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원상현,신봉석,배경남,손진화,신기혁,김훈수,고현창,김문범,김병수 대한피부과학회 2023 Annals of Dermatology Vol.35 No.1
Background: Psoriasis localized to certain body areas, such as the scalp, nails, palms, soles,intertriginous regions, and genital regions, is reportedly difficult to treat. Objective: To investigate the biologics-resistant areas in South Korean patients with psoriasistreated with biologics. Methods: The study included 50 patients with chronic moderate to severe plaque psoriasisfrom the Pusan National University Hospital and Chosun University Hospital between October2019 and September 2020. The patients had at least one psoriatic lesion, were treatedwith biologics for more than six months, and exhibited a partial or good response (reachinga Psoriasis Area and Severity Index [PASI] score of 1~5 after biologics treatment). Results: A total of 50 patients with psoriasis (32 male, mean±standard deviation 47.8±11years), with a median PASI score of 1.8, were included. The most common biologics-resistantareas were the anterior lower leg (56.0%), followed by the knee (48.0%) and posteriorlower leg (42.0%). The proportion of biologics-resistant areas were obtained for body regionstraditionally considered as difficult-to-treat entities, including the fingernails (10.0%), toenails(14.0%), scalp (38.0%), palm (12.0%), sole (14.0%), and genital areas (10.0%). Conclusion: This study determined the biologics-resistant areas in South Korean patients,successfully treated with biologics, in a real-world clinical setting.
BCG 예방 접종 후 발생한 특이 피부 이상반응에 대한 임상 연구
원상현 ( Sang-hyeon Won ),신기혁 ( Kihyuk Shin ),김우일 ( Woo-il Kim ),양민영 ( Min-young Yang ),이원구 ( Won-ku Lee ),김훈수 ( Hoon-soo Kim ),김병수 ( Byung-soo Kim ),김문범 ( Moon-bum Kim ),고현창 ( Hyun-chang Ko ) 대한피부과학회 2020 대한피부과학회지 Vol.58 No.7
Background: Bacille Calmette-Guérin (BCG) vaccination has been widely used to prevent severe infections caused by Mycobacterium tuberculosis. Although BCG vaccination is generally safe, some cutaneous complications may occur. However, cutaneous complications related to BCG infection have been rarely investigated in Korea. Objective: This study aimed to investigate the clinical characteristics of cutaneous complications following BCG vaccination in Korean patients. Methods: We identified 18 patients with cutaneous complications following BCG vaccination in the Pusan National University Hospitals (Busan and Yangsan) from 2002 to 2019. Clinical manifestations and course were examined by the review of medical records and photographs. Results: Among BCG-vaccinated persons, 18 patients manifested with BCG-specific cutaneous complications. The mean age of the patients was 10.6±10.1 months, and 10 (55.6%) were female. The specific cutaneous complications following BCG vaccination were local abscess (7, 38.9%), lymphadenitis (4, 22.2%), BCG reactivation in incomplete Kawasaki disease (4, 22.2%), tuberculid (3, 16.7%), and scrofuloderma (1, 5.6%). Disseminated BCG infection was detected in 2 brothers (11.1%) who had an immunocompromised state and a family history of BCG complication. Conclusion: Specific cutaneous complications after BCG vaccination are rare, but may occur in various manifestations. (Korean J Dermatol 2020;58(7):453∼458)
혼합결합조직질환에서 발생한 ‘소금후추가루양상 (Salt and Pepper Appearance)’의 피부색소변화 1예
원상현 ( Sang-hyeon Won ),신기혁 ( Kihyuk Shin ),김우일 ( Woo-il Kim ),양민영 ( Min-young Yang ),이원구 ( Won-ku Lee ),김훈수 ( Hoon-soo Kim ),고현창 ( Hyun-chang Ko ),김병수 ( Byung-soo Kim ),김문범 ( Moon-bum Kim ) 대한피부과학회 2020 大韓皮膚科學會誌 Vol.58 No.6
The salt and pepper appearance of the skin is composed of salt (vitiligo-like depigmentation) and pepper (perifollicular pigmentation). Mixed connective tissue disease (MCTD) is a distinct disease entity with mixed features of systemic lupus erythematosus, systemic sclerosis, myositis, and rheumatoid arthritis with high titers of antibodies to U1 ribonucleoprotein (U1RNP). There are a few reports of pigmentary changes in MCTD. A 51-year-old woman presented with variably sized hypopigmented macules along with relative hyperpigmentation of the perifollicular areas on the face and neck; she was diagnosed with MCTD in a rheumatology clinic. Histopathology revealed dermal sclerosis in both hypo- and hyperpigmented areas, loss of melanocyte and pigment only in the hypopigmented area, and normal number of melanocyte and pigment in the hyperpigmented area. To the best of our knowledge, ‘salt and pepper appearance of the skin’ has rarely been reported in MCTD. (Korean J Dermatol 2020;58(6):423∼426)
중등증 및 중증의 한국인 건선 환자에서 Ixekizumab의 효과와 안전성에 관한 연구
원상현 ( Sang-hyeon Won ),신기혁 ( Kihyuk Shin ),김훈수 ( Hoon-soo Kim ),고현창 ( Hyun-chang Ko ),김문범 ( Moon-bum Kim ),김병수 ( Byung-soo Kim ) 대한피부과학회 2020 대한피부과학회지 Vol.58 No.6
