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한국인 인슐린 비의존형 당뇨병 및 이차성 당뇨병 환자에서 글루코키나제 유전자 변이
남재현(Jae Hyun Nam),이현철(Hyun Chul Lee),김연의(Youn Euy Kim),권석호(Suk Ho Kwon),윤용석(Yong Suk Yoon),박석원(Suk Won Park),원영준(Young Jun Won),차봉수(Bong Su Cha),송영득(Young Duk Song),이은직(Eun Jig Lee),임승길(Sung Kil Lim) 대한내과학회 1998 대한내과학회지 Vol.54 No.6
Objectives: Mutations in the glucokinase (GCK) gene are considered a possible cause of maturity-onset diabetes of the young. The purpose of this study was to evaluate the contribution of this gene to the development of non insulin dependent diabetes mellitus (NIDDM), gestational diabetes mellitus (GDM) and post-renal transplantation diabetes mellitus (PTDM). Method: Identification of GCK mutation was attempted on 39 NIDDM patients, 2 GDM patients and 58 selected renal allograft recipients with PTDM and 45 normal controls. The exons in the GCK gene were examined by polymerase chain reaction (PCR), followed by analysis of single-stranded DNA conformational polymorphism (SSCP). The abnormal bands were also confirmed by DNA sequencing analysis. The exons of affected family members were also investigated for mutations of the GCK gene. Results: Two of the 58 PTDM patients (3.4%) were found to have CKK mutations. One had the mutation on exon 5 and the other on intron 7. One control subject had the mutation on intmn 9. The mutation of exon 5 was identified as a substitution of CCT (proline) for CTT (leucine) at codon 164, which has not ever reported before. The family members of the PFDM patient with mutation of exon 5 were analyzed by PCR followed by SSCP, and two of them revealed the same mutation. The abnormal band on the SSCP analysis of exon 7 was identified as the insertion of base C/T at the 39th nucleotide in intron 7. Two family members of this patients also had same band on SSCP. The one mutation of 45 normal controls was CT located at the 8th nucleotide in intron 9, which was a common polymorphism. Conclusion: We found GCK mutations in subjects with PTDM and we speculate that these mutations may be one of the contributing cause of PTDM.
질경이가 실험적으로 유발된 흰쥐의 위염 및 위궤양에 미치는 영향
원영준(Young Jun Won),나명순(Myung Soon Na),이명렬(Myung Yul Lee) 한국식품영양과학회 2004 한국식품영양과학회지 Vol.33 No.4
본 실험에서는 흰쥐에서 실험적으로 급성위염, 위궤양 및 십이지장궤양을 유발하고 질경이 에칠아세테이트분획을 투여하여 항위염 및 항위궤양작용에 미치는 영향을 검토하였던 바 다음과 같은 결과를 얻었다. 1. 질경이 에탄올추출물을 n-hexane, chloroform, ethylactae 및 n-butanol로 계통분획하고 농축하여 in vitro에서 항산화력을 측정한 결과 ethylacetate분획이 가장 우수하였다. 2. 