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증례 : 위상피 종양의 내시경 점막절제술 후 치유되지 않은 인공 위궤양
이수현 ( Soo Hyeon Lee ),천재희 ( Jae Hee Cheon ),김지현 ( Jie Hyun Kim ),박종필 ( Jong Pill Park ),이상길 ( Sang Kil Lee ),이용찬 ( Yong Chan Lee ) 대한소화기학회 2007 대한소화기학회지 Vol.51 No.2
Endoscopic mucosal resection (EMR) is widely accepted as a standard treatment for early gastric cancer or gastric adenoma. However, EMR inevitably results in the formation of large iatrogenic ulcer at the resected area. Although the characteristics of EMR-induced ulceration are not fully understood, this type of ulcer is thought to heal faster and to recur less often than non-iatrogenic gastric ulcer. Current available evidences have suggested that EMR-induced ulcers heal within 2-3 months. Herein, we report two cases of non-healing persistent gastric ulcers after EMR. One is a case of gastric carcinoma which developed at the same site of previous EMR site for the low grade dysplasia. The other is a case in which persistent EMR-induced ulcer was healed in the long run after Helicobacter pylori eradication therapy. (Korean J Gastroenterol 2008;51:127-131)
이수현,손영진,이선엽,박봉우,변성범,정지예,이시형,Lee, Su-Hyoun,Sun, Yung-Chen,Lee, Seon-Yeop,Park, Bong-Woo,Byun, Sung-Bum,Jeong, Ji-Ye,Lee, Si-Hyeong 대한한의학방제학회 2013 大韓韓醫學方劑學會誌 Vol.21 No.2
Objectives : A 55-year-old male patient whose symptoms were not improved by western drugs(including steroids) was hospitalized in Korean medical hospital for 22 days. Methods : This patient was diagnosed as Han-po-yeol(寒包熱) and treated with herbal decoctions, acupuncture, and moxibustion. And he answered the quality of life questionnaire for adult Korean asthmatics (QLQAKA) at 1st, 15th, and 22th day of hospitalization. Results : After 2 weeks herbal medical treatment, score of QLQAKA was increased by 0.53 point. Conclusion : This result suggest that Korean medical treatment has the potential for asthma patients who did not responded to western drugs.
각종 위장질환의 위액 내의 Nitrite 농도에 관한 연구
이수현(Soo Hyun Lee),지무영(Moo Young Chi) 대한소화기학회 1986 대한소화기학회지 Vol.18 No.1
Nitrosamines are powerful carcinogens in animal .and they can be formed easily from nitrite by combining these with secondary, tertiary and quaternary amines. This reaction is influenced by nitrite concentration and pH of gastric juice, bacterial colonization and some inorganic ions in gastrointestinal tract. But there are few reports for nitrite concentration in gastric juice still yet. It should be more interesting to detect the nitrosamine concentration in gastric juice to find out the relationship to the stomach cancer, but the procedure itself is very complex. So we chose to examine the nitrite concentration and pH of gastric juice, and by comparing these two, we tried to detect the relationship of these to the various gastric and duodenal disorders. We selected 90 subjects and divided them into 5 groups normal, chronic gastritis, stomach ulcer, duodenal ulcer and stomach cancer according to the gastrofiberscopic findings and pathologic examination of biopsy specimen. The fasting nitrite concentration of gastric juice was measured and was compared to the pH of gastric juice. In this study, the mean gastric juice pH was highest in the cases of stomach cancer (1.85+-1.07 in normal subjects, 2.30+-1.28 in chronicgastritis, 2.78+-1.93 in stomach ulcer, 1.94+-1.25 in duodenal ulcer and 3.89+-1.71 in stomach cancer) and was statistically significant in normal subjects only. The nitrite concentration of gastric juice was highest in cases of stomach cancer(2.29+-0.53ug/ml) and was lower in order of stomach ulcer (l. 62+-1.32), duodenal ulcer (l.48+-1.18), chronic gastritis.(l.22+-1.70) and the normal subjects(0.95+-0.27), and the results in cases of stomach cancer, stomach ulcer and chronic gastritis were stastically significant. The gastric pH was significantly related to the nitrite concentration in the cases of stomach cancer, stomach ulcer and chronic gastritis. Also, the pH of overall subjects was significantly correlated to the nitrite concentration of gastric juice. But we couldn't find any correlation between the nitrite concentration and the age or sex of the subjects.
