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생약으로부터 산화적 결합 효소인 갑상선 peroxidase의 저해제 검색
이현정(Hyun Jeong Lee),장미영(Mi Young Jang),김미리(Mee Ree Kim),배기환(Ki Hwan Bae),석대은(Dai-Eun Sok) 대한약학회 1999 약학회지 Vol.43 No.3
Thyroid peroxidase is a biochemical target protein for the antithyroid drugs. Ethanol extracts from one hundred and thirty seven natural products were screened for the inhibition of thyroid peroxidase activity. Thyroid peroxidase was purified from porcine thyroids, and the inhibition of peroxidase activity was evaluated using guaiacol oxidation (C-C coupling) assay. Twenty one natural products expressed a remarkable inhibition (>50%) of peroxidase activity at 330mcg solid weight/ml. The 50% inhibitory concentration (IC50) of 70% ethanol extract from six potent natural products ranged from 3.1 to 31.2mcg solid weight/ml, in contrast to the range (0.33~0.54mcg/ml) of IC50, values for catechin and epigallocatechin gallate as positive controls. Noteworthy, the extract of Camellia taliensis showed an irreversible inhibition of the enzyme. It is suggested that extract from some natural products such as Camellia taliensis, Rheum undulatum or Euphorbia pekinsis, exhibiting a potent inhibition of peroxidase activity, may be developed as sources of potent antithyroid agents.
암환자를 돌보는 간호사의 도덕적 민감성과 도덕적 고뇌가 직무만족에 미치는 영향
정현진(Hyeon Jin Jeong),장미영(Mi Young Chang) 한국자료분석학회 2022 Journal of the Korean Data Analysis Society Vol.24 No.1
본 연구는 암환자를 돌보는 간호사를 대상으로 도덕적 민감성과 도덕적 고뇌, 직무만족을 파악하고, 직무만족에 영향을 미치는 요인을 규명하여 암환자를 돌보는 간호사의 직무만족을 증진시킬 수 있는 근거자료를 제공하고자 한다. 본 연구의 대상은 서울, 경기, 전남소재 대학병원의 암 병동 및 외래에서 근무하는 간호사 128명을 대상으로 하였고, 자료수집 기간은 2020년 4월 1일부터 29일까지였다. 수집된 자료는 SPSS/WIN 25.0프로그램을 사용하여 기술통계, t-검정, ANOVA, Pearson 상관계수 및 다중회귀분석을 실시하였다. 분석결과 도덕적 민감성은 7점 만점에 4.69±.61점, 도덕적 고뇌는 총 366점 만점에 99.20±48.87점, 직무만족은 5점 만점에 3.45±.55점으로 나타났다. 직무만족은 도덕적 민감성(r=.292, p<.001)과 정적 상관관계, 도덕적 고뇌(r=-.285, p<.001)와 부적 상관관계로 나타났다. 직무만족에 영향을 미치는 요인은 도덕적 고뇌(β=-.385, p<.001), 총 임상경력(β=.374, p<.001), 도덕적 민감성(β=.244, p=.002)의 순으로 나타났으며 이들 변인의 설명력은 31.5%이었다(F=20.44, p<.001). 이상의 결과를 바탕으로 암환자를 돌보는 간호사의 도덕적 민감성을 높이고 도덕적 고뇌를 감소시킬 수 있는 프로그램의 적용으로 직무만족을 높일 수 있을 것이다. The purpose of this study were to identify the moral sensitivity and moral distress of nurses who take care of cancer patients, and identified influencing factors on job satisfaction of nurses who take care of cancer patients. A descriptive survey was conducted with 128 nurses working in cancer wards and outpatient department at university hospitals in Seoul, Gyeonggi-do and Jeonnam. The data were collected from April 1 to 29, 2020 and analyzed using percentage, frequency analysis, average, standard deviation, t-test, ANOVA, Pearson correlation coefficient and stepwise multiple linear regression analysis, with SPSS/WIN 25.0. The factors affecting job satisfaction are total of nursing experience (β=.374, p=.000, moral sensitivity (β=.244, p=.002), moral distress (β=-.385, p=.000). These variables explained 31.5% of the variance. Findings indicate that moral distress, total of nursing experience and moral sensitivityare important variables influencing job satisfaction of nurses who take care of cancer patients. Development of programs that can increase moral sensitivity and reduce moral distress will increase the job satisfaction of nurses who are in care of cancer patients.
IgA 신병증 환자에서 발생한 신장을 침범한 전신홍반루푸스
송지은 ( Ji Eun Song ),장미영 ( Mi Young Jang ),오왕국 ( Wang Guk Oh ),김정관 ( Jeong Gwan Kim ),박성현 ( Sung Hyun Park ),김기회 ( Ki Hoi Kim ),황민호 ( Min Ho Huang ) 대한류마티스학회 2010 대한류마티스학회지 Vol.17 No.3
Renal involvement in systemic lupus erythematosus (SLE) is a typical manifestation of the disease. The occurrence of non-lupus nephritis, especially IgA nephropathy (IgAN), in patients with SLE has rarely been reported. We describe the case of a 21-year-old woman who was diagnosed with IgAN and subacute necrotizing lymphadenitis, and her renal lesion biopsy was typical of lupus nephritis (ISN/RPS Class III). Although IgAN and lupus nephritis share some common physiopathological characteristics, their laboratory, histopathologic findings, and the extra-renal clinical manifestations are different and support a different pathogenesis. Our case highlights the importance of a renal biopsy in patients with lupus and urinary alterations despite underlying IgAN. A correct diagnosis would permit the most appropriate immunosuppressive treatments to be considered.
고지방식이 유도 비만 마우스에서 Eugenol의 항우울효과
장효민(Hyo-Min Jang),장미영(Mi-Young Jeong),김남재(Nam-Jae Kim),김동현(Dong-Hyun Kim) 한국생약학회 2023 생약학회지 Vol.54 No.4
The excessive intake of a high-fat diet (HFD) leads to psychiatric disorders with obesity through gut dysbiosis. In the present study, we examined whether eugenol could alleviate obesity, depression, cognitive impairment, with neuroinflammation. Long-term exposure to high-fat diet induced depression and cognitive impairment with gut dysbiosis. However, oral administration of eugenol alleviated HFD-induced depression, but not obesity, and suppressed hippocampal tumor necrosis factor (TNF)-α expression in the hippocampus and colon-shortening and myeloperoxidase activity in the colon. Furthermore, eugenol treatment suppressed HFD-induced Proteobacteria and Actinobacteria populations in the gut microbiota. Eugenol increased corticosterone-suppressed brain-derived neurotropic factor (BDNF) expression in SH-SY5Y cells and decreased lipopolysaccharide-induced NF-κB activation in BV2 cells. These results suggest that eugenol may alleviate depression/anxiety by inducing gut microbiota-involved NF-κB activation-suppressed BDNF expression.