레이저 시술 후 발생한 피부 장벽 손상과 자극 증상에 대한 APDDR-1001 제제 국소 도포의 효과

김명신 ( Myoung Shin Kim ),허식 ( Sik Haw ),이형민 ( Hyung Min Lee ),김정환 ( Jeong Hwan Kim ),정연수 ( Yeon Su Jeong ),신홍주 ( Hong-ju Shin ),원종현 ( Chong Hyun Won ),장성은 ( Sung Eun Chang ),이미우 ( Mi Woo Lee ),최지호 ( Je 대한피부과학회 2012 대한피부과학회지 Vol.50 No.12

Background: Because cosmetic laser treatments are getting popular, post-laser wound care becomes more important.Currently, topical moisturizers are reported to be sufficient to accelerate re-epithelialization and reduce downtime inpost-laser wound care.Objective: This study was performed to evaluate the effects of the moisturizer APDDR-1001 for post-laser woundcare, after ablative fractional laser on the face.Methods: In this double-blind, split-face study, 41 patients with photo-aged face received ablative fractional laser.They were divided into two groups, APDDR-1001 and vehicle (group 1) or control moisturizer (group 2), whichwere applied to the opposite sides of the face for 1 week after the laser treatment. The treatment efficacy wasevaluated by the transepidermal water loss (TEWL), erythema index, investigator`s assessment for recovery inerythema and overall improvement of the wound. Subjects ranked irritating symptoms and overall satisfaction ratingsin the overall improvement.Results: APDDR-1001 was well-tolerated and showed improvement in the erythema index and TEWL during the 7days of treatment. In group 2, improvement in erythema graded by investigators was significantly higher forAPDDR-1001 on day 3 (p<0.05). The overall improvement of wound ranked by investigators was significantlyhigher for APDDR-1001, compared with the controls in both groups. Subjective assessment demonstratedsignificantly less erythema (p=0.043), edema (p=0.041) and overall satisfaction ratings in the overall improvement (p<0.048) with APDDR-1001; however, no differences were detected in pain and edema between APDDR-1001 andvehicle (group 1). In group 2, subjects ranked ``much or very much improved`` in 75 % of APDDR-1001 side and55% of control moisturizer side. No significant differences in erythema, edema, pain and itching were reportedbetween APDDR-1001 and control moisturizer in group 2.Conclusion: The moisturizer APDDR-1001 demonstrated effective improvements in wound healing and subjectivesymptoms after ablative fractional laser therapy. (Korean J Dermatol 2012;50(12):1017∼1026)

Human herpesvirus 8이 병인에 관여될 것으로 추정되고 있는 수종 피부 질환의 한국인 검체를 대상으로 시행한 PCR 연구 결과 보고

최지호,이화정,성경제,문기찬,고재경,장경애,안세진 대한피부과학회 2000 大韓皮膚科學會誌 Vol.38 No.9

Background: The association of Kaposi's sarcoma-associated human herpesvirus, or human herpesvirus 8 (HHVS) with various skin diseases has been described in many reports. However, only 3 human diseases: Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman disease were proved to be associated with HHV8. In addition to Karposis sarcoma, sarcoidosis and Kikuchi's disease were also described to be associated with HHV8. Objective: The purpose of this study was aimed at the association of HHV8 with various skin diseases, such as Kaposis sarcoma, sarcoidosis, and Kikuchis disease. Methods: We performed PCR to examine whether the 233-bp segment of the viral DNA of HHV8 was detected in Korean patient. with Kaposi's sarcoma, sarcoidosis, Kikuchi's disease, angiosarcoma, and angiolymphoid hyperplasia with eosinophilia. The medical records and histopathological specimens of patients diagnosed at Asan Medical Center from 1989 to 1999 were reviewed. Results: HHV8 DNA sequences were identified in 9 (69%) of sarcoid tissues from 12 patients with sarcoidosis and in all (100%) of from 8 patients with Kaposi's sarcoma but not in 2 tissues from 2 patients with Kikuchi's disease, in 3 tissues from 2 patients with angiosarcoma and 2 tissues from 2 patients with angiolymphoid hyperplasia with eosinophilia. Conclusion: HHV8 may be strongly associated with the pathogenesis of Kaposis sarcoma and sarcoidosis. However, the association with Kikuchi's disease, angiosarcoma, and angiolymphoid hyperplasia with eosinophilia was denied in this study. Further extensive study will be needed.

