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차동현,이윤호,유용균,Cha, Dong-Hyun,Lee, Yoon-Ho,Yoo, Yong-Kyun 대한생식의학회 1994 Clinical and Experimental Reproductive Medicine Vol.21 No.3
Combined intrauterine and extrauterine pregnancy is rare, occuring 1 in 30,000 pregnancies. The early diagnosis of combined pregnancy is very difficult, and so there is a higher maternal morbidity and fetal loss. Recently the incidence of combined pregnancy is increased. We experienced a case of combined intrauterine and right tubal pregnancy, and this case was presented with a brief review of the literatures.
중합연쇄반응 제한효소 단편 장다형을 이용한 듀센형 근이영양증 산전 진단
차동현(Dong Hyun Cha),이국(Kook Lee),최종락(Jong Rak Choi),송경순(Kyung Soon Song) 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.6
Objective : Duchenne muscular dystrophy(DMD) is a X-linked recessive disease and results from mutation in the dystrophin gene. In this study, we evaluate the efficacy of polymerase chain reaction-restriction fragment length polymorphism in prenatal genetic diagnosis of DMD.Methods : DNA was isolated from DMD family's blood and fetal amniocyte and used to perform PCR-RFLP. In DMD family(3 cases), linkage analysis was tried with 5 RFLP probes.Results : DMDs of the family A had mutiple exon deletions(6, 8, 12, 13, 17). The mother was a heterozygote of pERT84;MaeIII. The male fetus had a same allele and also same exon deletions with the affected males. The pregnancy was terminated at IUP 18 gestational weeks. Pregnant woman of the family B was heterozygote of both pERT84;MaeIII and pERT87-15;BamHI, and pregnant woman of the family C was of pERT84;MaeIII. The both male fetuses , as compared with the affected male of each family, had a different allele. Thus, the fetuses were probably not affected with a confidence level of 95%. Conclusion : Prenatal diagnosis in prevention of DMD is most important. PCR-RFLP analysis in DMD family is rapid and useful diagnostic tool.
12-o-tetradecanoyl-phorbol-13-acetate가 배양된 임신 중 산모 말초혈액 단핵세포의 β-hCG 생산 및 분비에 미치는 영향
차동현(Dong Hyun Cha),유승민(Seung Min Yoo),민경희(Gyung Hee Min),김덕령(Duk Ryung Kim),김근하(Geun Ha Kim),성연준(Yeon Joon Sung),김동규(Dong Gyu Kim),이병석(Byung Suk Lee),서경(Gyung Seo),이윤호(Yoon Ho Lee),이국(Gook Lee) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.1
Objective : Peripheral blood mononuclear cells (PBMC) in culture release a biologically active human chorionic gonadotropin (hCG). This effect is detectable during pregnancy with a maximum between the 16th and 19th week. HCG plays an important role for the corpus luteum rescue during the early gestational age and possibly for the immunotolerance. This study was performed to investigate the relationships between the productivity of cultured PBMC of pregnant women and the ability to maintain early pregnancy, and whether 12-o-tetradecanoyl-phorbol-13-acetate (TPA) increases hCG sectetion by cultured PBMCs. Materials and Methods : PBMC were obtained from 20 pregnant women between 16th to 19th week of gestation , and cultured with TPA. Culture cells were harvested and hCG mRNA were extracted and RT-PCR were performed. Culture supernatants were collected and hCG concentration were determined by commercial RIA methods. Results : The mean age was 31.0 years old, 19 of 20 (95%) pregnant women's PBMC secereted hCG and expressed hCG mRNA, but in control group exept male hepatitis B patient, none of them produced hCG. TPA activated expression of hCG in PBMC in linear manner. Conclusion : Pregnant women's cultured PBMC secreted hCG, but not in non-pregnant or male. We could confirm the mRNA of hCG in PBMC as well in the placental control. The productivity of hCG in PBMC might be closely related with maintenance of early pregnancy.
초기 임신에 있어서 질식 초음파에 의한 태아 심박동수의 의의
차동현(Dong Hyun Cha),이윤호(Yoon Ho Lee),김종석(Jong Seok Kim),서승현(Seung Hyun Suh),박병주(Byung Joo Park),김종화(Jong Wha Kim) 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.7
Objective : Fetal heart rate in embryos(6-8 gestational weeks) have been significantly related to fetal outcome, but have rarely been studied. We attempted to identify fetal heart rate during 6-8 gestational weeks. Our purpose was to determine the lower limit of the heart rate associated with a favorable outcome and to evaluate the prognosis for those embryos with slow heart rates in early period. Methods : We prospectively studied 798 singleton pregnancies between Jul. 1997-Dec. 1999 visiting our hospital. Gestational age was calculated from the beginning of the last menstrual period in the case of regular cycle and was confirmed by the crown-rump length. Other cases were measured by crown-rump length or mean gestational sac diameter. Color doppler sonography was used to calculate the fetal heart rate in beats per minute as the mean of 3 waves.Results : Mean fetal heart rate (±SD) were 114.08±15.40 bpm for group 1, 126.49±18.78 for group 2, 139.83±19.92 for group 3, and 149.58±23.34 for group 4(p<0.001). Prognosis in the first trimester improved as heart rate increased to 100 bpm in group 1 and 120 bpm in group 2. In group 3 and 4, most of fetus with heart rates below 110 bpm died.Conclusion : The fetal heart rate during 6-8 gestational weeks is associated with fetal outcome at the end of the first trimester and we can identify the fetuses that are in risk.
