봉약침(Bee Venom)과 Sweet Bee Venom의 Allergy 반응에 대한 비교연구

이진선,이종영,권기록,이희춘,Lee, Jin-Seon,Lee, Jong-Young,Kwon, Ki-Rok,Lee, Hee-Choon 대한약침학회 2006 Journal of pharmacopuncture Vol.9 No.3

Objectives : Sweet bee venom is made by removing allergen from the bee venom through gel filtration chromatography and propionic acid/urea polyacrylamide gel electrophoresis. The aim of this study was to verify allergy inhibitory action in Sweet Bee Venom in which the allergy causing enzyme is removed. Methods : 95 healthy adult men and women were selected through a survey whom had never received the bee venom therapy in the past. The concentration of bee venom pharmacopuncture and Sweet BV pharmacopuncture was equally at 0.1mg/ml and the experiment was conducted as the double blind test. Experiment groups were classified into low dosage groups(0.1ml for both bee venom pharmacopuncture and Sweet BV) and high dosage groups where 0.4ml of respective administrations were rendered made observations for allergic responses. Results : Participants of the study was comprised of 71 men and 24 women with the average age of 29.0 years. According to results of the low dosage groups, Sweet BV group showed significant reduction in pain after 4 hours and 24 hours compared to the bee venom pharmacopuncture group. Other allergic responses were insignificant between the groups. For the high dosage groups, Sweet bee venom group showed reduction in pain after 30 minutes and 4 hours. Other allergic responses such as edema, itchiness, dizziness from hypersensitivity, and fatigue were significantly lower in the Sweet bee venom administered group after 30 minutes. Conclusions : As a result of removed allergen, Sweet bee venom significantly inhibits allergic responses both locally and throughout the body. This indicates wider and easier application of Sweet bee venom for the symptoms applicable to the bee venom pharmacopuncture. Further comparative studies should be conducted to yield more objective verification.

안면견갑상완형(Fascioscapulohumeral:FSH) 근이영양증 1례에 대한 증례보고

이진선,안창석,권기록,Lee, Jin-seon,An, Chang-suk,Kwon, Gi-rok 대한침구의학회 2001 대한침구의학회지 Vol.18 No.3

Objective : There was no report on the treatment of Fascioscapulohumeral (FSH) Muscular Dystrophy by Oriental medicine. But the treatment conducted on the patient admitted to the Sangji Oriental Medicine Hospital from January 9, 2001 to February 23, 2001, a significant treatment result was yielded and would like to suggest treatment plan for the future treatments. Methods : Under the assumption that Korean Bee-Venom Therapy may be affective for treating FSH Muscular Dystrophy, the following points were administered : SI10(노유), SI11(天宗), BL23(腎兪), BL26(關元兪), ST36(足三里), LI4(合谷), Liv3(太衝), SI9(肩貞). CFC(Carthami Flos;紅花 and Cervi Pantotrichum Cornu;鹿茸) herbal extract was treated on the other acupuncture points. Sa-Am(Four needle technique) Acupuncture (tonifying SI5 and ST42, sedating GB41 and ST43) was done every day. For herbal medicine, TaeEumIn ChoWiSeungChung-Tang was given based on the constitutional diagnosis. Results : After 7 weeks of treatment, a remarkable improvement was made for facial muscular movement and muscular strength of the scapular and another regions. Conclusions : 1. Significant improvement in the muscular strength for the case of FSH Muscular Dystrophy was obtained with through Korean Bee-Venom Therapy, Four needle technique, and herbal medication. 2. For progressive muscular dystrophy, it is necessary to practice muscular strength recovery exercise in conjunction with Korean Bee-Venom Therapy. 3. Although this case yielded favorable result, further observation and study must be made to concretely prove the effectiveness of Korean Bee-Venom Therapy for treating muscular dystrophies.

