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한용남(Y. N. Han),이근억(K. E. Lee),최국지(K. C. Choi),천병익(B. I. Chun) 한국생약학회 1981 생약학회지 Vol.12 No.1
세포표면이나 생체막에 존재하는 복합당질은, 각종 면역현상, 염증, 세포융합, 보체결합, 암화, 암전이, 바이러스 감염 등의 여러 현상에 중요한 역할을 하고 있으며, 이러한 복합당질을 가수분해하는 효소가 동물의 뇌, 간의 리소즘, 마크로파지, 세균 등에서 분리되어 그 성상이 알려지고 있다. 이러한 당 가수분해 효소의 저해제에 관한 연구를 목적으로, 본 연구에서는 우선 β-galactosidase를 선정하여 생약 150여종을 대상으로 저해 활성을 검색하였다.
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신원철,윤주천,김갑수,최승락,이근억,유주현 江原大學校 産業科學硏究所 1981 産業技術硏究 Vol.1 No.-
In order to use as a starter after drying, optimum growth conditions of Str. thermophilus and L. bulgaricus were investigated. The results were as follows. The growth of Str. thermophilus was reached at stationary phase after 12 hours incubation and L. bulgaricus was after 6 hours. Str. thermophilus was grown well, in the medium containing 10% of skim milk, 2%5 of sucrose, 0.1% of KCl and 0.015%(v./v.) of soy-sauce. In the case of L. bulgaricus, 10% of skim milk, 2% of glucose, 0.5% of bacto-peptone, 0.1% of K₂HPO₄ and 0.02% of pyridoxine was suitable for the maximum growth.
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Jeong Seok Kwon,이종석,신원철,이근억,홍억기 한국생물공학회 2009 Biotechnology and Bioprocess Engineering Vol.14 No.6
Both crude exo-biopolymers and mycelial biomass, produced by liquid culture of Cordyceps species, are believed to possess several potential health benefits. As a result of its known biological activities, Cordyceps militaris has been extensively characterized in regards to potential medicinal applications. However, optimized liquid culture conditions for enhanced polysaccharide productivity have yet to be developed, which is a necessary step for industrial applications. Therefore, in this study, the liquid culture conditions were optimized for maximal production of mycelial biomass and exo-polysaccharide (EPS) by C.militaris . The effects of medium composition, environmental factors, and C/N ratio were investigated. Among these variables 80 g, glucose; 10 g, yeast extract; 0.5 g, MgSO₄ ∙7H₂O; and 0.5 g, KH₂PO₄ in 1 L distilled water were found to be the most suitable carbon, nitrogen, and mineral sources, respectively. The optimal temperature, initial pH, agitation, and aeration were determined to be 24oC, uncontrolled pH, 200 rpm, and 1.5 vvm, respectively. Under these optimal conditions, mycelial growth in shake flask cultures and 5 L jar bioreactors was 29.43 and 40.60 g/L, respectively, and polysaccharide production in shake flask cultures and 5 L jar bioreactors was 2.53 and 6.74 g/L, respectively
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Immunostimulating Activity by Polysaccharides Isolated from Fruiting Body of Inonotus obliquus
Dong Pil Won,이종석,Duck Soo Kwon,이근억,신원철,홍억기 한국분자세포생물학회 2011 Molecules and cells Vol.31 No.2
In this study, we investigated the immunostimulating activity of polysaccharides isolated from fruiting body of Inonotus obliquus (PFIO). Additionally, the signaling pathway of PFIO-mediated macrophage activation was investigated in RAW264.7 macrophage cells. We found that PFIO was capable of promoting NO/ROS production, TNF-α secretion and phagocytic uptake in macrophages, as well as cell proliferation, comitogenic effect and IFN-γ/IL-4 secretion in mouse splenocytes. PFIO was able to induce the phosphorylation of three MAPKs as well as the nuclear translocation of NF-κB, resulting in activation of RAW264.7 macrophages. PFIO also induced the inhibition of TNF-αsecretion by anti-TLR2 mAb, consequently, PFIO might be involved in TNF-α secretion via the TLR2 receptor. In addition, our results showed that oral administration of PFIO suppressed in vivo growth of melanoma tumor in tumorbearing mice. In conclusion, our experiments presented that PFIO effectively promotes macrophage activation through the MAPK and NF-κB signaling pathways, suggesting that PFIO may potentially regulate the immune response.
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