Background: Ixekizumab is a humanized IgG4 monoclonal antibody that selectively binds to the IL-17A cytokine and inhibits its interaction with the IL-17 receptor. It has emerged as an effective treatment for moderate to severe psoriasis. However, to date, there are no real-world data for the use of ixekizumab in the treatment of psoriasis in Korean patients. Objective: To evaluate the effectiveness and safety of ixekizumab in the treatment of moderate to severe psoriasis in Korean patients. Methods: This was a retrospective single-center study. Thirty psoriasis patients who were treated with ixekizumab were analyzed. All patients’ medical records, Psoriasis Area and Severity Index (PASI) score, body surface area (BSA), Physicians’ Global Assessment (PGA), and adverse events were investigated. Results: A significant reduction in mean (±standard deviation) baseline PASI score (14.1±2.6) was detected at 4 weeks of ixekizumab therapy (3.8±2.7, p<0.001), with a further improvement at weeks 12 and 24 (0.9±0.7 and 0.5±0.5, respectively) (p<0.001). Our analysis showed that 100%, 87.5%, and 50% of patients achieved PASI 75, 90, and 100 responses, respectively, after 48 weeks of therapy. However, nine patients (30%) experienced a mild adverse event such as injection site reaction, urticaria, upper respiratory tract infection, and stomatitis. No serious adverse events were observed. Conclusion: This study provides evidence for the use of ixekizumab in real-world clinical practice and confirm that it is effective and safe in treating Korean patients with moderate to severe psoriasis. (Korean J Dermatol 2020;58(6):389∼396)
신기혁,원상현,박찬규,김건욱,김훈수,고현창,김문범,김병수 대한피부과학회 2022 大韓皮膚科學會誌 Vol.60 No.4
Background: Ultrasonography (US) is a simple and reliable tool that can aid in the diagnosis of benign subcutaneous lesions such as epidermal cysts and lipomas. Objective: This study aimed to determine the efficacy of US for the differential diagnosis of epidermal cysts and lipomas. Methods: A retrospective study of 100 patients with epidermal cysts (n=45) or lipomas (n=55) who underwent US and then received a pathological diagnosis in the dermatology department of Pusan National University Hospital was conducted. Results: US and clinical impressions accurately diagnosed the epidermal cysts in 90.0% and 88.0% of the patients, respectively, and the lipomas in 92.0% and 88.0% of the patients, respectively. US combined with clinical impression significantly increased the diagnostic yield of epidermal cysts (98%) and lipomas (99%). On US, the frequency of posterior acoustic enhancement was higher for the epidermal cysts than for the lipomas (82.2% and 29.1%, respectively; p<0.001), and striated echoes such as internal linear echogenic reflections and dark clefts were more frequently found in the lipomas than in the epidermal cysts (90.9% and 6.7%, respectively; p<0.001). Conclusion: This study implies that the diagnostic role of US can be greatly enhanced by knowledge of the clinical presentation
Schottky Barrier Gate Charge Coupled Device의 전위와 전계 분포에 관한 2차원 해석
송영섭,원상현,정관수 慶熙大學校 材料科學技術硏究所 1997 材料科學技術硏究論集 Vol.10 No.-
Two dimensional analysis for the potential and electric field distribution of Schottky barrier gate charge coupled device has been carried out by nonlinear over relaxation method for various channel thickness, plate length, doping concentration and gap size. More exact results are obtained by the two dimensional analysis which considers plate gap effect and other plate influence ignored in one dimensional analysis. As compared with SCCD and BCCD, the SBG-CCD is found to have advantages of providing a higher charge handling capacity and a higher efficiency. The maximum potential is found to be considerable sensitive to the doping concentration, gate length, channel thickness and gate voltage. It is also found that the fringing field and gap barrier were influenced by gate length, channel thickness and gate voltage.
FGFR3 유전자(p.Lys650Thr) 변이로 인해 나타난 연골저형성증이 동반된 흑색가시세포증 1예
김태림,김연아,원상현,배경남,이정수,신기혁,김훈수,고현창,김병수,김문범 대한피부과학회 2023 대한피부과학회지 Vol.61 No.5
Acanthosis nigricans (AN) is characterized by velvety hyperpigmented plaques, usually observed in skin folds. The different types of the condition include obesity-associated, syndromic, drug-induced, malignancy-related, and other types of AN. AN, an FGFR3 gene mutation-related disease, is associated with varying degrees of skeletal disorders. FGFR3 gene mutations are known to cause excessive inhibition of chondrocyte growth and keratinocyte proliferation, which is responsible for AN development. To our knowledge, only a small number of cases of AN with hypochondroplasia due to FGFR3 gene mutation (p.Lys650Thr) have been described in the literature. However, there are no reports of genetically confirmed AN with hypochondroplasia in Korea. Physicians should consider syndromic AN when symptoms develop at an early age or when associated skeletal anomalies are present.