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최승진,장은덕,권성오,계대곤,박춘근,이상원,강준기,Choi, Seung Jin,Chang, Eun Deok,Kwon, Seung Oh,Kye, Dae Kon,Park, Choon Keun,Lee, Sang Won,Kang, Joon Ki The Korean Neurosurgical Society 2000 Journal of Korean neurosurgical society Vol.29 No.9
목 적 : 양성 뇌수막종에 비하여 이형성 및 악성 뇌수막종이 나쁜 임상적인 예후 및 양상을 보이는 것은 잘 알려져 있으나, 양성 뇌수막종에 있어서 각각의 병리조직학적 아형에 따른 생물학적 양상의 차이에 대해서는 잘 알려지지 않거나 일부 논란이 되고있다. 본 연구에서는 이형성 뇌수막종 및 양성 뇌수막종의 각각의 병리조직학적 아형에 따른 증식능의 차이여부를 알아보고자 PCNA와 Ki-67표지지수를 분석하였다. 방 법 : 본원에서 뇌수막종으로 수술을 시행하여 얻은, 재발을 보여 재수술을 시행한 2례를 포함하여, 파라핀에 포매시킨 27개의 조직을 대상으로 병리학적인 증식능을 분석하기 위해, PCNA에 대한 단일항체 및 MIB-1 단일항체를 이용한 면역조직화학적 염색을 시행하였다. 조직학적 분류상 meningothelial type이 8례, transitional type이 9례, fibroblastic type이 5례였으며, 이형성 수막종이 5례였다. 결 과 : PCNA표지지수의 평균값은 양성 수막종에서 meningothelial type이 $4.82{\pm}5.10%$, transitional type이 $9.01{\pm}4.25%$, fibroblastic type이 $5.66{\pm}5.32%$를 보였으나 이형성 수막종에서는 $27.62{\pm}19.67%$의 높은 지수를 나타냈고, Ki-67 표지지수의 평균값은 양성 수막종의 아형에서 각각 $0.43{\pm}0.85%$, $0.44{\pm}1.08%$, $0.24{\pm}0.18%$를 보이고, 역시 이형성 수막종에서는 $0.84{\pm}0.59%$의 높은 지수를 보였다. 즉, 양성 수막종에서 각각의 아형에 따른 PCNA 및 Ki-67 표지지수는 통계학적으로 의미있는 차이는 없었으나(p>0.05), 이형성 수막종에서는 의미있는 높은 표지지수를 보여(p<0.05) 양성 수막종에서 보다 높은 증식능을 보임을 알 수 있었다. 결 론 : PCNA 및 Ki-67 표지지수를 이용한 증식능의 비교결과, 양성 뇌수막종에서는 각각의 아형에 따른 생물학적 양상이나 예후는 차이가 없을것으로 생각되나, 이형성 수막종에서는 높은 증식능을 보여 이에 대한 예후를 예상할 수 있을것으로 생각되며, 또한 이러한 표지지수가 병리조직학적으로 양성과 이형성의 감별에 많은 도움이 될것으로 사료된다. Objective : The clinical prognosis and biological behavior of atypical and especially malignant meningiomas are well known to be worse than benign meningioma, but the degree of biological aggressiveness in each classical subtypes of benign meningioma is controversy. This study was performed to see whether there is a difference in the proliferative activity between each different histological subtypes of benign meningioma as well as atypical meningioma. Methods : Paraffin-embedded surgical specimens of 27 meningiomas, including two recurrent tumors, were studied to evaluate proliferative activity by immunohistochemical method with monoclonal antibodies to proliferating cell nuclear antigen(PCNA) and MIB-1. The specimens consisted of 8 cases of meningothelial, 9 cases of transitional, 5 cases of fibroblastic subtypes and 5 cases of atypical meningiomas. Results : Mean PCNA labeling indices of meningothelial, transitional and fibroblastic meningiomas were $4.82{\pm}5.10%$, $9.01{\pm}4.25%$ and $5.66{\pm}5.32%$, but that of atypical meningiomas was $27.62{\pm}19.67%$, noting a higher value compared to all three subtypes of benign meningiomas. Mean Ki-67 labeling indices of the above 3 subtypes were $0.43{\pm}0.85%$, $0.44{\pm}1.08%$ and $0.24{\pm}0.18%$, and that of atypical meningiomas was also revealed to be of higher value ($0.84{\pm}0.59%$). PCNA and Ki-67 labeling indices were not statistically different between histological subtypes of benign meningioma(p>0.05), but the differences of both immunolabeling between benign and atypical meningiomas were statistically significant(p<0.05). Conclusion : Immunolabeling of PCNA and Ki-67 in intracranial meningiomas reveals no prognostic difference between meningothelial, transitional and fibroblastic subtypes in classical benign meningiomas by measuring expression of PCNA and Ki-67, but it seems to be helpful in differentiating benign and atypical meningioma, later showing more proliferative activity and biological aggressiveness.
고현선 ( Hyun Sun Ko ),이희중 ( Hee Joong Lee ),이근호 ( Keun Ho Lee ),장은덕 ( Eun Deok Chang ),강석구 ( Seok Gu Kang ),신종철 ( Jong Chul Shin ),박태철 ( Tai Churl Park ) 대한주산의학회 2005 Perinatology Vol.16 No.4
Lymphocytic hypophysitis, a rare inflammatory disorder in the pituitary gland that is often associated with pregnancy, is caused by autoimmune destruction of the pituitary gland evidenced by diffuse lymphocytic infiltration in the pituitary gland. We report a case of lymphocytic hypophysitis in a 38-year-old woman presenting with aggravating headache and sudden visual loss during pregnancy, which was misdiagnosed as pituitary adenoma before neurosurgery. Magnetic resonance imaging, with enhancement, showed an expanding 2.5×2.0×1.7 cm sized sellar mass. The patient underwent transsphenoidal surgery with a preoperative diagnosis of pituitary macroadenoma. A histological examination revealed diffuse lymphocytes and fibrosis of adenohypophysis with atrophy, which are characteristic of lymphocytic hypophysitis. We report a case of lymphocytic hypophysitis occurred during pregnancy with a brief review of literatures.
