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진행성 비소세포폐암 환자에서 Vinorelbine과 Ifosfamide 복합화학요법의 효과 및 안정성
윤범,김선임,김응주,임충현,유영진,김성록 인제대학교 백병원 2001 仁濟醫學 Vol.22 No.2
Objective: The cisplatin-based combination chemotherapy can improve survival rates of unresectable non-small cell lung cancer. However, the toxicity of cisplatin is substantial. We assessed the efficacy and toxicity of vinorelbine and ifosfamide combination chemotherapy for the unresectable non-small cell lung cancer. Methods and Materials: Patients with unresectable biopsy-proven non-small cell lung cancer who had measurable lesion entered onto this study. From January 1998 to March 1999, 18 patients was enrolled onto this study, and the response was evaluable in 16 patients. The treatment consisted of vinorelbine 25 ㎎/㎡ on days 1 and 8 and ifosfamide 2 g/m2 with mesna 3 consecutive days from day 1. This schedule was repeated every 3 weeks. For patients with grade 4 myelosuppression, the dose of both vinorelbine and ifosfamide was reduced by 10% from the next cycle. Results: Partial response was observed in 7 patients (response rate: 41.1%, 95% C.I. 23.1∼66.8%) without complete response. The treatment-related mortality was observed in 1 patient, but the toxicities of this regimen were generally tolerable. Conclusion: Vinorelbine and ifosfamide combination chemotherapy was active and tolerable for inoperable non-small cell lung cancer.