신경망을 이용한 필기 숫자 인식에서 부류 분별에 기반한 특징 선택

이진선,Lee, Jin-Seon 한국정보처리학회 1999 정보처리논문지 Vol.6 No.2

The primary purposes in this paper are to analyze the class separation of features in handwritten numeral recognition and to make use of the results in feature selection. Using the Parzen window technique, we compute the class distributions and define the class separation to be the overlapping distance of two class distributions. The dimension of a feature vector is reduced by removing the void or redundant feature cells based on the class separation information. The experiments have been performed on the CENPARMI handwritten numeral database, and partial classification and full classification have been tested. The results show that the class separation is very effective for the feature selection in the 10-class handwritten numeral recognition problem since we could reduce the dimension of the original 256-dimensional feature vector by 22%. 본 논문의 목적은 필기 숫자 인식에서 특징의 부류 분별력을 분석하고, 이를 특징 선택에 활용하는 것이다. 부류 분별력을 측정하기 위하여 Parzen 윈도우를 이용하여 부류 분포를 추정하였고, 서로 다른 부류의 부류 분포간의 거리를 부류 분별로 정의하였다. 이렇게 계산된 부류 분별을 이용하여, 특징 벡터에서 쓸모 없거나 중복성을 갖는 특징을 제거하여 특징 벡터의 차원을 줄인다. 실험은 CENPARMI 필기 숫자에 대해 수행하였으며 10개 부류 전체 뿐 아니라 2개 부류에 대해서도 수행하였다. 실험 결과 10-부류 필기 숫자 인식에서 256-차원 원래 특징 벡터를 인식률 손실 없이 22% 줄일 수 있어, 부류 분별이 특징 선택을 위한 유용한 도구임을 보였다.

사독(蛇毒)에 대한 문헌적(文獻的) 고찰(考察)

이진선,권기록,Lee, Jin-Seon,Kwon, Gi-Rok 대한약침학회 1999 Journal of pharmacopuncture Vol.2 No.1

This study was carried out to invastigate the researches of Snake Venom and snakes which used in treatment 1. The fist literature that used the snake for treatment is Shin Nong Ben Cao Jing 2. Composition of Snake Venom is consist of Enzymatic proteins ; Phospholipase A(A1-2), Protease, L-amino acid oxidase etc, and Non-enzymatic proteins ; Crotamine(Cytolysin), Proteolytic factor(Hematoxin), Crotoxin(Neurotoxin) etc. 3. Main toxins in Snake Venom are Hematoxin, Cytolysin, Neurotoxin and Cardiotoxin. Lethal dose 50 value of Agkistrodon brevicaudus is $45.87{\mu}g$/18g, Agkistrodon saxatilis is $10.28{\mu}g$/18g, Agkistrodon ussuriensis is $8.68{\mu}g$/18g, therefore Agkistrodon ussuriensis has strongist Snake Venom of all in Korea. 4. Pharmacological actions of Snake Venom are anticoagulation, thrombolytic function, hypotensor etc. 5. Systemic syndromes and signs after snakebite are Dizziness(25.7%), Vomitting(23.1%), Fever(22%), Visual disturbance(18%), Headache(17.7%) and Dyspnea(17.6%), etc. 6. Local syndrome and sign after snakebite is Discoloration(54.2%), Bleeding(20.2%), Bullae(10.7%), Skinulcer(10.8%), etc. 7. Pathological syndromes after snakebite are WBC increase, Urine protein, Urine sugar, Haematuria and elevation of S-GDT, S-GPT etc. These syndromes are leaded by Hematoxin and Cytolysin. 8. Complication signs after snakebite are Cellulitis, Gastritis, Lympoma, Abscess etc. 9. Common function of Viperidae(Agkistrodon acutus or Zaocys dhumnades etc) is expelling the wind(祛風), removing obstruction in the channels(通絡), antipastic function(止痙). And it is used in order to cure hemiparesis, hemiplegia, facial palsy and CVA disease, etc. 10. Using way of snake for medical treatment is various like Herbal alchol therapy, pill, powder and injection etc. The Study on the Snake Venom should be carried out continuously for using of medical treatment.

