단기간 탄수화물 섭취가 유도선수들의 운동수행력에 미치는 효과

남광우(Nam Kwang-Woo),전승훈(Jeon Seung-Hoon),김범수(Kim Bum-Soo),조준용(CHo Jun-Yong),조인호(Cho In-Ho) 한국체육과학회 2008 한국체육과학회지 Vol.17 No.3

The purpose of this study was to investigate the effects of carbohydrate supplementation on rating of Perceived Exertion (RPE), CK(creatine kinase), LDH(Lactate dehydrogenase), plasma insulin, glucose, and isokinetic contraction in elite judokas who have performed regular judo training for 2-3 years. For this study, elite judokas (male, n=10) were voluntarily participated in two different experiment trials. During experiments period, elite judokas were supplemented both placebo(P) and carbohydrate(CHO)) by double blinded trial. Serum CK level was significantly decreased after CHO supplementation. Interestingly, RPE level was significantly lower after CHO supplementation. There was no different both insulin and glucose concentration in both supplementation trial. Isokinetic muscle power (total, mean) was slightly higher in CHO trial, but not in placebo trial. In conclusion, Elite judokas who have performed long period regular training developed overreaching phase. but this syndrome might be alleviated by CHO supplementation during training session.

트레드밀 운동이 알츠하이머 형질전환 생쥐 뇌의 인지기능과 미토콘드리아의 PGC-1α, cytochrome-c 발현에 미치는 영향

구정훈 ( Jung Hoon Koo ),조준용 ( Jun Yong Cho ) 한국체육대학교 체육과학연구소 2013 스포츠사이언스 Vol.30 No.2

Mitochondrial dysfunction and oxidative stress are early event in Alzheimer Disease``s by the accumulation of Aβ-42 in the brain mitochondria. The purpose of this study was to investgate the effects of treadmill exercise training on cognitive performance, Cytosolic Cytochorme c and mitochondria function and biogenesis factors such as PGC-1α. All mice were divided into 4 gourps (Non Tg-CON, Non Tg-exe, Tg-CON, Tg-EXE). The running speed and duration of the exercise were gradually increased and on the last week of the 12 weeks training protocol, ran 12m/min, 60m/day, 5days/week. First of all, treadmill exercise has been shown to improve cognitive and behavior function in Tg-EXE group compared with Tg-CON group. Levels of cyto-Cytochrome c in Tg-CON group were very significantly higher than all other groups, whereas treadmill exercise training decreased the expression of cyto-Cytochrome c in Tg-EXE group. In addition, level of mt-PGC-1α and cyto-PGC-1α in Tg-CON group were very significantly lower than all other groups, whereas treadmill exercise significantly enhanced the expression of mt-PGC-1α and cyto-PGC-1α in Tg-EXE group. Taken together, these finding suggest that treadmill exercise training in Tg mice alliviated the cognitive performance and up-regulation of mitochondria biogenesis in the AD brain is the main targets for prevention and treatment.

운동과 면역체계: 신경퇴행성 질환을 중심으로

최동훈 ( Dong-hun Choi ),조준용 ( Jun-yong Cho ) 한국체육대학교 체육과학연구소 2015 스포츠사이언스 Vol.32 No.2

Alzheimer``s Disease(AD) is one of the fatal neurodegenerative disease in the world. AD is commonly known that the major two pathological features are nerofibrillary tangles and neuritic senile plaque by aggregation of hyperphosphorylated tau protein and amyloid-β (Aβ) protein, inducing neuronal inflammation and cell death with severe memory loss and cognitive function in brain. Particularly, It has been suggested that aggregation of Aβ protein evokes immune system and inflammatory response in AD. When Toll-like receptors (TLRs) is activated by Aβ, it activates immune and transcription regulating factor NF-κB, which finally stimulates inflammatory cytokines; Tumor necrosis factor-α(TNF-α), Interleukin-1(IL-1) and Interleukin-6(IL-6). These days, several studies show that regular exercise can restrain Aβ protein and hyperphosphorylated tau protein levels in AD. However, it has been suggested that excessively high intensity of exercise accelerates inflammatory response, implying that exercise can has a positive/negative effects depend on intensity, duration and type of exercise. Most of recent studies presented positive effects of exercise on immune and inflammatory system. Especially, exercise regulates activation of TLRs and NF-κB and decreases expression of inflammatory cytokines in AD, but most of therapies to cure AD have only focused on pharmacological treatments. Therefore, it is necessary to find out the role of exercise on AD by further studies.

