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피라미(Zacco platypus)의 난자형성에 관한 연구
장성재,김동희,류동석,등영건,Jang, Seung-Jae,Kim, Dong-Heui,Reu, Dong-Suck,Deung, Young-Kun 한국현미경학회 1995 Applied microscopy Vol.25 No.3
The development of pale chub oocyte from the immature oogonium to mature oocyte was investigated by light and electron microscope. The cytoplasm of pale chub oogonia was acidic and many vesicles were located at inner side of nuclear membrane. In primary oocytes, yolk vesicles were distributed in cytoplasm. Also, fibrous materials and protuberances were distributed on the surface of zona radiata. The nucleus of secondary oocyte was enlarged and yolk vesicles in cytoplasm migrated to zona radiata. In early egg, yolk mass are formed and yolk vesicles were located at inner side of zona radiata. Three-layered zona radiata was about $3{\mu}m$ in thickness. The three layers were an outer fibrous material layer, a middle nurse cell layer in which microvilli of early egg cytoplasm contact with processes of nurse cells, and an inner layer with high electron density. In mature egg, euchromatin and a germinal vesicle were developed, mitochondria, free ribosomes, and yolk mass were distributed in cytoplasm. But, yolk vesicles were disappeared. Specially, zona radiata of matured eggs were better thin than the one of immature eggs In conclusion, it is summerized that the oogenesis of pale chub were the increase of cell size, the formation and accumulation of yolk, the decrease in nucleat electron density, changes of zona radiata, and the development of microvilli.
재조합 인간상피세포 성장인자(rhEGF, DWP401)가 랫트의 수태능, 태자와 신생자 발달 및 모체기능에 미치는 영향
박귀례(Kui Lea Park),한순영(Soon-Young Han),신재호(Jae-Ho Shin),이유미(Yoo Mie Lee),김판기(Pan Gyi Kim),장성재(Seung Jae Jang) 대한약학회 2001 약학회지 Vol.45 No.2
This study was conducted to investigate for its effects on reproductive and developmental toxicity of recombinant human epidermal growth factor(rhEGF) in Sprague-Dawley rats. Male rats were administered rhEGF at doses of 1,10, 100 and 1000 mcg/kg/day, respectively, by subcutaneous injection from 63 days before and throughout to mating period until the day before sacrifice. Female rats were administered rhEGF at the same doses form 14 days before mating to day 20 of gestation or to day 21 of lactation. We examined the male and female fertility indices and maternal toxicity of F0 parental animals. Also we examined the external, visceral, of skeletal malformation of fetuses, growth and development, behavior, and/or reproductive performance of F1 animals. At the highest dose(1,000mcg/kg), the mean body weights of F0 animals were significantly increased in males and females at 3 or 2 weeks after treatment, respectively. No clinical signs and food intakes were observed at any time during the experimental period by rhEGF treatment. In autopsy examination, the relative and absolute liver weights siginificantly increased in both sexes of 1,000mcg/kg. At the highest dose(1,000mcg/kg), there was a statistically significant increase of pregnancy period and the number of dead fetuses. Moreover, siginificant increase of mean fatal body weight and decrease of number of live fetuses, which related to the difficult delivery were observed in highest dose group. In F1 examination, no adverse effects on external, visceral, and skeletal malformation, physical and functional development, behavior, or reproductive ability of F1 animals were observed in any group. Also there was no significant difference between control and treated groups in copulation or fertility indices of F1 animals. These results indicate that rhEGF had no adverse effect on fertility and reproductive ability of Sprague-Dawley rats.
