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김영호,황방연,김세은,김환묵,오구택,노재섭,이경순,이정준,Km, Young-Ho,Hwang, Bang-Yeon,Kim, Se-Eun,Kim, Hwan-Mook,Oh, Goo-Taeg,Ro, Jai-Seup,Lee, Kyong-Soon,Lee, Jung-Joon 대한약학회 1994 약학회지 Vol.38 No.1
The MeOH extract of the fruits of Melia toosendan was selected for futher study by its cytotoxicity and effect on the human breast cancer cell line, MCF-7. The active principle obtained by activity guided fractionation followed by purification gave rise to a needle crystal. The structure was deduced by employing NMR and was determined to be identical with 28-deacetyl sendanin by comparison with published data. This compound induced morphological change of MCF-7 to be rounded with tubule at concentrations between $50\;{\mu}g/ml$ and $0.025\;{\mu}g/ml$. This compound, however, showed strong cytotoxic effect on Hepalclc7 and HepG2, and their $GI_{50}$ on the hepatoma cell lines were $0.238\;{\mu}g/ml$ and $0.805\;{\mu}g/ml$, respectively. Its effect on lymphocyte of mouse was stronger than hepatoma cell lines, and their $ED_{50}$ of polyclonal antibody response was $0.011\;{\mu}g/ml$, and $ED_{50}$ of cell viability was $0.039\;{\mu}g/ml$.
생체내 이식된 배아줄기세포 유래 세포의 추적을 위한 형광표지 배아줄기세포주의 수립
김은경 ( Eun Kyoung Kim ),이형희 ( Hyung Hee Lee ),오구택 ( Goo Taeg Oh ),윤미정 ( Mi Chung Yoon ),이영희 ( Young Hee Lee ),김형진 ( Hyoung Chin Kim ),최양규 ( Yang Kyu Choi ),이철호 ( Chul Ho Lee ),남기환 ( Ki Hoan Nam ) 한국조직공학과 재생의학회 2004 조직공학과 재생의학 Vol.1 No.2
It is important to chase the cells injected into animal body for evaluation of cell therapy. We established EGFP labeled mouse embryonic stem cells that could be easily detected by their fluorescence expression in frozen tissue sections. The established embryonic stem cells expressed EGFP even after differentiated into various types of cells. They also could form EGFP expressing teratomas when they were injected into NOD-scid mice or nude mice. When these cells were injected into peripheral blood of ICR mice, the cells disappeared within 30 sec from the peripheral blood. The injected cells were found mainly in the lung when injected through tail vain. However, they were evenly distributed onto organs when injected into the left ventricle. These cells could be detected by fluorescence microscopy, flow cytometric analysis or confocal microscopy without any treatment on the cells. Accordingly, the embryonic stem cells labeled with EGFP might be very useful in analyzing cells derived from embryonic stem cells in mixed cell culture in vitro, and also very helpful in analyzing transplanted cells derived from differentiated embryonic stem cells.
Peptidomimetic Small-Molecule Compounds Promoting Cardiogenesis of Stem Cells
오세웅,김대용,Jung Bok Lee,Bora Kim,Se-Jin Jeong,Min-Kyoung Kim,남기환,Jong-Ryul Ha,오구택,Goo Taeg Oh 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.11
Embryonic stem (ES) cells may be used as an alternative source of functionally intact cardiomyocytes for ischemic heart disease. Several natural and synthetic small molecules have been identified as useful tools for controlling and manipulating stem cell renewal and differentiation. Currently, there is an urgent requirement for novel small molecules that specifically induce differentiation of stem cells into cardiomyocytes. To identify compounds that promote cardiomyogenesis of stem cells, cell-based screening of a peptidomimetic small-molecule library was carried out. A series of β-turn peptidomimetic compounds, including CW209E, increased the expression of α-MHC promoter-driven enhanced green fluorescent protein (EGFP) and ratio of beating embryoid bodies (EBs) without inducing cytotoxicity in mouse embryonic stem cells. CW209E also increased the number of beating EBs in human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs). Thus, this chemical compound should be useful for elucidation of the molecular pathway of cardiogenesis and generation of cardiomyocytes ex vivo, which can be further applied for experimental or clinical cell therapy for ischemic heart diseases.