인공피부모델 KeraSkinTM을 이용한 유전독성 평가
이수현 ( Su-hyon Lee ),정행선 ( Haeng-sun Jung ),김설영 ( Seol-yeong Kim ),김혜수 ( Hye Soo Kim ),임경민 ( Kyung-min Lim ),정영신 ( Young-shin Chung ),최태부 ( Tae-boo Choe ) 대한화장품학회 2016 대한화장품학회지 Vol.42 No.3
소핵시험은 세포분열 단계 중 간기 세포의 세포질 내 소핵 유무를 조사함으로써 유전독성을 평가하는 시험법이다. 최근 화장품 안전성 평가에 동물실험을 금지하거나 최소화하려는 노력이 확산되고 있어 유전독성 평가에 있어서도 기존의 동물실험이 아닌 새로운 in vitro 시험법이 요구되고 있다. 본 연구에서는 3차원 배양인공피부모델인 KeraSkin<sup>TM</sup>을 이용하여 도포 처치된 물질의 유전독성을 평가하였다. 2종의 유전독성물질인 mitomycin C (MMC)와 methyl methanesulfonate (MMS)는 농도 의존적으로 세포독성과 소핵 형성이 유도된 반면, 대조물질인 4-nitrophenol (4-NP)와 trichloroethylene (TCE)에서는 농도 의존적으로 세포독성은 관찰되었으나 소핵은 형성되지 않았다. 따라서 인공피부모델을 이용한 소핵시험이 화장품과 같은 피부적용물질의 in vitro 유전독성 평가에 유용할 것으로 사료된다. Micronucleus test is genotoxicity assay for detection of micronuclei in the cytoplasm of interphase cells. The reduction and replacement of in vivo toxicity testing on animals require the development of in vitro models to predict the genotoxicity or other tests for cosmetic products. In this study, we evaluated a genotoxicity assay for topically applied chemicals using a three-dimensional human reconstructed skin model, KeraSkinTM. Two genotoxins, mitomycin C (MMC) and methyl methanesulfonate (MMS), induced significant dose-related increases in cytotoxicity and micronuclei induction in the skin model. In contrast, two non-genotoxins, 4-nitrophenol (4-NP) and trichloroethylene (TCE), induced cytotoxicity but not micronucleus formation. In conclusion, micronucleus test using human skin model may be useful for predicting in vitro genotoxic potentials of cosmetic products.
이수현(Su-Hyun Lee) 한국컴퓨터정보학회 2017 韓國컴퓨터情報學會論文誌 Vol.22 No.1
In recent years there has been a rise in the use and interest of the flipped learning as a teaching and learning paradigm. The flipped learning model includes any use of Internet technology to enrich the learning in a classroom, so that a professor can spend more time interacting with students instead of lecturing. In the flipped model, students viewed video lectures online outside of class time. Students then performed two kinds of assignments, a teamwork assignment and an individual work assignment, through the class time. In this paper, we propose a flipped educational model for a college class. This experimental research compares class of college algorithm using the flipped classroom methods and the traditional lecture-homework structure and its effect on student achievement. The result data of mid-term exam and final exam were analyzed and compared with previous year data. The findings of this research show that there was not a significant difference in the scores of student between two lecturing methods. The survey result and lecture evaluation by students show that students are in favor of the flipped learning.