재조합 인간상피세포 성장인자(rhEGF, DWP401)의 배, 태자 발달 독성 연구
박귀례(Kui Le Park),한순영(Soon Young Han),신재호(Jae Ho Shin),이유미(Yoo Mie Lee),박희정(Hee Jung Park),장성재(Seung Jae Jang) 대한약학회 1998 약학회지 Vol.42 No.5
Effect of recombinant human epidermal growth factor (rhEGF, DWP401) on fetal external, visceral and skeletal malformation during organogenesis was examined. Pregnant Sprauge-Dawley rats were administered with 0.2, 1 and 5mg/kg/day subcutaneously on gestation day 6 through 16. Dams were sacrified at 20th day of gestation. Materal body weight, food consumption and clinical observation were not changed. Significant dose-dependent increase of relative and absolute liver weight were observed in the treatment group, whereas other organ weights were not changed. Placental weight of 1 and 5mg/kg/day group and number of resorption in 5mg/kg/day treatment group were significantly increased. External and visceral malformation of fetuses were not observed with treatment. However, skeletal variations(increase of asymmetry sternebrae, decrease of dumb-bell and asymmetry sternbrae at 5mg/kg/day, and fused stemebrae at 5mg/kg/day) were observed. These results showed that rhEGF (DWP401) may not have embryo and/or fetal developmental toxicity effect in rats.
퀴놀론 유도체인 Q-35 의 랫드에서의 주산 수유기시험 연구
박귀례(Kui Lea Park),한순영(Soon Young Han),김판기(Pan Gyi Kim),신재호(Jae Ho Shin),조인구(In Koo Cho),장성재(Seung Jae Jang) 한국응용약물학회 1998 Biomolecules & Therapeutics(구 응용약물학회지) Vol.6 No.1
Pregnant Sprague-Dawley rats were administered with Q-35 at the dose levels of 0, 30, 100 and 300 mg/kg/day by oral gavage from gestation day 17 to lactation period. Effects of the test chemical on general findings, reproductive performance of dams and development of F1 generation were examined. There were no treatment related changes in physical signs, body weight, necropsy findings, organ weights, delivery and nursing behavior. In 100 and 300 mg/kg/day treated groups, the food consumption of dams was decreased significantly during gestational day 19∼21. The gestation length of 300 mg/kg/day treated group was increased significantly compared to the control group (22.3 ±0.48 vs 22.0 ±0.39). Although the gestational length of all groups were in normal range of the rat, potential effect of the drug could not be ruled out. External anomaly of F1 fetus induced by Q-35 was not detected in any groups. There were no treatment related changes in physical development, reflex functions, sensory functions, locomotor activity and motor coordinating activity. Estrus cycle, fertility and reproductive performance of F1 were not changed in all treated groups. There was no external abnormality related to the drug administration on the examination of F2. These results suggest that Q-35 has no adverse effect on the peri- and postnatal period in rats except the reduction of food consumption at the beginning of drug administration, and the potential effect on the elongation of gestation length.
랫드 자궁비대반응시험(Uterotrophic assay)을 이용한 phthalate esters의 에스트로겐성 작용 연구
한순영 ( Soon Young Han ),문현주 ( Hyun Ju Moon ),김형식 ( Hyung Sik Kim ),김철규 ( Cheul Kue Kim ),신재호 ( Jae Ho Shin ),오세동 ( Se Dong Oh ),장성재 ( Seung Jae Jang ),박귀례 ( Kui Lea Park ) 한국응용약물학회 2000 Biomolecules & Therapeutics(구 응용약물학회지) Vol.8 No.2
방사선 조사 인삼이 랫드의 수태능 및 일반 생식독성에 미치는 영향에 관한 연구
박귀례(Kui Lea Park),한순영(Soon-Young Han),김판기(Pan Gyi Kim),이유미(You-Mie Lee),신재호(Jae-Ho Shin),장성재(Seung Jae Jang) 한국독성학회 2001 Toxicological Research Vol.17 No.2
Korean ginseng products have been fumigated with ethylene oxide (EO) for sterilization and prolongation of storage periods. However, there had been controversies indicating that the consumption of food treated with EO might cause harmful effects in human. Since, in Korea the use of EO gas for food treatment was banned in 1991. Since then, irradiation technique has been developed as an alternative. This study was carried out to investigate the effects of irradiated ginseng on fertility, and reproductive and developmental toxicity. Either EO gas fumigated or gamma-irradiated ginseng was administered to male rats by oral gavage for 63 days during the premating period. Female rats were administered from 14 days before mating to day 20 of gestation or to day 21 of lactation. The exposure amount of irradiation used was 5, 10 and 30 kGy, respectively. There were no treatment related changes of dams in clinical signs, and parturition. No treatment related changes in food consumption, body/organ weights, male/female reproductive and fertility performances were observed. F1 fetuses showed no external abnormality. Reflex/sensory functions, physical/behavioral development, and reproductive performance of F1 rats were not adversary affected. The results of this study show that gamma-irradiated ginseng, up to 30 kGy, has no adverse effects on the fertility, reproduction and development in Wistar rats.