비정상 초기 임신에서 β-hCG 식별대와 질식 초음파의 진단 정확도
차동현(Dong Hyun Cha),이윤호(Yoon Ho Lee),김종석(Jong Seok Kim),김중열(Joong Yul Kim),원형재(Hyung Jae Won) 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.6
Objective : To evaluate the accuracy of combined transvaginal ultrasound and β-hCG discriminatory zone for diagnosing intrauterine pregnancy, abortion, and ectopic pregnancy in early abnormal pregnancy.Methods : Initial ultrasound findings and β-hCG level were compared with final pregnancy outcome in 164 early pregnant women who visit our hospital with vaginal bleeding or abdominal pain. The sensitivity, specificity, and predictive value by the combination of two diagnostic tools were calculated. Statistic analysis of collected data used χ2 of SPSS(9.0).Results : Of 90 women with normal outcome, 64(71.1%) had a gestational sac 5mm, and in 47 cases, the hCG level was above 1,800 mIU/ml. Transvaginal ultrasound was non-diagnostic in 47(28.6%) of 164 women, and especially, 43(53.1%) of 81 cases with β-hCG levels below 1,800 mIU/ml. The portion of accurate ultrasound diagnosis was significantly higher in women above 1,800 mIU/ml (85.5%, 71 of 83 cases) compard with levels below 1,800 mIU/ml (37.0%, 30 of 81 cases) : P < 0.001; Relative Risk(RR) 2.31; CI 95%. Sensitivity of transvaginal ultrasound diagnosis of intrauterine pregnancy, abortion, and ectopic pregnancy was 90.2%, 79.3%, and 66.7% in women who presented with β-hCG levels above 1,800 mIU/ml, and 41.0%, 23.5%, and 75% below 1,800 mIU/ml, respectively. And, negative predictive value was 83.9%, 89.7%, and 98.8% in each of intrauterine pregnancy, abortion, and ectopic pregnancy above 1,800 mIU/ml, and 64.6%, 60%, and 97.3% below 1,800 mIU/ml, respectively. Conclusion : The sensitivity, specificity, and predictive value of transvaginal ultrasound for diagnosing abnormal early pregnancy were poor except cases of ectopic pregnancy when β-hCG levels were low than discriminatory zone. Ultrasound impressions were well related with β-hCG levels.
이병석,차동현,정경아,이희대,박기현,조동제,송찬호,Lee, Byung-Seok,Cha, Dong-Hyun,Jung, Kyung-Ah,Lee, Hye-Dae,Park, Ki-Hyun,Cho, Dong-Jae,Song, Chan-Ho 대한생식의학회 2002 Clinical and Experimental Reproductive Medicine Vol.29 No.4
Objectives: To investigate the distribution of $ER{\alpha}$, $ER{\beta}$, c-fos and c-jun in the uterine myoma and myometrium in oder to know how the tamoxifen cause the growth of myoma. Methods: Myoma and myometrial tissue were obtained from the postmenopausal women treated with tamoxifen in the patients with breast cancer and in the premenopausal patients, who were undergoing myoma of uterus from 1998 through 2000. The espression of each gene was quantitated with quantitative RT-PCR. Results: The expression of $ER{\alpha}$ was slightly increased in the myoma than the myometrium in the proliferative phase, and was slightly decreased in the myometrium than the myoma in the secretory phase. However it was not significant statistically. In the postmemopausal women treated with tamoxifen, $ER{\alpha}$ was expressed in all myoma and myome1rial tissues and the expression was not statistically significant. The expression ofER~ was slightly increased in the myome1rium than the leiomyoma in the proliferative and secretory phase, but it was not significant statistically. In the postmemopausal women treated with tamoxifen, the expression of ER~ was significantly incresed in the myome1rium than the leiomyoma. The expression of c-fos was significantly increased in the myome1rium than the leiomyoma in the proliferative and secretory phase. In the postmemopausal women treated with tamoxifen, the expression of c-fos was slightly increased in the leiomyoma than the myomelrium, however, it was not statistically significant. Conclusion: Tamoxifen may cause the growth of leiomyoma by $ER{\alpha}$ with AP-l pathway reducing the counteraction of 6$ER{\beta}$ to $ER{\alpha}$.
완전 중격 자궁에서 메틸렌 블루가 들어 있는 풍선을 이용한 자궁경하 중격 제거술
장지현,조정현,차동현,한원보,Jang, Ji-Hyon,Cho, Jung-Hyun,Cha, Dong-Hyun,Han, Won-Bo 대한생식의학회 2010 Clinical and Experimental Reproductive Medicine Vol.37 No.4
드문 기형인 두 개의 자궁 경부와 세로막 질 중격을 가지고 있는 완전 중격 자궁인 경우 자궁경으로 양측 자궁강을 각각 관찰할 때 중격의 정확한 위치와 길이를 측정하기가 어렵고 시술 시 중격 제거의 시점과 중격 제거의 길이와 방향 및 종점을 잡기가 매우 어렵다. 이에 methylene blue를 넣은 풍선을 이용한 중격 제거술에 관해 소개하고 2년 이상의 불임 기간을 가지고 있는 완전 중격 자궁 환자 3예에 있어서 이 수술을 이용하여 좋은 산과적 결과를 보인 증례를 보고하고자 한다. A complete septate uterus with cervical duplication and a longitudinal vaginal septum is a rare uterine malformation. The dissection of the septum can be difficult because it is difficult for hysteroscopists to find out initial point, direction and final point of a complete septum. This study aimed the introduction of more efficient surgical procedure using a balloon with methylene blue. We have experienced three cases with a complete septate uterus. We performed hysteroscopic dissection of a complete uterine septum using a balloon with methylene blue and obtained good reproductive outcomes. So we report three cases with a brief review of literatures.