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Repositioning of a mucolytic drug to a selective antibacterial against Vibrio cholerae
정인영,Bi-o Kim,Hye-Jeong Jang,You-Hee Cho 한국미생물학회 2020 The journal of microbiology Vol.58 No.1
Drug repositioning, the approach to explore existing drugs for use in new therapeutic indications, has emerged as an alternative drug development strategy. In this study, we found that a mucolytic drug, N-acetylcysteine (NAC) showed antibacterial activity against Vibrio cholerae. NAC can provide acid stress that selectively inhibited the growth of V. cholerae among other bacterial pathogens. To address the antibacterial mechanism of NAC against V. cholerae, six acr (acetylcysteine- resistant) mutants were isolated from 3,118 random transposon insertion clones. The transposon insertion sites of the six mutants were mapped at the five genes. All these mutants did not display NAC resistance under acidic conditions, despite their resistance to NAC under alkaline conditions, indicating that the NAC resistance directed by the acr mutations was independent of the unusual pH-sensitivity of V. cholerae. Furthermore, all these mutants displayed attenuated virulence and reduced biofilm formation, suggesting that the acr genes are required for pathogenesis of V. cholerae. This study validates the relevance of drug repositioning for antibacterials with new modes of action and will provide an insight into a novel antibacterial therapy for V. cholerae infections to minimize side effects and resistance emergence.
부분 조절 내사시의 근거리각 기준 수술 후 장기간의 경과 관찰
정인영,박영걸,박상우,In Young Jeong,Yeoung Geol Park,Sang Woo Park 대한안과학회 2008 대한안과학회지 Vol.49 No.4
Purpose: To analyze the long-term outcome of near geared standard surgery with full hyperopic correction for partially accommodative esotropia. Methods: The medical records of a total of 24 patients with partially accommodative esotorpia, who had undergone bilateral or unilateral medial rectus recession were retrospectively reviewed. The amount of medial rectus recession was measured based on the near deviation after full hyperopic correction. During the follow-up period the changes of refractive error and angle of deviation were evaluated, and the titmus test and Worth 4-Dot test were performed. Results: The mean ages were 36.63±13.38 months (14~59 months) at the time of wearing glasses and 61.25±25.55 months (25~132 months) at the time of operation. The average follow-up period was 59.67±32.12 months (18~120 months) and preoperative refractive errors were +3.93±1.73 D sph and refractive errors at final visit were +3.64±2.07 D sph (p=0.53). The mean amount of esodeviation were 26.08±8.13PD and 4.25±6.63PD for pre- and post-operatively respectively. Nineteen patients showed postoperative deviation of 10PD or less, one patient was overcorrected, and four patients were undercorrected. Worth 4-Dot test resulted in a fusion response at near and far in one patient preoperatively and in 17 patients postoperatively (p=0.30). A titmus stereotest of less than 100 seconds of arc resulted in 1 of 7 patients and 6 of 14 patients at the time of preoperation and postoperation each (p=0.34). The results were not statistically significant. Four of ten high hyperopic patients (≥ +4.00 diopter) had under- or over-correction (p=0.12), though it was not statistically significant. There were no significant differences in combined conditions. Conclusions: Near geared standard surgery with full hyperopic correction in partially accommodative esotropia patients gave a good surgical result for patients in the mean follow-up duration of 59.67 months.
각막이식술 후 재발한 단순포진바이러스 각막염에 대한 분석
정인영,이광훈,유인천,윤경철,In Young Jeong,MD,Kwang Hoon Lee,MD,In Cheon You,MD,PhD,Kyung Chul Yoon,MD,PhD 대한안과학회 2009 대한안과학회지 Vol.50 No.5
Purpose: To analyze the clinical aspects and risk factors for recurrent herpes simplex keratitis (HSK) after penetrating keratoplasty (PKP). Methods: Records from 78 eyes of 41 patients who underwent PKP for HSV keratitis with a mean follow-up duration of 31.83±21.35 months (24~97 months) were reviewed. The clinical aspects of recurrent keratitis, rejection, and survival rate were evaluated. Previous operation history, preoperative inflammation and neovascularization, graft size, suture methods, and antiviral use were analyzed to elucidate the risk factor for recurrent HSK after PKP. Results: HSK recurred in 47.4% of the patients at a mean time of 18.36±21.02 months after PKP. The mean duration of keratitis was 2.16±1.71 months and the mean frequency of recurrence was 1.41±0.69 times. Epithelial keratitis developed in 46.2% of the patients, and epithelial keratitis combined with stromal inflammation developed in 36.5%. Previous graft failure due to recurrent HSK and preoperative inflammation were significant risk factors for recurrent HSK after PKP (p=0.019, p=0.006). There were no statistically significant differences in graft rejection and survival rate between the two groups with and without recurrent HSK. Conclusions: The majority of cases of recurrent HSK after PKP were epithelial keratitis or epithelial keratitis combined with stromal inflammation, and risk factors for the recurrence of HSK were previous graft failure due to recurrent HSK and preoperative inflammation.
