무릎이 있는 무동력 이족보행 로봇의 보행 리밋 사이클 연구

이중빈,구승범 대한기계학회 2016 대한기계학회 춘추학술대회 Vol.2016 No.4

Real-time초음파촬영을 이용한 태아체중의 예측

이중빈,문장주,한원희,이윤호,왕동훈 대한산부인과학회 1986 Obstetrics & Gynecology Science Vol.29 No.1

Action Mechanism of Antiestrogens on Uterine Growth in Immature Rats

이중빈,윤미정,김창미,홍사석,유경자,Lee, Jung-Bin,Yoon, Mi-Chung,Kim, Chang-Mee,Hong, Sa-Suk,Ryu, Kyung-Za The Korean Society of Pharmacology 1990 대한약리학잡지 Vol.26 No.2

비스테로이드성 항에스트로젠제는 표적기관에서 estrogen 수용체와 상경적으로 결합하므로써 estrogen의 작용을 억제하는 것으로 알려져 있다. 비스테로이드성 항에스트로젠제는 대체로 triphenylethylene계로서 tamoxifen, clomiphene, LYl17018등이 있으며 표적기관에서 estrogen의 작용을 억제하기 때문에 estrogen과 관련된 질환을 치료하는데 이용되어 오고 있다. 본 연구에서는 생후 21-23일된 미성숙 흰쥐를 재료로 항에스트로젠제중 tamoxifen과 LY117018이 자궁세포 성장에 어떠한 영향을 미치며 어떠한 기전으로 estrogen의 작용을 길항하는지를 규명하고자, 항에스트로젠제가 estrogen작용의 중요 지포에 미치는 영향을 비교 관찰하여 다음과 같은 결과를 얻었다. Tamoxifen과 LY117018은 자궁세포에서 estrogen의 영향이 없는 경우에는 estrogen agonist로, estrogen작용하에서는 estrogen antagonist로서 작용하였다. Estrogen 작용의 여러 가지 지표에 대해 tamoxifen이 LY117018보다 agonistic effect는 더 컸으나, antagonistic effect는 LY117018이 더 큰 것으로 나타났다. Estrogen 수용체에 대한 결합능은 LY117018이 estradiol보다는 약간 낮았으나 용량에 비례하여 estrogen 수용체와 결합하였다. 그러나 tamoxifen은 estrogen 수용체에 대한 결합이 아주 낮았다. Estrogen 수용체에 대한 binding affinity는 estradiol(100%), LY117018(77%), tamoxifen(6.3%) 순으로 나타났다. 항에스트로젠제의 생체내 투여는 estrogen 존재 유무에 따라 estrogen 수용체 농도에 agonist 또는 antagonist로 작용하였다. 항에스트로젠제의 단독투여는 progesterone 수용체 생성을 증가시키나, estrogen에 의하여 유도된 progesterone 수용체 생성을 억제하였다. 이상의 결과로 보아, tamoxifen과 LY117018은 estrogen유무에 따라 흰쥐 자궁세포에서 estrogen antagonist로서 뿐만 아니라 agonist로서도 작용함을 알 수 있다. 그러나 estrogen수용체와의 결합능력이 아주 낮은 tamoxifen은, 용량에 비례하여 estrogen수용체에 결합하므로써 작용하는 LY117018과는 다른 기전으로 작용하는 것으로 생각된다. In the present study, we examined the effects of tamoxifen and LY117018 on various parameters for the estrogenic actions in order to understand the mechanism by which tamoxifen and LY117018 act on the uterine cells in 21-23 day old immature rats. Tamoxifen and LY117018 stimulated uterine weight and uterine contents of DNA, protein, and peroxidase activity in the absence of estradiol while inhibited above parameters in the presence of estradiol. Both cytosolic and nuclear progesterone receptors were increased by the treatment of tamoxifen and LY117018 as well as estradiol, but estradiol-induced increase in the progesterone receptors were reduced by the treatment of antiestrogens. These effects were enhanced by the multiple injections of antiestrogens. It seemed that tamoxifen was more agonistic than LY117018 but less antagonistic than LY117018, judged by their effects on various parameters for the estrogenic action. The affinities of estradiol, tamoxifen, and LY117018 for the estrogen receptor were $0.17{\pm}0.01nM(100%)$, $1.10{\pm}0.01nM(6.3%)$, and $0.23{\pm}0.01nM(77%)$, respectively. Furthermore, LY117018 was the competitive ligand for the estrogen receptor in dose-related manner but tamoxifen was not. Following estradiol treatment, nuclear estrogen receptor was sharply increased by 1 h, reaching the maximum by 16 h, while tamoxifen and LY117018 slightly increased nuclear estrogen receptor by 1 h and then decreased thereafter. It is therefore concluded that LY117018 is a competitive antagonist for the estrogen receptor with less estrogenic activity, compared to tamoxifen with low affinity to the estrogen receptor, and tamoxifen may act through other binding site than the estrogen receptor.

