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윤준혁(Joon Hyeok Yoon),김도원(Do Won Kim),전재복(Jae Bok Jun),정상립(Sang Lip Chung) 대한피부과학회 1994 大韓皮膚科學會誌 Vol.32 No.5
Background : The changes in lipid composition during epidermal differentiation has been reported in human and animal models. Because of the difficulties in getting adeguate specimens from human subjects, the authors used easily obtainable circumcised prepuce for lipid analysis. Objective : To investigate the changes in lipid composition duriig cornification of the epidermis, the lipid compositions of whole epidermis and stratum corneum were analyzed by thin layer chromatography(TLC). Methods : From circumcied prepuce whole epidermis and stratum orneum were separated by 10mM EDTA(ethylene diamine tatraacetate) in PBS(phosphate-buffered saline) or heat(60C), and 0.5% trypsin in PBS respectively. Lipids were extracted with methanolctloroform-HO mixture(4:2:1.6, v/ v, Bligh-Dyer solvent), TLC was performed and lipid composition was quantitated by photodensitometer. Results : In the composition of stratum corneum lipids, sphingoliids were the highest(33.3+2.9%) followed by cholesterol, free fatty acids and cholesterol esters in cleceasing order, there were small percentages of triglycerides, cholesterol sulfate and squalene. Conclusion : In this study the lipid composition of epidermis was similar to that of stratum corneum rather than those of previous reports on epidermal lipids, which may indicate the regional characteristics of epidermal/stratum orneum lipids in hyperkeratotic prepuie. (Kor J Dermatol 1994;32(5):778-786)
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나종희(Jong Hee Na),윤준혁(Joon Hyeok Yoon),전재복(Jae Bok Jun),김도원(Do Won Kim) 대한피부과학회 1994 대한피부과학회지 Vol.32 No.1
Blue rubber bleb nevus syndrome is a rare disease of cutaneous hemangioma of a variant of the carvenous type which is clinically characterized by multiple, protutert nt, dark blue, generally soft, rubbery, and compressible cutaneous masses usually sssocia
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윤준혁,김도원,전재복,정상립 慶北大學校 醫科大學 1995 慶北醫大誌 Vol.36 No.1
목적 : 전풍(Tinea versicolor)은 특히 여름철에 흔한 피부에 표재성 진균 감염증으로 Malassezia furfur에 의해 발생한다^3,5,18). 본 증은 피지선의 활동이 왕성해지는 사춘기 이후 호지성(好脂性) 진균에 의해 지루부위에 호발하기 때문에 피부 표면 지질의 조성이 정상인과 차이가 있을 것으로 생각할 수 있으나, 그 변화는 대체로 없거나 뚜렷하지 않은 것으로 알려져 있으며^6,16) 최근에는 이에 대한 자세한 보고가 없다. 저자들은 여름철에 호발연령군 전풍환자의 호발부위에서 피부 표면 지질을 채취, 분석하여 그 조성 성분을 동일 조건의 정상인과 비교해봄으로써 본 중과 피부 표면 지질조성의 관계를 규명해보고자 본 연구를 시행하였다. 대상 및 방법 : 1993년 6월과 7월에 경북대학교병원 피부과와 칠곡 가톨릭피부과의원을 방문한 전풍환자 중 청년 20명과 정상인 청년 20명에서 Downing 등의 ring/cup 법을 이용하여 피부 표면지질을 채취한 다음 thin layer chromatography(TLC)와 Photodensitometer로 그 조성 성분을 분석하고 정상인과 비교하였다. 결과 : 1) 전풍환자의 피부 표면 지질 조성은 squalene이 21.3±2.3%로 가장 많았으며, cholesterol esters 24.3±2.6%, triglycerides 12.9±4.0%. free fatty aceds 11.7±3.1%, cholesterol 13.0±2.2%, sphingolipids 9.6±2.2%, cholesterol sulfate 1.6±0.8%이었다. 2) 정상인의 피부 표면 지질 조성은 squalene 21.4±4.1%, cholesterol esters 25.2±3.0%, triglycerides 11.3±3.7%, free fatty acids 14.9±3.7% , cholesterol 11.6±1.8%, sphingolipids 8.4±3.9%, cholesterol sulfate 1.7±1.0%이었다. 3) 전풍환자가 정상인에 비해 free fatty acids는 유의하게 낮게(P<0.01), cholesterol은 유의하게 높게(P<0.05) 나타났으며, 나머지 지질성분은 유의한 차이가 없었다. 결론 : 전풍 환자의 피부 표면 지질 조성은 정상인과 큰 차이는 없으나 free fatty acids와 cholesterol은 차이를 보이므로 앞으로 지방산의 성분 분석을 포함한 자세한 연구가 필요하리라 사료된다. To investigate the importance of skin surface lipids in the pathogenesis of tinea versicolor, the compositions of skin surface lipids were analyzed by thin layer chromatography(TLC). Skin surface lipids were extracted from the back of patients with tinea versicolor and normal controls by the ring method using organic solvents(Acetone:Ether=1:1, v/v), TLC was. performed and lipids composition were quantitated by photodensitometer. In the compositions of skin surface lipids in patients with tinea versicolor, free fatty acids were lower(P<0.01) and cholesterol was higher(P<0.05) than those of normal controls respectively. However, other compositions of skin surface lipids including squalene, cholesterol esters, triglyce-rides, sphingolipids and cholesterol were not significantly different in both group. Low free fatty acids in this study may reflects the proliferation of yeast forms of Pityrosporum orbiculare therefore, further investigations will be needed.
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Amphotericin B 크림 밀봉요법으로 치유된 색소분아진균증 1예
김성화,오수희,최성관,이영헌,윤준혁,방용준,서순봉 대한의진균학회 2000 대한의진균학회지 Vol.5 No.3
We report a case of chromoblastomycosis in a 65 year-old woman. She had a 3×4 cm sized, annular, erythematous, plaque with crusts and ulcers on the right lower arm. The lesion had grown slowly for 2 years. In fungal and histopathologic examinations, several muriform cells were found in dermis as well as in scales and crusts on the lesional skin surface. Isolated fungus was identified as Fonsecaea pedrosoi. We treated the patient occlusive dressing of amphotericin B (3%) ointment for 8 weeks and achieved a good response without any evidence of recurrence. We propose that the occlusive dressing therapy of amphotericin B cream is a good modality among the various treatments of small localized chromoblastomycosis. [Kor J Med Mycol 5(3): 144-149]
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