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Glucose Transporter-1 Expression in Squamous Cell Carcinoma of the Tongue
최윤석,Seok Jin Kim,Dae Sik Kim,Seh Jong Park,Yong Park,Hye Jin Shin,Kwang-Yoon Jung,Seung-Kuk Baek,Bong Kyung Shin,Jung Woo Choi,Byung Soo Kim,Sang Won Shin,Yeul Hong Kim,Jun Suk Kim 대한암학회 2007 Cancer Research and Treatment Vol.39 No.3
Purpose: Tumor cells are known to express hypoxia-related proteins such as glucose transporter-1 (Glut-1). These hypoxia-induced changes may allow tumor cells to survive under sustained hypoxic microenvironments, and the surviving tumor cell under hypoxia may develop a more aggressive phenotype and so result in a poor prognosis. Materials and Methods: The Glut-1 expression was analyzed by immunohistochemistry, and its association with the prognosis was assessed in 60 patients with squamous cell carcinoma of the tongue.Results: The Glut-1 expression was diffuse with a membranous pattern, and the median percentage of Glut-1 positive tumor cells was 60% (range: 0.0∼90.0%). A high Glut-1 expression (the percentage of positive tumor cells ≥ the median value, 60%) was associated with the location of primary lesion, lymph node metastasis status and disease stage (p〈0.05).Theexpression of Glut-1 was correlated with the Ki-67 expression (r=0.406, p=0.001). Microvessel density, as represented by CD31 staining, was also correlated with the Glut-1 expression although its significance is weak (r=0.267, p=0.039). On the univariate analysis, the group with a high Glut-1 expression showed poorer overall survival than the group with a low Glut-1 expression (p〈0.05). However, the Glut-1 expression failed to show any independent prognostic significance on the multivariate analysis.Conclusion: The expression of Glut-1 may be useful for predicting the prognosis and determining the treatment strategy for the management of squamous cell carcinoma of the tongue. (Cancer Res Treat. 2007;39:109-115)
변형구배 결정소성 유한요소해석법을 이용한 니켈기 다결정 합금의 Hall-Petch 관계 모델링
최윤석,조경목,남대근,최일동,Choi, Yoon Suk,Cho, Kyung-Mox,Nam, Dae-Geun,Choi, Il-Dong 한국재료학회 2015 한국재료학회지 Vol.25 No.2
A strain-gradient crystal plasticity constitutive model was developed in order to predict the Hall-Petch behavior of a Ni-base polycrystalline superalloy. The constitutive model involves statistically stored dislocation and geometrically necessary dislocation densities, which were incorporated into the Bailey-Hirsch type flow stress equation with six strength interaction coefficients. A strain-gradient term (called slip-system lattice incompatibility) developed by Acharya was used to calculate the geometrically necessary dislocation density. The description of Kocks-Argon-Ashby type thermally activated strain rate was also used to represent the shear rate of an individual slip system. The constitutive model was implemented in a user material subroutine for crystal plasticity finite element method simulations. The grain size dependence of the flow stress (viz., the Hall-Petch behavior) was predicted for a Ni-base polycrystalline superalloy NIMONIC PE16. Simulation results showed that the present constitutive model fairly reasonably predicts 0.2%-offset yield stresses in a limited range of the grain size.