이수현(Su Hyeon Lee),진경숙(Kyong-Suk Jin),권현주(Hyun Ju Kwon),김병우(Byung Woo Kim) 한국생명과학회 2018 생명과학회지 Vol.28 No.9
본 연구에서는 식물자원으로부터 생리활성을 보유한 새로운 기능성 소재를 찾고자 하였다. 이를 위해 수종의 식물 추출물을 분석하여 강한 항산화능을 보유한 5종(Apios fortunei Maxim., Colubrina arborescens Sarg., Croton caudatus Geiseler, Osmanthus matsumuranus Hayata 그리고 Schima noronhae Reinw.)을 선별하고, 각 추출물의 항산화 활성을 시험관 분석법, 세포실험 모델계, 대상 단백질 발현 분석 등을 통해 평가하였다. 먼저 각 추출물의 항산화 활성을 DPPH 라디칼 소거능을 통해 분석한 결과 모두 양성 대조군으로 사용한 아스코르빈산과 유사한 정도의 높은 활성을 보여 각 소재가 매우 강한 항산화능을 보유함을 확인하였다. 또한 RAW 264.7 세포주에서 H₂O₂에 의해 유도된 ROS에 대한 각 추출물의 소거능을 분석한 결과에서도 농도의존적인 강한 소거능을 보였다. 뿐만 아니라 대표적인 항산화효소 중 하나로 항산화능 보유 천연물에 의해 발현이 유도되는 HO-1 및 그 전사인자인 Nrf2의 단백질 발현이 각 추출물의 처리에 의해 증가됨을 보였다. 이러한 결과를 통해 5종 식물 추출물의 강한 항산화 활성을 처음으로 확인하였으며 향후 기능성 소재로서 유용하게 활용될 수 있을 것으로 판단된다. This study was orchestrated with the purpose of uncovering new nutraceutical resources possessing biological activities in the plant kingdom. To fulfill our objective, we analyzed several plant extracts and selected five species possessing powerful anti-oxidative activity. The anti-oxidative effect of these five plants, Apios fortunei Maxim., Colubrina arborescens Sarg., Croton caudatus Geiseler, Osmanthus matsumuranus Hayata and Schima noronhae Reinw. ethanol extracts were then evaluated by using in vitro assay, cell model system, and Western blot analysis of target proteins. As the results, all of them possessed the potent scavenging activity against 1,1-diphenyl-2-picryl hydrazyl (DPPH), similar with that of ascorbic acid, used as a common positive control. Moreover, they strongly inhibited hydrogen peroxide (H₂O₂)-induced reactive oxygen species (ROS), in a dose-dependent manner, in RAW 264.7 murine macrophage cells. Furthermore, they induced the protein expression of an anti-oxidative enzyme, heme oxygenase 1 (HO-1), and its upstream transcription factor, nuclear factor-E2-related factor 2 (Nrf2). Taken together, these results indicate that these five plants possess potent anti-oxidative activity and thus appear to be useful sources as potential anti-oxidant agents. Therefore, they might be utilized as promising materials in the field of nutraceuticals.
이수현 ( Soo Hyun Lee ),노미령 ( Mi Ryung Roh ),정기양 ( Kee Yang Chung ) 대한피부과학회 2012 대한피부과학회지 Vol.50 No.5
Squamous cell carcinoma (SCC) of the nail bed is rare, and it usually mimics a variety of diseases. Thus, a true diagnosis of subungual SCC may be delayed for years. The appearance of a subungual tumor at presentation is often non-diagnostic, and exploratory nail-plate removal with biopsy is recommended. We have experienced four patients with subungual SCC, and they were treated by Mohs micrographic surgery (MMS). In an average follow-up of 13.5 months, there was no recurrence in all cases. However, in one case, amputation was performed due to local periosteal invasion. In cases of subungual SCC without bone involvement, particular virtue of MMS over amputation is that it permits the preservation of both function and cosmesis of the nail unit. Since the maintenance of function is of the utmost priority, MMS can be considered the most appropriate technique, as it enables us to maximize the preservation of normal anatomy of the finger. (Korean J Dermatol 2012;50(5):425∼431)