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세로토닌 재흡수 억제제에 대한 아리피프라졸 및 부프로피온 부가요법의 우울증 세부증상에 대한 효과 비교 : 다기관, 개방표지, 무작위 연구
이가원,이광헌,박영우,이종훈,구본훈,이승재,성형모,천은진,Lee, Ga-Won,Lee, Kwang-Hun,Park, Young-Woo,Lee, Jong-hun,Koo, Bon-Hoon,Lee, Seung-Jae,Sung, Hyung-Mo,Cheon, Eun-Jin 대한불안의학회 2017 대한불안의학회지 Vol.13 No.2
우울증은 높은 유병률을 가지며 심각하고 만성화 될 수 있는 질병이다. 환자가 증상 없이 기능적 회복이 되어 일상을 영위하기 위해 임상가는 단독요법 이상의 치료 전략이 필요하다. 본 연구에서 SSRI와 aripiprazole 또는 bupropion 부가 요법은 우울증의 증상 호전을 보였다. SSRI와 aripiprazole 부가 요법은 우울증의 전반적 점수의 호전뿐 아니라 세부척도의 핵심 증상에서 bupropion 병합 요법에 비해 더 의미 있는 변화를 보였다. 또한 두 약제 모두 핵심 우울증상이라 할 수 있는 개별증상(우울한 기분, 일과 활동, 정신적 불안)에서 가장 큰 변화를 보였다 Objective : The purpose of this study was to examine the effects of adjunctive aripiprazole versus bupropion on specific symptoms of depression. Methods : Data were from 6-week, randomized, prospective, open-label multi-center study in 103 patients with major depressive disorders. Participants were randomized to receive aripiprazole (2.5-10 mg/day) or bupropion (150-300 mg/day) for 6 weeks. Change in four subscales of the 17-item Hamilton Depression Rating Scale (HAM-D17) that capture core depression symptoms was determined, and change in individual HAM-D17 items was also assessed. Changes in three composite subscales-anxiety, insomnia, and drive were also examined. Results : Within-group change in the four core subscales was large [effect size (ES)=1.30-1.47] and it was similar to that in the HAM-D17 total score. Differences between aripiprazole and bupropion were significant for each of the four core subscales and the HAM-D17 total score favored aripiprazole (p<0.001). On three composite scales, both treatments caused substantial changes in anxiety (within-group ES=1.10 (aripiprazole) vs. 1.00 (bupropion)], insomnia (ES=0.75 vs 0.50), and drive (ES=1.17 vs 1.15). Conclusion : This results suggested that both aripiprazole and bupropion adjunctive therapies with selective serotonin reuptake inhibitors resulted in significant and clinically meaningful changes in core symptom subscales for depression.
리스페리돈(Risperidone)을 투약 중인 정신분열병 환자에서 지프라시돈(Ziprasidone)으로 교체 투약 시 보이는 임상적 및 대사적 이득에 대한 전향적 개방 연구
이종훈(Jong Hun Lee),송진옥(Jin Ok Song),이승재(Seung Jae Lee),정성원(Sung Won Jung),구본훈(Bon Hoon Koo),이광헌(Kwang Heun Lee) 대한생물치료정신의학회 2009 생물치료정신의학 Vol.15 No.1
Objectives:The purpose of this study was to assess clinical effectiveness and metabolic benefits by switching from risperidone to ziprasidone in chronic stable schizophrenic patients. Methods:A total of 19 patients taking risperidone were switched to a 12-week, open label, flexible dose(80- 160㎎/day) of ziprasidone. Current psychiatric status was evaluated by Positive and Negative Syndrome Scale(PANSS), Clinical Global Impression(CGI), and Global Assessment of Functioning(GAF). Drug induced abnormal movements were assessed using various scales. Laboratory tests including lipid profiles, HbA1c, fasting plasma glucose and electrocardiography were carried out. Results:Of the 19 enrolled patients, 14 patients(73.7%) completed the study. Mean daily dose were 6.1±2.0㎎ for risperidone at the baseline and 123.1±8.1㎎ for ziprasidone at the end point of the study. Significant improvements were found on PANSS negative subscale scores(p<.05), with trends towards improved positive and psychopathology subscale scores. Among metabolic parameters, mean total cholesterol, triglyceride, and free fatty acid showed significant improvements(all ps<.05). In line with these findings, mean body weight and hip size significantly decreased from baseline(each p<.05). Regarding tolerability, frequency and severity of abnormal movements were not significantly different between two drugs. The ECG results showed no significant change from baseline in the QTc interval. Conclusion:Our findings supported the use of ziprasidone as a good option for the treatment of stable yet partially resolved outpatients with schizophrenia who has been taking risperidone continually, with benefits in efficacy particularly negative symptoms, reduction of body weight as well as hip size, and improvements in metabolic risk factors.