투과체에 적용된 채광방식이 사무소공간의 색도 및 색온도분포에 미치는 영향 분석
정인영,김정태,Jeong, In-Young,Kim, Jeong-Tai 한국조명전기설비학회 2007 조명·전기설비학회논문지 Vol.21 No.3
투과체는 기본적으로 외부환경과 접촉할 수 있는 친화적이고 생태학적인 기능을 가지고 있으며, 이를 통해 유입되는 빛은 실내공간에 다양한 분위기를 연출할 수 있도록 해준다. 이에 본 연구는 투과체가 적용된 사무소건물을 대상으로 채광유입을 증대시킬 수 있는 채광방식을 설계하여 적용 시 실내의 색도와 색온도에 미치는 영향을 분석하였다. 이를 위하여 1/10축소모형을 제작하였으며, Prometric 1421이라는 측정기기를 이용하여 실험을 수행하였다. 측정결과 투과체가 갖는 파장대별 투과특성이 실내의 색도에 영향을 미치는 것으로 나타났으며, 빛의 유입을 증대시키는 채광방식을 설치할 경우 천정면의 색온도에 많은 영향을 주었으며, $5{\sim}20[%]$정도의 색온도를 증가시키는 것으로 나타났다. 따라서 채광시스템을 설치할 경우 활동적인 분의기의 공간이 연출될 수 있을 것으로 기대된다. One basic function of glazing system has always been the maintenance of visual contact with the natural environment-a fundamentally ecological function. In addition, penetration light through glazing system have an effect on variable atmosphere of interior. In this study, a typical office space was selected as a evaluation model and a 1/10 scale model was made. The conventional window, differentiated window and interior lightshelf were designed to enhance daylighting performance. The chromaticity and color temperature of interior space was measured using Prometric 1421. The result showed that transmittance by wavelength range of the glazing had an effect on chromaticity and color temperature. Also, color temperature of indoor environment were increased by $5{\sim}20[%]$ using differentiated window and interior lightshelf. Accordingly, it is thought that the use of a daylighting system will create activate indoor atmosphere.
감염성 각막궤양에 의한 절박천공에서 구조 전층각막이식술의 효과
정인영,유인천,박영걸,윤경철,In-Young Jeong,In-Cheon You,Yeoung-Geol Park,PhD,Kyung Chul Yoon 대한안과학회 2007 대한안과학회지 Vol.48 No.7
Purpose: To investigate the effect of tectonic penetrating keratoplasty for the treatment of impending perforations caused by infectious corneal ulcers. Methods: We analyzed preoperative and postoperative visual acuity, lesion location and size, graft size, postoperative outcome, and complications in 19 patients (19 eyes) with impending perforations due to infectious corneal ulcers. All patients underwent tectonic penetrating keratoplasty and had a minimum follow-up period of 6 months. Results: In our study, eight eyes (42.1%) had herpes simplex keratitis, 6 eyes (31.6%) had bacterial keratitis, and 5 eyes (26.3%) had fungal keratitis. Twelve eyes had a lesion located in the central cornea, while 7 eyes had a lesion located in the paracentral cornea. Visual acuity improved in 13 eyes (68.4%) and anatomical success was achieved in 16 eyes (84.2%). Three eyes (15.8%) developed a graft melting secondary to rejection. Complications included bullous keratopathy (3 eyes, 15.8%), graft infection (3 eyes, 15.8%), neovascularization (2 eyes, 10.5%), and secondary glaucoma (1 eye, 5.3%). Conclusions: Tectonic penetrating keratoplasty maintains ocular integrity and effectively treats impending perforations caused by infectious corneal ulcers.