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신규 합성 퀴놀론계 항생물질(DWQ-013)의 일반 약리 작용 -중추신경계에 대한 작용-
임승욱(Seung Wook Lim),김영만(Young Man Kim),유영효(Young Hyo Yu),이재욱(Jae Wook Lee) 대한약학회 1994 약학회지 Vol.38 No.5
The general pharmacological effects of DWQ-013, a new synthetic quinolone antibacterial agent, were examined on the central nervous system in experimentral animals and the following results were obtained. Drug interaction of DWQ-013 with theophylline, fenbufen and nonsteroidal antiinflammatory drugs was also examined. DWQ-013 decreased touch escape effect on the general behavior and decreased body temperature at a concentration of 1000 mg/kg in mice. But DWQ 013 had no effect on the locomotor activity, rotarod perfomance and traction test in mice. Furthermore, DWQ-013 increased pentobarbital-induced sleeping time and affected the onset time in acetic acid-induced writhing test in mice. DWQ-013 reduced onset time and death time on strychnine-induced convulsions and death time on pentylenetetrazole-induced convulsions at a concentration of 1000mg/kg in mice. But, the drug had no effect on the electroshock. DWQ-013 did not interact with fenbufen and any other NSAIDs but it did interact with theophylline. From these results, it could be suggested that DWQ-013 had less pharmacological effect than other quinolones on the central nervous system.
Phosphorylation of 44-kilodalton Proteins in Peripheral T-lymphocyte of Rat
안영수,주일로,오도연,임승욱,박경선,Ahn, Young-Soo,Jou, Il-O,Oh, Do-Yeun,Lim, Seung-Wook,Park, Kyung-Sun The Korean Society of Pharmacology 1991 대한약리학잡지 Vol.27 No.2
Using T-lymphocytes obtained from rat peripheral blood, we found that the 44kD/pI6.8 protein was the major phosphoprotein of T-lymphocytes under basal condition, and that the 44kD/pI6.3 protein was a new phosphoprotein appeared in T-lymphocytes stimulated with ${\beta}-agonist$. The phosphorylation of the 44kD/pI6.3 protein was also induced by forskolin but inhibited by H-8 pretreatment. To clarify the character of the 44kD/pI6.3 protein, we used Con-A and kinase inhibitors, H-7 and W-7. Con-A stimulation induced phosphorylation of 44kD/pI 6.3 protein but that was inhibited by W-7 pretreatment. The phosphorytation of 44kD/pI6.3 protein was not induced by the PKC activator, PMA. Instead, the phosphorylation of 44kD/pI6.8 protein was reduced by H-7, a PKC inhibitor. From the above results,it can be concluded that the 44kD/pI6.3 protein can be a common substrate for A-kinase and CaM kinase. The two dimensional tryptic peptide mapping revealed that the 44kD/pI6.8 and 44kD/pI6.3 proteins are different. 흰쥐 말초혈액에서 얻은 T 림프구를 아드레날린성 ${\beta}-$수용체 효현제 및 concanavalin A(Con-A)로 자극해 다음과 같은 결과를 얻었다. 자극이 없는 상태에서의 주 인산화 단백은 분자량 44kD, 등전점 6.8의 단백이었으며 효현제로 자극시키면 분자량 44kD, 등전점 6.3의 단백이 새로이 인산화되어 나타났다. 이 분자량 44kD, 등전점 6.3의 단백은 forskolin에 의해 역시 인산화되며 A-kinase 억제제인 H-8을 전처치하면 인산화의 억제가 나타났다. 또한 Con-A로 자극시키면 44 kD/pI 6.3 단백의 인산화가 증가되었으며 이 인산화의 증가는 CaM kinase 억제제인 W-7 전처치에 의해 억제되었다. H-7은 분자량 44 kD, 등전점 6.8 단백의 인산화를 감소 시켰다. 이상의 결과로 분자량 44 kD 등전점 6.3의 단백은 A-kinase와 CaM kinase 모두에 의해 인산화 되는 기질단백으로서 tryptic peptide map상에서 44 kD/pI 6.8 단백과 44 kD/pI 6.3 단백은 서로 다른 단백임을 알 수 있었다.
