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전재범(JaeBuhm Chun),한소희(Sohee Han),윤형석(Hyungsuk Yoon),이은정(Eunjung Lee),이경무(Kyoung-Mu Lee) 한국환경보건학회 2011 한국환경보건학회지 Vol.37 No.5
Objectives: In order to evaluate the association between occupational exposure to chloroethylene (TCE) and risk of non-Hodgkin lymphoma (NHL), we conducted a meta-analysis of retrospective cohort studies and casecontrol studies and attempted to summarize the evidence of the association from molecular-epidemiological studies and experiments with human cells. Methods: In the meta-analysis, we restricted the analysis to those studies with data for chlorinated solvents, degreasers, or TCE. Studies involving dry cleaners or launderers were excluded from the analysis because use of TCE as a dry cleaning fluid has been rare since the 1960s. The data were combined using a random-effects model to estimate the summary risks (OR and RR) and 95% confidence intervals (CIs). Molecular evidence of the effect of TCE on human immune system were also reviewed and summarized. Results: Occupational exposure to TCE was strongly associated with NHL among cohort studies (number of studies=13, summary RR=1.33, 95% CI=1.04-1.70) whereas the association was not statistically significant among case-control studies (number of studies=15, summary OR=1.10, 0.98-1.23). When exposure level was considered, it became statistically significant for the highest exposure level (number of studies=5, summary OR=1.70, 1.25-2.32). Molecular evidences showed that TCE exposure in human or cultured human cells may cause a significant decrease immune cell subsets and changes in hormone levels related to immune response. Conclusions: Our results from meta-analysis and additional molecular evidence suggest that occupational exposure to TCE may cause NHL. However, unmeasured potential confounding and unclear dose-response relationships warrant further study on the role of TCE exposure in NHL carcinogenesis.
제부라린의 침종처리가 보리 생육초기 생장 및 체세포 염색체에 미치는 영향
한지윤,강성욱,전재범,김양길,윤영미,조성우,Han, Ji-Yoon,Kang, Seong-Wook,Chun, JaeBuhm,Kim, Yang-Kil,Yoon, Young-Mi,Cho, Seong-Woo 한국작물학회 2020 한국작물학회지 Vol.65 No.4
The objective of this study was to identify the effect of zebularine soaking on the early growth stage of barley (Hordeum vulgare L.). Hence, root elongation was measured daily according to the different concentrations of zebularine (1.0, 2.5, 5.0, and 10.0 μM) for 4 days. On the first day, root length at 2.5 and 5.0 μM was significantly longer than that in the non-treated control. On the second day, root length was not significantly different among all concentrations and controls. On the third day, root elongation was suppressed by the effect of zebularine, except at 2.5 μM. The treatment time of zebularine accounted for the largest proportion of the variation in root elongation. After transplanting, plant growth velocity was similar to that of the control; however, plants at 2.5 μM showed faster growth velocity than that of the other concentrations and the control. In the metaphase of mitosis, most chromosomes of cells under zebularine treatment were ordinary regardless of the concentration, while some cells with short chromosomes were investigated at around 2%. The short chromosome showed a centromere. In addition, it showed short and long arms based on the centromere. The lengths of the short and long arms were different for each short chromosome. It is necessary to study the effect of the short chromosome as a chromosomal function on plant growth and phenotype through investigation of meiosis and fertilization at the chromosome level.
EMS 유도 내염성 증진 사료용 옥수수 돌연변이체 선발 및 특성 분석
조철오,김경화,서미숙,최만수,전재범,진민아,김둘이,Cho, Chuloh,Kim, Kyung Hwa,Seo, Mi-Suk,Choi, Man-Soo,Chun, Jaebuhm,Jin, Mina,Kim, Dool-Yi 한국작물학회 2020 한국작물학회지 Vol.65 No.4
Maize (Zea mays L.) is one of the most valuable agricultural crops and is grown under a wide spectrum of environmental conditions. However, maize is moderately sensitive to salt stress, and soil salinity is a serious threat to its production worldwide. In this study, we used ethyl methane sulfonate (EMS) to generate salt-tolerant silage maize mutants. We screened salt-tolerant lines from 203 M<sub>3</sub> mutant populations by evaluating the morphological phenotype after salt stress treatment and selected the 140ES91 line. The 140ES91 mutant showed improved plant growth as well as higher proline content and leaf photosynthetic capacity compared with those of wild-type plants under salt stress conditions. Using whole-genome re-sequencing analysis, 1,103 single nucleotide polymorphisms and 71 insertions or deletions were identified as common variants between KS140 and 140ES91 in comparison with the reference genome B73. Furthermore, the expression patterns of three genes, which are involved in salt stress responses, were increased in the 140ES91 mutant under salt stress. Taken together, the mutant line identified in our study could be used as an improved breeding material for transferring salt tolerance traits in maize varieties.
