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수종의 페니실린들이 안지오텐신 변화효소 활성에 미치는 영향
윤혜숙,정성현,한병훈 ( Hye Sook Yun ( Choi ),Sung Hyun Chung,Byung Hoon Han ) 생화학분자생물학회 1982 BMB Reports Vol.15 No.2
Thirteen different penicillins and cephalosporins were tested against the activities of angiotensin converting enzyme(ACE). Pivampicillin and talampicillin showed mild inhibitory activities against ACE. The inhibitory activities were confirmed by observing that pivampicillin and talampicillin inhibited the contractions induced by angiotensin I but not the contractions by angiotensin II on isolated rat ileum. Penicillins and cephalosporins cephalosporins have some resemblance on their chemical structure to captopril, one of the most potent inhibitory of ACE. However, the result showed that the overall structure of penicillins and cephalosporins are unfavorable for the compounds to be inhibitory to ACE. On the other hand, esterification of the free acid resulted in increase the inhibitory activities.
HPLC 및 GC/MSD를 이용한 식물 중의 Higenamine 함량 분석
윤혜숙,서영배,한영희,송윤선,류재천,정교순,YunChoi, Hye-Sook,Suh, Young-Bae,Hahn, Young-Hee,Song, Yun-Seon,Ryu, Jae-Chun,Chung, Kyo-Soon 한국생약학회 1998 생약학회지 Vol.29 No.2
Higenamine is known as a cardiotonic principle of Aconiti tuber. The analytical procedures were established for the detection of higenamine in plants. The amounts of higenamine in several Aconiti tubers and the embryo of Nelumbo nucifera, another plant species known to contain higenamine, were determined. The $H_2O$ soluble fraction prepared from MeOH extract was first treated with AD-2 resin and then applied to either HPLC or GC/MSD systems. With HPLC, $6.4{\sim}19.2\;{\mu}g/g$ of higenamine were detected from various Aconiti tubers and $182.3\;{\mu}g/g$ of higenamine from the embryo of Nelumbo nucifera. The results obtained with GC/MSD also provided comparable data with those obtained with HPLC.
Phenylacetates 의 Acetylcholinesterase 에 의한 가수분해
윤혜숙,Yun, Hye-Sook 생화학분자생물학회 1974 한국생화학회지 Vol.7 No.1
Phenylacetate와 그 유도체의 acetylcholinesterase에의 한 hydrolysis 속도를 비교 측정하였다. Acetylcholine의 quaternary group과 같은 trimethylammonium을 o- 나 p-위치에 넣을경우 phenylacetates의 hydrolysis 속도는 빨라졌지만 m-위치에 trimethylammonium을 넣을경우 hydrolysis 속도는 매우 느려졌다. ter-butyl group은 cationic charge를 갖지 않은 trimethylammonium의 carbon analog 이지만 m-position에 넣은경우 hydrolysis 속도는 빨라졌다. The hydrolysis rates of o-, m- and p-trimethylammonium phenylacetates by acetylcholinesterase were compared in relation with phenylacetate and m-ter butyl phenylacetate. o- or p-Trimethylammonium and m-ter butyl substitution gave favorable effect on the hydrolysis by the enzyme. However, the hydrolysis rate of phenylacetate was decreased with the m-trimethylammonium substitution which makes the compound most sterically resemble to acetylcholine, the natural substrate of acethylcholinesterase. It appears that trimethylammonium group increased the hydrolysis rate by the enzyme not by having electrostatic interaction with the anionic site of the enzyme but by stabilizing the phenoxy ion by electron attracting properties of the group.
