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LPS를 처리한 RAW 264.7 세포에서 털여뀌와 양지꽃 추출물의 NF-κB 활성화 및 Nitric Oxide 생성 저해
최재훈 ( Je Hun Choi ),이승은 ( Seung Eun Lee ),이정훈 ( Jeong Hoon Lee ),김금숙 ( Geum Sook Kim ),노형준 ( Hyung Jun Noh ),김승유 ( Seung Yu Kim ) 한국응용생명화학회 2014 Journal of Applied Biological Chemistry (J. Appl. Vol.57 No.3
Persicaria orientalis (L.) Spach (Po) and Potentilla fragarioides var. major Maxim (Pf) extracts were analyzed to investigate anti-inflammation through their suppressing effects on free radicals such as reactive oxygen species (ROS). In addition, with regard to Po and Pf, an analysis was conducted of their inhibitory effect on nitric oxide, which is produced in lipopolysaccharide (LPS)-treated murine macrophage RAW 264.7 cells, and their inhibitory effect on the translocation of the nucleus of nuclear factor-kappa B (NF-κB). The IC50 value of ROS, which was induced by 50 μM 3-morpholinosydnonimine hydrochloride (SIN-1), was found to be 23.35±1.27 μg/mL due to the effect of the Po extract, and 8.46±1.22 μg/mL due to the effect of the Pf extract. In addition, the IC50 value of peroxynitrite treated with the Po extract was 2.19±0.04 μg/mL, whereas that of peroxynitrite treated with the Pf extract was 0.80±0.02 μg/mL. ROS and peroxynitrite were induced by 50 μM 3-morpholinosydnonimine hydrochloride. There was an increase in the amount of nitric oxide in the RAW 264.7 cells treated with LPS (1 μg/mL), whereas the level of NO was observed to significantly and dose-dependently decrease in the cells treated with Po and Pf. The amount of nitric oxide produced by the group treated with 10 μg/mL of the Pf extract was 11.45±0.57 μM. Furthermore, the Po extracts inhibited the translocation of the nucleus of NF-κB in LPS-treated RAW 264.7 cells. Therefore, it is highly possible that Po and Pf have anti-inflammatory properties.
장귀영,최재훈,김형돈,서경혜,이승은,지윤정,강민혜,김동휘,최수지,Jang, Gwi Yeong,Choi, Je Hun,Kim, Hyung Don,Seo, Kyung Hye,Lee, Seung Eun,Jee, Yun Jeong,Kang, Min Hye,Kim, Dong Hwi,Choi, Su Ji 한국식품영양학회 2020 韓國食品營養學會誌 Vol.33 No.3
The aging treatment was applied to Rehmannia glutinosa rhizome (RGR) to improve the digestibility by the enzymatic hydrolysis of undigestible sugars. However, RGR spoils easily during the aging treatment. Thus, the purpose of this study was to investigate the influence of ethanol addition as preservatives on sugars and microbial growth of aged RGR. The RGR was treated with the addition of ethanol (0~10%) at 55℃ for eight days. Reducing, free sugars, and total bacterial counts of RGR with ethanol concentrations were analyzed during the aging periods. The aged RGR with 0-2% ethanol appeared spoiled in appearance, and total bacterial counts of these samples increased from 1.1×10<sup>5</sup> to 2.2×10<sup>7</sup> CFU and then decreased again. When treated with 4~10% ethanol, the total bacterial counts of aged RGR decreased by more than 99.9% at eight days. In all samples, reducing and digestible sugars increased, and stachyose decreased by the aging treatment. Sucrose content was highest in the 6% ethanol sample (18.2% at six days). These results indicate that the ethanol addition can be applied to the aging treatment of the RGR for improving qualities (sweetness, digestibility, and microbial growth), and can be considered for the stable production of high quality aged RGR.