맥주보리의 large-InDel 마커 개발을 위한 whole genome re-sequencing의 이용
김태헌(Tae-Heon Kim),김양길(Yang-Kil Kim),손재한(Jae-Han Son),전재범(JaeBuhm Chun),윤영미(Young-Mi Yoon) 한국육종학회 2021 한국육종학회지 Vol.53 No.3
Barley is an economically important cereal crop grown under diverse environmental conditions and ranked fourth in terms of productionvolume. Barley is a diploid self-fertilizing plant with seven chromosomes, and has a 5.1 Gbp genome with more than 80% repeat sequences. Whole genome re-sequencing (WGR) has provided substantial information on sequence variation distributed on all chromosomes, such as singlenucleotide polymorphisms, insertions, and deletions, which are used in the development of DNA markers. In this study, we performed WGRto detect sequence variations among six Korean malting varieties. An average of 92,552 insertions and deletions (InDels) were detected inthese varieties in comparison to the high-quality reference genome sequences. The InDel density of the six Korean malting varieties rangedfrom 17 to 19 InDel/1Mbp with an average of 18 InDel/1Mbp. No InDel could be detected in 193 regions in all chromosomes except chr. unassigned. One interval with high-density InDel, more than 150 InDel/1Mbp, was located on the 1H, 3H, 6H, and 7H chromosomes. Atotal of 145 InDel markers were developed using 225 large-InDel markers, longer than 50 bp. Seventeen large-InDel makers showedpolymorphisms among 31 malting barley varieties. These 31 malting barley varieties were divided into four groups based on phylogeneticanalysis. These results presented a development method of agarose-resolvable large-InDel markers using WGR. Seventeen polymorphic large-InDelmarkers were used to conserve and identify barley germplasms. This vast information on sequence variation in six Korean malting barleyscould be used for the development of DNA markers and marker-assisted selection.
벼 생태형별 아프리카인의 쌀 외관품질 및 밥맛 선호도 평가
이점식 ( Jeom Sig Lee ),이정희 ( Jeong Heui Lee ),윤미라 ( Mi Ra Yoon ),곽지은 ( Jieun Kwak ),천아름 ( Areum Chun ),강경호 ( Kyung Ho Kang ),정지웅 ( Ji Ung Jeung ),전재범 ( Jaebuhm Chun ),김보경 ( Bo Kyeong Kim ) 한국국제농업개발학회 2014 韓國國際農業開發學會誌 Vol.26 No.3
The objective of this study was to evaluate grain appearance and cooked rice taste preferred by Africans for the rice ecotype of one Japonica variety, one Indica variety, and two varieties of Tongil type as compared with Korean’s preference. The preferred grain appearance by Africans who have participated as panelists was in the order of grain length, aroma, and shape, while Korean preferred rice quality in the order of appearance(head rice) and grain length. Africans preferred imported Indica rice from Thailand the most, while Korean preferred Japonica Haimi the most. Overall, African preferred aromatic rice with long grain, while Korean preferred short grain rice with high head rice ratio. In the evaluation of cooked rice taste, there was no significant statistical difference between varieties preferred by Africans. Whereas, Koreans showed clear preference in the order of Haiami > Dasan 1 = Hanareum > Indica rice. The preference analysis results of cooked rice taste subjected to Japonica and Indica which showed clear preference by Koreans revealed that Africans from Cameroon, DR Congo, and Tanzania preferred Haimai. Meanwhile, the Africans from Uganda, Mali, and Nigeria preferred imported Indica rice from Thailand. The Africans from Kenya, Malawi, Ghana, and Sudan showed similar preference among Japonica and Indica varieties. The study results indicated that Africans had different preference of cooked rice taste for eco-type rice varieties by different nations. It is regarded that additional research would be conducted to evaluate cooked rice taste by the appropriate numbers of panelists from various field and by the various rice varieties including rice variety preferred by different African countries.