간장질환 치료용 의약조성물 ( DWP 305 ) 의 이반약리작용
심점순(Jeom Soon Shim),박남준(Nam Jun Park),유영효(Young Hyo Yu),임승욱(Seung Wook Lim),염제호(Je Ho Yeom),김영만(Young Man Kim),장병수(Byeong Su Jang),박명환(Myung Hwon Park),연제덕(Je Duk Yeon),김병오(Byung O Kim),강진석(Jin Seok K 한국응용약물학회 1994 Biomolecules & Therapeutics(구 응용약물학회지) Vol.2 No.2
The general and some pharmacological actions of DWP 305 were investigated in animals and the following results were obtained. In central nervous system, DWP 305 had no effects on the pentobarbital induced anaesthesia, locomotor activity, rotarod test, traction test, analgesic action in mice and body temperature in rat. DWP 305 showed no depressive action on convulsion induced by strychnine, electronic shock and pentylenetetrazole. From these results, DWP 305 was considered to have no pharmacological effect on the central nervous system. Furthermore, DWP 305 had no influences on the normal blood pressure and heart rate. In the isolated ileum of guinea pig, DWP 305 inhibited contrastive effects against the acetylcholine (10^(-6)g/㎖), histamine (10^(-6)g/㎖), 5-hydroxytryptamine (10^(-6)g/㎖) and BaCl₂ (10^(-4)g/㎖) at a concentration of 2.15 X 10^(-4)g/㎖ in bath. In the isolated trachea and vas deference, DWP 305 showed no effect on the contractions produced by histamine and norepinephrine, respectively. DWP 305 showed inhibitory effect on the contractions produced by acetylcholine and oxytocin at a concentration of 2.15 X 10^(-4)g/㎖ on the isolated nonpregnant rat uterus. DWP 305 had no effect on the isolated right atrium of guinea pig, bile excretion urine volume, pH, gastrointestinal motility, gastric secretion and blood aggregation.
위장질환 치료용 의약조성물 ( DWP 301 ) 의 일반약리작용
심점순(Jeon Soon Shim),박남준(Nam Jun Park),유영효(Young Hyo Yu),임승욱(Seung Wook Lim),염제호(Je Ho Yeom),김영만(Young Man Kim),장병수(Byeong Su Jang),연제덕(Je Duk Yeon),김병오(Byung O Kim),강진석(Jin Seok Kang),유은주(Eun Joo Yu) 한국응용약물학회 1994 Biomolecules & Therapeutics(구 응용약물학회지) Vol.2 No.4
The general and some pharmacological actions of DWP 301 were investigated in animals and the following results were obtained. In central nervous system, DWP 301 had no effects on the pentobarbital induced anaesthesia, rotarod test, traction test, analgesic action, anticonvulsant action in mice and body temperature in rat. But DWP 301 showed a little decrease of locomotor activity at a dose of 3,000 mg/kg. From these results, DWP 301 was considered to have little pharmacological effect on the central nervous system. Furthermore, DWP 301 had no influences on the normal blood pressure and heart rate. DWP 301 showed no effect on the isolated guinea pig ileum, trachea, right atrium, and nonpregnant rat uterus. But, in the isolated guinea pig vas deference, DWP 301 had showed inhibitory effect on the contractions produced by norepinephrine. DWP 301 showed rise of gastric juice pH and decrease of urine volume. Also, DWP 301 had no effect on the gastrointestinal motility and blood aggregation. From these results, it is concluded that the general pharmacological effect of DWP 301 are similar to or weaker than M and AGA.
흰쥐 말초 혈액 림프구의 분자량 44 kD 단백의 인산화
안영수(Young Soo Ahn),주일로(I-Lo Jou),오도연(Do Yeun Oh),임승욱(Seung Wook Lim),박경선(Kyung Sun Park) 대한약리학회 1991 대한약리학잡지 Vol.27 No.2
흰쥐 말초혈액에서 얻은 T 림프구를 아드레날린성 β-수용체 효현제 및 concanavalin A(Con-A)로 자극해 다음과 같은 결과를 얻었다. 자극이 없는 상태에서의 주 인산화 단백은 분자량 44kD, 등전점 6.8의 단백이었으며 효현제로 자극시키면 분자량 44kD, 등전점 6.3의 단백이 새로이 인산화되어 나타났다. 이 분자량 44kD, 등전점 6.3의 단백은 forskolin에 의해 역시 인산화되며 A-kinase 억제제인 H-8을 전처치하면 인산화의 억제가 나타났다. 또한 Con-A로 자극시키면 44 kD/pI 6.3 단백의 인산화가 증가되었으며 이 인산화의 증가는 CaM kinase 억제제인 W-7 전처치에 의해 억제되었다. H-7은 분자량 44 kD, 등전점 6.8 단백의 인산화를 감소 시켰다. 이상의 결과로 분자량 44 kD 등전점 6.3의 단백은 A-kinase와 CaM kinase 모두에 의해 인산화 되는 기질단백으로서 tryptic peptide map상에서 44 kD/pI 6.8 단백과 44 kD/pI 6.3 단백은 서로 다른 단백임을 알 수 있었다. Using T-lymphocytes obtained from rat peripheral blood, we found that the 44kD/pI6.8 protein was the major phosphoprotein of T-lymphocytes under basal condition, and that the 44kD/pI6.3 protein was a new phosphoprotein appeared in T-lymphocytes stimulated with β-agonist. The phosphorylation of the 44kD/pI6.3 protein was also induced by forskolin but inhibited by H-8 pretreatment. To clarify the character of the 44kD/pI6.3 protein, we used Con-A and kinase inhibitors, H-7 and W-7. Con-A stimulation induced phosphorylation of 44kD/pI 6.3 protein but that was inhibited by W-7 pretreatment. The phosphorytation of 44kD/pI6.3 protein was not induced by the PKC activator, PMA. Instead, the phosphorylation of 44kD/pI6.8 protein was reduced by H-7, a PKC inhibitor. From the above results,it can be concluded that the 44kD/pI6.3 protein can be a common substrate for A-kinase and CaM kinase. The two dimensional tryptic peptide mapping revealed that the 44kD/pI6.8 and 44kD/pI6.3 proteins are different.