싱글 카메라를 이용한 3 차원 보행 동작 추정 방법 개발

이중빈,구승범 대한기계학회 2017 대한기계학회 춘추학술대회 Vol.2017 No.4

보행자의 2차원 영상으로부터 3차원 자세 복원 연구

이중빈(Jungbin Lee),구승범(Seungbum Koo) 대한기계학회 2016 대한기계학회 춘추학술대회 Vol.2016 No.12

Gait is important motion that contains biological information. Individual gait pattern is determined by subject’s habit, body type and diseases. Motion capture system is used to measure joint motion but is limited to capture within a laboratory. Optical camera is portable, simple to configure and take photographs of movement of a person, while it produces only two-dimensional information. The purpose of the study was to estimate three-dimensional pose and joint angles from two-dimensional sequential images of walking motion. Three-dimensional trajectories of body markers from three subjects and five motions were pooled together and their mean pose and principal components were obtained. One of the motion capture data was projected to a camera plane by assuming a fixed camera position. Optimizations to calculate a weight matrix of the principal components of body pose were performed with and without a constraint of body segment length to match the plane projected marker positions. Mean three-dimensional errors (standard deviation) of estimated marker trajectory were calculated using measured marker trajectory. Three-dimensional errors with and without constraint of body segment length were 3.44(±0.65) cm and 3.25(±0.80) cm, respectively. Two-dimensional errors (standard deviation) of projected marker to image were calculated using original image. Two-dimensional errors were 1.63(±0.41) pixel and 1.40(±0.38) pixel respectively. Flexion and extension angle of knee was estimated as RMS error, 2.54degree and 2.28degree respectively.

무동력 이족보행 로봇에서 다리 무게 추 위치의 영향 연구

이중빈(Jungbin Lee),정해웅(Haewoong Jeong),강서호(Seoho Kang),조현준(Hyunjune Cho),권훈(Hoon Kwon),고현진(Hyeonjin Ko),정이환(Yihwan Jung),구승범(SeungBum Koo) 대한기계학회 2015 대한기계학회 춘추학술대회 Vol.2015 No.11

This study investigated the effect of center of mass in the passive bipedal walker. We made a SimMechanics model of a passive bipedal walker and compared it with experimental data of the real physical bipedal walker. In this simulation, the effect of gravity, contact force and joints were implemented. We obtained the foot clearance and knee angular velocity in accordance with the center of gravity location in simulation. The foot clearance during swing phase increased as the center of mass of thigh and shank move lower and higher, respectively. Angular velocity of the knee decreased as the center of mass of thigh and shank move higher and lower, respectively.

자궁세포 성장에 미치는 항에스트로젠제의 작용기전

이중빈(Jung Bin Lee),윤미정(Mi-chung Yoon),김창미(Chang-mee Kim),홍사석(Sa Suk Hong),유경자(Kyung-za Ryu) 대한약리학회 1990 대한약리학잡지 Vol.26 No.2