운동유발 전처지의 신호전달 체계

김철현 ( Chul Hyun Kim ),조준용 ( Jun Yong Cho ),이규성 ( Kyu Sung Lee ) 한국운동생리학회(구-한국운동과학회) 2005 운동과학 Vol.14 No.4

한국과 일본 고령자의 신체구성, 일상생활활동능력(ADL지표), 건강관련체력, 신체활동수준 평가

이미숙(Mi Sook Lee),조준용(Jun Yong Cho),차정훈(Jung Hoon Cha),조정환(Jung Hwan Cho),김현수(Hyun Soo Kim),田中喜代次(Tanaka Kiyoji),杉山佳生(Sugiyama Yoshio),竹島信生(Takeshima Nobuo) 한국체육측정평가학회 2008 한국체육측정평가학회지 Vol.10 No.2

이 연구는 한국과 일본의 65세 이상 여성 고령자를 대상으로 신체구성, 신체활동 수준, 일상생활 활동능력 및 건강체력 수준에 대한 탐색적 자료 분석과 주요 개인적 환경적 변인간 관련성을 검토하는데 목적이 있다. 연구에 참여한 고령자는 한국 141명, 일본 139명이며 평균연령은 71세이다. 대상자들은 대도시에 거주하고 자발적 공공 운동프로그램에 참여하는 고령자들이며, 자립적으로 일상생활이 가능하고 특별한 질병 없이 비교적 건강하다고 밝힌 고령자들이다. 연구결과 얻어진 결론은 다음과 같다. 첫째, 우리나라 여성 고령자들이 일본 여성고령자들에 비하여 체지방량 수준이 높다. 65세 이상 여성 고령자들도 연령이 증가함에 따라 체지방량이 증가하고 있다. 둘째, 높은 경향을 보인다. 셋째, 고강도 신체활동은 한국 여성 고령자, 중강도의 신체활동은 일본 여성 고령자들의 참여율이 높다. 신체활동 참여는 체력, 연령, 거주여건과는 무관하다. 보행시간은 국가, 체력, 연령과 무관하다. 넷째, 여성 고령자의 건강체력은 일본 고령자들이 우수하다. 65세 이상 고령자들의 경우 연령이 증가할수록 체력의 감소 추세가 뚜렷하다. This study compared health-related functional fitness, body composition, physical activity status of Korean and Japanese healthy and active adults over 60 years old. The subjects undertook performance test items related to activity of daily living and health in Japan and Korea by using same instruments. Body fat (%) as a body composition measured using bioelectrical impedance analysis (Physion XP, Japan). Physical activity, activity of daily living were identified via interviews where subjects self-reported including difficulty of walking 400m, climbing 10 steps and rising from chairs. Functional fitness was determined using a test battery that included grip strength, one-leg balance, tandem balance, alternate step, 5 chair sit-to stand, functional reach, timed up and go, walking around two cones, and 5 m habitual walk. In both countries, statistically significant difference according to advancing age was found for almost test items. Japanese older women scored better on almost functional fitness item and frequency of physical activity, body composition. Analysis of data indicated that, Koreans had significantly lower functional fitness scores, frequency of physical activity than Japanese. No differences were found in flexibility and balance factors (P>0.05). From the above results, it can be concluded that (1) Korean older women exhibit high level % body fat than the Japanese older women in all age group. (2)Activity of Daily Living(ADL) positively associated with physical activity participation and type of family members such as family size. (3) More Korean older women reported engaging in vigorously intensity activities but not moderate intense activities than Japanese older adults. There were no significant association between physical fitness, age, family type in participating physical activity. (4)A significantly higher health-related physical fitness level was observed for Japanese older adults compared with Korean, and health-related physical fitness level significantly decreased with aging in older women population.

운동이 파킨슨 질환 치료 및 예방에 미치는 영향

장용철 ( Yongchul Jang ),조준용 ( Cho Jun-yong ) 한국체육대학교 체육과학연구소 2020 스포츠사이언스 Vol.38 No.1

Parkinson’s disease (PD) is a progressive neurodegenerative disorder after Alzheimer’s disease and is pathologically characterized by the selective degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc), resulting in motor impairments including bradykinesia, tremor, rigidity and postural instability. Currently, Levodopa, a dopamine precursor, is a potent medication for PD. It mitigates PD symptoms by increasing striatum dopamine levels. Also, it has side effects of hypotension, arrhythmia, hallucination and dizziness in long-term administration. Regular exercise has been reported to improve brain function and mitigate motor impairment in PD. However, the cellular and molecular mechanisms underlying the exercise-induced neuroprotection remain unknown. There are growing evidence indicates that chronic neuroinflammation, mitochondrial and autophagy dysfunction involved in the pathogenesis and progression of neurodegenerative disease in PD. In this review, we focused on the potential mechanism of neuroprotection induced by exercise in PD.