질경이 에칠아세테이트분획(PEL 및 PEH)은 HCl-ethanol에 의한 위점막 손상에서 대조군(CON)에 비하여 각 용량별로 55.7% 및 62.1%의 유의적인 항위염작용을 나타냈으며, 특히 고용량투여군인 PEH의 경우 양성 대조약물투여군(60.5%)보다 우수한 효과를 나타냈다. 3. Indomethacin에 의해 유발된 위궤양에서, PEL 및 PEH는 양성 대조약물군인 CMT의 위궤양 억제율(61.6%)에는 다소 미치지 못하였으나 CON에 비하여 유의성있는 억제효과를 나타냈다. 4. Shay위궤양에서, 질경이 에칠아세테이트분획 200 ㎎/㎏을 십이지장에서 위내로 투여하였을 때 궤양억제율이 37.9%로 CON에 비하여 Shay위궤양을 억제하였으나 유의성있는 효과는 아니었으며 용량을 증량하여 투여한 PEH(400 ㎎/㎏)는 48.9%로 양성 대조약물인 omeprazol를 투여한 OMP의 저해효과(55.6 %)에 근접하였다. 5. 질경이의 에틸아세테이트분획을 용량별로 투여했을 때 위액의 pH가 대조군에 비해 약간의 감소되었으나 정상 범위내로 유의성은 인정되지 않았고 양성 대조약물군인 OMP는 유의적으로 위액의 pH를 유의성있게 감소시켰다. 위액량 및 총 위산분비량의 경우, 대조군에 비하여 PEL 및 PEH가 각각 33.8%와 38.7%의 감소효과를 나타냈으나 유의성은 없었으며 양성 대조약물인 omeprazol만큼 뚜렷한 효과는 볼 수 없었다. 6. Pepsin활성에서, 질경이 에틸아세테이트분획과 양성 대조약물투여로 pepsin 활성이 대조군에 비해 각각 약 17%, 22% 및 24%의 활성저해 효과를 나타냈으나 전군에서 유의성있는 변화는 아니었다. 7. 구속ㆍ수침스트레스에 의해 유발된 궤양의 경우, PEL 및 PEH에서도 출혈을 동반한 궤양이 관찰되었으나 CON에 비하여 궤양의 깊이가 다소 얕았지만 유의적인 효과는 아니었다. 양성 약물대조군의 경우 궤양의 형성이 CON과 PEL 및 PEH에 비하여 궤양형성의 부분이 다소 적었으나 점상출혈이 존재하였다. 8. Cysteamine에 의해 유발된 십이지장궤양에서, CMT가 52.2%의 유의한 궤양억제율을 나타냈고 PEH의 경우 유의성은 없었으나 약 43%의 궤양억제율을 나타냈다. Plantain has been used for antidiarrhea, antihemorrhage and the remedy of indigestion. Plantain was extracted with ethanol and fractionated systemically with n-hexane, chloroform, ethylacetate (EtOAC) and nbutanol. Antioxidant index (AI was expressed as induction period of oil containing various fractions/induction period of oil of 600 ppm) of EtOAC fraction was the highest among fractions in vitro. The protective effects of the EtOAC fraction of plantain (PE) administered 1 mL orally or intraduodenally on experimentally induced gastritis, gastric ulcer and gastric secretion were evaluated in rats. Sprague-Dawley rats weighing 250~300 g were divided into 4 groups; negative control group (CON), PE 200 ㎎/㎏ treated group (PEL), PE 400 ㎎/㎏ treated group (PEH) and positive control group (cimetidine 100 ㎎/㎏-CMT or omeprazol 100 ㎎/㎏ treated group-OMT), respectively. PE significantly suppressed HCl-ethanol induced gastric lesions and indomethacin-induced gastric ulcers (administered subcutaneouly) in rats. Specially PE 400 ㎎/㎏ showed significantly inhibitory effect, which was more potent than that of 100 ㎎/㎏ of commercial drug, cimetidine, and elevated an inhibitory effect to be close to the level in inhibitory ratio of omeprazol administered group in Shay's ucler. On gastric secretion in pylorus ligated rat, PE 200 ㎎/㎏ and 400 ㎎/㎏ decreased the gastric volume and acid output, but did not show an apparent effect on pepsin activity. In addition, PE 400 ㎎/㎏ depressed gastric ulcers induced by water immersion stress and duodenal ulcers induced by cysteamine administered subcutaneouly. These results suggest that the ethylacetate fraction of plantain can be used in prevention and treatment of experimentally induced gastric mucosal damage and ulcers.
