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송병주 ( Byung Joo Song ),김지일 ( Ji Il Kim ),김한성 ( Han Seong Kim ),박성혜 ( Sung Hye Park ),장석효 ( Seok Hyo Chang ) 대한소화기학회 2003 대한소화기학회지 Vol.41 No.5
Background/Aims: The Fas-FasL system is the main pathway for the induction of apoptosis in normal and malignant tumor cells. The binding of FasL in the cytotoxic T lymphocytes or Anti-Fas antibody to Fas receptor in cell membrane induces apoptosis. Loss of Fas expression has been demonstrated in a variety of tumor cells. Recently, it is reported that gastric cancers express Fas ligand and downregulate Fas to escape from the host immune surveillance. Methods: We performed clinicopathological and immunohistochemical studies for Fas, FasL, P53, E-cadherin, beta-catenin, and Ki-67 in the specimens obtained from 52 gastric cancer patients treated with curative resections from 2000 to 2002. Results: Loss of Fas and expression of FasL were observed in 15 (28.8%) and 19 (36.5%) patients respectively. The loss of Fas expression was dominantly demonstrated in poorly differentiated and diffuse type of gastric carcinoma. Loss of Fas expression had a significant correlation with nuclear expression of beta-catenin (p=0.027). Conclusions: Loss of Fas expression in gastric cancer is significantly influenced by histological grade, Lauren classification, and nuclear expression of beta-catenin. These findings indicate that loss of Fas expression correlates with aggressiveness of gastric cancer. (Korean J Gastroenterol 2003;41:335-342)
김철남,장석효 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.3
A new type of neurogenic gastrointestinal stromal tumours(GIST) was described. This neoplasm represents a newly described entity that grossly and histologically resembles leiomyomas and showed neurogenic differentiation. Neural type of gastrointestinal stromal tumors contains neuroaxonal and Schwann cell elements arranged in a way that differs from the usual schwannoma orneurofibroma. The clinicopathologic, histologic, immunohistologic characterisctics of neural type of gastrointestinal stromal tumors are similar to GIST. Ultrastructural examination provides the definitive distinguishing criteria for diagnosing a neural type of gastrointestinal stromal tumor. The presence of electron-dense granules or small vesicles suggests the presence of post-ganglionic neurotransmitter vesicles. We experienced a 65-year-old female patient who complained bloody diarrhea. She was diagnosed as neural type of gastrointestinal stromal tumor by abdominal CT and operation. Thus we report a case of neural type of gastrointestinal stromal tumor with a review of relevant literatures.
이명수,박영진,장석효 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.2
Objective: The oxygen free radical causes DNA damage and consequent cancer development. However, the implication of oxygen free radical on colon carcinogenesis was not clearly demonstrated. This study was aimed to test the involvement of oxygen free radical on colon carcinogenesis. Methods and Materials: The activities of antioxidant enzymes (catalase and SOD), the extent of oxidative cellular damage (the content of 8ohGua) and the DNA repairing ability (oh8Gua glycosylase) was measured in 20 paired normal and tumorous colon specimens. Results: The antioxidant activity was decreased (p<0.01 in both the catalase and SOD) in tumor tissue than in normal. Contrary, the extent of oxidative DNA damage (content of 8ohGua) was increased by 1.6 times in tumor tissue (p<0.01). The overall activity of 8ohGua glycosylase was higher in tumors than in normal tissues (4.5 and 2.5 pmol oh8Gua released/2hr respectively, p=0.01). Conclusion: Although our sample size is limited, these results indicate that the greater oxidative DNA damage in cancer tissue as a possible result of the impaired antioxidant activity implies an important role of oxygen free radical in colon carcinogenesis. The DNA repairing activity enhance in colon cancer in response to the oxidative DNA damage, however, it is not sufficient enough to fully compensate the adverse effect of oxygen free radical.