배나리(Na-lee Bae),이광헌(Kwang-hun Lee),이관(Kwan Lee),곽경필(Kyung-phil Kwak) 대한노인정신의학회 2015 노인정신의학 Vol.19 No.2
Objective:This study was aimed to investigate the efficacy of cognitive training in community-dwelling elderly, and to sup-port mental health care system for the elderly. Methods:We investigated 1,994 and aged over 65 years elderly visiting senior center from April 2014 to July 2014. Their de-mographic data was investigated. Cognitive functions were evaluated by Korean Version of Mini Mental Status Examination for Dementia Screening (MMSE-DS) and Global Deterioration Scale. Quality of life was evaluated by Korean Quality of Life-Alzheim-er’s Disease (KQoL-AD) and depression by Short Korean Form of Geriatric Depression Scale. Before and after cognitive training, we analysed these data. Results:MMSE-DS, KQoL-AD were significantly higher in score after the cogintive training than before of that (p<0.001). SGDS-K were significantly lower in score after the cognitive training than before of that (p<0.001). Conclusion:Cognitive training resulted in improvement in cognitive functions, quality of life and depression for community-dwelling elderly. These results suggest that future mental health care policy has to consider the importance of community-dwelling elderly.
Neonicotinoide계 농약 dinotefuran과 thiacloprid의 오이 중 잔류특성
이은영(Eun Young Lee),노현호(Hyun Ho Noh),박영순(Young Soon Park),강경원(Kyung Won Kang),이광헌(Kwang Hun Lee),박효경(Hyo Kyung Park),윤상순(Sang Soon Yun),진충우(Chung Woo Jin),한상국(Sang Kuk Han),경기성(Kee Sung Kyung) 한국농약과학회 2009 농약과학회지 Vol.13 No.2
This study was carried out to investigate the residue patterns of two neonicotinoid insecticides, dinotefuran and thiacloprid, commonly used for cucumber, were subjected to indicate a residual characteristic under greenhouse conditions. The pesticides were sprayed onto the crop at recommended and double doses 7 days before harvest and then sampling was done 0, 2, 3, 5, and 7 days after spraying. The amounts of their residues in the crop were analyzed with an HPLC. Their detection limits were 0.01 ㎎/㎏ for dinotefuran and 0.005 ㎎/㎏ for thiacloprid. Mean recoveries of dinotefuran and thiacloprid were from 85.78 to 89.52 and from 85.71 to 95.31%, respectively. Half-lives of dinotefuran and thiacloprid were 2.8 and 1.8 days at the recommended dose and 2.8 and 1.5 days at the doubled dose, respectively. The ratios of the EDI to ADI by intake the crop harvested 7 days after spraying were less than 0.1% of their ADIs.
이재윤(Jae Yun Lee),노현호(Hyun Ho Noh),이광헌(Kwang Hun Lee),박효경(Hyo Kyoung Park),오재호(Jae Ho Oh),임무혁(Moo Hyeog Im),권찬혁(Chan Hyeok Kwon),이중근(Joong Keun Lee),우희동(Hee Dong Woo),권기성(Ki Sung Kwon),경기성(Kee Sung Kyu 한국농약과학회 2012 농약과학회지 Vol.16 No.3
This study was carried out to evaluate the residual characteristics of azoxystrobin in fresh ginseng and calculate its processing factors in processed products, such as dried ginseng, red ginseng and their extracts. Azoxystrobin was sprayed annually onto four-year-old ginseng according to its pre-harvest interval (PHI) for two years. Harvested ginsengs were processed according to the commercially well-qualified conventional methods provided by the Korea Ginseng Corporation. Limits of detection (LODs) of azoxystrobin in fresh ginseng and its processed products were 0.001 and 0.002 mg/kg, respectively. Also limits of quantitation (LOQs) in fresh ginseng and its processed products were 0.003 and 0.007 mg/kg, respectively. Recoveries of the analytical methods in fresh ginseng and its processed products ranged from 69.3 to 114.8%. Highest residue amounts in fresh ginseng and its processed products were 0.025 and 0.118 mg/kg, respectively. Processing factors of the processed products ranged from 1.85 to 3.17 in four-year-old ginseng and from 2.48 to 5.84 five-year-old ginseng.