전기영동법(Electrophoresis)을 이용한 봉약침의 주요 성분에 관한 연구

이진선,권기록,이승배,Lee, Jin-Seon,Kwon, Gi-Rok,Lee, Seung-Bae 대한약침학회 2000 Journal of pharmacopuncture Vol.3 No.2

This study was designed to study on major components of various Bee Venom(Bee Venom by electrical stimulation in Korea; K-BV I, Bee Venom by Microwave stimulation in Korea; K -BV II, 0.5rng/ml, Fu Yu Pharmaceutical Factory, China; C-BV, 1mg /ml, Monmouth Pain Institute, Inc., U.S.A.; A-BV) using Electrophoresis. The results were summarized as follows: 1. In 1:4000 Bee Venom solution rate, the band was not displayed distinctly usmg Electrophoresis. But in 1: 1000, the band showed clearly. 2. The results of Electrophoresis at solution rate 1:1000, K-BV I and K-BVII showed similar band. 3. The molecular weight of Phospholipase $A_2$ was known as 19,000 but its band was seen at 17,000 in Electrophoresis. 4. Protein concentration of Bee Venom by Lowry method was different at solution rate 1:4000 ; C-BV was $250{wmu}g/ml,\;K-BV\;I\;was\;190{wmu}g/ml,\;K-BVII\;was\;160{wmu}/ml\;and\;C-BV\;was\;45{wmu}/ml5$. Electrophoresis method was unuseful for analysis of Bee Venom when solution rate is above 1:4000 but Protein concentration of Bee Venom by Lowry method was possible. These data from the study can be applied to establish the standard measurement of Bee Venom and prevent pure bee venom from mixing of another components. I think it is desirable to study more about safety of Bee Venom as time goes by.

HPLC를 이용한 봉약침의 주요 성분에 관한 연구

이진선,권기록,최호영,Lee, Jin-Seon,Kwon, Gi-Rok,Choi, Ho-Young 대한침구의학회 2000 대한침구의학회지 Vol.17 No.4

This study was designed to study on major components of various Bee Venom(Bee Venom by electrical stimulation in Korea; K-BV I, Bee Venom by Microwave stimulation in Korea; K-BV II, 0.5mg/ml, Fu Yu Pharmaceutical Factory, China; C-BV, 1mg/ml, Monmouth Pain Institute, Inc., U.S.A.; A-BV) using HPLC(High performance liquid chromatography). The results were summarized as follows : 1. HPLC method is useful for analysis of Bee Venom when solution rate is above 1:4000. 2. Analysis of Apamin using HPLC, the Retention time was 8.7min, and standard measurement curve was a function of y=4E+06x+21245. 3. Analysis of Melittin using HPLC, the Retention time was 29.0 min, and standard measurement curve was a function of y=4E+06x+23015. 4. Concentration of Melittin was about 297times than Apamin in K-BV I, and about 329times in K-BV II at same 1:500 solution rate, abnormally about 12 times in C-BV at 1:4000 solution rate. 5. Chinese Bee Venom using HPLC, the point from 5 to 7min(Retention time) showed a big extraordinary peak. These data from the study can be applied to establish the standard measurement of Bee Venom and prevent pure bee venom from mixing of another components. I think it is desirable to study more about safety of Bee Venom as time goes by.

