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Codon 311 Polymorphism of Paraoxonase-2 Gene and Hypertension in Korean
장대호,감병용,이강오 한국환경독성학회 2004 환경독성보건학회지 Vol.19 No.2
고혈압에서 지질대사 이상은 빈번히 나타나는 현상으로 지질대사 이상에 관여하는 유전자들은 고혈압의 발병원인을 규명하기 위한 후보 유전자로 인식되어 왔다. 이에 본 연구에서는 paraoxonase 2(PON2) 유전자에 존재하는 Cys311Ser 다형성을 유전자 표지로 이용하여 한국인 집단에서 이 유전자 표지가 고혈압과 관련성이 있는 지를 조사하고자 하였다. 연구 대상은 총 195명으로, 이들 중에서 82명은 고혈압 환자군이었고, 나머지 113명은 정상 혈압군이었다. PON2 유전자의 Cys311Ser 다형성을 분석하기 위해서 중합효소 연쇄반응과 제한 효소인 Dde I 처리를 수행하여 유전자형을 결정하였다. 연구 결과, Cys/Ser 이형접합체를 갖는 사람들이 고혈압군에서 유의하게 높은 빈도로 나타났으며(P<0.05), 다른 신체 계측치 및 혈청내 지질 농도와는 유의한 관련성을 나타내지 않았다. 본 연구에서 관찰된 이러한 관련성이 기능적인 연관인지 혹은 연관불평형에 의한 결과인지에 대해서는 보다 더 많은 연구 대상을 이용한 추시를 통해 밝혀질 수 있을 것으로 생각된다.
장대호,한석영 한국정밀공학회 2015 International Journal of Precision Engineering and Vol. No.
The purpose of this study is to suggest a method of applying the artificial bee colony algorithm (ABCA) in the frequency topology optimization for a structure with multiple eigenfrequencies. In order to replicate the multiple eigenfrequencies of a structure, suboptimization procedure for multiple eigenfrequencies was additionally developed. In order to obtain a stable and robust optimal topology the waggle index update rule, evaluation method of fitness values and changing filtering size scheme were also employed. And the optimized topologies of ABCA for examples were compared with those of the solid isotropic material with penalization (SIMP) method for investigating the applicability and effectiveness of the ABCA. The following conclusions were obtained through the results of examples; (1) The ABCA implemented with sub-optimization procedure and the three suggested schemes, is very applicable and effective in dynamic topology optimization. (2) The multiple eigenfrequencies of a structure are successfully replicated by the ABCA in optimization procedure. (3) The fundamental frequency of the ABCA is almost the same or slightly higher than that of the SIMP.
장대호,윤철희,최병선,정윤석,김혜영,지성길,김성순 대한의학회 2014 Journal of Korean medical science Vol.29 No.3
HIV-1 gp41 is an envelope protein that plays an essential role in virus entry. The mutationof gp41 affects HIV-1 entry and susceptibility to the fusion inhibitor T-20. Therefore, weanalyzed the natural polymorphism of gp41 of 163 HIV-1 isolates from T-20-naïve Koreansinfected with HIV-1. This study of gp41 polymorphisms showed that insertions in thefourth threonine (74.8%) and L7M substitutions (85.3%) were more frequent in the fusionpeptide motif in Korean HIV-1 isolates compared with those from other countries. MinorT-20 resistance mutations such as L45M (1.2%), N126K (1.2%), and E137K (6.7%) weredetected, but the critical T-20 resistance mutations were not detected in the gp41 HR1 andHR2 regions. In addition, the N42S mutation (12.9%) associated with T-20 hypersusceptibilitywas detected at a high frequency. These results may serve as useful data forstudies considering T-20 for use in the development of a more effective anti-retroviraltreatment in Korea.
Miniaturized Fluorometer Based on Total Internal Reflector and Condensing Mirror
장대호,유재천 한국광학회 2013 Current Optics and Photonics Vol.17 No.1
A miniaturized fluorescence detection system based on total internal reflection (TIR) configuration,which is applicable to detecting the presence of biological materials labeled with fluorescence dye in micro total analysis systems (μTAS), is proposed. In conventional fluorescence testing and analysis devices,interference between the excitation light beam and the emitted light from dyes is unavoidable. This paper presents a fluorescence detection system based on TIR configuration that allows the excitation light beam and the emitted light to be spatially perpendicular to each other so as to minimize the interference where fluorescence emission is detected at the orthogonal angle to the excitation beam. We achieved the limit of detection of about 5 nmol/L with a high linearity of 0.994 over a wide range of 6-FAM mol concentration, being comparable to that in earlier studies.
실내 보안 응용을 위한 사람 감지 레이다 시스템의설계 및 구현
장대호,김현,정윤호 한국전기전자학회 2020 전기전자학회논문지 Vol.24 No.3
In this paper, the human detecting radar system for indoor security applications is proposed, and its FPGA-basedimplementation results are presented. In order to minimize the complexity and memory requirements of the computation,the top half of the spectrogram was used to extract features, excluding the feature extraction techniques that requirecomplex computation, feature extraction techniques were proposed considering classification performance and complexity. In addition, memory requirements were minimized by designing a pipeline structure without storing the entirespectrogram. Experiments on human, dog and robot cleaners were conducted for classification, and 96.2% accuracyperformance was confirmed. The proposed system was implemented using Verilog-HDL, and we confirmed that alow-area design using 1140 logics and 6.5 Kb of memory was possible. 본 논문에서는 실내 보안 응용을 위한 사람 감지 레이다 시스템을 제안하고, 이의 FPGA 기반 설계 및 구현 결과를 제시하였다. 연산의 복잡도와 메모리 요구량을 최소화하기 위해 스펙트로그램의 상측 절반만 특징점 추출에 사용하였으며, 복잡한연산이 필요한 특징점 추출기법을 배제하고, 분류 성능과 연산 복잡도를 고려한 효율적인 특징점 추출기법이 제안되었다. 또한, 전체 스펙트로그램에 대한 저장이 불필요한 파이프라인 구조로 설계하여 메모리 요구량을 최소화하였다. 제안된 시스템의 분류 학습을 위해 사람, 개, 로봇 청소기에 대한 실험이 수행되었고, 96.2%의 정확도 성능을 확인하였다. 제안된 시스템은Verilog-HDL을 이용하여 구현되었으며, 1140개의 logic과 6.5 Kb의 메모리를 사용하는 저면적 설계가 가능함을 확인하였다
한국인 남성 운동 선수군에서 Calcitonin Receptor 유전자의 AluI RFLP 분석
장대호,황영철,강병용,최성숙,강진양,하남주 대한약학회 2004 약학회지 Vol.48 No.1
Bone mineral density (BMD) is influenced by genetic and environmental factors. Among genetic study; calcitonin receptor (CTR) gene is a good candidate influencing the inter-individual difference in BMD because CTR is involved in calcium and bone metabolism. Thus, we investigated the distribution of C1377T polymorphism in the CTR gene among male Korean elite athletic and control groups, respectively and also an association with BMD in lumbar spine and femoral neck. Our results suggested that this polymorphism of CTR gene was not significantly associated with lumbar spine or femoral neck BMDs in the both groups, respectively. However, we found that there was the racial difference in genotype distribution of this polymorphism between Caucasian and Asian populations. Though we could not detect the significant association between C1377T polymorphism of CTR gene and lumbar spine or femoral neck BMDs, further studies using other ethnic groups are necessary to clarify the precise role in BMD of CTR gene.