운동과 뇌기능: 알츠하이머 질환을 중심으로

구정훈 ( Jung Hoon Koo ),조인호 ( In Ho Cho ),조준용 ( Jun Yong Cho ) 한국체육대학교 체육과학연구소 2014 스포츠사이언스 Vol.31 No.2

Alzheimer``s disease (AD) is a representative neurodegeneration disorder that is increasing rapidly with the prolonging life expectancy and increasing elderly population· The two major pathological hallmarks of AD are the β-amyloid (Aβ) protein and neurofibrillary tangles (NFTs) in the brain and leading to neuronal cell death and ultimately cognitive dysfunction· Also brain insulin resistance and mitochondria dysfunction may significantly contribute to the AD, indicating that inhibiting and reducing of Aβ protein and NFTs is the main targets for prevention and treatment of AD· Recently, exercise decrease the Aβ protein, NFT and neuronal cell death and increase the neurogenesis and ultimately enhancement of cognitive function in AD· Moreover, exercise increase the insulin signaling pathway- relatived protein and mitochondria biogenesis factor, indicating that exercise may be beneficial in prevention or treatment of AD· However, in AD, the most of therapies have depended primarily drugs until now and effects of exercise is very short research· Therefore, more research is necessary to prove effect of exercise on AD·

Signaling pathway of exercise-induced preconditioning

Chul-Hyun Kim,Hyun-Sub Eum,Kyu-Sung Lee,Jun Yong Cho(조준용) 한국실험동물학회 2005 한국실험동물학회 학술발표대회 논문집 Vol.2005 No.-

알츠하이머 형질전환 마우스의 출생 후 뇌에서 유전자 발현

지승완(Seung Wan Jee),송연숙(Youn Suk Song),오재호(Jae Ho Oh),김용규(Yong Kyu Kim),심선보(Sun Bo Shim),황대연(Dae Youn Hwang),이수해(Su Hae Lee),서수진(Su Jin Seo),조준용(Jun Yong Cho),조정식(Jung Sik Cho) 한국실험동물학회 2005 Laboratory Animal Research Vol.21 No.3

DNA microarrays are a well-established technology for measuring gene expression levels. The aim in the study was to gain insight into potential over-expressed effect of amyloid precursor protein sw (APPsw) on modulation of genes for Alzheimer's Disease (AD). APPsw-transgenic mice, which has been produced by us previously, provide an important resource for identifying differentially expressed genes, since this transgenic line was shown cognitive deficits along with Aβ-42 depositions at 12 months of age. Using cDNA microarray, we compared mRNA levels in 7.4K cDNA clones from postnatal brain of age-matched wild-type mice and Alzheimer's diseased transgenic mice. A total of 44 differentially expressed genes with a 15 up-regulated and with a 29 down-regulated were found in brains from moderatively transgenic mice compared to non-transgenic littermates. Thus, the results allow to the future studies in the functions of each gene, which may be targeted for developing drugs.

증례보고 : 관상동맥 우회술 중 내시경하 복재정맥 수확동안 발생한 과탄산혈증

홍성욱 ( Seong Wook Hong ),김시오 ( Si Oh Kim ),백운이 ( Woon Ei Baek ),이종태 ( Jong Tae Lee ),조준용 ( Jun Yong Cho ) 대한마취과학회 2006 Korean Journal of Anesthesiology Vol.51 No.5

Hypercarbia is a potential complication during laparoscopic surgery. However, is more likely to occur in extraperitoneal surgery than in intraperitoneal surgery because insufflated CO2 gas can diffuse easily into the surrounding tissues. We report the anesthetic course and complications encountered during endoscopic harvesting of a saphenous vein with CO2 insufflation in coronary artery bypass surgery. Although the surgery was successful, the patient developed signs and symptom of CO2 absorption: tachycardia, hypertension, hypercarbia and acidosis. Possible mechanisms are presented, along with a discussion of the prompt diagnosis and treatment. For the management of laparoscopic extraperitoneal surgery, care must be taken to monitor the CO2 insufflation pressure, perform a routine examination and palpation of the chest wall, use of N2O with caution, increase the level of ventilation to eliminate CO2, and excluding other causes of subcutaneous emphysema and hypercarbia. (Korean J Anesthesiol 2006; 51: 622~6)