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이종석,전법주,정일현,홍인권 ( Jong Suk Lee,Bup Ju Jeon,Il Hyun Jung,In Kwon Hong ) 한국공업화학회 1995 공업화학 Vol.6 No.2
최근 초임계유체를 이용한 추출공정은 비교적 휘발성이 낮은 생화학 물질의 분리와 고분자 물질의 분획 기술로 많은 분야에 적용되어 활발한 연구가 진행되고 있다. 그러나 공정설계와 scale-up에 필수적으로 요구되는 확산계수와 같은 전달특성에 관한 데이타의 부족은 상업적인 수준의 기술로 발전을 저해하고 있다. 초임계유체 추출공정에서 지배적인 속도 메카니즘이며, 장치설계에 중요한 변수가 확산특성이므로 초임계유체 내에서 추출물의 확산계수를 예견할 수 있는 능력이 추출공정의 설계와 효율적인 조작에 있어 매우 중요하다. 본 연구에서는 초임계유체 크로마토그래피를 이용하여 capillary peak-broadening법으로 초임계 이산화탄소 내에서 naphthalene의 확산계수를 308.15∼328.15K와 175∼275bar의 압력 범위에서 정량적으로 결정하였고, 일정 온도에서 압력이 증가됨에 따라 낮은 압력 범위에서는 확산계수에 미치는 압력의 영향이 크고, 높은 압력범위에서는 압력의존성이 작음을 확인하였다. 또한 초임계유체계의 압력과 온도의 변화는 밀도, 점도 및 몰 부피와 같은 유체의 전체적인 물성을 변화시켜 용질의 확산특성에 영향이 있음을 확인하였고, 기존의 액체계에 대한 확산계수 상관식 중에서 Matthews-Akgerman식의 확장적용이 실험적으로 측정한 데이타와 잘 일치함을 확인 하였다. Supercritical fluid extraction(SFE) has been studied in recent years as a technique for the separation of an available component from the material of low volatility and the fractionation of polymers, but the lack of data for transport characteristics essentially required for the extraction process design and scaleup has hindered development of the technology to a commercial level. Because diffusion is the dominant rate mechanism in extraction process, the ability to predict the diffusion coefficient is of considerable importance in process design and efficient operation. In this study, binary diffusion coefficients of naphthalene in supercritical carbon dioxide were measured by using the capillary peak broadening(CPB) method. Quantitative measurements were obtained by SFC in the temperature range 308.15∼328.15K and at pressures between 175 and 275bar. The experimental values of the diffusion coefficients have a magnitude of 10^(-4)㎠/s and were approximately in the range 0.5598∼1.1914×10^(-4)㎠/s. The influence of pressure on the diffusion coefficients at higher pressure range was less than that at lower pressure. As the pressure and temperature change, it is clear that the physical properties of fluid such as density, viscosity and molar volume determined the diffusion characteristics of the solute in SC-CO₂. Among the various theoretical equations, the Matthews-Akgerman equation provided a more successful correlation for the experimental data.
위암환자에서 임상적 양상 및 치료에 따른 혈청 CEA치의 변화에 관한 연구
이종석(Jong Suk Lee),장세호(Se Ho Chang),이삼철(Sam Cheol Lee),김건용(Kun Young Kim),이원주(Won Joo Lee),최성란(Seong Lan Choi),정순일(Sun Il Jung) 대한핵의학회 1990 핵의학 분자영상 Vol.24 No.2
N/A Serum carcinoembryonic antigen (CEA) levels were measured by radioimmunoassay in 82 patients with stomach cancer and were related to their clinical status and to the response to therapeutic modalities. Serum CEA in patients over 40 years of age was higher (p〈0.05) than that of younger age group and was higher (p〈0.0025) in patients with advanced stages (IIII and IV) than in patients with earlier stages (EGG and stage II). No significant differences in serum CEA levels were seen between the tumor cell types. In 9 patients who underwent successful radical resection of the cancer, serum CEA decreased significantly (p〈0.05) after surgery, whereas the changes in serum CEA levels after palliative surgery in other 7 patients were statistically insignificant (p〉0.01). Eleven patients who were given chemotherapy were followed up until death, the changes in their serum CEA levels were significant reverse-correlation (r=-0.72) with duration of survival.
이정열 ( Jung Youl Lee ),이종석 ( Jong Suk Lee ),박준홍 ( Joon Hong Park ),이성열 ( Sung Yul Lee ),황규왕 ( Kyu Uang Whang ),정현 ( Hyun Chung ) 대한피부과학회 1998 대한피부과학회지 Vol.36 No.3
Phakomatosis pigmentovascularis is a rare cutaneous malformation characterized by a combination of nevus flammeus and pigmentary nevus such as nevus of Ota, nevus of Ito, mongolian spots, nevus spilus. It is often associated with systemic organ involvement. We report two cases of phakomatosis pigmentovascularis. The first was a 11-year-old boy, who had had diffuse nevus flammeus, mongolian spots since birth, and congenital glaucoma. The second case was a 9-year-old boy who had had nevus flammeus, mongolian spots, nevus of Ota, and nevus of Ito over various parts of his body since birth. He also had leg-length discrepancy, avascular necrosis of the femur head, congenital temporal alopecia and varicose veins. (Korean J Dermatol 1998;36(3): 506-510)
이호정 ( Ho Jung Lee ),홍정연 ( Jeong Yeon Hong ),박태흠 ( Tae Heum Park ),이성열 ( Sung Yul Lee ),이종석 ( Jong Suk Lee ),정의현 ( Euy Hyun Chung ),이상훈 ( Sang Hoon Lee ),김정은 ( Jung Eun Kim ) 대한피부과학회 2020 대한피부과학회지 Vol.58 No.6
Fixed drug eruption (FDE) is a drug-induced disorder that may appear as patches or bullae. It recurs at the same sites as those involved in exposure to the same drug (causative drug). We encountered two cases of generalized FDE, and both patients had a history of diclofenac exposure before the onset of skin lesions. In the first case, an 82-year-old female patient presented with multiple erythematous patches on the trunk and lower extremities. In the second case, a 71-year-old male patient developed multiple bullae on violaceous patches on the trunk and extremities. The findings of histopathologic examinations were indicative of the diagnosis of FDEs. Although diclofenac is commonly used as a non-steroidal inflammatory drug, diclofenac-induced generalized FDE occurs rarely and has not been reported in Korea. With reuse of causative drugs, the size and number of lesions tend to increase. Therefore, early diagnosis of FDE is important, and avoidance of repeated exposure to drugs should be educated