Inflammatory Fibroid Polyp of the Stomach Mimicking Gastric Cancer
Kee Hwan Kim(김기환),Hak Jun Seo(서학준),Ji Il Kim(김지일),Chang Hyeok Ahn(안창혁),Jeong Soo Kim(김정수),Young Mi Ku(구영미),Ok Ran Shin(신옥란),Eun Deok Chang(장은덕),Eun Jung Lee(이은정),Keun Woo Lim(임근우) 대한외과학회 2003 Annals of Surgical Treatment and Research Vol.65 No.1
갑상선 미세유두암에서 MMP-2, MMP-9과 HIF-1α 발현의 임상적 의의
최재영(Jae Young Choi),배자성(Ja Seong Bae),김영애(Young Ae Kim),장은덕(Eun Deok Chang),조항주(Hang Joo Cho),김기환(Ki Hwan Kim),안창혁(Chang Hyeok Ahn),박우찬(Woo Chan Park),김정수(Jeong Soo Kim) 대한외과학회 2010 Annals of Surgical Treatment and Research(ASRT) Vol.78 No.3
Purpose: Papillary Thyroid Microcarcinoma (PTMC) is rapidly increasing due to increased interests in the public health care system and improvements in ultrasonographic instruments and fine-needle-aspiration technique. The aim of this study is to investigate relationships between clinicopathologic features and molecular markers of PTMC and to help in developing therapeutic strategies in PTMC. Methods: Tissue samples from patients with 38 PTMC and 21 benign thyroid tumors that were operated on from Jan. 2006 to Nov. 2008 were used to make microarrays and immunohistochemical staining for ER-α, E-CD, VEGF, MMP-2, MMP-9, and HIF-1α were performed. Clinicopathologic features of each immunohistochemical staining group were analyzed retrospectively. Results: There is no immunohistochemistry staining in cases with benign thyroid lesions. The expression rate of ER-α, E-CD, VEGF, MMP-2, MMP-9, and HIF-1α in PTMC group was 66%, 58%, 82%, 66%, 71% and 63%, respectively. Bilateral tumor was statistically significant (48.0% vs 7.7%, P=0.015) related to MMP-2(+) PTMC group than in MMP-2(?) group. Bilateral tumor (44.4% vs 9.1%, P=0.060) and lymphovascular invasion (25.9% vs 0%, P=0.084) seemed to have greater relation to MMP-9(+) PTMC group than to MMP-9(?) group, but there is no statistically significant difference. Bilateral tumor (50.0% vs 7.1%, P=0.012), lymph node metastasis (45.8% vs 0%, P=0.003) and lymphovascular invasion (29.2% vs 0%, P=0.033) were significantly related to HIF-1α (+) PTMC group compared to HIF-1α(?) group. Conclusion: Our findings suggest that MMP-2, MMP-9 and HIF-1α expression could be used as a prognostic marker in PTMC. Larger studies are needed to assess its prognostic value in PTMC.
위아전절제술 후 발생한 위공장결장루(Gastrojejunocolic Fistula)
김신선(Sin Sun Kim),김기환(Kee Hwan Kim),김지일(Ji Il Kim),안창혁(Chang Hyeok An),김정수(Jeong Soo Kim),유승진(Seung Jin You),임근우(Keun Woo Lim),채현석(Hiun Suk Chae),구영미(Young Mi Ku),장은덕(Eun Deok Chang) 대한외과학회 2006 Annals of Surgical Treatment and Research(ASRT) Vol.71 No.3
김기홍(Ki Hong Kim),서상용(Sang Yong Seo),김재훈(Jae Hoon Kim),양용재(Yong Jae Yang),박동춘(Dong Choon Park),이형근(Hyung Gun Lee),정대영(Dae Young Chung),장은덕(Eun Deok Chang),유영옥(Young Ok Lew),김대훈(Dae Hoon Kim),남궁성은(Sung 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.9
A 41-year-old woman was operated under the impression of ovarian malignancy. The ovarian mass was diagnosed as a non-Hodgkin's lymphoma, diffuse large cell type of B lineage pathologically. Because regional lymph nodes and bone marrow were not involved and Ga67 whole body bone scan was normal, we suspected that ovary was a primary site of lymphoma. After six cycles of CHOP (cyclophosphamide, adriamycin, vincristine, prednisone) chemotherapy, complete remission status was maintained for 16 months. We report a case of primary ovarian lymphoma with a review of literatures.
이성원(Sung Won Lee),이영석(Young Sok Lee),한석원(Suk Won Han),한남익(Nam Ik Han),김욱(Wook Kim),원종만(Jong Man Won),장은덕(Eun Deok Chang),이해규(Hae Giu Lee) 대한소화기학회 1993 대한소화기학회지 Vol.25 No.3
Malignant fibrous histiocytoma is the major subset of soft tissue sarcomas which occurs most commonly in the extremities and trunk, but rarely in the visceral organs. This report documents a case of malignant fibrous histiocyoma arising in the omentum in 36 year-old female whose chief complaints were growing non-tender masses. After surgical resection, there are no evidences of recurrencee or metastasis during 4 months follow up period. Electron microscopic study of the tumor showed irregular, spindle-shaped histiocyte with large indented nuclei and prominent nucleoli. The cytoplaem was abundant with microfilament and distended mitochondria. There was no evidence of myofibril in the tumor.