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하부위장관 기능장애 치료의 한의학적 접근방법에 관한 연구
이건업,원진희,문구,문석재,류수택,Lee, Gun-Up,Won, Jin-Hee,Moon, Gu,Moon, Seok-Jae,Ryu, Su-Taek 대한한방내과학회 2000 大韓韓方內科學會誌 Vol.21 No.1
Irritable Bowel Syndrome(IBS) is the most common disease in the western male, and it is founded in $70{\sim}80%$ patient who has Gastrointestinal trouble. It is characterized by the formation of disorders of Gastrointestinal tract, for example, constipation, diarrhea, abdominal pain& discomfort, stool urgency, and so on. The etiology of IBS is uncertain, but the majority of patients has emotional problems. The aims of this study are to investigate and summarize the current trends of treatment for IBS so as to suggest the effective and available way to treat this disease. In Oriental Medicine, the IBS is recognized as Stagnation of the Iiver-qi(肝氣鬱結), Incoordination between the liver and the stomach(肝胃不和). So the point of treatment of IBS is Invigorating the spleen and relieving the depression of Iiver-qi(疏肝健脾), Regulating the function of the liver and the flow of qi(調肝理氣), Regulating the stomach and lowering the adverse flow(和胃降逆), and the treatment can be approached in several ways through herb drugs, acupuncture. Some of the herb drugs have substances which promote gastric and small intestinal emptying. Acupuncture and moxibustion therapies stimulate the meridian points of LR(足厥陰肝經), ST(足陽明胃經), LI(手陽明腸經), SI(手太陽小腸經) and is reported to be effective for releafing syndromes. Anal therapy, attachment of herb drug to umbilicus are annunced as the effective treatments. So, this study of the approach and application of these treatments on IBS would be necessary.
팔물탕합화적환(八珍湯合化積丸)의 항종양(抗腫瘍) 효과(效果)에 관(關)한 연구(硏究)
송봉길,이건업,원진희,문구,문석재,소홍섭,박래길,김성진,Song, Bong-Gil,Lee, Gun-Up,Won, Jin-Hee,Moon, Gu,Moon, Seok-Jae,So, Hong-Sup,Park, Rea-Gil,Kim, Sung-Jin 대한한방내과학회 2000 大韓韓方內科學會誌 Vol.21 No.1
Objectives : The effects of cotreatment of adriamycin and ethanol extract of herb (Palgin-tang hab Hwajuck-hwan a traditional medicine for cancer treatment in oriental medicine) on the induction of apoptotic cell death were investigated in human liver origin cell lines, Chang. Methods : Chang(ATCC) liver cells were cultured in RPMI-1640(Gibco SRL Co, Gaithersburg, MD) badge including 10% fetal bovine serum. Chang liver cells were treated with various concentrations(from 10 to $0.16{\mu}l$) of adriamycin and herb extract(from 500 to $31.25{\mu}l$) After 48h later, the cells were tested for viability by Crystal violet staining assay. Adriamycin and Herb extract induced ladder pattern of DNA fragmentation in Chang cells. Genomic DNA was isolated and separated on 1.5% agarose gels. The DNA was stained with ethidium bromide and visualized under UV light. Results : The death of Chang cells was synergistically induced by the cotreatment of adriamycin and ethanol extract of herb. In addition, the cotreatment-induced cell death of Chang cells was mediated by apoptotic death signal processes. The phosphotransferase activity of JNK1 remained in a basal level in Chang cells which was treated individually with the adriamycin and ethanol extract of herb. However, it was markedly increased in Chang cells which was cotreated with adriamycin and ethanol extract of herb. In addition, the expression of Fas and FasL was markedly induced by the cotreatment of adriamycin and herb extract. For a while, the expression of Sax was a eminently increased by the ethanol extract of herb. However, Scl2 expression was not affected by the individual or cotreatment of adriamycin and herb extract. Conclusions : our results suggest that the cotreatment of adriamycin aM ethanol extract of herb induces synergistic apoptotis of human liver origin Chang cells via the upregulation of JNK, Fas, FasL and Bax.
조정연,원진희,강태희,이건업,송봉길,이상관 대한한방성인병학회 2000 韓方成人病學會誌 Vol.6 No.1
Systemic contact dermatitis may be produced by the systemic administration of a drug to an individual who has been previously sensitized by the topical application of the drug or related chemicals. Rhus is a hot and a warm property, and is toxic. In Korea, Combination of the rhus and chicken, as a traditional food, has been used for the treatment of diseases such as gastrointestinal disorders(peptic ulcer, gastritis etc), stomach chill, general weakness and so forth. We treated a 31 year-old male patient who complained of fever, chilling, itching, burning pain, edema and vesicle etc. he had frequent rhus dermatitis and took rhus with chicken before above symptoms occurred. He was diagnosed as systemic contact dermatitis due to rhus, and responded well to treatment with Hwabanhaedok-tang(化斑解毒湯) and steroid drug(predinisolone) etc.