비스테로이드성 항에스트로젠제는 표적기관에서 estrogen 수용체와 상경적으로 결합하므로써 estrogen의 작용을 억제하는 것으로 알려져 있다. 비스테로이드성 항에스트로젠제는 대체로 triphenylethylene계로서 tamoxifen, clomiphene, LYl17018등이 있으며 표적기관에서 estrogen의 작용을 억제하기 때문에 estrogen과 관련된 질환을 치료하는데 이용되어 오고 있다. 본 연구에서는 생후 21-23일된 미성숙 흰쥐를 재료로 항에스트로젠제중 tamoxifen과 LY117018이 자궁세포 성장에 어떠한 영향을 미치며 어떠한 기전으로 estrogen의 작용을 길항하는지를 규명하고자, 항에스트로젠제가 estrogen작용의 중요 지포에 미치는 영향을 비교 관찰하여 다음과 같은 결과를 얻었다. Tamoxifen과 LY117018은 자궁세포에서 estrogen의 영향이 없는 경우에는 estrogen agonist로, estrogen작용하에서는 estrogen antagonist로서 작용하였다. Estrogen 작용의 여러 가지 지표에 대해 tamoxifen이 LY117018보다 agonistic effect는 더 컸으나, antagonistic effect는 LY117018이 더 큰 것으로 나타났다. Estrogen 수용체에 대한 결합능은 LY117018이 estradiol보다는 약간 낮았으나 용량에 비례하여 estrogen 수용체와 결합하였다. 그러나 tamoxifen은 estrogen 수용체에 대한 결합이 아주 낮았다. Estrogen 수용체에 대한 binding affinity는 estradiol(100%), LY117018(77%), tamoxifen(6.3%) 순으로 나타났다. 항에스트로젠제의 생체내 투여는 estrogen 존재 유무에 따라 estrogen 수용체 농도에 agonist 또는 antagonist로 작용하였다. 항에스트로젠제의 단독투여는 progesterone 수용체 생성을 증가시키나, estrogen에 의하여 유도된 progesterone 수용체 생성을 억제하였다. 이상의 결과로 보아, tamoxifen과 LY117018은 estrogen유무에 따라 흰쥐 자궁세포에서 estrogen antagonist로서 뿐만 아니라 agonist로서도 작용함을 알 수 있다. 그러나 estrogen수용체와의 결합능력이 아주 낮은 tamoxifen은, 용량에 비례하여 estrogen수용체에 결합하므로써 작용하는 LY117018과는 다른 기전으로 작용하는 것으로 생각된다. In the present study, we examined the effects of tamoxifen and LY117018 on various parameters for the estrogenic actions in order to understand the mechanism by which tamoxifen and LY117018 act on the uterine cells in 21-23 day old immature rats. Tamoxifen and LY117018 stimulated uterine weight and uterine contents of DNA, protein, and peroxidase activity in the absence of estradiol while inhibited above parameters in the presence of estradiol. Both cytosolic and nuclear progesterone receptors were increased by the treatment of tamoxifen and LY117018 as well as estradiol, but estradiol-induced increase in the progesterone receptors were reduced by the treatment of antiestrogens. These effects were enhanced by the multiple injections of antiestrogens. It seemed that tamoxifen was more agonistic than LY117018 but less antagonistic than LY117018, judged by their effects on various parameters for the estrogenic action. The affinities of estradiol, tamoxifen, and LY117018 for the estrogen receptor were 0.17 ± 0.01nM(100%), 1.10 ± 0.01nM(6.3%), and 0.23 ± 0.01nM(77%), respectively. Furthermore, LY117018 was the competitive ligand for the estrogen receptor in dose-related manner but tamoxifen was not. Following estradiol treatment, nuclear estrogen receptor was sharply increased by 1 h, reaching the maximum by 16 h, while tamoxifen and LY117018 slightly increased nuclear estrogen receptor by 1 h and then decreased thereafter. It is therefore concluded that LY117018 is a competitive antagonist for the estrogen receptor with less estrogenic activity, compared to tamoxifen with low affinity to the estrogen receptor, and tamoxifen may act through other binding site than the estrogen receptor.

조기임신과 동반된 결핵성 복막염에서의 자연유산 1례

문장주,이중빈,이충호,이윤호,항동훈 대한산부인과학회 1986 Obstetrics & Gynecology Science Vol.29 No.11

2기 전력계통의 동적 안정도 해석을 위한 단순화된 모델

장성환,안태천,이중빈 원광대학교 공업기술개발연구소 1981 工業技術開發硏究誌 Vol.1 No.-

Dynamic stability analysis of a large interconnected power system may even exceed the storage capacity of modern fast computers because of the high order of the matrix. In this paper two methods hav teen introduced to obtain simplified models of the systems bared on the magnitude of the variables or the eigenvalves. The difference between the eigenvalves of the reduced models and that of the original models was within 0.53% and the difference of the rerponse during the transient time in negligible. This method can be used to calculate the eigenvalues and analyze the dynamic stability of systems of high order matrix.

Fuzzy-Basian법에 의한 R.C도로교의 신뢰성 및 안전도평가

정철원 ( Jung Chul-won ),이중빈 ( Lee Cheung-bin ),나기현 ( Na Gi-hyun ),박주원 ( Park Ju-won ) 한국구조물진단유지관리공학회 1997 한국구조물진단유지관리공학회 학술발표대회 논문집 Vol.1 No.1

In this paper, an attempt is made to apply the concept of Fuzzy-Bayesian theory to the Reliability Analysis of R.C(Reinforced Concrete) Bridge, uncertainty states are represented in terms of fuzzy sets which define several linguistic variables such as “good”, “average”, ”poor”, etc. Especially, the concept of fuzzy conditional probability aids to derive a new reliability analysis which includes the subjective assessment of engineers without introducing any additional correction factors. Several numerical examples are presented to illustrate the method proposed herein.