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유진수,이교원,박재범,김성주 대한이식학회 2018 Korean Journal of Transplantation Vol.32 No.4
Background: This study was designed to analyze the clinical usefulness of mycophenolic acid trough concentration monitoring in kidney transplantation patients who were maintained with cyclosporine. Methods: The data of patients who underwent mycophenolic acid trough concentration monitoring after their first kidney transplant between November 2006 and August 2013 and were prescribed with cyclosporine, mycophenolate, and methylprednisolone were reviewed retrospectively. Cox analysis was used to analyze the risk factors for acute rejection within 1 year post-transplantation. Results: Among 90 patients, 41 (45.6%) achieved both the target levels of cyclosporine and mycophenolic acid, while three patients (3.3%) failed to achieve the target level of either cyclosporine or mycophenolic acid. Nine patients (10.0%) only achieved the mycophenolic acid target level and 37 patients (41.1%) only achieved the cyclosporine target level. While patients who achieved only the mycophenolic acid target concentration had no statistically increased risk compared to patients who achieved both target levels (hazard ratio [HR], 1.569; 95% confidence interval [CI], 0.316 to 7.778; P=0.581), patients who only achieved the cyclosporine target concentration showed an increased risk of rejection compared to the both achievement group (HR, 4.112; 95% CI, 1.583 to 10.683; P=0.004). Patients who had no achievement in the target levels showed significantly increased rejection risk compared to the patients who achieved both target levels (HR, 17.811; 95% CI, 3.072 to 103.28; P=0.001). Conclusions: Mycophenolic acid trough concentration monitoring combined with cyclosporine trough concentration monitoring is useful for avoiding acute cellular rejection if the first 1 year post-transplantation.
안전 영역 기반 자율주행 차량용 주행 경로 생성 및 추종 알고리즘 성능평가 연구
유진수,강경표,이경수,Yoo, Jinsoo,Kang, Kyeongpyo,Yi, Kyongsu 한국자동차안전학회 2019 자동차안전학회지 Vol.11 No.2
This paper describes the tracking algorithm performance evaluation for autonomous vehicle using a safety envelope based path. As the level of autonomous vehicle technologies evolves along with the development of relevant supporting modules including sensors, more advanced methodologies for path generation and tracking are needed. A safety envelope zone, designated as the obstacle free regions between the roadway edges, would be introduced and refined for further application with more detailed specifications. In this paper, the performance of the path tracking algorithm based on the generated path would be evaluated under safety envelop environment. In this process, static obstacle map for safety envelope was created using Lidar based vehicle information such as current vehicle location, speed and yaw rate that were collected under various driving setups at Seoul National University roadways. A level of safety was evaluated through CarSim simulation based on paths generated with two different references: a safety envelope based path and a GPS data based one. A better performance was observed for tracking with the safety envelop based path than that with the GPS based one.
유진수 대한의사협회 2020 대한의사협회지 Vol.63 No.5
The history of organ transplantation is limited to the last century. To overcome the barrier of the host immune system, which results in transplant rejection, the pioneers of transplantation achieved their first success by performing a kidney transplantation between identical twins. This achievement led the transplant clinicians to perform transplantations with immunological barriers present. Strategies such as whole-body irradiation combined with steroids yielded success in kidney transplantation between non-identical twins and siblings. However, owing to the toxicity related to irradiation, the paradigm shifted to the use of immunosuppressants. Azathioprine, steroids, and anti-lymphocyte globulin became the first multiple immunosuppressive regimens. With the introduction of cyclosporine, the 1-year survival rate increased by more than 80%. Cyclosporine, azathioprine, and steroids became the new standard maintenance regimens until the introduction of tacrolimus and mycophenolate mofetil, which replaced cyclosporine and azathioprine, respectively. The most recent change in immunosuppressants was the development of monoclonal antibodies with specific binding sites, such as CD20 (rituximab) and CD25 (basiliximab). With the innovation of molecular engineering and new insights into the costimulatory pathways, new molecules are under investigation in the field of transplantation.