경상북도 거주 노인의 정신건강과 자살 위험인자에 관한 연구
김정령(Jeong Ryeong Kim),이광헌(Kwang Hun Lee),김상규(Sang Kyu Kim),곽경필(Kyung Phil Kwak),사공정규(Jeong Kyu Sakong) 대한생물치료정신의학회 2021 생물치료정신의학 Vol.27 No.3
Objectives:The purpose of this study was to identify suicide risk factors among elderly residents in Gyeongsangbuk-do and to reveal the relationships between them. In addition, the differences in suicide risk factors were analyzed between the cognitively impaired group and the cognitively normal group. Methods:We investigated 20,127 elderly over 65 years of age, from January 2019 to December 2019. Participants were asked to complete a questionnaire survey. Cognitive function, depression, anxiety, sleep disturbance, and suicidal ideation data were assessed using a Korean version of the Mini-Mental Status Examination for Dementia Screening (MMSE-DS), Short Geriatric Depression Scale for Korean version (S-GDS), Geriatric Anxiety Inventory (GAI), Athens Insomnia Scale (AIS), and Scale for Suicidal Ideation (SSI). Data were analyzed using the chi-squared test and logistic regression analysis to examine suicide risk factors and the relationships between them. Furthermore, differences in suicide risk factors according to cognitive function were examined. Results:Age, cognitive function, depression, anxiety, and sleep disturbance were identified as suicide risk factors among elderly residents in Gyeongsangbuk-do. Depression was the factor that increased risk of suicide the most, followed by anxiety, impaired cognitive function, sleep disturbance, and 65-74 years of age. In addition, depression increased risk of suicide by 1.86 times in the cognitively impaired group. Conclusions:Among elderly residents in Gyeongsangbuk-do, depression was the factor that contributed the highest risk for suicide. More active prevention and treatment measures for depressive symptoms should be implemented in the cognitively impaired group.
Bifenthrin과 Imidacloprid의 호박 중 잔류특성
이은영(Eun Young Lee),노현호(Hyun Ho Noh),박영순(Young Soon Park),강경원(Kyung Won Kang),이광헌(Kwang Hun Lee),이재윤(Jae Yun Lee),박효경(Hyo Kyung Park),윤상순(Sang Soon Yun),진충우(Chung Woo Jin),한상국(Sang Kuk Han),경기성(Kee Sun 한국농약과학회 2009 농약과학회지 Vol.13 No.2
In order to elucidate the residual characteristics of the insecticides, bifenthrin and imidacloprid, the pesticides were sprayed onto the squash and their residues were analyzed with GC-ECD and HPLC. Detection limits of the pesticides were 0.005 ㎎ ㎏<SUP>-1</SUP> and recoveries of bifenthrin and imidacloprid in squash were from 100.87 to 104.31, and from 79.71 to 92.54%, respectively. Half-lives of bifenthrin and imidacloprid in squash were from 1.8 to 2.9 and from 1.5 to 2.5 days, respectively. Initial concentration of bifenthrin and imidacloprid sprayed at the recommended rate and double rate of recommendation were less than their MRLs. And also, residueal concentrations of the pesticides were rapidly decreased in squash with time. At harvest, estimated daily intakes (EDIs) of the pesticides were less than 0.6% of their acceptable daily intakes (ADIs).
