지속적 외래 복막투석환자에서 투석 연결방법에 따른 복막염의 양상

정인경(In Kyung Jeong),홍성표(Seung Pyo Hong),이태원(Tae Won Lee),임천규(Chun Gyoo Ihm),김명재(Myung Jae Kim),안재형(Jae Hyung Ahn) 대한내과학회 1998 대한내과학회지 Vol.54 No.1

Objectives : The purpose of the present study was to compare the general conditon of peritonitis through a study of three connector systems : The Straight transfer set with Spike-and-Pork system (SPS), The Straight transfer set with Luer-Lock system(SLS), and The Y-set with Two Bag system(YS). Methods: We reviewed our experience with 134 patients from 1988.1 to 1995.12. According to various kinds of connector system, we divided cases into 3 groups: The SPS(1988. 1-1991. 3) was used on 55 patients(mean age 47±12, M:F=30:25); The SLS (1991.4-1993.8) on 45 patients(mean age 55±11, M:F=30:15); and The YS(1993.9-1995.12) on 34 patients(mean age 49±15, M:F=15:19). Results: 1) Total CAPD duration was 1.22 patient ·year in SPS, 1.08 in SLS, and 0.96 in YS. The incidence of peritonitis is 1.71 episodes per patient ·year in SPS, 1.03 in SLS, and 0.61 in YS. 2) Among the causative organisms of peritonitis, coagulase negative Staphylococcus was most common in the three groups(SPS:10.4%, SLS:10%, YS: 20%). In SPS and SLS, S. aureus(7.7%, 8%), Pseudomonas(6.5%, 8%), E.coli(5.2%, 6%) were present in decreasing order. In YS, Pseudomonas (15%), S.aureus(15%), Ecoli(10%) were present in decreasing order. There were no growth of organisms in 55.9% of SPS, 38% of SLS, and 30% of YS. 3) The probability of experiencing the first peritonitis at 1, 3, 6, and 12 months was 21.4%, 21.4%, 21.4%, and 23.9% respectively in SPS, 3.4%, 34.5%, 34.5%, and 10.3% respectively in SLS, and 0%, 28.5%, 35.7%, and 28.5% respectively in YS. 4) In the response to the treatment of peritonitis, 59.7% of the peritonitis episodes in SPS, 72% in SLS, and 85% in YS were cured with antibiotics. In 37.7% of the peritonitis episodes in SPS, 24% in SLS, and 10% in YS, the catheter was removed due to fungal, tuberculous, recurrent, or peritonitis not responding to antibiotics. 2 patients in SPS, 2 patients in SLS, and 1 patient in YS died due to peritonitis. 5) The catheter survival rate at 3, 6, 12 months was 72%, 63.6%, and 40% respectively in SPS, 89%, 78.3%, and 46.7% respectively in SLS, and 94%, 85.3%, and 76.6% respectively in YS. Conclusion: Our study suggests that there is a relationship between the development of connector system and a decrease of peritonitis in CAPD.

일제하 경성고등공업학교의 설립과 운영

정인경 ( In Kyung Jeong ) 한국과학사학회 1994 한국과학사학회지 Vol.16 No.1

글루카곤양펩티드-1의 췌장 외 효과

정인경 ( In Kyung Jeong ) 대한내과학회 2015 대한내과학회지 Vol.89 No.4

Glucagon like peptide-1 (GLP-1) is an intestinal L cell derived incretin hormone which stimulates insulin secretion of beta cell and inhibits glucagon secretion of alpha cell of pancreatic islets. GLP-1 receptors are located in pancreas as well as in a wide variety of tissue such as gastrointestinal tract, heart, blood vessel, lung, brain, kidney, and bone. Therefore GLP-1 and GLP-1 based treatment have multiple extrapancreatic effects which are inhibition of gastrointestinal motility, reduction of appetite, weight loss, increase of cardiac output, cardiovascular protection, neuroprotection, renoprotection, and increase of bone mineral density. Recently, besides GLP-1 receptor dependent pathway, GLP-1 receptor independent pathway has been identified in the extrapancreatic effect of GLP-1 in liver, adipose tissue, muscle, cardiovascular system. This review provides an overview of the pleiotropic effect of GLP-1 in the extrapancreatic organ through review of animal and clinical research. (Korean J Med 2015;89: 404-412)