등고선 추출을 위한 효과적인 다음점 결정 방법

이진선,정성종,Lee, Jin-Seon,Jeong, Seong-Jong 한국정보처리학회 1994 정보처리논문지 Vol.1 No.3

고도행렬로부터 등고선을 추출하는데 있어, 가장 중요한 문제는 하나의 격자에 네개의 통과점이 발생하는 이상 상황(degenerate case)의 해결이다. 본 논문은 이상 상황 검사와 다음점 결정을 동시에 수행하는 방법을 기술한다. 이 방법은 최소 횟수 의 배열 인덱싱을 필요로 한다. 또한 통과점을 모서리점의 높이차에 따라 LOWER/ HIGHER로 표시하고, 이 정보를 이용하여 보다 적은 횟수의 배열 인덱싱을 필요로하는 방법을 제안한다. 그리고 통과점을 표시하고 이들을 추적하기에 적합한 자료구조를 구체적으로 기술한다. In extracting contours from elevation matrix, the most important problem is to solve the degenerate case where four cross point arise in a grid. This paper describes a technique which performs the checking of degenerate case and determination of next point simultaneously. It requires minimum number of array indexing. Also this paper proposes a technique which reduces the number of array indexing by using LOWER/HIGHER information of a cross point designated according to height difference of grid vertices. In addition, we describe a data structure which is proper for representing cross points and tracing them.

대용량 분류에서 SVM과 신경망의 성능 비교

이진선,김영원,오일석,Lee Jin-Seon,Kim Young-Won,Oh Il-Seok 한국정보처리학회 2005 정보처리학회논문지B Vol.12 No.1

이 논문은 대용량 분류 문제를 위한 모듈러 신경망(modular feedforward MLP)과 SVM(Support Vector Machine)의 성능을 비교 분석하였다. 전반적으로 SVM이 상당한 성능 차이로 우수함을 확인하였다. 또한 부류 수가 많아짐에 따라 SVM이 신경망보다 완만하게 성능 저하가 있음도 확인하였다. 또한 기각에 따른 정인식률 추이를 분석하였고, 대용량 분류에 적합한 SVM 파라메터(kernel 함수와 관련 변수들)를 도출하였다. In this paper, we analyzed and compared the performances of modular FFMLP(feedforward multilayer perceptron) and SVUT(Support Vector Machine) for the large-set classification problems. Overall, SVM dominated modular FFMLP in the correct recognition rate and other aspects Additionally, the recognition rate of SVM degraded more slowly than neural network as the number of classes increases. The trend of the recognition rates depending on the rejection rate has been analyzed. The parameter set of SVM(kernel functions and related variables) has been identified for the large-set classification problems.

비영리조직 종사자의 다문화수용성에 영향을 미치는 요인 연구 : 지역아동센터 종사자를 중심으로

이진선(Lee, Jin Seon),민선옥(Min, Sun Ok),김재남(Kim, Jae Nam),강영숙(Kang, Young Sook) 한국비영리학회 2020 한국비영리연구 Vol.19 No.2

다문화사회에 접어들면서 지역아동센터에 다문화가정 이용아동수가 늘어나는 추세이다. 지역아동센터에 종사하는 종사자들의 다문화수용성 제고가 중요하다고 여기며, 지역아동센터 종사자들의 다문화수용성의 수준은 어느 정도인지, 또한 다문화수용성에 영향을 미치는 요인들이 무엇이 있는지 통계를 통하여 살펴보았다. 그 결과 지역아동센터 종사자들의 다문화 수용성은 52.4점으로 나타났으며, 이들의 다문화수용성에 영향을 미치는 변인은 다문화가정아동이 지역아동센터를 이용하는지의 여부와 외국여행경험여부로 나타났다. 연구 결과를 바탕으로 다음과 같은 실천적·정책적 제언을 한다. 첫째, 지역아동센터의 종사자들은 다문화아동들의 지역아동센터 이용을 확대하거나 다양한 프로그램을 만들 필요가 있다. 다문화아동과의 접촉을 통해서 다문화수용성을 높일 필요가 있다. 둘째, 다문화사회와 다문화아동을 이해할 수 있는 다문화사회전문가를 교육하고 양성할 필요가 있다. 훈련받는 다문화사회전문가는 지역아동센터에서 일상생활지도의 부분이나 학습의 부분, 한국어 교육, 학교생활 적응 등과 관련한 지원서비스를 제공하여 다문화가정의 아동들의 학교와 지역사회 적응을 도울 것이다. As we enter a multicultural society, the number of children and multicultural families going to the local children s centers are increasing. It is important to enhance multicultural acceptance of social workers at local children s centers, and we looked at the level of multicultural acceptability of the local children s centers through statistics and what factors affect multicultural acceptability. As a result, the multicultural acceptability of the local children s centers was 52.4 points, and the variables affecting their multicultural acceptability were whether children from multicultural families were used and whether they had foreign travel experience at the local children s centers. Based on the research results, the following practical and policy suggestions are made: First, social workers at the local children s centers need to expand the usage of the local children s centers or create various programs for multicultural children. It is necessary to increase multicultural acceptability through contacts with multicultural children. Second, it is necessary to educate and train multicultural social experts who can understand multicultural societies and multicultural children. The trained multicultural social experts will help the children from multicultural families adapt to schools and communities by providing support services related to parts of daily life guidance or learning, Korean language education, and school life adaptation at local children s centers.

