Intravenous Toxicity Study of Water-soluble Ginseng Pharmacopuncture in SD Rats

유준상,선승호,이광호,권기록 대한약침학회 2015 Journal of pharmacopuncture Vol.18 No.4

Objectives: Radix Ginseng has been used for thousandsof years to treat a wide variety of diseases. Radix ginsenghas also been used as a traditional medicine for boostingQi energy and tonifying the spleen and lungs. Traditionally,its effect could be obtained orally. Nowadays, anew method, the injection of herbal medicine, is beingused. This study was performed to investigate the single-dose intravenous toxicity of water-soluble ginsengpharmacopuncture (WSGP) in Sprague-Dawley (SD)rats. Methods: All experiments were carried out at Biotoxtech,an institute authorized to perform non-clinicalstudies under the regulation of Good Laboratory Practice(GLP). At the age of six weeks, 40 SD rats, 20 male ratsand 20 female rats, were allocated into one of 4 groupsaccording to the dosages they would receive. The WSGPwas prepared in the Korean Pharmacopuncture Instituteunder the regulation of Korea-Good ManufacturingPractice (K-GMP). Dosages of WSGP were 0.1, 0.5 and1.0 mL/animal for the experimental groups, and normalsaline was administered to the control group. The rat'sgeneral conditions and body weights, the results of their hematological and biochemistry tests, and their necropsyand histopathological findings were investigatedto identify the toxicological effect of WSGP injected intravenously. The effect was examined for 14 days afterthe WSGP injection. This study was performed underthe approval of the Institutional Animal Ethics Committeeof Biotoxtech. Results: No deaths were found in this single-dose toxicitytest on the intravenous injection of WSGP, and nosignificant changes in the rat's general conditions andbody weights, the results on their hematological andbiochemistry test, and their necropsy findings wereobserved during the test. The local area of the injectionsite showed minial change. The lethal dose wasassumed to be over 1.0 mL/animal in both sexes. Conclusion: These results indicate that WSGP is safeat dosages up to 1 mL/animal.

Partial Convexification Based surrogate-RLT Cuts for 0-1 Integer Program

유준상,이영호 대한산업공학회 2014 대한산업공학회 춘계학술대회논문집 Vol.2014 No.5

빠른 2차 성징이 우려되는 여아에 대한 사상의학적 치험 5례

유준상,Yu, Junsang 사상체질의학회 2017 사상체질의학회지 Vol.29 No.2

Objectives Five cases of early puberty patients were diagnosed and treated according to Sasang constitutional medicine. Methods Seven year-old girl and four nine year-old girls visited the children's development clinic and were diagnosed as Sasang constitutional types according to clinical investigations. Their breast stages were in the 2nd degree of SMR(sexual maturity rating). Three were Taeeumin and two were Soeumin, so they were prescribed according to their Sasang constitutional types and complaints. Results and Conclusions It could show that early puberty patients can be given treatments and managements according to Sasang constitutional medicine.

사상의학의 예방의학사상

유준상 사상체질의학회 2018 사상체질의학회지 Vol.30 No.1

Objectives On the point of modern preventive medicine, Sasang Constitutional Meidicine(SCM) has the thoughts of preventive medicine. Modern preventive medicine has the three dimensional prevention; primary, secondary and tertiary prevention. The preventive thoughts of SCM concerning three dimensional prevention have been investigated in this article. Method Materials and references were collected about the prevention of SCM. Lee Jema’s books such as Donguisusebowon, Gyeokchigo and Donguisusebowon Chobonguen were included. Result and Conclusions As the primary prevention of SCM, Regimen according to ages, explanation according to health index as Myeongmaeksilsu(命脈實數), moderation of four ruinous causes such as intoxication, seduction, opulence and authority, adequate social life and control of 4 kinds of emotions(sorrow, anger, joy and pleasure) are included. As the secondary prevention of SCM, explanation according to disease index , fragile Organs and frequently acquired diseases according to constitutions are included. As the tertiary prevention of SCM, rehabilitation for the stroke patients according to constitutions is included. In conclusion, SCM has all of 3 dimensional prevention methods although that might be applied with modern considerate modification.