중학생의 전통 식생활교육에 대한 인식 및 요구도 조사

김유정(Kim Yu-Jeong),오수진(O Soo-Jin),정인경(Jung In-Kyung) 한국가정과교육학회 2007 한국가정과교육학회지 Vol.19 No.2

본 연구는 중학교 기술 · 가정 교과를 통한 우리나라 전통 식생활 교육의 활성화 방안을 모색해 보고자 중학생들을 대상으로 학교 교육과정에서의 전통 식생활 교육의 실태와 인식 및 내용별 요구도를 알아보기 위하여 실시되었다. 본 조사대상 중학생은 학교에서 주로 기술 · 가정 교과를 통해 전통식생활 교육을 받고 있었으며, 학교 교육과정에서의 전통식생활 교육은 필요하며, 실생활에 도움이 많이 되는 것으로 인식하고 있었다. 전통식생활 교육의 교수 · 학습방법에 대한 조사결과, 현재 전통식생활 교육은 주로 강의식 설명위주로 진행되는 경우가 가장 많았으나 학생들은 좀 더 실천적인 교수 · 학습방법을 원하는 것으로 나타났다. 또한 내용에 있어서도 실생활에 도움이 될 수 있는 내용의 교육이 이루어지질 바라고 있었다. 따라서 학교 교육과정을 통한 전통식생활 교육이 효과적으로 이루어지기 위해서는 현재 중학교 기술 · 가정교과 내 전통식생활 관련 내용 및 교수 · 학습방법이 실생활에 도움이 될 수 있는 내용과 학습자의 요구를 반영한 교수 · 학습 방법으로 수정 · 보완되어져야 할 것이다. The purpose of this study was to find out the way to activate the Education of Korean Traditional foods and culture from middle school subject, Technology and Home Economics Education. We investigated the middle school students perception and needs for the Education of Korean Traditional foods and culture in their educational curriculum. This study was carried out by using a self-administered questionnaire and 600 middle school students in Gyeonggi province were participated. Most of subjects took the Education of Korean Traditional foods and culture as a part of Technology and Home Economics Education. They recognized that this lecture is necessary and effective, since it is of great help to their life. However, lecture was descriptively given by teacher and not actively participated by students. Therefore, students requested for more practical methods of teaching and learning. They also desired that the education should comprise what will be helpful in a real life. These results suggested that current teaching and learning methods should be corrected and complemented in such a way as to reflect relevant contents and learners demands which are useful in a real life, so that the Education of Korean Traditional foods and culture may be conducted through middle school subjects of Technology and Home Economics Education in an effective way at school.

염모제 처리 시의 모발손상도 및 모발색도의 변화

정남영 ( Nam Young Jeong ),정인경 ( In Kyung Jung ) 한국미용학회 2008 한국미용학회지 Vol.14 No.1

A variety of cosmetic treatment is performed as the way of the pursuit of beauty according to the change in human`s life. For this reason, it is necessary to conduct the research on the methods to reduce hair damage when hair dye is treated repeatedly or after permanent wave. This study compared the group treated by permanent wave or hair dye with the control group not treated by chemical agents. There was significant chemical damage in hair cuticle damage, but neutral hair dye was found to have much lower damage. For tensile strength, alkaline hair dye was found to have much severer damage than neutral hair dye. For the maintenance of wave efficiency, neutral hair dye was much better than alkaline hair dye. In conclusion, while neutral hair dye was much lower in hair damage than alkaline hair dye, the change in the color of hair was higher in the alkaline hair dye group. Thus, when treating permanent wave and hair dye at the same time, it seems right to select alkaline hair dye only for the color of hair. However, it is recommended to select neutral hair dye to reduce hair damage.