인슐린 비의존형 당뇨병 환자에서의 당뇨병 유병기간에 의한 미세혈관 합병증 발생 시기의 추정
원영준(Young Jun Won),신영구(Young Goo Shin),심광용(Kwang Yong Shim),홍애라(Ae La Hong),송창호(Chang Ho Song),정춘희(Choon Hee Chung),서병기(Byeong Ki Seo) 대한내과학회 1996 대한내과학회지 Vol.51 No.4
Objectives: Microvascular complications in NID-DM patients have a positive correlation with the duration of diabetes. However, it is difficult to know about the duration of diabetic period before clinical diagnosis that the microvascular complications have been progressed, Harris et al previously presented in Diabetes Care that the patients with NIDDM had the prediagnostic period of 4-7 years before clinical diagnosis. We can find frequently the microvascular complications at the time of clinical diagnosis of diabetes, and thus assume that the microvascular complications have developed before the clinical diagnosis of diabetes. We estimate the periods, between the onset of diabetes and its clinical diagnosis in Korean diabetic patients. Methods - We studied 281 NIDDM patients who were admitted at Wonju Christian Hospital from January 1993 to July 1994. Weighted linear regression was performed to examine the relationship between the duration of diabetes and the prevalence of microvascular complications of diabetes. We can find the linear relationship between the two parameters (prevalence and duration of diabetes). By extraplotting at this linear relationship to the time when the prevalence of microvaseular complication was estimated to be zero, the time of onset of detectable complication was calculated. Results: 1) Prevalence of neuropathy at clinical diagnosis of diabetes was estimated to be 35.9%, and neuropathy has occurred 10.6 years before the clinical diagnosis of NIDDM. 2) Prevalencd of retinopathy at clinical diagnosis of diabetes was estimated to be 21.6%, and retinopathy has occurred 6.4 years before the clinical diagnosis of NIDDM. 3) In the cases of nephropathy, the correlation between the duration of diabetes and the prevalence was not statistically significant. Conclusion: In our study, the microvascular complications may develop several years before the clinical diagnosis of diabetes, and therefore, checkup for the microvascular complications is essential at the diagnosis of diabetes.
녹각교가 난소절제 흰쥐에서 골수기질 간세포의 증식 및 분화에 미치는 영향
원영준 ( Young Jun Won ),안혜은 ( Hye Eun Ahn ),문경호 ( Kyoung Ho Moon ),민병현 ( Byung Huyn Min ),황태숙 ( Tae Sook Hwang ),서창국 ( Chang Kook Suh ),박소라 ( So Ra Park ) 한국조직공학과 재생의학회 2004 조직공학과 재생의학 Vol.1 No.2
Herbal medicines have been claimed to have beneficial effects for the fracture healing and bone formation. Extracts of antler and old antler were known to have effects on the immune modulation, lowering of cholesterol, correction of anemia, detoxification of hepatic injuries, and the growth. However, beneficial effects on the bone metabolism were not determined. In order to investigate the effects of bone metabolism, extracts of old antler were used for in vivo and in vitro study. Eight rats (2-month-old female Sprague-Dawley rats) were placed on Chow diet and served as control (C), and eight rats were got Chow diet with old antler (C+OA) for 12 weeks. Eight rats were done ovariectomy for 4 weeks and had Chow diet (OVX), and another eight ovariectomized rats had Chow diet with old antler (OVX+OA). Sixteen rats were fed Chow diet with 0.4g/kg old antler daily. After 12 weeks, all experimental rats were sacrified for removing the bone marrow stromal stem cells. Bone marrow stromal stem cells rats were cultured and resuspend α-MEM containing 10 % heat inactivated fetal bovine serum (FBS) and antibiotics. Total colony forming unit-fibroblasts (CFU-Fs) and alkaline phosphate stained CFU-Fs cells were counted at 12 days after cell culture. In addition, mineralized nodule was also measured by light microscope at 21 days after cell culture. Total CFU-Fs colony counts were not significant difference among the study groups. Alkaline phosphatase positive colonies of ovariectomized rats with treating of extracts of old antler were significantly increase than those of ovariectomized with Chow diet. The amounts of mineralized nodule of OVX+OA group were significantly increase than those of OVX group. In conclusion, osteogenic differentiation of mesenchymal stem cells were enhanced after treated with extracts of old antler on ovariectomized rats.
