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산화질소 ( Nitric Oxide ) 의 기도내 신경성 염증 조절에 관한 연구
심재정(Jae Jeong Shim),박상면(Sang Myun Park),이진구(Jin Goo Lee),조재연(Jae Yeun Cho),인광호(Kwang Ho In),유세화(Se Hwa Yoo),강경호(Kyung Ho Kang),김철환(Chul Hwan Kim) 대한내과학회 1994 대한내과학회지 Vol.47 No.4
Baekground: Asthma is classified as an inflammatory disease because there are inflammatory changes in the asthmatic airways. There are many evidences that sensory neuropeptides are involved in these inflammatory responses. Neurogenic inflammation is caused by the antidromic nonadrenergic noncholinergic (NANC) release of neuropeptides from vagal nerves. Recently nitric oxide (NO) has received considerable attention as a messenger molecule in the peripheral nervous system and relaxes airway smooth muscle. Also NO is a potent vasodilator and involved in plasma exudation from airway vessels, To investigate the role of nitric oxide in neurogenic inflammation, neurogenic inflammatory responses in rat airways according to duration of NANC stimuation and effects of NO were evaluated, Method: Neurogenic inflammation was produced in rat airways of 2 experimental groups of 1 min and 2 min stimulation with 5V, 1mSec, 5Hz after cholinergic and adrenergic blockade and compared with sham NANC, The magnitude of airway microvascular leakages was checked in the trachea, main bronchus, peripheral bronchus, and lung parenchyme and the leakeage was measured by Evans blue dye extravasation. NW-nitro-L-arginine (L-NNA, 5 mg/kg iv), L-NNA and L-arginine (50 mg/kg iv) were given 15 min before 2 min stimulation on 3 separate groups for evaluation of NO effects, and microvascular leakage was compared with 2 min NANC stimulation group. Results: 1) Vascular permeability of 1 min NANC stimulation group was increased trachea (208.2%, p<0.05), main bronchus (169.4%, p<0.05), and peripheral bronchus (123.6, p=0.18) compared with sham NANC group. 2) There was about l.5 times increase of vascular permeability in 2 min stimulation group compared with 1 min stimulation group (p<0,05), but not significantly increased permeability of lung parenchyme in both groups. 3) In L-NNA pretreated stimulation oup, there was increased vascular permeability of the trachea (133.3%, p<0.05), main bronchus (167.4%, p<0.05), and peripheral bronchus (197.1%, p<0.05) compared with 2 min stimulation group. 4) L-NNA and L-arginine pretreated stimulation group revealed suppressed vascular permeability com- pared with L-NNA pretreated stimulation group. Conclusion: These results revealed that neurogenic inflammation in the rat airway increases inflammatory responses according to duration of stimulation and blocking of NO synthetase increases neurogenic inflammation. These results provide that nitric oxide modulates inflammatory response of NANC stimulation of the vagal nerves in the rat airways.
최형윤,강복수,정종학,조재연 中央醫學社 1987 中央醫學 Vol.52 No.9
To investigate the status of the acute poisoning, the medical records were reviewed for 290 acute poisoning cases, who had been admitted to the Yeungnam University Hospital via emergency room between January and December, 1986. Among the total 290 cases, 109 (37.6%) were male and 181 (62.4%) were female. The most frequent age group was 20-29 years of age in the both sexes. Out of 6 causative substances, CO gas was the most frequent cause of poisoning (42.4%), followed by sedatives and hypnotic (18.3%), pesticides and rodenticides (17.8%), others (16.9%), and unknown (6.6%). The occurrence of acute poisoning was the highest in winter (33.9%) and the, lowest in summer (14.7%). According to intent of poisoning, the suicidal poisoning (57%) was higher than the accidental poisoning (43%). Among CO poisoning cases, 96.7% were poisoned accidentally, but 92.5% in sedatives and hypnotic, and 86.5% in pesticides and rodenticides were poisoned by suicidal pur-pose. The case fatality rate of the accidental acute poisoning was 1.8%, and the suicidal 8.0%. The mean case fatality rate of acute poisoning was 4.5%. Based on these findings, a nationwide survey should be carried out for more reliable data on acute poisoning.