효모추출복합물과 헛개나무 열매추출 복합물이 알코올 대사에 미치는 영향 -무작위, 이중맹검, 위약 대조군, 교차 인체적용시험-

조보람 ( Bo-ram Cho ),남충우 ( Choong-woo Nam ),정세영 ( Se-young Choung ),정인경 ( In-kyung Jeong ),문민선 ( Min-sun Moon ) 한국식품영양학회 2017 韓國食品營養學會誌 Vol.30 No.4

This study was conducted to investigate if the supplement formula may improve alcohol metabolism in healthy adult men. In a double-blinded, randomized, crossover study, subjects were administrated yeast extract mixtures (YEM, n=15), Hovenia dulcis mixtures (HDM, n=15), placebo (PLA, n=15), and control (CON, n=15) in an oral dose followed by one week washout periods. At each visit (0, 1, 2, 3, 4 week), subjects drank 450 mL, 20.1 percent alcohol after administered mixtures. Blood was drawn periodically (0, 0.25, 0.5, 1, 2, 4, 6, 15 hours). Fifteen subjects completed the protocol and were included in the analysis. Plasma ethanol concentration was lower in YEM (10 percent) and the HDM (5 percent) groups. The area under the curves (AUC) and Cmax for plasma ethanol were significantly decreased only in the YEM group, when compared with the CON group. The AUC and Cmax for plasma acetaldehyde concentration were significantly decreased in the YEM (45 and 54 percent) and the HDM (35 and 53 percent) groups respectively, when compared with PLA (p<0.01). Together, these findings validate that YEM or HDM improved alcohol metabolism and hangover syndromes, leading to reduce alcohol concentration and acetaldehyde concentration without adverse effects.

당뇨병에 동반된 폐결핵의 임상적 연구

정인경 ( In Kyung Jeong ),유지홍 ( Jee Hong Yoo ),이선미 ( Seon Mee Lee ),고관표 ( Kwan Pyo Koh ),한민수 ( Min Soo Han ),강홍모 ( Hong Mo Kang ) 대한결핵 및 호흡기학회 1998 Tuberculosis and Respiratory Diseases Vol.45 No.4

의학강좌: 개원의를 위한 모범처방전 : 고프로락틴혈증의 임상적 접근 및 치료

정인경 ( In Kyung Jeong ) 대한내과학회 2007 대한내과학회지 Vol.72 No.6

ʻ지구적 숙의 거버넌스ʼ 로서 유엔기후변화협상에 관한 세계시민회의

이영희(Lee, Young Hee),정인경(Jeong, In Kyung) 한국과학기술학회 2015 과학기술학연구 Vol.15 No.2

원저 : 제2형 당뇨병 동물모델에서 항 혈관내피세포 성장인자(Anti-Vascular Endothelial Growth Factor (VEGF)) 투여 시 췌장에 대한 효과

김지원 ( Ji Won Kim ),함동식 ( Dong Sik Ham ),박헌석 ( Heon Seok Park ),안유배 ( Yu Bai Ahn ),송기호 ( Ki Ho Song ),윤건호 ( Kun Ho Yoon ),유기동 ( Ki Dong Yoo ),김명준 ( Myung Jun Kim ),정인경 ( In Kyung Jeong ),고승현 ( Seung Hy 대한당뇨병학회 2009 Diabetes and Metabolism Journal Vol.33 No.3