재조합 인간 상피세포 성장인자(DWP 401)의 일반약리작용
천선아(Seon Ah Cheon),김상미(Sang Mee Kim),이은방(Eun Bang Lee),임승욱(Seung Wook Lim),유영효(Young Hyo Yu),박명환(Myung Hwan Park) 대한약학회 1995 약학회지 Vol.39 No.5
The recombinant human epidermal growth factor(DWP 401) was investigated on the pharmacological actions. DWP 401 had no effects on the hexobarbital-induced sleeping time, locomotor activity, rotarod test, body temperature, analgesic action and anticonvulsant action in mice. It also had no influences on the isolated tracheal muscle and ileum of guinea-pig, isolated uterus and fundus strip of rats. Slight hypotensive action with effect on respiration was revealed at a dose of 8g/kg i.v. of DWP 401 in rabbits. DWP 401 exhibited a weak inhibitory action of glucose tolerance in normal rats, significantly lowered the blood glucose contents in adrenalectomized rats at a concentration of 160g/kg, and produced a significant inhibitory effect on leucocyte migration in CMC-pouch of rats at a concentration of 32g/rat. Furthermore, DWP 401 showed a significant decrease on gastric juice volume and acidity. However, DWP 401 had no intestinal propulsion rate and influence on urine excretion.
Strut-and-Tie Model을 利用한 鐵筋콘크리트 部材의 剪斷解析
林承旭,朴弘用 명지대학교 공학기술연구소 1992 공학기술연구소 논문집 Vol.7 No.-
Recently, Strut-and-Tie Model(STM) is proposed as a rational and consistent basis for analysis and design of any part of cracked reinforced and prestressed concrete structures which include so called disturbed or discontinuity regions, subject to bending, shear and torsion. In this paper, first, theoritical backgrounds of STM as well as modelling and analyzing methods are introduced. Then, the funtion of STM is confirmed by applying STM to some examples of other reseacher's experiments on reinforced concrete deep beams and comparing with test results and ACI Code provisions.
위장질환 치료용 의약조성물 (DWP 302) 의 일반약리작용
김영만,남권호,유영효,임승욱,염제호,장병수,김동오,박명환 한국응용약물학회 1993 Biomolecules & Therapeutics(구 응용약물학회지) Vol.1 No.2
The general and some pharmacological actions of DWP 302 were investigated in animals and the following results were obtained. In central nervous system, DWP 302 had no effects on the pentobarbital induced anaesthesia, locomotor activity, rotarod test, traction test, analgesic action in the mice and body temperature in the rat. DWP 302 showed no depressive action on the convulsion induced by strychnine and electronic shock. From these results, DWP 302 was considered to have no or little pharmacological effect on the central nervous system. Furthermore, DWP 302 had no influences on the normal blood pressure and heart rate. In the isolated ileum of guinea pig, DWP 302 showed neither contractive nor relaxing effects against the acetylcholine (10^(-6) g/ml), histamine (10^(-6) g/ml) and BaCl₂ (10⁴g/ml) at a concentration of 1.9X 10⁴g/ml in bath. But it caused a slight increase in basal tone at a concentration of 6.3 X 10^(-4) g/ml and this effect was inhibited by atropine 10^7 g/ml. In the isolated trachea and vas deference, DWP 302 showed no effect on the contractions produced by histamine and norepinephrine, respectively. And DWP 302 showed no effect on the contractions producd by acetylcholine and oxytocin in the isolated nonpregnant rat uterus. DWP 302 had no effect on bile excretion, urine volume, pH and gastrointestinal motility. But, DWP 302 showed a significant inhibitory effect on gastric secretion in the rat.