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흑지마(黑芝麻)가 Leydig cell의 항산화에 미치는 영향
장문석 ( Mun Seog Chang ),정규진 ( Kyu Jin Chung ),장원규 ( Won Kyu Chang ),박성규 ( Seong Kyu Park ) 대한본초학회 2011 大韓本草學會誌 Vol.26 No.1
Objectives: The purpose of this study was to estimate the antioxidant activity of Sesami Semen Nigrum extract (SSN) on mouse Leydig cells, TM3. Methods: Cell viability assays were performed. The protective effects of SSN against hydrogen peroxide-induced oxidative stress in Leydig cells were examined by measuring cell viability. Lipid peroxidation levels and antioxidant enzyme concentrations such as SOD and catalase were measured. Results: Cell viability of Leydig cells increased with SSN concentration. Cell viability of Leydig cells was 136.66% when SSN concentration was 50 μg/ml. Cell viability of the hydrogen peroxide group was statistically decreased (p<0.01) compared with the control group. Antioxidant effect of SSN was measured and the protective effect of SSN concentration were 5, 10, 50 μg/ml. LPO were decreased significantly at 5, 50 μg/ml of SSN concentrations. SOD activity was increased at 1, 10, 50 ug/ml of SSN concentrations. Catalase activity was significantly increased at 123.7, 133.3 and 131.9 units/mg protein when SSN concentrations were 5, 10 and 50 μg/ml, respectively. Conclusions: In conclusion, Sesami Semen Nigrum extract has antioxidant activities in Leydig cells against oxidative stress.
부동액 섭취 후 급성 신부전 및 후기 신경병증이 발생한 1 예
장원규,김영중,송명준,윤수진,박병익,김윤권,조민구,김소연,이권전,황남철,백운희,임수진 대한내과학회 2001 대한내과학회지 Vol.61 No.1
Antifreeze contains ethylene glycol up to ninty five percent. Ethylene glycol is colorless, odorless, sweet-tasting and water-soluble compound and has been widely used as a chemical solvent. Ethylene glycol has been reported as a common cause of incidental poisoning all over the world because of its easy access. However, in Korea, it is not easy to find statistical references on incidences of ethylene glycol intoxication, except two reported cases. Ethylene glycol itself is not toxic substance. But, many other daughter metabolites are very toxic and lethal. Acid metabolites among them can cause metabolic acidosis. Oxalate, end-product of ethylene glycol, is quickly transformed to calrium oxalate crystals, which precipitate in body tissues such as brain, kidney, heart, liver, and pancreas. We report a case of acute renal failure and neuropathy due to ethylene glycol intoxication along with a review of toxic effects of ethylene glycol. (Korean J Med 61:64-70, 2001)