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Filter aid 류에 의한 약제의 흡수에 관한 연구
민신홍,김용배,현영우,이상희 한국약제학회 1973 Journal of Pharmaceutical Investigation Vol.3 No.4
緩衝液에서의 caffeine, niacinamide, pyridoxine hydrochloride, thiamine hydrochloride의 濾過助劑에 依한 吸着현상을 比較檢討하였다. 實驗에 使用한 vitamin類의 吸着은 Langmvir 吸着式의 pattern에 따랐으며 caffeine은 거의 吸着되지 않았다. 濾過助劑中 Dawsonite는 Celite 545 보다 큰 吸着현상을 나타냈으며 pH 變化에 따른 影響은 niacinamide가 가장 예민하였고 pH의 增加는 吸着量을 현저히 감소시켰다.
민신홍,권종원,양중익,차봉진,정비환 한국약제학회 1988 Journal of Pharmaceutical Investigation Vol.18 No.1
Physical properties of oral adhesive tablets prepared with four kinds of gums for topical or systemic drug delivery were investigated. Oral adhesive tablets containing 5㎎ of brilliant blue (BB) were prepared from direct compression. Viscosity of 2% gum solutions, water absorption, fracture resistance, stickiness of tablets, and dissolution of BB in pH 6.8 dissolution medium were tested. Acacia showed good stickiness and fracture resistance, and tragacanth showed good retarding effect on the release of BB from tablets. Therefore, tablets with varing ratios of acacia and tragacanth were prepared and their physical properties were examined. In conclusion, it was possible to obtain some adequate properties by compounding acacia and tragacanth.
민신홍 한국미생물학회 1990 微生物과 産業 Vol.16 No.2
이글은 (주)동아제약 연구소의 간단한 연혁과 조직, 연구활동, 현재 진행중인 연구 과제와 앞으로의 연구소 활동 방향에 대해 적고 있다.
Acrylic - methacrylic Ester 공중합체 필름의 약물 지속방출효과에 관한 연구
민신홍,김용배,이상희,김근혁,권종원 한국약제학회 1980 Journal of Pharmaceutical Investigation Vol.10 No.2
Spherical granules obtained by extrusion-spheronization processing were used to prepare sustained release spherical granules by pan coating method. Acrylic-methacrylic ester copolymer and mixtures of ethylcellulose, cellulose acetate phthalate and hydroxypropylmethylcellulose were utilized for prolongation of drug release from spherical granules containing acetaminophen as a model drug. In vitro release rate of sustained release spherical granules was investigated by varying the quantity of release retardants applied. Dissolution studies revealed that sustained release spherical granules coated with acrylic-methacrylic ester copolymer showed more protracted release than those granules coated with ethylcellulose mixtures.
민신홍,이상희,이강춘,김용배 한국약제학회 1975 Journal of Pharmaceutical Investigation Vol.5 No.1
Extrusion-Spheronization Processing (ESP) was applied to preparate sustained release spherical particles as a form of matrix spherical particle (MSP). dl-methylephedrine HCI (ME) was the drug chosen and several dissolution retardants and binders were selected to estimate a relatively good formulation on this purpose. The effect of physicochemical nature, concentration, and solvents of these dissolution retardants and binders on regularity in shape of MSP and in vitro release rate was investigated. The effect of particle size of matrix particles was also evaluated. It is, therefore, concluded that this ESP would be a relatively good preparation method of sustained release MSP of ME which has the sustained action of about 5 and 8 hours by formulating of ethylcellulose and ethylcellulose-paraffin as a dissolution retardant, respectively, and then ethylcellulose solution of 80% EtOH is recommended as a binder.
민신홍,김용배,이병국,신현종 한국약제학회 1976 Journal of Pharmaceutical Investigation Vol.6 No.2
Tablet product design problem was structured as constrained optimization problem and subsequently solved by multiple regression analysis and Lagrangian method of optimization. We used Lagrangian method for the purpose of finding the reason of the previous results. Biodiastase and cellulase were the enzymes, chosen, Avicel^ⓡ and corn starch or calcium carboxy methyl cellulose were the binder and disintegrant, respectively. The effect of the dry binder and disintegrant concentration on tablet hardness, friability, volume, disintegration time was recorded. Optimization of this parameter was studied by using the constrained optimization method. In addition to finding a optimal condition of the enzyme tablets, the application of sensitivity analysis studies to such problems was also illustrated. In order to get a stable preparations of the enzyme tablets, accelerated test of coating tablets was carried out in this study. the results are as follows. 1) The minimum disintegration time, such that the average tablet volume did not exceed 0.0154 cubic inch and the average friability value did not exceed 0.62%, was 6.6 minutes and then Avicel^ⓡ and corn starch were 15.4% and 17.2%, respectively. 2) The multiple-correlation coefficients for the regression models of tablet hardness, friability, disintegration time and volume were with in the 95% confidence range. 3) According to the test results, calcium carboxymethyl cellulose can be used as a disintegrant instead of corn starch.
Polyethylene 과 Glycol - modified Polyethylene Terephthalate 용기내에서의 Chlorobutanol 용액의 안정성
민신홍,권종원,정구충 한국약제학회 1986 Journal of Pharmaceutical Investigation Vol.16 No.1
There have been many difficulties in utilization of polyethylene (PE) container for volatile ingredients because of its high permeability. We selected glycol-modified polyethylene terephthalate (PETG) lately being used and evaluated the stability of 0.5% chlorobutanol solution for PETG. We used PE bottle, glass flask and rubber stoppered vial for comparison and assayed chlorobutanol contents of the samples stored at various temperatures for nine weeks by HPLC method. The results indicated that the stability of chlorobutanol in PETG container was almost similar to that in glass flask, and was superior to that in PE bottle and rubber stoppered vial.