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Interleukin 17-expressing Innate Synovial Cells Drive K/BxN Serum-induced Arthritis
조왕식,장은경,김호연,윤지희 대한면역학회 2016 Immune Network Vol.16 No.6
K/BxN serum can induce arthritis in normal mice because of abundant autoantibodies that trigger an innate inflammatory response in joints. To determine whether IL-17 is involved in the pathogenesis of serum-induced arthritis, we injected wild-type and IL-17–/– mice with K/BxN serum and evaluated them for signs of arthritis. Unlike wild-type mice, IL-17–/– mice did not show any signs of arthritis. IL-17 was produced predominantly by CD3– CD4– gdTCR– NK1.1– Sca1int Thy1hi cells residing in the inflamed synovial tissue. When synovial cells extracted from normal joints were stimulated with IL-23 or autoantibody-containing immune complexes, a substantial fraction of Sca1int Thy1hi cells produced IL-17. Thus, we have identified a novel population of IL-17-producing innate synovial cells that play a crucial role in the development of K/BxN serum-induced arthritis.
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Cytoprotective Role of the Flavonoid Quercetin in Mammalian Cells
DONGGUANGZHI,김창연,조왕식,신용주,이경호 한국유전학회 2006 Genes & Genomics Vol.28 No.3
The unfolded protein response (UPR) is an intracellular signal transduction mechanism that is activated when unfolded proteins acumulate in the endoplasmactivated UPR induces transcription of ER resident chaperones and folding enzymes, atenuates translation of general proteins, and induces genes that play roles in protein degradation. Depending on the ER stres level, the UPR decides whether cells live or die. In t h i s s t u d y , w e t e s t e d w h e t h e r f l a v o n o i d s a f e c t t h e U P R a n d c e ll viability under stres ltured mamalian cells from death under ethanol stres and doxorubicin stres, probably by activating the UPR. Quercetin treatment increased the viability of both ethanol-treated human HepG2 hepatocytes and doxorubicin-treated rat H9c2 myocardiocytes. Quercetin treatment induced the expresion of Grp78/BiP, one of the UPR target genes, increased splicing of Xexpression of the UPRE reporter gene. Interestingly, ectopic expresion of Grp78/BiP protected cels under ethanol and doxorubicin stres from death, suggesting that the flavonoid quercetin somehow activates the UPR in mamalian cells and plays a protective role under certain stres conditions.
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이지연,양시용,고은지,이승구,김시관,조왕식,송민동 建國大學校 自然科學硏究所 2002 建國自然科學硏究誌 Vol.13 No.2
본 연구가 VRSA에 대한 신규 항생물질 생산 균주를 얻기 위하여 실시하였다. 국내외에 채취한 토양시료에서 분리한 방선균 중, 임상분리 VRSA와 돌연변이 유발 VRSA에 대해 항균성을 나타내는 JY-24를 선별하였다. 선발 균주는 원통형의 포자 모양을 갖고 있으며, Bennett's 배지에 배양시 aerial mycelium color는 흰색을 나타냈으며, reverse side color는 대체로 노란색을 나타내었다. 항균물질 생산을 위한 탄소원으로는 fructose, mannose, 질소원으로는 yeast extract가 가장 우수하였으며 glucose의 첨가로 항균 물질 생산성이 증가하는 것으로 나타났다. 최적 초기 pH는 pH 7로 나타났으며, 28 ℃, 37℃, 45 ℃의 온도에서 균이 성장하는 것으로 나타났다. 또한 배양기간에 따라 항균물질 생산성을 조사한 결과, 임상분리 균주에 대해 5일 배양 시 가장 높았으나, 3일 배양과 7일 배양 시 동일한 생산성을 나타내 생산속도가 빠르며, 안정한 물질인 것이 파악되었다. 향후 균주동정 및 항균물질 정제에 관한 연구를 수행하고자 한다. An antibiotic substance producing strain JY-24, effective to the VRSA (Vancomycin-resistant Staphylococcus aureus), was isolated from soil. The spore chain of JY-24 was cylindrical, and its sulface was smooth. The aerial mass color of the strain was white, and its reverse side color was yellow. The strain did not produce soluble pigment. For the production antibiotics, fructose, mannose and yeast extract were favorable as carbon and nitrogen sources. Optimal initial pH for the production of the antibiotic was pH 7. Accumulation of the antibiotic in the culture broth reached at maximal level after 5 days cultivation in Bennett's medium.
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