Effects of Some Penicillins on Angiotensin Converting Enzyme
윤혜숙,정성현,한병훈,Yun, Hye-Sook,Chung, Sung-Hyun,Han, Byung-Hoon 생화학분자생물학회 1982 한국생화학회지 Vol.15 No.2
Penicillin 및 Cephalosporin들이 안지오텐신 변환효소(ACE) 활성에 미치는 영향을 검사하였다. 검사한 13종의 약물중 talampicillin 및 pivampicillin은 ACE에 저해작용을 나타내었으며 이들 talampicillin 및 pivampicillin의 ACE활성에 대한 저해작용은 rat의 적출장관 실험으로도 확인할 수 있었다. 즉 angiotensin I에 의한 장관의 수축은 Pivampicillin 및 Talampicillin에 의해 저해되었으나 angiotensin II에 의한 장관수축은 영향을 받지 않았다. Penicillin 및 cephalosporin들은 강력한 ACE 저해제의 하나인 captopril과 구조적으로 유사점을 갖이고 있으나 실험결과 penicillin 및 cephalosporin의 전체구조는 ACE 저해작용을 나타내기에 적합하지 않은 것으로 판명되었다. 그러나 free corboxylic acid를 esterification 하였을때 저해작용이 상승함을 관찰할 수 있었다. Thirteen different penicillins and cephalosporins were tested against the activities of angiotensin converting enzyme(ACE). Pivampicillin and talampicillin showed mild inhibitory activities against ACE. The inhibitory activities were confirmed by observing that pivampicillin and talampicillin inhibited the contractions induced by angiotensin I but not the contractions by angiotensin II on isolated rat ileum. Penicillins and cephalosporins cephalosporins have some resemblance on their chemical structure to captopril, one of the most potent inhibitory of ACE. However, the result showed that the overall structure of penicillins and cephalosporins are unfavorable for the compounds to be inhibitory to ACE. On the other hand, esterification of the free acid resulted in increase the inhibitory activities
윤혜숙(Hye Sook Yun-Choi),유경숙(Kyung Sook Yoo),이숙연(Sook Youn Lee),이연희(Youn Hee Lee),곽의종(Wie Jong Kwak),김기협(Ki Hyup Kim) 한국생약학회 1990 생약학회지 Vol.21 No.4
Crude Aconiti Tubers were irradiated with microwave for 5 or 10 min with or without NaHCO₃. Ten min-irradiation reduced the contents of aconitine and mesaconitine to the level of those of commercially available processed Aconiti tuber power which is prepared with the high pressure-high temperature technique. The contents of benzoylaconine of the 10 min-irradiated Aconiti tubers were also comparable to those of commerciallized processed Aconiti tuber powder. However, irradiation with 1%o NaHCO₃ soln. resulted in the drastic reduction of all the three above alkaloids.
윤혜숙(Hye Sook Yun-Choi),김제훈(Jae Hoon Kim),이종난(Jong Ran Lee) 한국생약학회 1986 생약학회지 Vol.17 No.1
As a continuation of the previous work, a second group of sixty solvent fractions prepared from twenty plant species were screened for their inhibitory effects on adenosine 5`-diphosphate (ADP)-, arachidonic acid (AA)- or collagen-induced rat platelet aggregation. The results suggested that five plant species including Angelica koreana, Cassia obtusifolia, Gastrodia elata, Paeonia lactiflora and Salvia miltiorrhiza are potential sources of inhibitors of platelet aggregation.
윤혜숙(Hye-Sook Yun),장일무(Il-moo Chang) 한국생약학회 1980 생약학회지 Vol.11 No.1
보간성 생약, 차전자의 보간효과를 나타내는 분획인 물분획으로부터 C<sub>12</sub>H_(20)O_(10) m.p 186°의 disaccharide를 분리하였으며 그 구조는 6-0-(3`,6`-anhydro-glucosyl)-glucose로 추정하였다.
윤혜숙(Hye Sook Yun-Choi),이종란(Jong Ran Lee),이희주(Hee Joo Lee),윤성미(Sung Mee Yun),이선(Sun Lee) 대한약학회 1987 약학회지 Vol.31 No.1
The preparation of substituted benzoylamino acids and mercaptoacylamino acids as inhibitors of angiotensin converting enzyme is described. The bulky phenyl ring directly attacted to an amino acid as of benzoylamino acid seemed unsuitable for the inhibitory activities. Among the mercaptosuccinylamino acids, L-proline was more favorable than L-phenylalanine while S-acetylation was unfavorable.
강간제로 사용된 생약의 조사연구(Ⅴ) : 백술 및 용담의 강간효과에 관한 연구
윤혜숙(Hye Sook Yun),유재천(Jae Chun Yu),장일무(Il Moo Chang) 한국생약학회 1981 생약학회지 Vol.12 No.1
Methanol extracts of the roots of Atractylodes japonica (alba) (Compositae) and Gentiana scabra (Gentianaceae) were further fractionated with n-butanol, chloroform, n-hexane and water. Then each fraction was p.o. administered to an animal model of hepatitis caused by CCl₄ intoxication. Measurements of sleeping time of mice induced by hexobarbital administration indicated that n-butanol and chloroform fractions of Atractylodes japonica (alba), and chloroform and n-hexane fractions of Gentiana scabra showed significant liver protective activities. Measurements of the activities of serum transaminase, S-GOT and S-GPT appeared to support these results.