연구배경: 대표적인 당뇨병성 합병증인 당뇨병성 신증과 망막병증은 공통적으로 혈관내피세포성장인자(Vascular endothelial growth factor, VEGF)가 합병증의 발생에 중요한 역할을 하는 것이 알려져 있으나 항 VEGF 치료가 췌도나 베타세포에 직접적으로 어떠한 영향을 주는지는 거의 알려진 바가 없다. 이에 당뇨병성 합병증 치료를 목적으로 하는 항 VEGF 치료가 췌장과 당뇨병의 경과에 미치는 영향을 관찰하고, 당뇨병이 진행되면서 나타나는 췌도 및 베타세포의 변화에 있어서 VEGF의 역할을 규명하고 치료에 응용하고자 하였다. 방법: 이에 당뇨병 동물모델인 db/db mouse에 12주간 VEGF 수용체 type 2 antagonist (ATWLPPR, 5 mg/kg)를 복강 내 투여하여 혈당의 변화와 함께 췌장의 면역염색을 통하여 베타세포 질량 및 췌도의 형태적인 변화를 관찰하고 VEGF의 췌도 내 발현 및 혈관신생 정도를 평가하였다. 결과: 12주간 항 VEGF peptide를 투여한 결과, 복강 내당부하검사 시 db/db mouse에 비해 항 VEGF 투여군에서 현저한 고혈당을 보였으며 고혈당이 심해지면서 항 VEGF 투여군에서 체중의 증가가 적었다. 췌장의 무게(db/dm vs. db/db vs. anti-VEGF group, 0.321±0.05 vs. 0.206±0.13 vs. 0.158±0.12 g) 및 베타세포 질량(db/dm vs. db/db vs. anti-VEGF group, 4.08±0.1 vs. 3.77±0.2 vs. 2.89±0.2 mg, P<0.05) 역시 db/db군에 비해 항 VEGF군에서 더 감소되었다. 또한 정상 췌도에 비해 당뇨병이 발생한 군에서 췌도 내 VEGF 발현이 증가되었으나, 항 VEGF 투여시 췌도 내 VEGF 단백의 발현이 감소하였고(db/dm vs. db/db vs. anti-VEGF group, 3.63±2.86 vs. 6.60±3.56 vs. 2.74±1.55%, * P<0.05) 췌도의 크기가 감소하였으며, 췌도 내 섬유화 진행이 더 심하게 관찰되었고(db/dm vs. db/db vs. anti-VEGF group, 3.37±1.51 vs. 13.96±3.20 vs. 16.99±4.96%, * P<0.05) 췌도 내 내피세포의 증식이 더 감소되어 있었다. 결론: 제2형 당뇨병 동물모델에서 혈관내피세포 성장인자(VEGF)는 정상 췌도보다 당뇨병이 발생한 췌도에서 발현이 증가되므로 당뇨병의 발병 기전과 관련이 있을 것이며, 베타세포의 증식 및 췌도 변형에 중요한 역할을 하므로 당뇨병의 치료에도 응용할 수 있을 것으로 생각되고, 당뇨병성 미세혈관 합병증의 치료나 예방을 목적으로 제2형 당뇨병모델에 항 VEGF를 투여할 경우 고혈당 상태를 더 악화시키고 베타세포 증식을 억제하며 췌도 파괴를 가속화 시키므로, 항 VEGF 치료 시 이에 대한 충분한 고려가 필요할 것이다. Background: Vascular endothelial growth factor (VEGF) is associated with the development of diabetic complications. However, it is unknown whether systemic VEGF treatment has any effects on the pancreatic islets in an animal model of type 2 diabetes mellitus. Methods: Anti-VEGF peptide (synthetic ATWLPPR, VEGF receptor type 2antagonist) was injected into db/db mice for 12 weeks. We analyzed pancreatic islet morphology and quantified beta-cell mass. Endothelial cell proliferation and the severity of islet fibrosis were also measured. VEGF expression in isolated islets was determined using Western blot analysis. Results: When anti-VEGF was administered, db/db mice exhibited more severe hyperglycemia and associated delayed weight gain than non-treated db/db mice. Pancreas weight and pancreatic beta-cell mass were also significantly decreased in the anti-VEGF-treated group. VEGF and VEGF receptor proteins (types 1 and 2) were expressed in the pancreatic islets, and their expression was significantly increased in the db/db group compared with the db/dm group. However, the elevated VEGF expression was significantly reduced by anti-VEGF treatment compared with the db/db group. The anti-VEGF-treated group had more prominent islet fibrosis and islet destruction than db/db mice. Intra-islet endothelial cell proliferation was also remarkably reduced by the anti-VEGF peptide. Conclusion: Inhibition of VEGF action by the VEGF receptor 2antagonist not only suppressed the proliferation of intra-islet endothelial cells but also accelerated pancreatic islet destruction and aggravated hyperglycemia in a type 2 diabetes mouse model. Therefore, the potential effects of anti-VEGF treatment on pancreatic beta cell damage should be considered. (Korean Diabetes J 33:185-197, 2009)