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김규한 ( Kyu Han Kim ),조광현 ( Kwang Hyun Cho ),정진호 ( Jin Ho Chung ),박경찬 ( Kyoung Chan Park ),은희철 ( Hee Chul Eun ),윤상웅 ( Sang Woong Youn ),박경찬 ( Kyoung Chan Park ),김규한 ( Kyu Han Kim ),조광현 ( Kwang Hyun Cho 대한피부과학회 1995 대한피부과학회지 Vol.33 No.6
Background : Neurofibiomat,osis type 1(NF-1) is a multisystemic disorder of genetic ori gin, affecting one in every 3000 to 4000 people. It is clinically important in the aspect of dermatology, pediatrics, orthopedic surgery, neurology, neurosurgery and ophthalmology. Objective : The purpore of this study was to elucidate the clinical characteristics of NF-1 in Korean people. Methods : We carried out a retrospective study on 112 patients which were compatible to the diagnostic criteria of Riccardi and Neurofibromatosis Conference Statement. The results were compared with other western studies. Results : The age of onset, sex ratio, family history of neurofibromatosis, and clinica features of cafe-au-lait spot, neurofibroma, and axillary freckinings did not differed from western countries. However, some characterist,ics of NF 1(e.g. Lisch nodule) were not as sessed in the most of the cases and incomplete evaluations of the systemic diseases wen found. Conclusion : In this study t.he clinial features of NF-1 did not differ from western coun tries in many aspects. A more intensive evaluation of patient,s status is needed to manag; NF-1 patients appropritely. (Kor J Dermatol 1995;33(6): 1091-1098)
조광현 ( Kwang Hyun Cho ),이미경 ( Mi Kyung Lee ),조성진 ( Sung Jin Jo ),김규한 ( Kyu Han Kim ),박경찬 ( Kyoung Chan Park ),은희철 ( Hee Chul Eun ),정진호 ( Jin Ho Chung ) 대한피부과학회 2003 대한피부과학회지 Vol.41 No.6
N/A Background : In white people, a distinction between intrinsic aging and photoaging has been well documented in histologic studies. However, no histological studies to date have attempted to announce morphological changes with photoaged skin of Koreans. Objective : Our purpose was to compare the histologic change with advancing age between exposed skin and nonexposed skin of Koreans. Methods : Twenty-one male volunteers between 20 and 80 years of age were recruited. The histochemical and immunhistochemical studies were performed with the skin obtained from face and buttock. Results : 1. With advancing age, there was a decreasing tendency in the epidermal thickness. However, there was no difference between exposed skin and non-exposed skin. 2. Density of dopa-positive melanocytes was much higher in the face than in the buttock at all ages. Decline of melanocyte density with advancing age is not prominent in the facial skin. 3. In the facial skin, accumulation of thickened degraded elastic fibers and a decrease in collagen fibers are evident with advancing age. In the facial skin, increase of acid mucopolysaccharides is also found with advancing age. Conclusion : Koreans, the histologic changes in the skin with photoaging are distinct from those in the skin with intrinsic aging. (Korean J Dermatol 2003;41(6) : 754~760)
조광현(Kwang Hyun Cho),전호수(Ho Su Chun),김선훈(Seon Hoon Kim),박경찬(Kyung Chan Park),김규한(Kyu Han Kim),이승철(Seung Chul Lee),지제근(Je Geun Chil) 대한피부과학회 1993 大韓皮膚科學會誌 Vol.31 No.4
Background : since congenital nevi may not always be identified clirically, it remains a challange for histologists to separate an acquired from a congehital nevus. The camparative histologic feature of congenital and acquired lesions have been described by several authors. Objective : In an attempt to establish reliable microscopic recognition of congenital nevi, the histologic features of 52 congenital melanocytic nevi were studied. Material and methods By reviewing HMB slides, histologic paterns were observed depending on the extent of nevus cell infiltration. An immunohistochemical study wi h anti S-100 protein and HMB-45 antibody was also performed. Results : Diffuse infiltratien of upper and lower dermis with nevu. cells was observed in 21 cases (40.0%). Nevus cell infiltration of appendages and neurovascular structures was observed in 29 cases (55.8%). Indian filing of dermal nevus cells was observed in 33 casesl(64.7%). Epidermis showed elongation of rete ridges in 36 ca.es(69.2%). Immunohistochemical staining with HMB 45 showed a positive raction in 9 cases out of 51 having dermal nevus cells, and epidemal melanocytes showed positive reaction in 20 cases. Conclusion : Congenital melanocytie nevi can be classified by histolcgic appearance into several patterns. Nevus cells had a trend to infiltrate into the deeper dermis as the clinieal size increrased. Nevus cell infiltration of appendages and neurovascular structure was a common finding in congenital melanocytic nevi. (Kor J Dermatol 1993;31(4):523-531)
조광현(Kwang Hyun Cho),김규한(Kyu Han Kim),장승호(Seung Ho Chang),함의근(Eui Keun Ham) 대한피부과학회 1990 大韓皮膚科學會誌 Vol.28 No.6