6-[(N-4-클로로페닐)아미노]-7-클로로-5,8-퀴놀린디온의 in vivo 항진균 작용 및 독성 평가
유충규(Chung Kyu Ryu),김동현(Dong Hyun Kim),윤여표(Yeo Pyo Yun),이병무(Byung Mu Lee),허문영(Moon Young Heo),장성재(Seung Jae Jang),김효정(Hyo Jung Kim),박윤미(Yun Mi Park) 대한약학회 1995 약학회지 Vol.39 No.4
6-[(N-4-Chlorophenyl)amino]-7-chloro-5,8-quinolinedione (RCK20) was tested for antifungal activities, in vivo, against Candida albicans. RCK20 was compared with ketoconazole and fluconazole in the treatment of systemic infection with Candida albicans in normal rats. The therapeutic potential of RCK20 had been assessed by evaluating their activities (survival rate) against systemic infections with in normal mice with Candida albicans. RCK20 improved survival rates as well as ketoconazole. RCK20 had ED50, 0.25 +/- 0.18mg/kg but ketoconazole and fluconazole had ED50, 8.00 +/- 0.73, 10 +/- 0.43mg/kg respectively. Activities of RCK20 showed superior to that of ketoconazole and fluconazole. Intraperitoneally administered RCK20 at the ED50, 0.25mg/kg for 7 days and 14 days reduced Candida albicans colony count in the kidneys and livers as well as ketoconazole and fluconazole at these ED50, 8.00 and 10mg/kg. Acute oral toxicity studies of RCK20 were carried out in ICR mice of both sexes. These acute oral toxicities of RCK20 were low and LD50 values were over 2,850mg/kg in ICR mice. The Genotoxicities of RCK20 had been evaluated. RCK20 was negative in Ames test with Salmonella typhimurium(TA98 and TA1OO). The clastogenicity was tested on the RCK20 with in vivo mouse micronucleus assay. RCK20 did not show any clastogenic effect in mouse peripheral blood and was negative in mouse micronucleus assay. These results indicate that RCK20 has no genotoxic potential under these experimental condition.
흰쥐 배양 전배자 및 중뇌세포에서 Ochratoxin A의 독성
홍진태(Jin Tae Hong),박귀례(Kui Lea Park),한순영(Soon Young Han),박기숙(Ki Sook Park),김형식(Hyung Sik Kim),오세동(Se Dong Oh),박희정(Hee Jung Park),이이다(Rhee Da Lee),장성재(Seung Jae Jang) 대한약학회 1998 약학회지 Vol.42 No.3
Effects of ochratoxin A (OTA) on embryo development were studied in cultured whole embryos from 9.5 day gestation rat for 48 h. OTA (more than 0.5mcg/ml) induced microcephaly in the cultured rat whole embryos. Protein and DNA content, and DNA synthesis were significantly inhibited by OTA. We next examined whether the microcephaly seen in cultured whole embryo partially results from inhibition of differentiation of embryonic midbrain cells. Embryonic midbrain cells were extracted from 12 day gestation rat embryos, and cultured for 96 hr. OTA ibhibited cell differentiation about 50% over control. We also tested whether OTA-induced embryotoxicity would be associated with oxidative damages. We measured the gamma-glutamyltranspeptidase (gamma-GT) and glutathione peroxidase (GPX) activities, and glutathione (GSH) content in both cultured whole embryos and embryonic midbrain cells. OTA decreased GSH content, whereas slightly increased gamma-GT activity, but GPX activity was not significantly changed. These results show that OTA caused the microcephaly and its effect may be partially due to the inhibition of cell differentiation of embryonic midbrain cells, but the role of oxidative damages is not clear in embryotoxicity.