급성 백혈병 환자에서 골수 이식후 발생한 거대세포바이러스 감염증에 의한 자반증 1 예

최지호,성경제,문기찬,고재경,장성은,정의창 대한피부과학회 2000 大韓皮膚科學會誌 Vol.38 No.7

Cytomegalovirus(CMV) infection is very common in organ transplant recipients and other conditions such as lymphoproliferative disorders or acquired immunodeficiency syndrome. However, CMV rarely causes skin manifestations. We describe a leukemic patient with CMV induced purpuras which developed during cyclosporin therapy after a bone marrow transplantation. A biopsy revealed several foci of large irregular-shaped endothelial cells with large, basophilic intranuclear inclusions in the papillary dermis. Laboratory examination disclosed positive blood culture for CMV and polymerase chain reaction study performed with the skin sample revealed positive CMV DNA. Early intravenous gancyclovir made improvement of the skin lesions and negative conversion of viral antigenemia.

만성 신부전 환자의 후천성 천공성 피부증에 대한 연구

최지호,이미우,성경제,문기찬,고재경 대한피부과학회 2000 大韓皮膚科學會誌 Vol.38 No.9

Background: Acquired perforating dermatosis (APD) is a skin disorder occurring in patients with diabetes mellitus and/or chronic renal failure requiring dialysis. Objective : The purpose of this study was to clarify the clinical and histhopathological features of APD. Method: Twelve patients with APD who had biopsies done at Asan Medical Center were retrieved for this study. Clinical data and histopathologic specimens were reviewed. Results and Conclusion: 1. Sex ratio was 3:1 (9 male: 3 female) and mean age of onset was 52.1 years. 2. All patients had pruritic umbilicated papules with central keratotic plugs. The most predilection site was trunk. 3. Nine patients had an associated underlying non-insulin dependent diabetes mellitus 4. Skin lesions had developed on pre-dialysis in three patients, and after mean duration of 3.3 years on dialysis in remaining nine. 5. Histopathological examinations revealed the features of perforating folliculitis, Kyrle's disease or reactive perforating collagenosis. But we did not find any specimen resembling elastosis perforans serpiginosa. 6. It makes sense to designate the diseases as acquired perforating dermatosis rather than as one of the separate perforating diseases.

고용량 면역글로불린 정맥주사로 치료한 중독성 표피 괴사융해증

최지호,한만희,성경제,문기찬,고재경,강숙경 대한피부과학회 2000 大韓皮膚科學會誌 Vol.38 No.7

Toxic epidermal necrolysis(TEN) is the most dramatic, life-threatening cutaneous drug reaction. TEN is characterized by extensive detachment of the epidermis undergoing full-thickness necrosis. The pathogenetic pathway and specific treatments of TEN have not yet been identified. Recently, several reports suggested that apoptosis in TEN is promoted by proteins such as Fas antigen and high dose intravenous immunoglobulin(IVIG) inhibits Fas-mediated cell death by blocking the Fas receptor. We report a case of TEN in a 26-year-old woman who had been treated with prednisolone due to iritis. She was treated with high dose IVIG(0.4g/Kg/day for 4 days one day and 0.7g/Kg/day for consecutive). In our case, the progression of skin lesion was interrupted after IVIG infusion and favorable vital outcome was achieved with mild adverse effects.

