the existing natural river research is based on ecological environment such as water quality, quantity, animal and plant environment survey. It is a method to further revitalize the watersides of natural rivers within the city, taking the focus on research as a limit, and is meaningful as basic data when planning natural rivers. However, it is necessary to expand the research sample because six rivers are limited to represent local, neighboring and small rivers nationwide.
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이남헌(Lee Namhun),하혜경(Ha Hyekyung),이호영(Lee Hoyoung),정다영(Jung Dayoung),최지윤(Choi Jiyoon),최영재(Choi Youngjae),정승일(Jeong Seungil),신현규(Shin Hyunkyoo) 한국한의학연구원 2008 한국한의학연구원논문집 Vol.14 No.1
Objective : To provide information about the accessory product of Broussonetia kazinoki Siebold or Broussonetia papyrifera (L.) Vent by analyzing old books of oriental medicine, domestic/international papers and related patents Methods : Old books related to the accessory product in the field of oriental medicine were reviewed, Research papers regarding the pharmacological activity of the by-products were reviewed and analyzed. Patents about the residual products were examined and classified by year and subject. Results: Seven kinds of by-products from Broussonetia kazinoki Siebold or Broussonetia papyrifera (L.) Vent has been used as medicines in oriental medicine. Recently, anti-oxidating, anti-cancer, anti-mutagenic and anti-inflammation activity of the residual product of these plants has been investigated through scientific research. There were 19 patents related with the accessory products of these plants, which were in the subjects of functional cosmetics, anti-inflammation, cleansing goods, hair restorers or improvement of learning ability, Further investigations about the activity of these plants are needed in bone metabolism, water balance and hemostasis in the future. Conclusion : Residual products from these plants is being used in various ways. However, more studies on the efficacy and mechanism, as well as safety, of these plants should be conducted precisely in the future.
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중수로 원전 주변 환경 및 인체 삼중수소 방사능 모니터링에 관한 고찰
한상준,이홍연,김보길,하혜경,신용주,SangJun Han,HongYeon Lee,BoGil Kim,HyeKyung Ha,YongJu Sin 한국방사선산업학회 2023 방사선산업학회지 Vol.17 No.4
As a result of evaluating the level of tritium emitted from the nuclear power plant in the environment and the human body, it was confirmed that tritium was detected in the environmental media and human urine samples to be investigated. It was found that the tritium was clearly detected. After the operation of the Tritium Removal Facility (TRF), which was operated for the purpose of removing tritium from the Wolsong nuclear power plant, the tritium emission showed a decreasing trend, and the tritium level in the environmental media also showed a tendency to decrease accordingly. However, for precise evaluation, it was necessary to select and investigate points by distance, season, and wind direction from the nuclear power plant, but it also showed characteristics that did not reflect this. As the cycle, etc., implemented the previous environmental monitoring program as it is, there was also a limitations in not being able to reflect the changing environment. Therefore, it is necessary to review and supplement the environmental monitoring investigation plan and results so far, and by applying the supplemented investigation plan to secure valid and reliable investigation results, it is judged that it will be an appropriate measure for environmental conservation and human protection in the vicinity of the nuclear power plant.
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보관 온도 및 기간에 따른 청심연자음 전탕액의 지표성분과 약리 활성 변화에 관한 연구
유새롬 ( Sae-rom Yoo ),하혜경 ( Hyekyung Ha ),이나리 ( Nari Lee ),신현규 ( Hyeun-kyoo Shin ),서창섭 ( Chang-seob Seo ) 대한본초학회 2017 大韓本草學會誌 Vol.32 No.4
Objectives : Chungsimyeonja-eum (CSYJE; Qingxinlianzi-yin in Chinese; Seishinrenshi-in in Japanese), a traditional herbal medicine, has been used for treating mouth dryness, hyperuresis. This study was designed to determine preservation period of CSYJE. We investigated the stability and biological activity of CSYJE depending on the preservation temperature and periods. Methods : CSYJE decoction was preserved for 0-6 or 12 months at room temperature (RT, 23±1℃) or refrigeration (4℃). To evaluate the stability of CSYJE decoction, pH and dissolved solids content were measured. High-performance liquid chromatography (HPLC) analysis was performed to determine marker compounds-liquiritin apioside, liquiritin, baicalin, wogonoside, and glycyrrhizin-in CSYJE. To determine anti-inflammatory effect of CSYJE, prostaglandin E<sub>2</sub> (PGE<sub>2</sub>) was measured in LPS-stimulated RAW 264.7 macrophages. Results : Both at RT and 4℃, pH was decreased depending on the preservation periods. There was no changes in dissolved solids content depending on the preservation temperature and periods. Both at RT and 4℃, the contents of liquiritin apioside and liquiritin were slightly increased at 1 month of storage. The level of baicalin was decreased time-dependently and the disappearance rate at RT is larger than at 4℃. CSYJE inhibited PGE<sub>2</sub> production in LPS-stimulated RAW 264.7 cells and maintained inhibitory effect by 12 months both at RT and 4℃. Conclusions : Based on the disappearance rate of the baicalin in CSYJE, the preservation period is recommended within 8 months for RT and 12 months for 4℃.
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