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애엽추출물 , DA-9601 의 실험적 위궤양 모델에 대한 항궤양 효과 및 기전 연구
양중익(Junn Ick Yang),이상득(Sang Deuk Lee),이은방(Eun Bang Lee),오태영(Tae Young Oh),류병권(Byung Kweon Ryu),박정배(Jeong Bae Park) 한국응용약물학회 1996 Biomolecules & Therapeutics(구 응용약물학회지) Vol.4 No.2
Antiulcer effects of Artemisia herbs extract (DA-9601) were evaluated in various types of experimental gastric ulcer induced in rats. And the effects of DA-9601 on mucus, basal and stimulated gastric acid secretion were also investigated in rats. DA-9601 (12.5∼400 ㎎/㎏, p.o.) prevented the formation of gastric ulcers induced by 60% EtOH in 150 mM HCl, restraint water immersion stress, platelet activating factor (PAF), aspirin in 150 mM HCl with Pylorus-ligation and indomethacin. DA-9601 (4∼400 ㎎/㎏, p.o.) significantly accelerated the healing rate of acetic acid-induced gastric ulcer and significantly stimulated mucus secretion in a dose-dependent manner. DA-9601 (20∼200 ㎎/㎏, i.d.), however, did not inhibit basal gastric acid secretion in pylorus ligated rats and DA-9601 (200 ㎎/㎏, i.d.) failed to influence histamine-, pentagastrin- and carbachol- stimulated gastric acid secretion. These results suggest that DA-9601 has inhibitory action on gastric lesion and ulceration through increasing mucus secretion in the stomach of rats without influencing basal and stimulated gastric acid secretion.
고상 Agarose - anti - HBs 결합체를 이용한 B형 간염 표면항원 진단시약
김학주,양중익,민신홍,변시명 ( Hack Joo Kim,Jung Ick Yang,Shin Hong Min,Si Myung Byun ) 생화학분자생물학회 1989 BMB Reports Vol.22 No.1
A new format for agarose solid-phase enzyme immunosassay (ASEIA) has been developed in which a monoclonal antibody-coupled agarose, packed into a 1-ml disposable plastic syringe, regulates the sample and the enzyme reaction. The assay can be completed in less time at room temperature and in a simpler maner by use of this single-syringe system. The sensitivity of the technique is equivalent to a commercially available enzyme immunoassav kit and was able to detect 1 ㎍/L of hepatitis B surface antigen in this study.
A New Format for Agarose Solid-Phase Enzyme Immunoassay
김학주,양중익,민신홍,변시명,Kim, Hack-Joo,Yang, Jung-Ick,Min, Shin-Hong,Byun, Si-Myung 생화학분자생물학회 1989 한국생화학회지 Vol.22 No.1
B형 간염 표면항원의 모노크로날 항체를 CNBr로 활성화시킨 agarose에 결합시켜 만든 고상 agarose-anti-HBs를 사용하여 측정하고자 하는 시료, 효소결합체, 효소반응을 1회용 플라스틱 주사기에서 이루어지도록 하는 진단방법을 연구하였다. 이 방법으로 실온에서 3시간 이내에 간단한 조작으로 측정이 완료될 수 있었으며 민감도는 기존의 상품화 되어 있는 진단시약과 동일수준을 보여주었고 B형 간염 표면항원 1 ng/ml의 농도를 측정할 수 있었다. A new format for agarose solid-phase enzyme immunosassay (ASEIA) has been developed in which a monoclonal antibody-coupled agarose, packed into a 1-ml disposable plastic syringe, regulates the sample and the enzyme reaction. The assay can be completed in less time at room temperature and in a simpler maner by use of this single-syringe system. The sensitivity of the technique is equivalent to a commercially available enzyme immunoassay kit and was able to detect $1{\mu}g/L$ of hepatitis B surface antigen in this study.
약-약 상호작용 연구(IV) Warfarin의 혈장단백 결합에 대한 Niflumic Acid 및 Phenylbutazone의 영향 비교
조윤성,양중익 대한약학회 1980 약학회지 Vol.24 No.2
To determine in vitro effects of phenylbutazone and niflumic acid on warfarin binding to rabbit serum protein, warfarin was added to the rabbit plasma, and the bound fraction was determined by warfarin-protein complex fluorescence. The bound fraction was decreased by phenylbtazone and niflumic acid. From this effect niflumic acid was found to have the more potent ability to displace warfarin from protein binding sites than phenylbutazone.
Cephalexin Prodrug 연구(I) - Cephalexin Phthalidyl Ester의 Prodrug으로서의 유용성
조윤성,추연성,양중익 대한약학회 1980 약학회지 Vol.24 No.1
In order to increase the gastro-intestinal absorption of cephalexin, a new cephalexin phthalidyl ester was synthetized. Comparative studies of cephalexin phthalidyl ester in the gastro-intestinal absorption were conducted after oral administration in rabbits. The amounts of cephalexin in plasma were determined by a fluorometric method. Cephalexin phthalexin phthalidyl ester could not be identified in plasma, but only cephalexin was found by TLC method. In comparison with cephalexin, cephalexin phthalidyl ester produced much higher plasma levels of cephalexin than did cephalexin itself after its oral administration in rabbits.