유방외 Paget병의 임상적 연구

최지호,이미우,성경제,문기찬,고재경 대한피부과학회 2000 大韓皮膚科學會誌 Vol.38 No.8

Background: Extramammary Paget's disease (EMPD) is a rare skin neoplasm usually observed in apocrine-bearing regions. There were no comprehensive studies about the clinical features of EMPD in Korea. Objeetive: Our purpose was to study in detail the clinical findings of EMPD. Methods: The fifteen patients with EMPD at our institution over ten years were retrieved. Clinical records and pathology slides of the patients were reviewed retrospectively. Results: l. EMPD was seen more frequently in men than women (14:1 male:female ratio). 2. The most predilection site was penoscrotal area. 3. Thirteen percent of patients (2/15) with the disease had an associated underlying malignancy. 4. Twenty-two percent (2/9) of patients with wide excision had local recurrence during the follow-up period. Conclusion: EMPD in Korea may be characterized by male predominance and penoscrotal location. The incidence of concomitant malignancy may be lower than that in Caucasian. However, a search for internal malignancy and regular follow-up is still warranted.

과립세포종의 임상 및 병리조직학적 연구

최지호,이미우,성경제,문기찬,고재경 대한피부과학회 2000 大韓皮膚科學會誌 Vol.38 No.8

Background: Granular cell tumor is a rare neoplasm with characteristic histopathologic morphology. There were no comprehensive studies about the features of granular cell tumor in Korea. Objective: Our purpose was to find the clinical, pathological and immunohistochemical features of granular cell tumor. Methods: The sixteen patients with granular ce11 tumor seen at our institution over a 10-year period were retrieved. Clinical records and pathology slides of the patients were reviewed retrospectively. Results and Conclusion: 1. Granular cell tumor is rare, with a frequency of 0.006% of all surgical specimen. 2. Skin and subcutaneous tissues are the most predilection sites, and esophagus or gastric walls are the second common sites. 3. There are no multifocal cases and only one case of malignant granular cell tumor. 4. Granular cell lesions from many different sites share similar light microscopic features. 5. The Schwann cell origin of the tumor is demonstrated by reactivity with S-100 protein.

원방성 결절성 피부 유전분증 1 예

최지호,이미우,김소형,성경제,문기찬,고재경 대한피부과학회 2000 大韓皮膚科學會誌 Vol.38 No.8

Primary nodular cutaneous amyloidosis is a very rare type of amyloidosis, it must excluded the secondary nodular deposition of systemic amyloidosis. We report herein 47-year-old male with a erythematous waxy nodule on his parietal scalp for one year. Histopathologic examination showed homogenous amorphous eosinophilic deposition in the dermis with nodular fashion. In Congo red, amyloid material stained positively and showed apple-green birefringence with polarized light. On electron microscopic examination, extensive deposit of amyloid with typical 6-10 nm filament was confirmed. He had neither clinical nor laboratory evidence of systemic amyloidosis. We reviewed previously reported nodular amyloidosis in Korea.

Alexandrite 레이저를 이용한 편평사마귀의 치료 효과

최지호,이미우,성경제,문기찬,고재경 대한피부과학회 2000 大韓皮膚科學會誌 Vol.38 No.7

Background : Verruca plana is a common disease, which can cause substantial cosmetic problems. Traditional treatments are often ineffective and sometimes associated with complications. Objective: Our study was performed to determine the clinical effectiveness of Q-switched alexandrite laser for verruca plana. Methods: Eighteen patients with verruca plana were treated with Q-switched alexandrite laser (755nm wavelength, 100nsec pulse duration, 3mm pulse wide). Results: 1. Treatments with fluences that ranged from 7.0-7.5J/㎠ were given on average 1.6 times. 2. After 1 laser session, ≥75% of the lesions became clear in ten patients. 3. Hyperpigmentation occurred in three patients and had disappeared after a few months. Conclusion: The Q-switched alexandrite laser is an effective treatment modality for the verruca plana without adverse sequelae.