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은행잎 추출성분이 고혈압쥐의 뇌중 신경전달물질 함량에 미치는 영향
박혜영(Hea Young Pchoo),주지연(Ji Yeon Ju),김명희(Myung Hee Kim),신정희(Jeung Hee Shin) 한국응용약물학회 1995 Biomolecules & Therapeutics(구 응용약물학회지) Vol.3 No.1
Effects of Ginkgo biloba leaf extract (GBE) and its components kaempferol-coumaroyl glucosyl rhamnoside (Kc), quercetin-coumaroyl glucosyl rhamnoside (Qc), ginkolide (G) and bilobalide (B) on blood pressure and on the levels of neurotransmitters in the spontaneously hypertensive rat brain were examined. Blood pressure decreased about 10 mmHg after administration of GBE but without significance. The concentration of norepinephrine increased (3 times) and that of DOPAC was decreased (38%) after administration of Qc. And 3-MT concentration was increased (36%) by Kc administration in striatum. While Qc administration increased the concentration of Ach (260%) and Ch(29%) significantly, B administration increased Ch concentration in cerebral cortex.
인삼 사포닌이 일산화탄소중독 및 노화과정에서 흰쥐의 신경전달물질 함량 변화에 미치는 영향
박혜영(Hea Young Park),김춘미(Choon Mi Kim),주지연(Ji Yeon Ju),최현진(Hyun Jin Choi) 대한약학회 1992 약학회지 Vol.36 No.3
After rats were exposed to 5,000 ppm carbon monoxide for 30 minutes, the amounts of catecholamine neurotransmitters in stratum were measured using high performance liquid chromatograph equipped with electrochemical detector. The concentration of dopamine in stratum was significantly decreased after carbon monoxide intoxification, but those of dihydroxyphenylacetic acid, norepinephrine, and epinephrine was not changed. However the pretreatments of Ginseng total saponin and panaxatriol saponin increased the concentrations of dopamine and its acidic metabolites (DOPAC and HVA). Ginseng total saponin also increased the concentrations of norepinephrine and epinephrine. Similar results were obtained from aged rats.
대학생의 우울정도 : 간호학전공과 타전공대학생을 중심으로
김지연,류나은,이소라,이지희,정윤정,주지연,황인혜 이화여자대학교 간호과학대학 2012 이화간호학회지 Vol.- No.46
Purpose: This study was designed to investigate sample’s general characteristics and compare depression degree among sample’s general characteristics and students’ major(nursing vs. other major). Methods: The subjects consisted of 318 university students. Data was collected by self-reported questionnaires, which were constructed BDI score. Data was analyzed by the SPSS/PC WIN 19.0 program. Results: The depression of nursing students and other major students was not significantly different according to BDI score. Statistically significant difference was identified among sleeping. Conclusion: Specific study focused on the practice time should be done to confirm the depression of nursing major and other majors. Detailed support programs which specifically deal with sleeping should be developed to effectively reduce the harmful effects of individual vulnerability. Therefore, prevention and management system to reduce depression degree for university students is needed.
이주연,오선영,주지연,주현아 이화여자대학교약학회 1990 梨花藥學硏究 Vol.- No.29
1.인삼단백질의 정제 분리 본 실험에서 사용한 인삼단백질의 정제과정은 Fig.1과 같고 CM-cellulose column chromatography를 행하였을 때 Fig.2와 같이 CMC-A와 CMC-B의 두 분획을 얻었다. 이들 두 분획의 정성실험 결과, CMC-A 분획은 지속성 거품이 있고, LB test에 양성을 나타내어 saponin을 함유하는 분획임이 판명되었고, CMC-B분획은 LB test에 음성이고 UV 280nm 에서 흡수극대를 나타내므로 단백질을 함유한 분획임이 판명되었다. 2.Thiol group의 정량 본 실험에서 인삼 내에 thiol group을 동정하였으나, 처리한 sample이 정량 가능한 범위에 미달되어 정확한 양을 알아내지 못했다