980nm InGaAs / GaAs / InGaAsP SL-SCH-SQW구조 LD의 파장 변화 특성 고찰 ( Wavelength Shift of 980nm InGaAs / GaAs / InGaAsP SL-SCH-SQW Ridge Waveguide Laser Diode )

유준상,이상호,양승기,고용태,김태일 한국통신학회 1993 한국통신학회 광전자공학 학술회의 Vol.2 No.-

사상처방엑기스제의 한방보험 급여화에 대한 제안

유준상,Yu, Jun-Sang 사상체질의학회 2011 사상체질의학회지 Vol.23 No.1

1. Objectives: Sixty eight kinds of single herbal medicine extracts and fifty six kinds of mixed herbal medicine extracts have been used under a national health insurance since 1987. The number of herbal medicine extracts under an insurance coverage remains unchanged. The demand for covering complex herbal medicine extracts and Sasang Constitutional medicine extracts in a national health insurance increases. This study is to investigate the needs for the insurance coverage. 2. Methods: Advantages and disadvantages between herbal medicine decoction and extracts were explained and Sasang Constitutional medicine extracts according to Sasang constitution were surveyed in production nowadays. 3. Results: Herbal medicine decoction has many advantages of treating patients but herbal medicine extracts have advantages of the rapid adminstration and being easy to carry. From eleven to twenty two products of Sasang Constitutional medicine extracts have been in production in several factories. There are eleven kinds of Soyangin medicine extracts, nine kinds of Taeeumin medicine extracts and five kinds of Soeumin medicine extracts. 4. Conclusions: Complex herbal medicine extracts and Sasang Constitutional medicine extracts have to be in use under a national health insurance as soon as possible.

체질침법 연구 경향을 통한 사상체질침법 정립에 관한 연구

유준상,한수지,안다영 사상체질의학회 2019 사상체질의학회지 Vol.31 No.3

Objectives Sasang Constitutional Medicine(SCM) is uniquely established in the field of Korean Medicine. Taegeuk Acupuncture(TGA) and Eight Constitution Acupuncture(ECA) which are created upon SCM are applied in clinics. However, there exists no established theory but hypothesis with regard to the composition of acupoints of constitution acupuncture. The purpose of this study was to help establish the Sasang constitution acupuncture(SCA) method. Methods Thirties studies were found on various Oriental medicine journals and 17 literatures with the key words relevant to constitution and acupuncture. Results For the principle of acupoint selection, 12 studies were included which were classified into TGA, ECA, SCA, other constitution acupuncture. Among 17 literatures, most of them were relevant to SCA. For the clinical studies, eight of total 13 using ECA were for musculoskeletal diseases. Conclusions Among studies and literatures chosen, the application of Saam’s acupuncture method was most frequently found in SCA method. For establishing the SCA method, the two main concepts need to be considered, which are the consideration of four areas namely Lungs, Spleen, Liver and Kidneys and upward-downward-loosening-tightening movement of the Qi according to Sasang constitution type.

은진송씨의 수원 만의 세거과정연구

유준상 국민대학교 한국학연구소 2018 한국학논총 Vol.49 No.-

은진송씨의 수원만의에서의 세거에 대한 연구는 두 가지 측면으로 나누어 설명하였다. 첫번째는 은진송씨의 만의 세거배경을 다루었다. 수원 만의는 송시열이 서울과 회덕을 오가며 머물던 장소였으며, 근기지역에 거주하는 문인들에게 영향력을 발휘하는 거점이었다. 또한 갑인예송, 현종·인경왕후·명성왕후가 죽었을 때 머물렀던 곳이기도 하였다. 또한 용인의 심곡서원과 충렬서원에 영향력을 행사하였다. 매곡서원의 건과 도봉서원의 송시열 향사는 송시열 후손의 경기세거에 바탕이 되었다. 두 번째는 송시열 후손들의 경기세거이다. 송회석은 송시열의 손자 중 유일하게 수원 만의에 묘가 들어섬으로서 송시열 후손의 경기세거의 단초를 마련하였다. 송무원은 외가가 있는 양평에서 성장하고 여주에서 세거하였다. 송덕상은 만산정사를 세워 수원 만의의 세거를 시작하였다. 송덕상은 이재, 김원행 등 노론 벽파인물들과 교류하고, 정조초반에는 정조와 홍국영의 신임을 받으며 중앙정치무대에 등장할 수 있었다. 홍국영의 실각이후 송덕상은 몰락하였지만 후손들은 수원 만의에서 묘역을 유지하였다. The study of the Suwon living of Song's family was explained in two ways. The first dealt with Song's background in the Bay of Ancients. Suwon Bay was the home of Song Si-yeol, who stayed in Seoul and around, and was an influential hub for writers living in the Geungi area. It was also the place where Queen Yessong Kapsong, Queen Hyeonjong, Queen Ingyeong, and Queen Myeongmyeong stayed when they died. In addition, the king exerted influence on Simgokseowon and Chungnyeol vows in Yongin. Song Siyeol Hyangsa of the Geogooseowon and Dobongseowon is based on the economic development of Song Si-yeol's descendants. The second is the race of Song Si-yeol's descendants. Song Hoe-seok is the only grandson of Song Si-yeol to have his tomb built in the Gulf of Suwon, creating nearly a short period of economic tax for his descendants. Song grew up in Yangpyeong with his mother's side and lived in Yeoju. Songdeoksang set up a Mansanjeong Shrine and began the Segeo Bay of Suwon. Song Deok-sang was able to enter the central political arena, interacting with Roh's critics such as Jae-ha and Kim Won-haeng, and receiving the trust of King Jeongjo and Hong Guk-young in the beginning of the Joseon Dynasty. After the fall of Hong Guk-young, Songdeoksang was ruined, but his descendants maintained the graveyard in the Suwon Bay.

