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콜라겐유도관절염에서 Marginal Zone B 세포의 항체 생산능 증가
우윤주 ( Yun Ju Woo ),민준기 ( Jun Ki Min ),조미라 ( Mi La Cho ),김영주 ( Young Joo Kim ),전주연 ( Joo Yeon Jhun ),박민정 ( Min Jung Park ),문영미 ( Young Mi Moon ),박미경 ( Mi Kyung Park ),김호연 ( Ho Youn Kim ) 대한류마티스학회 2009 대한류마티스학회지 Vol.16 No.1
Objective: Mature B cells in the spleen of mouse can be divide into two main subsets: the follicular (FO) B cells and the marginal zone (MZ) B cells. In this study, we investigated which subtype of B cells is involved in the production of costimulatory molecules, cytokine and antibody during the induction of autoimmune arthritis. Methods: The MZB and FOB cells isolated from DBA/1J induced- and collagen-induced arthritis (CIA) mice were stimulated with LPS or CpG. The costimulatory molecules were measured by flow cytometry (FACs). The cytokines were measured by ELISA. Production of antibodies by the MZB cells or FOB cells was measured by ELISA and the results were observed by confocal microscopy. Results: The expression of co-stimulatory molecules was stronger in the MZB cells than that in the FOB cells. The production of cytokines (IL-10, IL-6) and antibodies was higher in the MZB cells. The IgG expression of the MZB cells, which is known to be associated with the acceleration of autoimmunity, was higher in the CIA mice than that in the DBA/1J mice. Conclusion: We observed that the MZB cells were increased in the CIA mice. The costimulatory molecules, cytokine and auto-antibodies were increased in the MZB cells compared to that of the FOB cells. Our results suggest that MZB cells mainly produce autoantibodies, and they play a key role in development of autoimmune arthritis.
간경변증 쥐 모델에서 혈청 Hyaluronic acid와 간섬유화의 정량적 측정치 간의 상관관계
김문영 ( Moon Young Kim ),백순구 ( Soon Koo Baik ),장윤옥 ( Yoon Ok Jang ),석기태 ( Ki Tae Suk ),김재우 ( Jae Woo Kim ),김현수 ( Hyun Soo Kim ),조미연 ( Mi Yun Cho ),최선주 ( Sun Joo Choi ),엄순호 ( Soon Ho Um ),한광협 ( Kwang Hyu 대한간학회 2008 Clinical and Molecular Hepatology(대한간학회지) Vol.14 No.2
11-deoxycortisol을 과분비한 부신피질암 1예
정춘희,김홍승,김영욱,조미연,이미덕,김윤미 대한내분비학회 1998 Endocrinology and metabolism Vol.13 No.2
The adrenocartical carcinoma is a rare tumor with an estimated incidence of 1 case per 1,700,000 population. Despite its rarity, a large number of investigators have studied this neoplasm for the following two reasons. The First is the occasional difficulty of differentiation between careinoma and adenoma at the time of initial surgery, even by histopathologic examination. The other is its unique feature of corticosteroidogenesis. Steroid metabolism of adrenocortieal carcinoma is characterized by its low efficiency of steroid production due to deficiency of steroidogenic enzyme. The deficieney of 11 B-hydroxylase has been indieated in case of adrenoeortical carcinoma by several investigators. In this study, the serum level of cortisol was within normal range, but the serum level of 11-deoxycortisol was 50 times higher than normal. After the removal of tumor, the serum level of ll-deoxycortisol was markedly decm. In conclusion, the results from the this case suggest that measurement of serum 11-deoxy- cortisol may be a useful tool in the diagnosis and follow-up of adrenocortical carcinoma (J Kor Soc Endocrinol 13:27I-279, 1998).
정춘희,김홍승,김도훈,신계철,조미연,김윤미,송광선 대한내분비학회 1997 Endocrinology and metabolism Vol.12 No.4
This is a case report of a 61 years old man with suprasellar and pituitary metastasis from bronchogenic adenocarcinoma who developed polyuria and polydipsia. The clinical diagnosis has been made by bronchoscopy with washing cytology, biopsy of cervical lymph node, and brain MRI scan. Brain MRI scan showed metastatic tumor in the suprasellar area and pituitary gland with invasion of pituitary stalk. Light microscopic findings revealed adenocarcinoma in bronchoscopic washing cytology, and metastatic adenocarcinoma in the cervical lymph node. The combined pituitary stimulation test showed decreased reserve capacity of anterior pituitary hormones. And the water deprivation test also showed complete central diabetes inspidus. We report a case of suprasellar and pituitary metastasis from bronchogenic adenocarcinoma with a review of the literature. (J Korean Soc Endocrinol 12:602-608, 1997)