라이프스타일 숍의 테이블연출 구성요소가 소비가치와 구매의도에 미치는 영향

이진선(Lee, Jin-Seon),김수인(Kim, Su-In) 한국식공간학회 2019 식공간연구 Vol.14 No.3

본 연구는 변화하는 라이프스타일(Life Style)과 다양한 상품의 가치를 제안하고, 상품 트랜드를 빠르게 반영 및 출시하여 복합문화공간으로 자리 잡은 라이프스타일숍(Life Style Shop)에서 테이블연출 구성요소를 구매한 소비자들을 대상으로 실증연구를 진행하고자 한다. 이를 바탕으로 테이블연출 구성요소에 대한 소비자의 소비가치, 구매의도와의 영향관계를 파악하고, 차후 테이블연출 구성요소를 판매하는 라이프스타일숍(Life Style Shop)에서 상품 연출 및 테이블연출 시 연출가를 위한 기초교육 자료 및 브랜드 매장 콘셉 연출을 위한 판매 마케팅 전략 기초자료로 활용하고자 하였다. 본 연구에서는 이러한 목적을 위하여 서울 및 경기지역의 거주자를 대상으로 하여 특정 라이프스타일숍에 방문 후 테이블 구성요소 구매경험이 있는 소비자에게 350부의 설문지를 수거하였으며, 이 중 21개의 이상점을 제거하고 총 329부의 자료를 통계분석에 활용하였다. 자료를 통계분석에 활용하였다. 연구 결과는 다음과 같이 나타났다. 첫째. 라이프스타일숍 테이블연출 구성요소의 하위요인은 소비가치의 하위요인에 부분적으로 유의한 영향을 미치는 것을 알 수 있었다. 둘째, 소비가치의 기능적 가치, 심미적 가치, 진귀적 가치 순으로 구매의도에 영향을 미치는 것으로 나타났다. 셋째, 라이프스타일숍에서의 테이블연출 구성요소는 디너웨어, 센터피스, 글라스, 린넨, 커트러리 순으로 구매의도에 영향을 미치는 것으로 나타났다. This study aims to conduct a study on consumers who purchase table decorating components at a life style shop which proposes the value of life style and various relevant products, quickly reflects product trends and are now regarded as complex cultural space. Based on the findings, it will help understand consumers’ consumption value of table decor components, provide materials for training table decorators for life style shops and marketing strategies for brand store concepts and target sales. For this purpose, this study asked residents in Seoul and Gyeonggi-do Province if they had experience in visiting lifestyle shops and purchasing table components, explaining the purpose and purpose of the survey when they answered yes, and collecting 350 questionnaires thanks to cooperation, of which 21 anomalies were removed and a total of 329 pieces of data were utilized for statistical analysis. The results of the study were as follows: First, the sub-factor of the lifestyle shop table-playing component was shown to have a significant effect on the sub-factor of consumption value. Second, the functional, the aesthetic, and the rarity value of consumption values affected the intention of purchase in order. Third, table-coordinate components in lifestyle shops affected purchase intent in the order of dinnerware, center piece, glassware, linen, and cutlery.