특허에 기반을 둔 기술융합 분석

유준상,이희상 대한산업공학회 2013 대한산업공학회 추계학술대회논문집 Vol.2013 No.11

현재 전 세계적으로 기술의 융합은 과학기술 분야에서 메가트렌드를 형성하고 있으며 선진국에서는 자국이 보유한 강점 기술을 기반으로 하는 새로운 융합기술의 도출에 주력하고 있다. 이에 본 연구에서는 기술융합의 실질적 현상을 분석하기 위하여 명시화된 지식인‘특허’와 특허에 인용된 ‘논문’ 그리고 특허분류와 산업 분류체계 연계를 통한 산업군 분석을 하였다. 첫째, 융합기술에 영향을 끼친 과학 분야를 분석하기 위해 특허의 비특허 문헌(특허에서 인용된 논문)을 이용하였다. 인용된 저널과 과학 분야를 대분류와 소분류로 나누어 융합기술에 영향을 준 과학 분야를 파악하여 정량적으로 정리하였다. 둘째, 융합기술의 원천기술과 흐름을 살펴보기 위해 인용분석을 하였다. 이를 통해, 바이오인포매틱스 기술융합분야에 영향을 준 기술 분야를 찾아냄으로써 융합기술의 다양한 원천기술 분야들과 핵심 분야를 분석하였다. 셋째, 특허분류체계에 따라 각 기술 분야의 교차영향분석(Cross Impact Analysis)을 하였다. 융합기술 특허들이 분류 체계를 통하여 영향력 지수를 측정하고 융합이 일어나는 양상을 살펴보았다. 넷째, 융합기술과 산업과의 흐름을 분석하기 위해 국제특허분류-국제산업분류 연계표를 사용하였다. 이를 통해, 융합기술들이 산업에서는 어떠한 영역에 속하며 활용되고 있는지를 찾아냄으로써 향후 산업 융합의 가능성에 대해 살펴보았다. 이 연구를 통해 기술융합에 앞서 과학 분야가 기술 융합에 미치는 영향, 기술융합의 양상을 분석하고 원천기술분야를 확인하였다. 또한 기술융합에 있어 핵심기술과 도움을 주는 기술을 구분하여 융합의 본질적 특성을 파악하였다. 하지만 단순히 바이오인포매틱스 한 분야에 대해서만 분석을 하였기에 향후 다른 기술융합의 연구와의 비교가 필요하고, 이를 통해 더 일반화 된 연구결과를 얻을 수 있을 것이다.

소양인 소양상풍증으로 진단한 군발두통 환자 치험 1례

유준상,Yu, Jun-sang 사상체질의학회 2016 사상체질의학회지 Vol.28 No.4

Objectives The symptom of nineteen-year-old male patient who had cluster headache was alleviated using Soyangin's diagnosis and treatment. Methods This patient was diagnosed as Soyangin in terms of QSCC II(Questionnaire of Sasang Constitutional Classification II) and ordinary symptoms and current symptoms. The disease pattern was diagnosed as Soyang-sangpung symptomology. The intensity of headache was assessed by VAS(Visual Analogue Scale). Results and Conclusions The patient's symptom was improved using Hyeongbangsabaek-san, acupuncture treatment and cupping treatment.