대구 , 경북 지역 혈액투석 환자에서 C 형 간염의 유병율
신영호(Young Ho Shin),김양식(Yang Sik Kim),김호규(Ho Kyu Kim),최성대(Sung Dae Choi),신현수(Hyun Su Shin),원영준(Young Jun Won),이일세(Ill Sae Lee),강문규(Mun Kyu Kang),이정호(Jung Ho Lee),박성배(Sung Bae Park),김현철(Hyun Chul Kim) 대한내과학회 1998 대한내과학회지 Vol.54 No.5
To determine the prevalence and risk factor of anti-HCV in ESBD patients under chronic maitenance hemodialysis, the prevalence of serum antibodies to hepatitis C Virus (Anti-HCV) was assessed by an enzyme immunoassay (Abbott HCV EIA) in 253 patients with long-term Hemodialysis in Daegu & Kyoungbuk. 15 patients (5.9%) were anti-HCV positive. All dialysis patients had the history of transfusion. The number of transfusion units was not significant in anti-HCV positive patients (mean 17±20 pints) in comparison with the number in anti-HCV negative patients (mean 16±17 pints). The frequency of hemodialysis was also not significant in anti-HCV positive patients (mean 477±618 ) compared with anti-HCV negative patients (mean 462±616). The mean duration of hemodialysis was significantly higher (p<0.001) in the anti-HCV positive patients (74±42 months) in comparison with anti-HCV negative patients (45±41 months). We concluded that the prevalence of anti-HCV in hemodialysis patients is 5.9% and that HCV infection is significantly mlated with the duration of hemodialysis rather than the number of transfusion units and the frequency of hemodialysis
Al 5083-O재에 있어서 K<SUB>Ⅲ</SUB> 모드 4점 전단 하에서의 피로파단면 무늬와 피로균열진전거동의 관계
김건호(Gun-ho Kim),원영준(Young-jun Won),케이코 사카쿠라(Keigo Sakakura),타케히로 후지모토(Takehiro Fujimoto),토시히나 니시오카(Toshihisa Nishioka) 한국마린엔지니어링학회 2006 한국마린엔지니어링학회 학술대회 논문집 Vol.2006 No.-
Generally almost all fatigue crack growth is affected by mode I. For this reason a study on mode I has concentrated in the field of fracture mechanics. However the fatigue crack initiation and growth in machines and structures usually occur in mixed mode loading. If there is any relationship between the cause of fracture in mixed mode loading and fracture surface, fracture surface pattern will be the main mean explaining reasons of fatigue fracture and obtaining further information about fracture process. In this paper four point shear-fatigue test with Aluminum alloy Al 5083-O is carried out from this prospect and then the mixed mode distribution of fracture surface is examined from the result after identifying the generation of fatigue crack surface pattern. It was found from the experimental results that the fatigue crack surface pattern and the fatigue crack shear direction are remarkably consistent. Furthermore It is possible that the analysis of distribution of mixed mode through the fatigue crack surface pattern.
송창호(Chang Ho Song),원영준(Young Jun Won),류정선(Jeong Seon Ryu),신영구(Young Goo Shin),정춘희(Choon Hee Chung),최동훈(Dong Hoon Choi),송영득(Young Duk Song),남문석(Moon Suk Nam),이지현(Ji Hyun Lee),이은직(Eun Jig Lee),임승길(Sung 대한내과학회 1996 대한내과학회지 Vol.51 No.2
Objectives : With increasing the incidence and prevalence of elderly diabetics, there were many reports of elderly diabetics in Korea. But there were few reports of elderly diabetics who were diagnosed at old age. The aim of this study was to elucidate the clinical characteristics of elderly diabetics diagnosed after 60 years old. Methods: On the basis of age when they were diagnosed at first, elderly diabetics(N=105) were more than 60 years old and adult diabetics were 40-59 years old. Some characteristic symptoms, laboratory findings, associated diseases, complications and treatment modalities of elderly diabetics were compared with those of adult diabetics. Results: 1) The prevalences of characteristic symptoms such as polydipsia, polyphagia and polyuria in elderly diabetics were much higher than those of adult diabetics. 2) Hypertension, coronary artery disease, malignancy and gall stone were more frequently associated in elderly diabetics than those in adult diabetics, but fatty liver was more frequent in adult diabetics. 3) The prevalences of diabetic retinopathy and nephropathy in elderly diabetics were similar to those of adult diabetics, but the prevalence of diabetic neuropathy in elderly diabetics was lower than those in adult diabetics, 4) Treatment modalities of elderly diabetics were oral hypoglycemic agents, diet and exercise, and insulin in order at discharge from hospital, and the use of diet and exercise was more frequent in elderly diabetics than in adult diabetics. Conclusion: Some clinical characteristics of elderly diabetics were different from those of adult diabetics. We suggest that these findings should be considered at diagnosis and treatment of Elderly diabetics.