We examined the amyloid deposit in various malignant cutaneous epithelial tumors by using Dylon stain. Histochemically identifiable amyloid deposits associated with basal cell epitheliomas(BCEs), squamous cell carcinomas(SCCs) and Bowens diseases were studied with monoclonal cytokeratin antibodies and anti-amyloid P antibodies. The results were as follaws, l. Amyloid deposits were detected in 5 of 12 BCEs, 4 of 11 SCCs, 3 of 9 Bowens diseases and 1 of 8 actinic keratoses. Amyloid deposits were not detected in o keratoacanthomas, 2 verrucous carcinomas, 1. Pagets disease and 3 extramammary Pagets diseases. 2. Anti-keratin antibody 34BE12 and anti-amyloid P antibody reacted with amyloid deposits in 3 of 5 BCEs which showed abundant amyloid deposits by Dylon stain. 3. Of 4 SCCs which showed amyloid deposits by Dylon stain, anti-keratin ant.ibody 34pE12 reacted with amyloid deposits in 2 cases and anti-amyloid P antibody reacted with amyloid deposits in 3 cases. 4. Anti-amyloid P antibody reacted with arnyloid deposits in 3 of 3 Bowens diseases which showed arnyloid deposits by Dylon stain. Anti-keratin antibody 34pE12 reacted with amyloid deposits only 1 of them. These findings suggest that epidermal keratins are the percursor substance of amyloid in malignant cutaneous epithelial tumors. The difference of antikeratin staining pattern between BCE-associated amyloid and SCC or Bowens disease-associated amyloid may be the results of difference in development stage of cutaneous amyloids. (Kor J Dermatol 28(6):715 121, 1990)
수장 . 족저부의 표피낭종 - 임상 및 조직학적 연구 -
한광호,문상은,조광현 ( Kwang Ho Han,Sang Eun Moon,Kwang Hyun Cho ) 대한피부과학회 1997 大韓皮膚科學會誌 Vol.35 No.3
Background: Although palmoplantar epidermal cysts have long been associated with develop ment following implantation of an epidermal fragment as a result of a penetrating or blunt injury, the pathogenic mechanism is still not fully understood. Since 1987, many cases have been reported in which human papillomavirus(HPV) could be associated with palmoplantar epidermal cysts. Objective : In this study, we evaluated the clinicopathological findings of palmoplantar epidermal cysts and investigated them for the presence of HPV in order to examine the role of HPV in the pathogenesis of this disorder in Korea. Methods : The clinical, histological, immunohistochemical studies were performed on seven cases of plantar cysts, and two cases of palmar cysts. Results : No previous trauma history was seen. Histopathologically, parakeratotic nuclei, or vacuolar strutures within the keratinous mass in the cyst cavity were found. However, we could not find intracytoplasirnic eosinophilic bodies in the wall, the cyst content, or the overlying epidermis. The dyskeratotic keratinocytes were observed in 3 cases. Papillomavirus common antigens were not detected by immunohissochemical staining. Conclusions . Palmoplantar epidermal cysts in Korea have some different histological features compared to those of HPV 60-associated cases in Japan and we could not detect the immunohistochemical evidence of HPV infection in our cases. (Kor J Dermatol 1997;35(3): 507-513)
호산구농포모낭염 환자에 대한 경구 Naproxen의 임상적 치료 효과
연제호 ( Je Ho Yeon ),윤상웅 ( Sang Woong Youn ),김규한 ( Kyu Han Kim ),조광현 ( Kwang Hyun Cho ) 대한피부과학회 2008 대한피부과학회지 Vol.46 No.12
Background: Eosinophilic pustular folliculitis (EPF) is characterized by erythematous patches of follicular papules and pustules that mainly involve the face. Although various treatments have been attempted for EPF, including systemic and topical steroids, dapsone and indomethacin, there is no consensus on the first choice for treatment. Objective: The purpose of this study was to evaluate the clinical efficacy and safety of naproxen treatment for EPF patients. Methods: We retrospectively reviewed the clinical records of 16 biopsy-proven EPF patients who were treated with naproxen. Initial dose of oral naproxen was 500 mg to 1,000 mg. Therapeutic effects were evaluated by 3 grades: NR (no response), PR (partial remission, >50% improvement), CR (complete remission). Results: Of the 16 EPF patients, 11 patients (69%) showed either complete remission (50%) or partial remission (19%). The median time to response for good responders (CR+PR) was 1.5 weeks. Two patients (13%) had mild gastrointestinal side effects, such as indigestion, but the symptoms disappeared soon after use of a gastrointestinal protectant. Conclusion: Oral naproxen may be an effective and safe treatment modality for EPF. (Korean J Dermatol 2008;46(12):1609∼1614)
한국판 단축된 자기보고형 MINI (MINI 정신건강 평가)의 타당도 연구
임세원,송한수,오윤희,신호철,조광현,정상근,오강섭,Lim, Se-Won,Song, Han-Soo,Oh, Yun-Hee,Shin, Ho-Chul,Cho, Kwang-Hyun,Chung, Sang-Keun,Oh, Kang-Seob 대한불안의학회 2007 대한불안의학회지 Vol.3 No.1
Objectives : To investigate the validity of an abbreviated self-rated Korean version of MINI (Mini International Neuropsychiatric Interview) patient health survey which screening social anxiety disorder, panic disorder, generalized anxiety disorder, and major depressive disorder. Methods : 115 subjects completed MINI and MINI patient health survey. The validity of MINI patient health survey was assessed by whether the results from MINI patient health survey were compatible with the results from MINI or not. The Cohen's kappa value, specificity, sensitivity, positive predictive value, and negative predictive value was calculated for this purpose. Results : The Kappa values of social anxiety disorder (0.60), panic disorder (0.49), generalized anxiety disorder (0.60) and major depressive disorder without other co-morbid disorder (0.59) were at least moderate in strength of agreement. Conclusion : The abbreviated self-rated Korean version of MINI patient health survey has the moderate to good validity in social anxiety disorder, panic disorder, generalized anxiety disorder, and major depressive disorder without other co-morbid disorders. Our result suggests that this instrument might be useful for screening above 4 disorders if it is used under careful supervision of experienced clinicians.