청주지역 도매시장과 재래시장 유통 엽채류 중 농약의 잔류 특성
노현호(Hyun Ho Noh),이광헌(Kwang Hun Lee),이재윤(Jae Yun Lee),박효경(Hyo Kyoung Park),박소현(So Hyun Park),김선호(Sun Ho Kim),경기성(Kee Sung Kyung) 한국농약과학회 2011 농약과학회지 Vol.15 No.4
This study was carried out to survey the residual characteristics of pesticides and assess their safety. Nineteen agricultural commodities, collected from wholesale and traditional markets in Cheongju. Nineteen agricultural commodities including perilla leaves were collected from the markets on October 29th, 2010. Total 240 pesticides which can be analyzed by multiresidue analysis method by GLC and HPLC were monitored and the pesticides detected were confirmed by GC-MSD and LC-MS. Five pesticides, alachlor, bifenthrin, endosulfan, procymidone and triflumizole, were detected from five samples, such as welsh onion, leek and celery in case of wholesale market and perilla leaves and welsh onion in case of traditional market. Detection rate of 13.2% was obtained as a result of pesticide analysis but 2.6% of the pesticides detected exceeded their maximum residue limits. The estimated daily intakes (EDIs) and maximum permissible intakes (MPIs) of the pesticides detected were less than 26% and 0.05% of their acceptable daily intakes (ADIs) respectively, representing that residue levels of the pesticides detected would be safe.
시설재배 토양 중 내분비계장애 추정농약의 잔류 모니터링 및 지하수 용탈 가능성
노현호(Hyun Ho Noh),이광헌(Kwang Hun Lee),이재윤(Jae Yun Lee),박효경(Hyo Kyung Park),이은영(Eun Young Lee),홍수명(Su Myung Hong),박영순(Young Soon Park),경기성(Kee Sung Kyung) 한국농약과학회 2011 농약과학회지 Vol.15 No.4
This study was carried out to survey the residual characteristics of endocrine dismptor (ED)-suspected pestic in greenhouse soils and assess their leachabilites to groundwater. Greenhouse soils were collected from 40 sites of greenhouse in 2008 in Korea. Sixteen ED-suspected pesticides which had been using in Korea, such as alachlor, benomyl, carbaryl, cypermethrin, 2,4-D, dicofol,endosulfan, fenvalerate, malathion, mancozeb, metribuzin, metiram, methomyl, parathion,trifluralin, and vinclozolin, in the soils, were analyzed by chromatographic methods using GLC-ECD and HPLC-DAD/FLD. Limits of detection (LODs) of the test pesticides ranged from 0.0004 to 0.005 mg/kg. Recoveries of the target pesticides from soil ranged from 72.69 to 115.28%. Four pesticides including cypermethrin were detected in the range of from 0.001 to 2.019 mg/kg, representing that their detection rate from greenhouse soils was 37.5%. The highest detection rate was observed from endosulfan which was detected from 16 site soils of the total samples, indicating that endosulfan is persistent in soil because of its very low mobility and high adsorption characteristics in soil. Based on the groundwater ubiquity scores (GUSs) of the pesticides detected from greenhouse soils, most of them have little possibilities of groundwater contamination except the fungicide vinclozolin with some leaching potential because of high water solubility and very low soil adsorption property.
유통 친환경 엽채류와 엽경채류 중 잔류농약 실태조사 및 안전성 평가
이재윤(Jae Yun Lee),노현호(Hyun Ho Noh),이광헌(Kwang Hun Lee),박소현(So Hyun Park),경기성(Kee Sung Kyung) 한국농약과학회 2012 농약과학회지 Vol.16 No.1
In order to monitor the levels of pesticides in environment-friendly stalk and stem vegetables and leafy vegetables selling at markets in Korea. A total of 637 (395 organic agricultural products, 242 pesticide-free agricultural products) samples of 21 stalk and stem vegetables and leafy vegetables were collected twice from markets in July and August 2010 in Korea. Pesticide residues in samples were analyzed by multiresidue method for 240 pesticides using GC-ECD/NPD and HPLC-DAD/FLD. The suspected-pesticides were confirmed with a GC-MSD. As a result of analysis, six pesticides were detected from eight samples, representing a detection rate of 1.3% and amounts of pesticide residues in samples were as follows: alachlor 0.043, chlorfenapyr 0.022-0.324, diazinon 0.024, dicofol 0.009-0.138, dithiopyr 0.008, metolachlor 0.025 mg/kg. Their residue levels were below the MRLs. Estimated daily intakes (EDIs) of the pesticides detected from stalk and stem vegetables and leafy vegetables were less than 25% of their acceptable daily intakes (ADIs), representing that residue levels of the pesticides detected were evaluated as safe for consumption. However, five samples containing pesticide residues were unsuitable environment-friendly products because of pesticides detected more than their 10% MRLs in organic and pesticide-free agricultural products.